Laryngeal Adaptation for Speech and Swallowing

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StatusTerminated

Keywords

Abstract

This study will test laryngeal adaptation in speech and swallowing function in healthy adults, in patients with cerebral stroke, and in patients with spinocerebellar ataxia type 6. The findings from this proposal will be the first step toward implementing rehabilitation techniques that help patients to prevent speech and swallowing errors before they occur.

Dates

Last Verified:	08/31/2019
First Submitted:	11/28/2018
Estimated Enrollment Submitted:	12/05/2018
First Posted:	12/09/2018
Last Update Submitted:	09/05/2019
Last Update Posted:	09/09/2019
Actual Study Start Date:	08/23/2018
Estimated Primary Completion Date:	08/29/2019
Estimated Study Completion Date:	08/29/2019

Condition or disease

Stroke

Spinocerebellar Ataxia

Cerebral Stroke

Dysphagia

Dysarthria

Intervention/treatment

Device: Intermittent Perturbation to Continuous Perturbation

Device: Continuous Perturbation to Intermittent Perturbation

Phase

Arm Groups

Arm	Intervention/treatment
Experimental: Stroke without Dysarthria Examine laryngeal adaptation across all study groups: (1) baseline measures of speech or swallowing , (2) a clinical examination of disease/condition severity and (3) the experimental paradigm.
Experimental: Stroke with Dysarthria Examine laryngeal adaptation across all study groups: (1) baseline measures of speech or swallowing , (2) a clinical examination of disease/condition severity and (3) the experimental paradigm.
Experimental: SCA6 without Dysarthria Examine laryngeal adaptation across all study groups: (1) baseline measures of speech or swallowing , (2) a clinical examination of disease/condition severity and (3) the experimental paradigm.
Experimental: SCA6 with Dysarthria Examine laryngeal adaptation across all study groups: (1) baseline measures of speech or swallowing , (2) a clinical examination of disease/condition severity and (3) the experimental paradigm.
Active Comparator: Age-Matched Controls Examine laryngeal adaptation across all study groups: (1) baseline measures of speech or swallowing , (2) a clinical examination of disease/condition severity and (3) the experimental paradigm.

Eligibility Criteria

Ages Eligible for Study	21 Years To 21 Years
Sexes Eligible for Study	All
Accepts Healthy Volunteers	Yes
Criteria	Patient Inclusion Criteria: All stroke and ataxia Ataxia - DNA diagnosis of SCA6 and phenotype consistent with the DNA diagnosis - No recessive, X-linked or mitochondrial Stroke - Bilateral or unilateral middle cerebral artery (MCA) stroke - No structural abnormalities (i.e. nodules) - Dysphagia involving laryngeal dysfunction Stroke and ataxia with speech and swallowing disorders - no structural abnormalities - dysphagia involving laryngeal dysfunction Patient Exclusion Criteria: - Montreal Cognitive Assess. <24 - Moderate to severe hearing loss - Barium allergy - Other confounding speech disorder (i.e. stuttering) - Chemo-radiation, surgical head and neck treatment - Smoking Hx in the past 5 yrs or >5 years at any one time - Twenty one years of age or older - Breathing disorders or diseases

Outcome

Primary Outcome Measures

1. Laryngeal Adaptation in Speech [Day 1]

To differentiate laryngeal adaptation during speech among cerebral stroke, SCA6, and healthy controls when vocal loudness is perturbed with expiratory loading.

2. Laryngeal Adaptation in Swallowing [Day 1]

To differentiate laryngeal adaptation among cerebral stroke, SCA6, and healthy controls when swallowing is perturbed with neck surface electrical stimulation to restrict laryngeal elevation.