Intestinal Ischemia as a Stimulus for Systemic Inflammatory Response After Cardiac Arrest
Keywords
Abstract
Description
Hypothesis 1 Intestinal ischemia during and following Caridac Arrest leads to increased gut permeability and endotoxin release that stimulates the Systemic Inflammatory Response that is responsible for subsequent death and disability after resuscitation.
Hypothesis 2: Different degrees of systemic endotoxin activity variably affect Basic Metabolic Rate during Therapeutic Hypothermia
Serial samples of blood, stool and expired gas will be measured at predetermined timepoints after ROSC from cardiac arrest.
Dates
Last Verified: | 09/30/2017 |
First Submitted: | 09/11/2013 |
Estimated Enrollment Submitted: | 09/11/2013 |
First Posted: | 09/16/2013 |
Last Update Submitted: | 10/04/2017 |
Last Update Posted: | 10/05/2017 |
Actual Study Start Date: | 08/31/2013 |
Estimated Primary Completion Date: | 03/29/2014 |
Estimated Study Completion Date: | 03/29/2014 |
Condition or disease
Phase
Arm Groups
Arm | Intervention/treatment |
---|---|
Cardiac Arrest patients undergoing Therapeutic Hypothermia Cardiac Arrest subjects with Return Of Spontaneous Circulation (ROSC) and undergoing treatment with Therapeutic Hypothermia will undergo sampling of blood, stool, and expired gas data at physiologically predetermined time points. |
Eligibility Criteria
Ages Eligible for Study | 18 Years To 18 Years |
Sexes Eligible for Study | All |
Sampling method | Probability Sample |
Accepts Healthy Volunteers | Yes |
Criteria | Inclusion Criteria: Adult, Cardiac Arrest with ROSC receiving Therapeutic Hypothermia- Exclusion Criteria: - Age < 18 - Cardiac Arrest of traumatic etiology - Known to be pregnant - Prisoner |
Outcome
Primary Outcome Measures
1. Detection of Endotoxin Activity [48 hours]
Secondary Outcome Measures
1. Detection of sCD14 [48 hours]
2. Detection of stool lactoferrin and stool α1-antitrypsin [48 hours]
3. Detection and quantification of inflammatory cytokines [48 hours]
4. BMR measurement elevation [48 hours]