Diagnosis of Cervical Lesions in Women With Unhealthy Looking Cervix
Only registered users can translate articles
Log In/Sign up
The link is saved to the clipboard
Status
Sponsors
Assiut University
CLINICAL TRIAL: NCT03150745
BioSeek: NCT03150745
Keywords
Abstract
Endocervix (cervical canal) is the cavity of the cervix and connects the external os with the internal os. It is fusiform in shape and has posterior and anterior oblique longitudinal ridges, the plicae palmatae. These are not exactly apposed but inter-lock like a zipper so that the canal is kept closed.
The original squamous epithelium is clearly identified as a smooth, usually featureless covering of the cervix; its uniform pink color contrasts with the redness of the original columnar epithelium. It joins the latter at the original squamocolumnar junction.
Many clinicians encounter cervical lesions that may or may not be associated with cytologic abnormalities. Such abnormalities as ectropion, Nabothian cysts, and small cervical polyps are quite benign and need not generate concern for patient or clinician, whereas others, including those associated with a history of exposure to diethylstilbestrol, cervical inflammation, abnormal cervical cytology, and postcoital bleeding, should prompt additional evaluation. Further, in some patients, the cervix may be difficult to visualize. Several useful clinical suggestions for the optimal examination of the cervix are presented.
Dates
| Last Verified: | 04/30/2017 |
| First Submitted: | 05/08/2017 |
| Estimated Enrollment Submitted: | 05/09/2017 |
| First Posted: | 05/11/2017 |
| Last Update Submitted: | 05/12/2017 |
| Last Update Posted: | 05/15/2017 |
| Actual Study Start Date: | 04/30/2016 |
| Estimated Primary Completion Date: | 05/31/2017 |
| Estimated Study Completion Date: | 06/30/2017 |
Condition or disease
Cervical Dysplasia
Intervention/treatment
Procedure: 3- Cervical Pap smears
Procedure: Colposcopic group
Procedure: office hysteroscopic group
Phase
-
Arm Groups
| Arm | Intervention/treatment |
|---|---|
| Other: Colposcopic group | Procedure: Colposcopic group 0.9% saline technique to assess the cervical lesion and vasculature of the cervix, 5% acetic acid technique to determine acetowhite-positive areas. Schiller's iodine technique to visualize high glycogen containing cells. Endocervical canal assessment using (Bossman forceps or endocervical speculum or counter pressure with Q stick).
e- Biopsy using the punch biopsy forceps. Biopsy will be obtained from every abnormal colposcopic examination |
| Other: office hysteroscopic group | Procedure: office hysteroscopic group 0.9% saline technique to assess the cervical lesion and vasculature of the cervix. 5% acetic acid technique to determine acetowhite-positive areas. Schiller's iodine technique to visualize high glycogen containing cells. Endocervical canal assessment. Endometrial cavity evaluation whenever possible. Biopsy. Biopsy will be obtained from every abnormal hysteroscopic examination. |
Eligibility Criteria
| Ages Eligible for Study | 20 Years To 20 Years |
| Sexes Eligible for Study | Female |
| Accepts Healthy Volunteers | Yes |
| Criteria | Inclusion Criteria: 1. Suspicious cervix 2. Age between 20 to 60 years Exclusion Criteria: 1. Previously diagnosed cervical lesions. 2. Pregnant women. |
Outcome
Primary Outcome Measures
1. The sensitivity of office hysteroscopy detection of cervical lesions [1 week]
2. The sensitivity of colposcopy [1 week]
