Development of Diagnostic and Treatment Strategy for Resistant Hypertension
Keywords
Abstract
Description
This study will enroll hypertensive patients who are in treatment or those who are referred from primary clinic based on inclusion or exclusion criteria. Basic clinical information, compliance with antihypertensive medications, concomitant use of other medications will be investigated and all patients will perform 24-hr ambulatory blood pressure measurement. Screening for renal artery stenosis and primary aldosteronism will be conducted. Office blood pressure will be taken every 3-6 months. Home blood pressure measurement and 24-hr ambulatory blood pressure measurement will be performed every year. The primary outcome is the newly developed MACE during the follow-up period. The secondary outcomes are newly developed target organ damage (LVH confirmed by echocardiography or EKG, carotid femoral PWV≥ 12m/s, microalbuminuria (Urine albumin-creatinine ratio ≥30 mg/g)) and decline of renal function (doubling of serum creatinine, dialysis). The follow-up period is 3 years.
Dates
| Last Verified: | 04/30/2018 |
| First Submitted: | 05/02/2018 |
| Estimated Enrollment Submitted: | 05/27/2018 |
| First Posted: | 05/29/2018 |
| Last Update Submitted: | 05/27/2018 |
| Last Update Posted: | 05/29/2018 |
| Actual Study Start Date: | 02/13/2018 |
| Estimated Primary Completion Date: | 02/27/2023 |
| Estimated Study Completion Date: | 02/27/2023 |
Condition or disease
Phase
Eligibility Criteria
| Ages Eligible for Study | 20 Years To 20 Years |
| Sexes Eligible for Study | All |
| Sampling method | Non-Probability Sample |
| Accepts Healthy Volunteers | Yes |
| Criteria | Inclusion Criteria: 1. 20 years and older 2. Office SBP>130 mmHg or office DBP >90 mmHg with 3 antihypertensive medications of different classes 3. Treated hypertensive patients with 4 antihypertensive medications of difference classes including diuretics Exclusion Criteria: 1. desired life time under 6 months due to non-cardiovascular disease (e.g. cancer, sepsis) 2. women with pregnancy or on nursing 3. within the first three months after transplantation 4. acute renal allograft rejection 5. within six months after discharge from hospitalization for acute coronary syndrome (myocardial infarction, unstable angina) or acute stroke 6. systolic heart failure (LVEF ≤40%) |
Outcome
Primary Outcome Measures
1. Major adverse cardiac events [3 years]
Secondary Outcome Measures
1. Progression of CKD [3 years]
2. Target organ damages [3 years]
3. Target blood pressure achievement [3 years]
