IDH in Diabetic Haemodialysis Patients and Association With Dialytic Age
Keywords
Abstract
Description
Intradialytic hypotension (IDH ) is a serious and the most frequent complication of hemodialysis of the hemodialysis.Intradialytic hypotension is a decrease in systolic BP by ≥20 mm Hg or a decrease in mean arterial pressure of 10 mm Hg associated with symptoms like cramps, dizziness, headache ,nausea and vomiting according to The National Kidney Foundation.Intradialytic hypotension occurs during 20%-30% of hemodialysis sessions. It is associated with poor long-term outcomes. Patients with Intradialytic hypotension show increased morbidity and mortality.The etiology of Intradialytic hypotension is multifactorial and depends on patient-related factors, as well as on complications related to the dialysis procedure. The main causes Intradialytic hypotension have been reported to be acute hypovolemia during ultrafiltration and inadequate compensatory mechanisms such as left ventricular dysfunction, inappropriate plasma refilling ,Impaired vasoconstriction induced by dysregulation of autonomic nervous system.
Diabetes mellitus is the most common cause of chronic renal failure .Diabetic patients are more prone to cardiovascular diseases than non-diabetics .Although diabetes is in relation with hypertension ,It is associated with autonomic neuropathy which contribute to intradialytic hypotension . Recent researches suggested that older age and long dialytic age may incease risk of intradialytic hypotension.
Dates
Last Verified: | 02/28/2019 |
First Submitted: | 03/04/2019 |
Estimated Enrollment Submitted: | 03/07/2019 |
First Posted: | 03/11/2019 |
Last Update Submitted: | 03/07/2019 |
Last Update Posted: | 03/11/2019 |
Actual Study Start Date: | 03/31/2019 |
Estimated Primary Completion Date: | 05/31/2019 |
Estimated Study Completion Date: | 06/30/2019 |
Condition or disease
Intervention/treatment
Diagnostic Test: glycated hemoglobin
Phase
Arm Groups
Arm | Intervention/treatment |
---|---|
diabetic patients suffer from diabetes mellitus | |
non diabetic patients free from diabetes with normal blood glucose level |
Eligibility Criteria
Ages Eligible for Study | 18 Years To 18 Years |
Sexes Eligible for Study | All |
Sampling method | Non-Probability Sample |
Accepts Healthy Volunteers | Yes |
Criteria | Inclusion Criteria: All haemodialysed end stage kidney disease patients of the haemodialysis unit in Assiut health insurance hospital Exclusion Criteria: - 1-Advanced heart failure 2-Clinical instability requiring hospital admission. 3-History of alcohol or substance abuse 4-previous history of psychotic disorders |
Outcome
Primary Outcome Measures
1. the correlation between diabetes and intradialytic hypotension [4 weeks]
2. the correlation between dialytic age and intradialytic hypotension [4 weeks]