Gait Mate: Examining Neural Networks Engaged During Lower Extremity Movement in the MRI
Keywords
Abstract
Description
The overarching goal of this Discovery Proposal is to evaluate neural activity during unipedal and bipedal movement in a cohort of healthy individuals (Aim 1).
The rigor and reproducibility will be evaluated by comparing the results of 1) active movement -Bipedal with 2) active movement -unipedal 4 and 3) imagined movement.
Dependent measures include: 1) head motion during the fMRI task, 2) BOLD signal in the ipsilateral and contralateral motor cortex during the fMRI task, 3) force applied during the fMRI task, and 4) participant feedback using a modified version of the Presence Questionnaire (a standard tool to assess ecological validity of virtual environments.
Each Aim has a development and evaluation aspect. Through this 1 year proposal the investigators will determine if the bipedal fMRI protocol (active movement) is able to engage neural networks more robustly (e.g. greater effect size) than bipedal imagery alone in Healthy Volunteers.
Specific Aim #1: Healthy volunteers: The investigators will test the hypothesis that with active bipedal movement there will be 1) no difference in head movement, but 2) greater motor cortex BOLD signal, 3) smoother force exchange between the feet, 4) higher participant satisfaction than unipedal movement or motor imagery alone. This sample size was selected based on a prior publication of imagined movement. The outcome of this aim may result in the first publication in the field to evaluate bipedal movement in an MR-environment.
Dates
Last Verified: | 02/29/2020 |
First Submitted: | 06/27/2018 |
Estimated Enrollment Submitted: | 07/18/2018 |
First Posted: | 07/26/2018 |
Last Update Submitted: | 03/09/2020 |
Last Update Posted: | 03/11/2020 |
Actual Study Start Date: | 01/31/2018 |
Estimated Primary Completion Date: | 06/13/2019 |
Estimated Study Completion Date: | 06/13/2019 |
Condition or disease
Intervention/treatment
Device: GAITRite assessment
Phase
Arm Groups
Arm | Intervention/treatment |
---|---|
GAITRite assessment Subjects will undergo the GAITRite assessment of functional walking and then complete the Functional MRI Bipedal paradigm followed by questionnaires and assessments regarding the virtual environment. | Device: GAITRite assessment The fMRI Bipedal Paradigm will allow investigators to study the effects treadmill-assisted gait training have on cortical control of bipedal movement in chronic stroke patients. |
Eligibility Criteria
Ages Eligible for Study | 21 Years To 21 Years |
Sexes Eligible for Study | All |
Sampling method | Non-Probability Sample |
Accepts Healthy Volunteers | Yes |
Criteria | Inclusion criteria: - Age 21-65 - Right hand dominant - Able to read and understand questionnaires and informed consent Exclusion criteria: - Self reported history of cardiac disease, COPD or oxygen dependence, neurological and psychiatric disorders, dementia or previous stroke, major head trauma, severe visual impairment, osteoarthritis, orthopedic problems that limit passive range of motion, illegal drug or alcohol dependence, claustrophobia - Non-mri compatible metal implants in the body - Pregnant females |
Outcome
Primary Outcome Measures
1. fMRI protocols will measure neural function activity during active bipedal movement in healthy volunteers [Duration of the study, approximately 1 year]