A Multidisciplinary Investigation of Cardiovascular Benefits of Wild Rice
Keywords
Abstract
Description
Cardiovascular disorders (CVD) including hypertension, myocardial infarction and stroke are still among the top causes of mortality and morbidity in both developed and developing countries. Several modifiable and non-modifiable risk factors play a crucial role in pathogenesis of CVD. Among modifiable risk factors, unhealthy diets and sedentary life style have been recognized worldwide. In this regard, many health authorities have developed guidelines to promote consumption of healthy diets and an active life style among the general population and for CVD patients. Furthermore, recent advances in the area of food and nutrition have revealed health promoting properties for some foods beyond their nutritional values. Such foods are generally known as "functional foods." The Department of Food and Human Nutritional Sciences at the University of Manitoba (U of M) is well-recognized for its contribution in this area of research. However, the effects of wild rice have not been tested in clinical trials. Hence, a pilot study is required before performing a large clinical trial to explore the effects of wild rice consumption and its potential mechanisms. This would not only benefit the populations, but also warranty its scope globally. In this study, the investigators will carry out such a study on the cardiovascular benefits of wild rice in 24 women and 24 men (20-40 years old) over a period of 4 weeks. "Test food" including fruit/vegetable salad, energy cookies and casserole will be prepared by Tall Grass Bakery, Winnipeg, Manitoba. These foods will contain approximately 30 grams of wild rice per serving. The participants will be recruited per our standard procedures. After completion of recruitment procedures, including obtaining a fully informed consent form and health information, the participant will be asked to consume one serving of the "test food" every day over 28 days. Vascular measurements, plus urine and blood samples will be collected at day 0 and day 28. Serum lipids, inflammatory markers and fecal bacterial type, and numbers will be determined.
Dates
| Last Verified: | 02/29/2020 |
| First Submitted: | 09/30/2019 |
| Estimated Enrollment Submitted: | 10/03/2019 |
| First Posted: | 10/07/2019 |
| Last Update Submitted: | 07/05/2020 |
| Last Update Posted: | 07/06/2020 |
| Actual Study Start Date: | 08/31/2020 |
| Estimated Primary Completion Date: | 09/29/2021 |
| Estimated Study Completion Date: | 09/29/2022 |
Condition or disease
Intervention/treatment
Other: Wild rice
Phase
Arm Groups
| Arm | Intervention/treatment |
|---|---|
| Experimental: Wild rice Participants will consume one serving of the test food containing wild rice every day over 28 days. | Other: Wild rice 30 grams of wild rice in the form salad, snack bar and soup |
Eligibility Criteria
| Ages Eligible for Study | 20 Years To 20 Years |
| Sexes Eligible for Study | All |
| Accepts Healthy Volunteers | Yes |
| Criteria | Inclusion Criteria: - Male - Female - Both genders are healthy - 20 - 40 years old Exclusion Criteria: - Non-pregnant - Non-lactating - Non-smokers - Not obese (Body Mass Index (BMI) < 30) - Not currently on any medications for cardiovascular, diabetes, and cancer diseases |
Outcome
Primary Outcome Measures
1. Wild rice alters gut microbiome. [4 weeks]
2. Changes in gut microbiome alters macronutrient metabolism. [4 weeks]
Secondary Outcome Measures
1. Wild rice consumption improves blood lipid profile. [4 weeks]
2. Will rice consumption improves endothelial cell function. [4 weeks]
