Diagnosis of Ascites in Infants and Children
Keywords
Abstract
Description
Definition : Ascites is the pathologic fluid accumulation within the peritoneal cavity .
causes of ascites in infants and children :
- Hepatobiliary disorders (cirrhosis, congenital hepatic fibrosis, acute hepatitis B,C ,Budd -chiari syndrome, Bile duct perforation)
- Serositis (crohn's disease, eosinophilic enteropathy , Henoch- Shonlein purpura )
- Neoplasm (lymphoma, wilm's tumor ,Glioma, Germ cell tumor, Ovarian tumor,mesothelioma, Neroblastoma )
- Cardiac (Heart failure )
- Metabolic disease
- Gastrointestinal disorder (Nephrotic syndrome, peritoneal dialysis ). Diagnosis of ascites :History of abdominal distention, increasing weight, respiratory embarrassement, jaundice, bleeding (haematemsis, melena, and epistaxis ),Pruritus ,Growth failure ,abdominal pain, fever,Cyanosis, ,dyspnea during suckling, Orthopnea, Buffy eyes, lower limb swelling, Haematrruria .
By examination : Tachycardia ,Tachypnea ,Hypertension ,cyanosis, jaundice, clubbing of fingers ,limb edema ,Hepatomegaly, splenomegaly, dilated abdominal wall veins.
Investigations :
Laboratory tests :complete blood count , complete urine examination, liver function tests, plasma proteins, renal function tests, clotting screen, tuberculin test.
Imaging studies :chest and abdominal plain films, abdominal ultrasound, upper gastrointestinal endoscopy CT, MR I, Abdominal paracentesis for ascitic fluid analysis :cell count / cytology ,Gram 'stain and culture, Total proteins (albumin /globulin ratio ), Glucose, Amylase, lactase dehydrogenase, Triglycerides,Bilirubin.
Serum ascites albumin gradient (SAAG )is the best single test for classification of ascites into portal hypertensive (SAAG >1.1g/dl) and non-portal hypertensive (SAAG <1.1g/dl) causes.
Dates
| Last Verified: | 09/30/2017 |
| First Submitted: | 10/27/2017 |
| Estimated Enrollment Submitted: | 11/09/2017 |
| First Posted: | 11/13/2017 |
| Last Update Submitted: | 11/09/2017 |
| Last Update Posted: | 11/13/2017 |
| Actual Study Start Date: | 11/30/2017 |
| Estimated Primary Completion Date: | 10/31/2018 |
| Estimated Study Completion Date: | 10/31/2018 |
Condition or disease
Phase
Arm Groups
| Arm | Intervention/treatment |
|---|---|
| One group Diagnosis of ascites in infants and children by history, examination and investigations |
Eligibility Criteria
| Ages Eligible for Study | 1 Month To 1 Month |
| Sexes Eligible for Study | All |
| Sampling method | Non-Probability Sample |
| Accepts Healthy Volunteers | Yes |
| Criteria | Inclusion Criteria: - age from 1month to 18 year - infants and children with ascites (hepatic, cardiac, renal, malignant or tuberculous ) - infants and children with peritonitis Exclusion Criteria: - age <1month - surgical conditions as ruptured viscous or located abscess |
Outcome
Primary Outcome Measures
1. Diagnosis of ascites in infants and children with hepatic, cardiac, renal disease, tuberculosis and malignancy [1 year]
