Impact of Dexmedetomidine on Acute Kidney Injury Following Living Donor Liver Transplantation
Keywords
Abstract
Description
Acute kidney injury (AKI) following liver transplantation (LT) has shown a wide range of between 17% and 95% and is associated with increased costs, morbidity, and mortality. The etiology of AKI after LT is multifactorial. Among these factors, renal ischemia-reperfusion injury (IRI) caused by perioperative renal hypoperfusion is considered as one of the most important independent risk factors and recent reports have indicated that IRI is associated with an inflammatory cascade. Dexmedetomidine which is a highly selective agonist of α2-adrenergic receptors has known have anti-inflammatory effect and has been shown to ameliorate IRI in several organs. However, the impact of Dexmedetomidine on AKI after LT is not determined yet. Therefore, this study aims to observe the renal protective effects of Dexmedetomidine after LT.
Dates
| Last Verified: | 06/30/2019 |
| First Submitted: | 04/30/2018 |
| Estimated Enrollment Submitted: | 04/30/2018 |
| First Posted: | 05/10/2018 |
| Last Update Submitted: | 07/24/2019 |
| Last Update Posted: | 07/28/2019 |
| Actual Study Start Date: | 05/31/2018 |
| Estimated Primary Completion Date: | 12/30/2019 |
| Estimated Study Completion Date: | 12/30/2019 |
Condition or disease
Intervention/treatment
Drug: treatment group
Phase
Arm Groups
| Arm | Intervention/treatment |
|---|---|
| No Intervention: control group The control group was given normal saline by constant intravenous (IV) infusion at a rate of 0.4mcg/kg/hour | |
| Active Comparator: treatment group The treatment group was given dexmedetomidine by constant intravenous (IV) infusion at a rate of 0.4mcg/kg/hour | Drug: treatment group The treatment group was given dexmedetomidine by constant intravenous (IV) infusion at a rate of 0.4mcg/kg/hour. |
Eligibility Criteria
| Ages Eligible for Study | 20 Years To 20 Years |
| Sexes Eligible for Study | All |
| Accepts Healthy Volunteers | Yes |
| Criteria | Inclusion Criteria: - living liver transplantation recipients Exclusion Criteria: - preoperative renal dysfunction - dual living donor liver transplantation - severe cerebral artery disease - severe cardio-pulmonary disease |
Outcome
Primary Outcome Measures
1. acute kidney injury [7 days]
Secondary Outcome Measures
1. early graft dysfunction [7 days]
