CMV Disease and IRIS in HIV-1 Infected Persons
Keywords
Abstract
Description
At present, human cytomegalovirus (HCMV) remains a major health threat in immune compromised patients. Especially HCMV will cause blind and death in HIV-1 infected person. Currently, few antiviral drugs can be chosen for treatment of HCMV infection. Besides, more and more drug resistant virus strains were reported and led failure in antiviral therapy.
Various diagnostic methods are available for CMV infection. Such as shell vial assay, CMV antigen test, pp65 antigen assay and polymerase chain reaction. But none of them could be a standard and highly valuable. Although CMV-PCR is very sensitive, it can't distinguish between active disease and asymptomatic infection or latency, can't predict symptomatic disease nor can't monitor the successful antiviral therapy.
Our first goal is to setup a series of molecular diagnostic tools for HIV-1 infected person. By using these tools, physicians can easily select cases with CMV disease or immune restoration inflammatory syndrome (IRIS) to enroll this study. Furthermore, we will seek for a predict marker for CMV reactivation, CMV disease and IRIS. Finally, our research will focus on the mechanism of the IE gene alternative splicing between lytic and latent stage. We may find out new therapeutic concept and prevent virus reactivation from latency.
Dates
Last Verified: | 04/30/2008 |
First Submitted: | 04/03/2007 |
Estimated Enrollment Submitted: | 04/03/2007 |
First Posted: | 04/04/2007 |
Last Update Submitted: | 01/31/2009 |
Last Update Posted: | 02/02/2009 |
Actual Study Start Date: | 10/31/2006 |
Estimated Primary Completion Date: | 06/30/2008 |
Estimated Study Completion Date: | 06/30/2008 |
Condition or disease
Intervention/treatment
Genetic: IE gene
Phase
Eligibility Criteria
Sexes Eligible for Study | All |
Accepts Healthy Volunteers | Yes |
Criteria | Inclusion Criteria: - Clinical diagnosis of HIV-1 Disease - Clinical diagnosis of CMV disease or immune restoration inflammatory syndrome (IRIS) |