RepurpoSing Old Drugs TO SuppRess a Modern Threat: COVID-19 STORM
Keywords
Abstract
Description
This study will randomize 20 patients with confirmed or highly suspected early stage severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to Doxycycline (100 mg BID) or Placebo and then assess the progression of their disease over the next three weeks with the primary endpoint being days alive and out of the hospital.
The investigators will collect specimens for measurement of viral burden (nasopharyngeal luminex (SARS-CoV-2), SARS-CoV-2 serum quantitative viral load, SARS-CoV-2 IgM/IgG antibodies), markers of inflammation (WBC, ESR, TNFa, IL-1, IL-6, IL-1B), and cardiac dysfunction (CRP, pro-BNP, hsTnT).
Eligibility will be based on history and physical examination findings - collated into a clinical suspicion score. The decision to enroll based on clinical suspicion score rather than confirmed SARS-CoV-2 disease is based on the variable and unacceptably high false negative rate of the nasopharyngeal PCR test for in early disease.
Clinical Suspicion Score: Greater than or equal to 6/20 (at least 4 points of which must be clinical) will be eligible for enrollment.
Clinical Criteria: Max 12 points
- Fever (2 points)
- Cough (2 points)
- Dyspnea (2 points)
- Chest pain (1 point)
- Myalgias (1 point)
- Fatigue (1 point)
- GI symptoms (1 point)
- Loss of Smell (1 point)
- Loss of Taste (1 point)
Exposure Criteria: Max 8 points
- Contact with known COVID+ (2 points)
- Healthcare worker -- frequent <6 feet contact for 15 minutes (2 points)
- High-risk work -- supermarket, deli, transportation (2 points)
- Endemic community -- prison/jail/nursing home/LTAC/SNF/rehab/homeless/homeless shelter (2 points)
Genetic variants may explain why patients who are infected with SARS-CoV-2 have either a relatively benign or an inappropriately aggressive response to an infectious insult. Medications may be more or less effective in that group of patients harboring genetic variants of a disease-related protein. To better understand this, whole genome sequencing and analysis will be performed on all study patients.
Dates
| Last Verified: | 05/31/2020 |
| First Submitted: | 06/09/2020 |
| Estimated Enrollment Submitted: | 06/11/2020 |
| First Posted: | 06/15/2020 |
| Last Update Submitted: | 06/21/2020 |
| Last Update Posted: | 06/23/2020 |
| Actual Study Start Date: | 06/21/2020 |
| Estimated Primary Completion Date: | 12/31/2020 |
| Estimated Study Completion Date: | 06/30/2021 |
Condition or disease
Intervention/treatment
Drug: Doxycycline
Drug: Placebo
Phase
Arm Groups
| Arm | Intervention/treatment |
|---|---|
| Experimental: Doxycycline Participants receive 100 MG BID for 21 days | Drug: Doxycycline 100 MG Tablet |
| Placebo Comparator: Placebo Participants receive Placebo BID for 21 days | Drug: Placebo Placebo Tablet |
Eligibility Criteria
| Ages Eligible for Study | 18 Years To 18 Years |
| Sexes Eligible for Study | All |
| Accepts Healthy Volunteers | Yes |
| Criteria | Inclusion Criteria: - Confirmed or highly suspected early stage severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), disease with clinical suspicion score >6/20, not requiring hospitalization - Age ≥18 years - Willing to sign the informed consent form - Willing to take study drug or placebo as directed for 21 days Exclusion Criteria: - Confirmed or highly suspected early stage severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), disease with clinical suspicion score >6/20, requiring hospitalization - Suspected or confirmed convalescent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), within the prior 4 weeks - Age <18 years' old - Inability to take medications orally - Inability to provide written consent - Known sensitivity/allergy to doxycycline or tetracyclines - Current use of doxycycline for another indication - Pregnancy - A known diagnosis of myasthenia gravis - History of Clostridium Difficile infection within past 12 months - Sun sensitivity - Individuals using medications which could lower doxycycline levels, including barbiturates, phenytoin, carbamazepine, warfarin - Individuals using isotretinoin |
Outcome
Primary Outcome Measures
1. Time Free of Either Hospitalization, Hypoxemia, ICU Admission or Death [21 days]
Secondary Outcome Measures
1. NP SARS-CoV-2 PCR [21 days]
2. SARS-CoV-2 Serum Quantitative Viral Load [21 days]
3. SARS-CoV-2 IgM/IgG Antibodies [21 days]
4. White Blood Cell Count (WBC) [21 days]
5. Absolute Lymphocyte Count (ALC) [21 days]
6. C-Reactive Protein (CRP) [21 days]
7. N-Terminal Pro-B-Type Natriuretic Peptide (Pro-BNP) [21 days]
8. High Sensitivity Troponin I (hsTnT) [21 days]
9. Tumor Necrosis Factor Alpha (TNF-a) [21 days]
10. IL-1 [21 days]
11. IL-1B [21 days]
12. IL-6 [21 days]
