A Preventive Treatment for Migrant Workers at High-risk of Covid-19
Keywords
Abstract
Description
This is a pragmatic, open-label, randomised study with 4 interventional and 1 control arms. Individuals will be recruited from migrant worker dormitories, and written informed consent taken prior to enrolment. Randomisation will be done by the level within the dormitory building and predetermined each day according to a randomisation schema done by an independent statistician. This will obviate the potential for bias due to drug exchange between study individuals.
The 5 arms consist of:
- Experimental arms
1. Hydroxychloroquine tablet 400mg loading dose, followed by 200mg daily for 42 days (1,000 study subjects)
2. Ivermectin tablet 12mg single dose (1,000 study subjects)
3. Zinc tablet 80 mg/vitamin C 500mg daily for 42 days (1,000 study subjects)
4. Povidone-iodine throat spray (3 times daily) for 42 days (1,000 study subjects)
- Control arm 5) Vitamin C tablet 500mg daily for 42 days (1,000 study subjects)
Study information sheet will be circulated in selected buildings within the dormitory 1-4 days before recruitment starts. All publicity materials and informed consent form will be translated to the different languages (e.g. Tamil, Bengali, Chinese, Burmese and Malay). A translator will be present to aid translation if necessary. Study subjects will be given ample time to ask questions relating to the study. Prospective participants will respond by showing up to recruitment stations at designated dates and times. Facilitators from the dormitory will be engaged to assist with the ground crowd-control. Prospective videos will be shown to inform the subject on the purpose, study inclusion and exclusion criteria, study medications, blood taking, reporting of adverse effects and follow-up visits. Informed consent will be taken before all study-related procedures are performed, including study eligibility. Translators will also help translate the daily questionnaires.
During the baseline recruitment,
1. History of symptoms, comorbidities and prior illnesses will be asked. Specific questions include presence or absence of the following symptoms: Fever, chills, myalgia, headache, diarrhoea, running nose, anosmia, loss of taste, sore throat, dry cough, shortness of breath.
2. Measurements of study subjects' parameters such as weight, height, temperature, pulse rate and blood pressure will be recorded. Subjects randomised to Ivermectin arm and subsequently found to weigh below 60 kg will be randomised to other treatment arms. Subjects randomised to hydroxychloroquine arm and found to have systolic blood pressure >150 mmHg and/or diastolic blood pressure >90 mmHg and/or heart rate >100 beats per minute will also be randomized to other treatment arms.
3. 12-lead electrocardiogram (ECG) will be performed in patients randomised to receive hydroxychloroquine. Only those with QTc values less than 450 ms, no cardiac arrhythmia and no ventricular hypertrophy will be allowed to receive hydroxychloroquine. Those with QTc values more than 450 ms, cardiac arrhythmia and ventricular hypertrophy will be randomised to other treatment arms.
4. Blood sample (20 mL) will be obtained to test IgG/M against SARS-CoV-2. Depending on the findings, additional tests will be performed to explore potential biological reasons underpinning these observations. The choice of markers may include pathway-specific biomarkers targeting inflammation, oxidative stress, lipid parameters, as well as organ-specific ones such as renal and liver parameters. Given the large sample size and high costs of analysis, the study team will prioritise more detailed investigations in a targeted group of patients depending on the final findings. None of these blood results is a screening criteria for study participation. The investigator will share abnormal to the study subjects abnormal results of their renal and liver parameters should these tests are tested following study completion. The extent on investigation, however, depends on funding support. In this study, renal and hepatic dysfunction will be based on physician-diagnosed and self-declaration on the part of the study subject. All clinical information will be verified by a senior physician on-site.
5. Study medications will be packed with clear instructions written on the packing bag. The package will be distributed to each subject based on the randomised treatment assigned.
6. Study participants will be given a study card to remind them to submit their symptoms daily and to record the times when they consume their medications. They will also be asked to present this card to doctors at the medical post or hospital should they seek medical assistance. In the events of acute respiratory infection and hospitalization, lab testing will be done as clinically indicated. Subjects on ventilator support who are not able to take oral medications may discontinue taking the study drug. However, subjects will remain in the study for collection of data on duration of mechanical ventilation for analysis.
During final study visit,
1. The study team, including investigators, will be present at the dormitory. A repeated blood sample (20mL) will be collected for serological tests. Measurements of study subjects' parameters such as weight (using Tanita BC-418 and Tanita BC-420MA for bio-electrical impedance analysis), height, blood pressure will be taken. ECG will be done only for subjects in hydroxychloroquine arm. History will be taken including symptoms of fever, chills, myalgia, headache, diarrhoea, running nose, anosmia, loss of taste, sore throat, dry cough, shortness of breath and the duration of such symptoms, if any.
2. Balance medication and packaging retrieval to do medication accounting and checking for adherence to assigned treatment arm
3. Discharged from study if no adverse events to follow-up.
Dates
| Last Verified: | 04/30/2020 |
| First Submitted: | 05/10/2020 |
| Estimated Enrollment Submitted: | 06/22/2020 |
| First Posted: | 06/23/2020 |
| Last Update Submitted: | 06/22/2020 |
| Last Update Posted: | 06/23/2020 |
| Actual Study Start Date: | 05/12/2020 |
| Estimated Primary Completion Date: | 06/30/2020 |
| Estimated Study Completion Date: | 06/30/2020 |
Condition or disease
Intervention/treatment
Drug: Hydroxychloroquine
Drug: Ivermectin
Drug: Zinc/ Vitamin C
Drug: Povidone-iodine throat spray
Dietary Supplement: Vitamin C
Phase
Arm Groups
| Arm | Intervention/treatment |
|---|---|
| Experimental: Hydroxychloroquine Participants will receive hydroxychloroquine tablet 400mg loading dose, followed by 200mg daily for 42 days | Drug: Hydroxychloroquine Hydroxychloroquine tablet 400mg loading dose, followed by 200mg daily for 42 days |
| Experimental: Ivermectin Participants will receive ivermectin tablet 12mg single dose | Drug: Ivermectin Ivermectin tablet 12mg single dose |
| Experimental: Zinc/ Vitamin C Participants will receive zinc tablet 80 mg/vitamin C 500mg daily for 42 days | Drug: Zinc/ Vitamin C Zinc tablet 80 mg/vitamin C 500mg daily for 42 days |
| Experimental: Povidone-iodine throat spray Participants will receive povidone-iodine throat spray (3 times daily) for 42 days | Drug: Povidone-iodine throat spray Povidone-iodine throat spray (3 times daily) for 42 days |
| Active Comparator: Vitamin C Participants will receive vitamin C tablet 500mg daily for 42 days | Dietary Supplement: Vitamin C Vitamin C tablet 500mg daily for 42 days |
Eligibility Criteria
| Ages Eligible for Study | 21 Years To 21 Years |
| Sexes Eligible for Study | Male |
| Accepts Healthy Volunteers | Yes |
| Criteria | Inclusion Criteria: Subjects must meet all the of following criteria to be included in this study: - Men residing in dormitory aged 21-60 years - Willing and able to give informed consent - Able to understand instructions and consume study medications according to the study protocol. - Weight more than 40kg - Owns a mobile phone (with WIFI and/or 3G connection and able to fill in online forms. Exclusion Criteria: Subjects who have any of the following criteria at baseline will be excluded from participating in this study: - Symptoms of acute respiratory illness (e.g. fever, runny nose, sore throat, cough, breathlessness, loss of smell and loss of taste) for the past 30 days - Known current or history of SARS-CoV-2 infection - Unable to read English or any of the available local languages used for this clinical trial - History of cardiac or neurological diseases - History of retinal diseases - History of diabetes on insulin treatment - History of depression - History of chronic alcohol use - History of renal or hepatic dysfunction - History of glucose-6-phosphate dehydrogenase deficiency - History of anaemia, after exposure to any given medications - History of thyroid disorder, hyperthyroidism, or sensitivity to iodine - History of allergies with systemic presentation to any given medication (e.g.: swelling of the face, throat, eyes and lips, respiratory disturbances, asthmatic attacks, widespread skin blistering or uticuria (hives)) - Concomitant medication that may lead to cardiac arrhythmia (azithromycin, amitryptilline, cimetidine, citalopram, nortriptylline, pantoprazole, quetiapine etc). - Unwilling to comply with study dosing, instructions or restrictions. |
Outcome
Primary Outcome Measures
1. Incidence of acute respiratory illness in treatment arms (hydroxycholorquine, ivermectin, zinc and povidone iodine) [At the end of study dosing, which is day 42]
Secondary Outcome Measures
1. Incidence of febrile respiratory illness in treatment arms (hydroxycholorquine, ivermectin, zinc and povidone iodine) [At the end of study dosing, which is day 42]
2. Rate of hospitalization for COVID-19 and non-COVID-19 related indications in treatment arms (hydroxycholorquine, ivermectin, zinc and povidone iodine) [At the end of study dosing, which is day 42]
3. Rate of oxygen supplementation and mechanical ventilation in treatment arms (hydroxycholorquine, ivermectin, zinc and povidone iodine) [At the end of study dosing, which is day 42]
4. Duration of oxygen supplementation and mechanical ventilation in treatment arms (hydroxycholorquine, ivermectin, zinc and povidone iodine) [At the end of study dosing, which is day 42]
5. Length of hospital stay in treatment arms (hydroxycholorquine, ivermectin, zinc and povidone iodine) [At the end of study dosing, which is day 42]
6. Rate of laboratory-confirmed COVID-19 in treatment arms (hydroxycholorquine, ivermectin, zinc and povidone iodine) [At the end of study dosing, which is day 42]
7. Incidence of adverse events and serious adverse events in control arm (Vitamin C) [At the end of study dosing, which is day 42]
8. Incidence of drug discontinuation due to adverse events in control arm (Vitamin C) [At the end of study dosing, which is day 42]
