Procalcitonin Level as a Surrogate for Catheter-related Blood Stream Bacteremia Among Hemodialysis Patients
Keywords
Abstract
Description
Catheter-related blood stream bacteremia is common among hemodialysis patients. Clinically, fever and/or rigors with laboratory indicator of inflammation as leucocytosis and elevated c-reactive protein level are considered as markers for CRBSI before blood culture results became available.
Procalcitonin is a valid indicator of sepsis. In this study, Procalcitonin level will be measured in any patient with suspected CRBSI and correlation will be tested for proved CRBSI by blood cultures.
Dates
| Last Verified: | 06/30/2017 |
| First Submitted: | 01/29/2017 |
| Estimated Enrollment Submitted: | 01/30/2017 |
| First Posted: | 01/31/2017 |
| Last Update Submitted: | 07/12/2017 |
| Last Update Posted: | 07/16/2017 |
| Actual Study Start Date: | 08/31/2016 |
| Estimated Primary Completion Date: | 02/27/2017 |
| Estimated Study Completion Date: | 02/28/2017 |
Condition or disease
Phase
Eligibility Criteria
| Ages Eligible for Study | 18 Years To 18 Years |
| Sexes Eligible for Study | All |
| Sampling method | Non-Probability Sample |
| Accepts Healthy Volunteers | Yes |
| Criteria | Inclusion Criteria: - Hemodialysis patients with a dialysis catheter - signs suggestive of CRBSI: fever/chills or leucocytosis with no other site of infection. - Informed consent signed to be enrolled in the study Exclusion Criteria: - Patient with identified cause of fever other than CRBSI |
Outcome
Primary Outcome Measures
1. Procalcitonin Level [2 minutes after start of fever/chills or other symptoms suggesting CRBSI]
Other Outcome Measures
1. Blood culture (central and peripheral) results [5 minutes after start of fever/chills or other symptoms suggesting CRBSI]
2. C Reactive Protein [2 minutes after start of fever/chills or other symptoms suggesting CRBSI]
3. erythrocyte sedimentation rate [2 minutes after start of fever/chills or other symptoms suggesting CRBSI]
4. Urea Reduction Rate [up to 30 days prior to start of fever/chills or other symptoms suggesting CRBSI]
5. creatinine [up to 30 days prior to start of fever/chills or other symptoms suggesting CRBSI]
6. ferritin [up to 30 days prior to start of fever/chills or other symptoms suggesting CRBSI]
7. Hemoglobin [up to 30 days prior to start of fever/chills or other symptoms suggesting CRBSI]
8. potassium [up to 30 days prior to start of fever/chills or other symptoms suggesting CRBSI]
9. Sodium [up to 30 days prior to start of fever/chills or other symptoms suggesting CRBSI]
