Intraoperative Floppy Iris Syndrome in Korean Patients Taking α1-Adrenergic Receptor Antagonists

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Abstract

Intraoperative floppy iris syndrome (IFIS) is a recently described condition observed during cataract surgery. It has been hypothesized that irreversible atrophy of the iris dilator muscle associated with α1-adrenergic receptor antagonists (α1-ARA) is responsible for IFIS. However the prevalence of IFIS in Korean population is not reported. The purpose of this study is to evaluate the prevalence and clinical manifestations of IFIS in relation to iris anatomical change in Korean patients taking α1-ARA.

Dates

Last Verified:	09/30/2012
First Submitted:	10/07/2012
Estimated Enrollment Submitted:	10/09/2012
First Posted:	10/10/2012
Last Update Submitted:	10/09/2012
Last Update Posted:	10/10/2012
Actual Study Start Date:	12/31/2009
Estimated Primary Completion Date:	02/28/2010
Estimated Study Completion Date:	02/28/2010

Condition or disease

Intraoperative Floppy Iris Syndrome

Phase

Arm Groups

Arm	Intervention/treatment
α1-ARA Group All patients on α1-ARA(α1-adrenergic receptor antagonists) medication who underwent cataract surgeries.
Control Group Age and sex-matched control subjects

Eligibility Criteria

Sexes Eligible for Study	All
Sampling method	Probability Sample
Accepts Healthy Volunteers	Yes
Criteria	Inclusion Criteria: - clinical diagnosis of cataract - korean patients Exclusion Criteria: - history of iridocyclitis, iris neovascularization, or prior iris surgery - traumatic cataracts, zonular dialysis, or cataracts associated with ocular disease (e.g., uveitis)

Outcome

Primary Outcome Measures

1. occurrence of intraoperative floppy iris syndrome [intraoperative]