COVID-19: Herd Immunity Study in the Czech Republic
Keywords
Abstract
Description
COVID-19 is caused by a new type of coronavirus called SARS-CoV-2. It is a highly infectious disease, manifested mainly by fever, respiratory problems, muscle pain, and fatigue. However, despite the publication of hundreds of papers in the literature, fundamental information about the spread and course of the disease is still lacking in COVID-19. One of such key pieces of information is the prevalence of asymptomatic individuals with SARS-CoV-2 infection, which has a significant effect on the dynamics of the spread of COVID-19 in the Czech Republic and within individual regions and localities.
The SARS-CoV-2-CZ-Preval study is aiming at quantification of the prevalence of individuals with a history of SARS-CoV-2 coronavirus infection in the Czech population, except for those diagnosed with COVID-19 by methods based on direct detection of SARS-CoV- 2, including individuals with a subclinical course of the disease.
Dates
| Last Verified: | 04/30/2020 |
| First Submitted: | 05/20/2020 |
| Estimated Enrollment Submitted: | 05/20/2020 |
| First Posted: | 05/25/2020 |
| Last Update Submitted: | 05/28/2020 |
| Last Update Posted: | 05/31/2020 |
| Actual Study Start Date: | 04/22/2020 |
| Estimated Primary Completion Date: | 04/30/2020 |
| Estimated Study Completion Date: | 04/30/2020 |
Condition or disease
Intervention/treatment
Diagnostic Test: SARS-CoV-2 diagnostic rapid test
Diagnostic Test: Population cohort from specific geographical areas
Phase
Arm Groups
| Arm | Intervention/treatment |
|---|---|
| Population area cohort - Control Cohort A population cohort of asymptomatic individuals (only adults). This is a representative sample of the population, which are part of the research project of Institute for Clinical and Experimental Medicine and Czech Academy of Sciences. The second subsample included individuals from the official household survey of Czech Statistical Office. This cohort allowed better comparative analysis of other population cohorts from specific geographical areas. | |
| Population cohort from specific geographical areas This cohort is based on epidemiologically defined demographic parameters. These are populations from the following geographical areas:
Brno and the South Moravian Region; Praha; Olomouc; Litoměřice; Litovel and Uničov. | Diagnostic Test: Population cohort from specific geographical areas The subsample from Olomouc region (Olomouc, Uničov, Litovel) is based on venous blood sampling and archiving for subsequent quantitative analysis of SARS-CoV-2 antibodies. These tests detect immunoglobulins M and G (IgM and IgG). |
| Chronically ill patients cohort A cohort of chronically ill people enrolled by Institute for Clinical and Experimental Medicine with chronic cardiovascular problems, hypertension, or diabetes. |
Eligibility Criteria
| Ages Eligible for Study | 8 Years To 8 Years |
| Sexes Eligible for Study | All |
| Sampling method | Non-Probability Sample |
| Accepts Healthy Volunteers | Yes |
| Criteria | Inclusion Criteria: - signed Informed Consent - residing in The Czech Republic - demographic criteria: (i) persons aged 8-17 (specific children's cohort), (ii) persons aged 18-89 - clinical criteria: (i) without acute health problems (ii) without a confirmed diagnosis of COVID-19 - geographic criteria: according to a particular cohort definition |
Outcome
Primary Outcome Measures
1. Estimation of the actual prevalence of SARS-CoV-2 positive persons in the Czech Republic. [May 2020]
Secondary Outcome Measures
1. Estimation of the proportion of people with a subclinical course of the disease [May 2020]
2. Estimation of the cumulative prevalence of the disease and the proportion of people with a subclinical course differences between subcohorts according to demographic, social and clinically relevant stratifications. [May 2020]
3. Estimation of the proportion of persons suitable for the donation of convalescent plasma [May 2020]
