The Safety and Efficacy Study of High Dose Atorvastatin After Thrombolytic Treatment in Acute Ischemic Stroke
Keywords
Abstract
Description
Study design It is a bi-center, randomized, open-label prospective study. Investigators will enroll the ischemic stroke patients who received IV-thrombolysis with rt-PA. Those who meet inclusion criteria will be randomized either to the high dose group (atorvastatin 80mg) or the moderate dose group (atorvastatin 20mg) within 24 hours after IVT. The initial dose of atorvastatin will last at least 2 weeks, and then be adjusted according to the stroke risk stratification and tolerance. All patients will be followed at 0, 1 month, 3 months, 6 months, and 12 months, and evaluated the neurological deficits and some patients will be randomly assigned to perform multimodality MRI scan. Other standard secondary prevention of stroke and life-style guidance will be provided according to 2014 AHA/ASA stroke secondary prevention guidelines. All patients will be followed up in stroke prevention clinic or on phone by trained investigators.
Study Endpoints Primary endpoint The percentage of patients with mRS (modified Rankin Score) equivalent to or less than 2 between high dose groups and moderate dose groups at 90 days.
Secondary endpoints NIHSS score at 7 day, 1 month mRS at 6,12 month Inflammation biomarkers at 6 month Imaging outcomes include the neuronal and vascular morphological changes indicated by multi-model imaging.
Safety and tolerability will be evaluated by recording the incidence and severity of adverse events, abnormal physical examination findings, and abnormal laboratory values through the study. Especially monitoring the patients who have any the following events:
Hemorrhagic complications including intracranial, digestive tract. New stroke or TIA Death from all-cause death, stroke events or cardiovascular events The patients having muscle symptoms such as myalgia, fatigue, weakness, creatinine kinase values 10 times the upper limit of normal, or rhabdomyolysis, and having persistent elevation in alanine aminotransferase (ALT), aspartate aminotransferase (AST), or both (defined as two consecutive measurements obtained 4 to 10 days apart that is more than three times the upper limit of the normal range).
Dates
| Last Verified: | 02/29/2020 |
| First Submitted: | 05/19/2015 |
| Estimated Enrollment Submitted: | 05/19/2015 |
| First Posted: | 05/21/2015 |
| Last Update Submitted: | 03/26/2020 |
| Last Update Posted: | 03/30/2020 |
| Actual Study Start Date: | 09/01/2015 |
| Estimated Primary Completion Date: | 10/31/2017 |
| Estimated Study Completion Date: | 07/31/2018 |
Condition or disease
Intervention/treatment
Device: atorvastatin
Phase
Arm Groups
| Arm | Intervention/treatment |
|---|---|
| Active Comparator: moderate dose Drug: Atorvastatin Atorvastatin 20 mg daily for 2 weeks administrated within 24 hours after receiving rt-PA thrombolysis, continued statin use for at least 12 months Other Name: Lipitor | |
| Experimental: high dose Drug: Atorvastatin Atorvastatin 80 mg daily for 2 weeks administrated within 24 hours after receiving rt-PA thrombolysis, continued statin use for at least 12 months Other Name: Lipitor |
Eligibility Criteria
| Ages Eligible for Study | 18 Years To 18 Years |
| Sexes Eligible for Study | All |
| Accepts Healthy Volunteers | Yes |
| Criteria | Inclusion Criteria: 1. Men or women ≧18 years of age 2. Able and willing to comply with study requirements 3. Signed informed consent by patient self or legally authorized representatives. 4. Baseline mRS before this stroke onset less than 2 5. Receive IV rt-PA thrombolysis with a final diagnosis of ischemic stroke 6. Liver transaminases (ALT and/or AST) ≤ 2 x upper limit of normal (ULN) with no active liver disease and creatine kinase (CK) ≤ 2 x ULN at screen visit. Exclusion Criteria: 1. History of mental instability, drug/alcohol abuse within the past 5 years, or major psychiatric illness not adequately controlled and stable on pharmacotherapy 2. Patients who have been treated with any other investigational drug within 3 months of enrollment 3. Impaired renal function ( serum creatinine ≧1.5 mg/dL) or nephrotic syndrome 4. Patients hypersensitive or have allergic response to HMG-CoA reductase inhibitors 5. Metastatic neoplasm at the onset or the follow-up 6. Prohibited concomitant therapies, e.g.: ① Medications that are potent inhibitors of CYP3A4, including cyclosporine, systemic itraconazole or ketoconazole, erythromycin or clarithromycin, nefazodone, verapamil and human immunodeficiency virus (HIV) protease inhibitors. ②Oral corticosteroids unless used as replacement therapy for pituitary/adrenal disease 7. Patient has evidence of severe congestive heart failure or has history of end-stage cardiovascular disease (e.g. CHF NYHA Class III or IV) 8. Any condition or situation which, in the opinion of the investigator, might pose a risk to the patient or confound the results of the study |
Outcome
Primary Outcome Measures
1. The percentage of patients with mRS (modified Rankin Score) equivalent to or less than 2 between high dose groups and moderate dose groups at 90 days. [90 days]
Secondary Outcome Measures
1. NIHSS score at 7 day, 1 month [7 day, 1 month]
2. mRS at 6,12 month [6 months, 12 months]
3. Hemorrhagic complications including intracranial, digestive tract [6 months, 12 months]
4. New stroke or TIA [12 months]
5. Death from all-cause death, stroke events or cardiovascular events [6 months, 12 months]
