Methods of detecting cancer

BACKGROUND

Field of Invention

This present application encompasses proteins and peptide fragments of those proteins produced by proteolytic digestion that are useful for diagnosing or monitoring for the presence of cancer in an individual.

Description of the Related Art

Screening mammograms typically have a sensitivity of 75% and specificity of around 98% resulting in a false positive rate of roughly 5% per mammogram

(Brown, Houn, Sickles, & Kessler, 1995; Kolb, Lichy, & Newhouse, 2002; Luftner & Possinger, 2002). Follow up imaging to evaluate false positives costs the US over 4 B with an additional 1.6 B for biopsies alone. In 2010 of the 1.6 M biopsies performed as little as 16% (only 261,000) were found to have cancer (Grady, 2012). The answer to increasing the diagnostic parameters of imaging can be found in the pre and post image diagnostics which focuses on genetic and proteomic information, more specifically, biomarkers (Armstrong, Handorf, Chen, & Bristol Demeter, 2013; Li, Zhang, Rosenzweig, Wang, & Chan, 2002).

Tissue and serum are commonly the most logical place for beginning biomarker research, however the large dynamic range of both mediums makes discovery quite difficult (Schiess, Wollscheid, & Aebersold, 2009). The answers may lie in less complex biological fluids, such as saliva and tears. The use of tears as diagnostic medium is not a novel application as the tear proteome has been extensively investigated previously (Bohm et al., 2012; 2011; Lebrecht, Boehm, Schmidt, Koelbl, & Grus, 2009a; Lebrecht et al., 2009b; Wu & Zhang, 2007). In this application a quantitative assay for the detection of a panel of tear-based biomarkers in response to cancer by triple quadrupole LC mass spectrometry is proposed. From this quantitative information, the framework for a Certified Laboratory Improvement Amendments (CLIA) protocol will be defined.

SUMMARY

Methods of determining whether a subject has cancer are provided herein. The methods include obtaining a sample from the subject and performing steps for or detecting the level of at least one of the markers provided in Table 2A or Table 2B in the sample. The subject is likely to have cancer if the levels of the markers of Table 2A are increased or if the markers in Table 2B are decreased as compared to the levels in a control sample lacking cancer. The sample is optionally lacrimal secretions, such as an ocular wash, saliva or other bodily fluid.

Kits for performing the methods described herein are also provided. The kits may comprise an eye wash solution and collection materials such as tubes. The tube for collection may comprise a protease inhibitor or other protein stabilizing agent.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 is a set of photographs of a NuPAGE showing the proteins collected from each of the pooled ocular wash samples. The lane numbers correspond to pool numbers with the even numbers being breast cancer pools and the odd numbers being control pools.

FIG. 2 is a graph comparing the protein expression in cancer and control samples showing increased expression of several proteins in breast cancer samples as compared to controls based on peak intensity as determined by LC-MS/MS.

FIG. 3 is a graph comparing the protein expression in cancer and control samples showing decreased expression of several proteins in breast cancer samples as compared to controls based on peak intensity as determined by LC-MS/MS.

DETAILED DESCRIPTION

Provided herein are proteins and trypsin produced polypeptides (as defined in Table 2A and 2B in the Examples and the actual trypsin sequences and full length amino acid sequences of the proteins identified as being up regulated and down regulated in cancer samples are provided in Appendix I and Appendix II, respectively) which are shown in the Examples to increase or decrease in biological samples in response to the presence of breast cancer as compared to controls. These proteins and peptides are biomarkers and will be used to determine the disease state of a patient or other subject.

Subjects include humans, domesticated animals such as cats, dogs, cows, pigs or other animals susceptible to cancer. A "patient" indicates a subject who is diagnosed with a disease or with cancer or being tested for having cancer. Thus subject and cancer may be used interchangeably herein. The subjects may be suspected of having cancer, in particular breast cancer. The subjects may have an increased risk of developing breast cancer. For example, the subject may be at increased risk of cancer or suspected of having cancer because of a positive mammography result, by detection of a lump in the breast, testing positive for a gene known to increase the risk of cancer such as BRCA, or already have had a resection, biopsy or other procedure to remove the cancer. The subject may be undergoing or have previously undergone treatment for cancer and the methods and kits herein are used to monitor progression of treatment or alternatively to monitor for recurrence or spread of the cancer. The cancer may be detected as early as stage I or II cancer, but later stages will also be detected.

Also provided herein are methods and kits to collect ocular wash samples for use to determine the expression levels of the identified proteins or polypeptides in lacrimal secretions. In addition, the use of tubes for collection containing protease inhibitor or protein stabilizing agents is covered. The kits further contain buffers or reagents for the elution of breast cancer biomarkers from the eye. The design of devices to collect the applied saline solution from the corner of the exposed ocular surface as well as the packaging of this device together with saline and a pre-prepared sample collection tube are also disclosed.

The methods disclosed herein encompass the use of these breast cancer biomarkers, singly or in multiples, in a CLIA based protocol utilizing a triple quadrupole LC-MS platform, which will be carried out at a centralized laboratory testing facility. The ocular wash samples collected from individuals may be shipped to the testing facility in this embodiment. The identified proteins and their subsequent proteolytic fragments are used for quantitative analysis of diagnostic peptides produced in the triple quad. A threshold value or a relative or actual value in terms of polypeptide concentration directly relating to the polypeptides listed in Tables 2A and 2B can be defined or samples can be compared directly to non-cancerous controls. The quantitative information in report form could be provided to physicians to help in making decisions regarding the pathway of patient care. Physicians may base treatment decisions on these results and the final step may include administration of an appropriate anti-cancer therapeutic to the subject.

In an alternative embodiment, the polypeptides of Tables 2A and 2B may be detected by implementing binding agents (i.e. antibodies, peptoids, coated surfaces) and reagents that accommodate a binding interaction specific to these proteins to produce a reaction which can be quantitated based on production of a detectable signal such as florescence, color change, or UV absorbance. Implementing these components in a cartridge with a partnering reading instrument that could be used at point of care is also provided. Binding agents for these proteins and polypeptides may also be used for detection in a lateral flow device. Thus methods of detecting the level of protein expression in the samples using a binding partner such as an antibody may be used to detect the markers provided herein in an immunoassay.

The immunoassay typically includes contacting a test sample with an antibody that specifically binds to or otherwise recognizes a biomarker, and detecting the presence of a complex of the antibody bound to the biomarker in the sample. The immunoassay procedure may be selected from a wide variety of immunoassay procedures known to the art involving recognition of antibody/antigen complexes, including enzyme-linked immunosorbent assays (ELISA), radioimmunoassay (RIA), and Western blots, and use of multiplex assays, including use of antibody arrays, wherein several desired antibodies are placed on a support, such as a glass bead or plate, and reacted or otherwise contacted with the test sample. Such assays are well-known to the skilled artisan.

The detection of the biomarkers described herein in a sample may be performed in a variety of ways. In one embodiment, the method provides the reverse-transcription of complementary DNAs from mRNAs obtained from the sample. Fluorescent dye-labeled complementary RNAs may be transcribed from complementary DNAs which are then hybridized to the arrays of oligonucleotide probes. The fluorescent color generated by hybridization is read by machine, such as an Agilent Scanner and data are obtained and processed using software, such as Agilent Feature Extraction Software (9.1). Such array based methods include microarray analysis to develop a gene expression profile. As used herein, the term "gene expression profile" refers to the expression levels of mRNAs or proteins of a panel of genes in the subject. As used herein, the term "panel of diagnostic genes" refers to a panel of genes whose expression level can be relied on to diagnose or predict the status of the disease. Included in this panel of genes are those listed in Tables 2A and 2B, as well as any combination thereof, as provided herein. In other embodiments, complementary DNAs are reverse-transcribed from mRNAs obtained from the sample, amplified and simultaneously quantified by real-time PCR, thereby enabling both detection and quantification (as absolute number of copies or relative amount when normalized to DNA input or additional normalizing genes) of a specific gene product in the complementary DNA sample as well as the original mRNA sample.

The methods of this invention include detecting at least one biomarker. However, any number of biomarkers may be detected. It is preferred that at least two biomarkers are detected in the analysis. However, it is realized that three, four, or more, including all, of the biomarkers described herein may be utilized in the analysis. Thus, not only can one or more markers be detected, one to 40, preferably two to 40, two to 30, two to 20 biomarkers, two to 10 biomarkers, or some other combination, may be detected and analyzed as described herein. In addition, other biomarkers not herein described may be combined with any of the presently disclosed biomarkers to aid in the diagnosis of cancer. Moreover, any combination of the above biomarkers may be detected in accordance with the present invention.

The markers of Table 2A may be increased at least 2 fold, 4 fold, 5 fold, 8 fold, 10 fold or more relative to the level of the marker in the control sample. The markers of Table 2B are decreased at least 1.5 fold, 2 fold, 3 fold, 4 fold or more relative to the level of the marker in the control sample. The control sample may be a sample from a subject that does not have cancer, a pooled sample from subjects that do not have cancer or may be a control or baseline expression level known to be the average expression level of subjects without cancer.

Several terms are used throughout this disclosure and should be defined as commonly used in the art, or as specifically provided herein. As provided herein, mass spectrometry or MS refers to an analytical technique generating electrical or magnetic fields to determine mass-to-charge ratio of peptides and chemical compounds in order to identify or determine peptide sequence and chemical structures. LC-MS/MS spectrometry refers to an analytical technique combining the separation capabilities of high performance liquid chromatography (HPLC) with the mass analysis of mass spectrometry. Triple quadrupole mass spectrometry refers to a tandem mass spectrometer with three ionizing chambers (Q1, Q2, &Q3). This technique allows for target detection of molecules of interest. Ion pairs refers to a parent peptide detected in Q1 in it's doubly or triply charged form and a resulting y or b ion as generated by Q2 and detected in Q3 of a triple quadrupole mass spectrometry instrument. SIS internal peptide refers to a synthesized isotopically-labeled peptide with the same sequence as the peptide to be monitored in Q1 and used as an internal standard for reference to quantify the peptide of interest. The -y ion refers to an ion generated from the c-terminal of a peptide fragment. The -b ion refers to an ion generated from the n-terminal of a peptide fragment. Quantitative Ion refers to the selected highest intensity y or b ion used to determine the quantity of it's parent protein in a biological sample. Qualitative Ion refers to ion/ions chosen to ensure the integrity of the Qualitative ion to selected protein of interest and labeled peptide to selected standards.

CLIA refers to Clinical Laboratory Improvements Amendments which are federal regulatory standards that apply to all clinical laboratory testing preformed on humans in the united states, except clinical trials and basic research. (CLIA related Federal Register and Code of Federal Regulation Announcements). CLIA approved laboratory refers to a clinical lab which preforms laboratory testing on human specimens for diagnosis, prevention, or treatment of disease or impairment and is approved and monitored by an FDA approved regulatory organization. CLIA waived test refers to a clinical laboratory test meeting specific criteria for risk, error and complexity as defined by the Food and Drug Association (FDA).

Point-of-care device refers to an instrument or cartridge available at the location of patient and physician care containing binding agents to a biomarker, or series of biomarkers of interest, and can generate information on the presence, absence, and in some cases concentrations of detected biomarkers. Analyte refers to any measurable biomarker which can be protein, peptide, macromolecule, metabolite, small molecule, or autoantibody. Biological fluid as used herein refers to tears, whole blood, serum, urine, and saliva. Biomarker refers to any substance (e.g. protein, peptide, metabolite, polynucleotide sequence) whose concentration level changes in the body (e.g. increased or decreased) as a result of a disease or condition. Marker and biomarker may be used interchangeably herein.

Lateral flow test refers to a device used to measure the presence of an analyte in a biological fluid using porous paper of sintered polymer. ELISA refers to Enzyme-linked immunosorbent assay which utilizes antibodies to detect the presence and concentration of an analyte of interest. Diagnostic Panel refers to a group of molecules (e.g. proteins or peptides) whose combined concentrations are used to diagnose a disease state. (e.g. cancer). A breast cancer marker refers to a molecule (e.g. protein, peptide, metabolite, polynucleotide sequence) whose concentration level in the body changes (e.g. is increased or decreased) as a result of breast cancer.

In addition to being useful to diagnose cancer and in particular breast cancer in a subject, the kits and methods provided herein may be used to monitor treatment or recurrence of cancer in an individual previously diagnosed with cancer. Thus if the levels of the markers in Table 2A begin to rise or the levels of the markers in Table 2B begin to decrease over time in the same subject after treatment, further chemotherapeutics targeting the cancer may be administered. The methods and kits may also be used to monitor the effectiveness of a chemotherapeutic treatment. In this alternative, the levels of the biomarkers in Table 2A would decrease over time if the treatment regime is effective and either would not change or may increase over time if the treatment regime is not effective in a single subject. The levels of the biomarkers in Table 2B would increase over time during treatment with a therapeutic that is effective and would either not change or decrease over time if the treatment regime is not effective in a single subject.

Treating cancer includes, but is not limited to, reducing the number of cancer cells or the size of a tumor or mass in the subject, reducing progression of a cancer to a more aggressive form, reducing proliferation of cancer cells or reducing the speed of tumor growth, killing of cancer cells, reducing metastasis of cancer cells or reducing the likelihood of recurrence of a cancer in a subject. Treating a subject as used herein refers to any type of treatment that imparts a benefit to a subject afflicted with a disease or at risk of developing the disease, including improvement in the condition of the subject (e.g., in one or more symptoms), delay in the progression of the disease, delay the onset of symptoms or slow the progression of symptoms, etc.

The present disclosure is not limited to the specific details of construction, arrangement of components, or method steps set forth herein. The compositions and methods disclosed herein are capable of being made, practiced, used, carried out and/or formed in various ways that will be apparent to one of skill in the art in light of the disclosure that follows. The phraseology and terminology used herein is for the purpose of description only and should not be regarded as limiting to the scope of the claims. Ordinal indicators, such as first, second, and third, as used in the description and the claims to refer to various structures or method steps, are not meant to be construed to indicate any specific structures or steps, or any particular order or configuration to such structures or steps. All methods described herein can be performed in any suitable order unless otherwise indicated herein or otherwise clearly contradicted by context. The use of any and all examples, or exemplary language (e.g., "such as") provided herein, is intended merely to facilitate the disclosure and does not imply any limitation on the scope of the disclosure unless otherwise claimed. No language in the specification, and no structures shown in the drawings, should be construed as indicating that any non-claimed element is essential to the practice of the disclosed subject matter. The use herein of the terms "including." "comprising," or "having," and variations thereof, is meant to encompass the elements listed thereafter and equivalents thereof, as well as additional elements. Embodiments recited as "including," "comprising," or "having" certain elements are also contemplated as "consisting essentially of" and "consisting of" those certain elements.

Recitation of ranges of values herein are merely intended to serve as a shorthand method of referring individually to each separate value falling within the range, unless otherwise indicated herein, and each separate value is incorporated into the specification as if it were individually recited herein. For example, if a concentration range is stated as 1% to 50, it is intended that values such as 2% to 40%, 10% to 30%, or 1% to 3%, etc., are expressly enumerated in this specification. These are only examples of what is specifically intended, and all possible combinations of numerical values between and including the lowest value and the highest value enumerated are to be considered to be expressly stated in this disclosure. Use of the word "about" to describe a particular recited amount or range of amounts is meant to indicate that values very near to the recited amount are included in that amount, such as values that could or naturally would be accounted for due to manufacturing tolerances, instrument and human error in forming measurements, and the like. All percentages referring to amounts are by weight unless indicated otherwise.

No admission is made that any reference, including any non-patent or patent document cited in this specification, constitutes prior art. In particular, it will be understood that, unless otherwise stated, reference to any document herein does not constitute an admission that any of these documents forms part of the common general knowledge in the art in the United States or in any other country. Any discussion of the references states what their authors assert, and the applicant reserves the right to challenge the accuracy and pertinence of any of the documents cited herein. All references cited herein are fully incorporated by reference, unless explicitly indicated otherwise. The present disclosure shall control in the event there are any disparities between any definitions and/or description found in the cited references.

The following examples are meant only to be illustrative and are not meant as limitations on the scope of the invention or of the appended claims.

EXAMPLES

Example 1: Methods for Collecting Ocular Wash Samples

This study was carried out under institutional review board approval and participants were recruited at two clinics based in Arkansas, The Breast Center and Highlands Oncology Group, as well as two clinics based in Washington, PeaceHealth Southwest and PeaceHealth Longview Surgery Center. Inclusion/exclusion criteria used by the clinic for patient selection is given in Table 1.

TABLE-US-00001 TABLE 1 Inclusion/Exclusion Criteria for participant selection Individuals who are: Between the ages of 18-100 years of age Presenting for a routine check up Presenting for the evaluation of an abnormal exam or test (mammogram, ultrasound, MRI, PET, ect.) Presenting for the evaluation of a palpable lump or mass Presenting with a mass, pre or post biopsy as long as a portion of mass is remaining Currently have or are in treatment for breast cancer. Individuals who are: <18 years of age or >100 years of age. experiencing a concurrent eye infection or trauma. Currently experiencing acute conjunctivitis Known to have abnormal production of tears (too much or too little)

Ocular wash samples were obtained by rinsing the exposed surface of the eye with Optics Laboratory single use Eye-Cept Rewetting drops. The single use dropper, selected to eliminate contamination, was used to apply approximately five drops of rewetting saline to the outside corner of the eye. After application the solution naturally flowed across the surface of the eye and pooled in the inner corner/duct next to the nose. The solution was then collected by suction using a one mL tuberculine syringe, with no needle attached, and transferred to a pre-labeled 0.5 mL tube with an o-ring screw top cap. The optimal total volume from each collection is approximately 100 .mu.L, however actual volumes can vary. Samples were stored between -20.degree. C. and -80.degree. C. (depending on freezer unit available) within two hours of collection.

Samples collected at participating clinics were retrieved by Ascendant personnel on a weekly basis and transferred on dry ice to Ascendant's laboratory facility. In the case of the Washington based clinics, samples were shipped to Ascendant on dry ice on a monthly basis.

Data collected from the participants included: sex, race, age, previous cancer history, family history of breast cancer, stage of current cancer (I, II, III, IV) tumor size, breast cancer subtype (Ductal Carcinoma In Situ, Invasive Ductal Carcinoma, Invasive Lobular Carcinoma, Lobular Carcinoma In Situ, and Unknown) and tumor grade. A spreadsheet was created to track data and stratify samples based on selected criteria.

Control samples were collected, using the procedure detailed above, from volunteers between the ages of 18-100 who reported they were cancer and mass free as per the inclusion criteria outlined in the IRB approved collection protocol. Exclusion criteria are the same as for the breast cancer patients. All control participants were recruited from the general population; consent and sample collected was performed by Ascendant Diagnostics personnel. Data collected from control participants included: sex, age, race, previous history of breast cancer, family history of breast cancer, and current medications.

All samples in the tear bank were stored at -80.degree. C. and freeze thaw cycles were limited to three times, as protein degradation was observed after three freeze thaw cycles. In some cases samples were aliquoted to minimize freeze thaw cycles further.

Example 2: Methods for Preparation of Sample Pools for LC MS/MS

Eight pooled samples (four breast cancer pools and four control pools) each with a total volume of 300 .mu.L were assembled from banked tear samples for the purpose of label free quantitation using in-gel digestion. All breast cancer ocular wash samples used were taken from individuals with stage I &II breast cancer and were collected prior to treatment. Controls were age matched for accuracy of comparison.

To ensure sample integrity, MALDI-TOF data was collected on aliquots from each of the individual samples, which were included in the pooled samples. Prior to MALDI testing, tear samples were purified using ZipTip.sub.c18. This procedure serves to remove any contaminates which may be present in the sample and to concentrate the proteins in order to increase ease of detection. A 15 .mu.L aliquot was removed from the freezer and thawed at room temperature for 10 minutes (.about.22.degree. C.). The protocol for ZipTip.sub.c18 was adapted from the user manual supplied by Millipore and a variable pipette with a total volume capacity of 10 .mu.L was used for all sample preparations. The ZipTip.sub.c18 was equilibrated in a wetting solution of acetonitrile (ACN) 0.1% TFA for 10 cycles (1 cycle involves aspirating 10 .mu.L of solution into the tip and dispensing). Following equilibration, the tip was washed with ddH.sub.2O (0.1% TFA) for 10 cycles. The sample was then loaded for 10 cycles, followed by a wash with ddH.sub.2O (0.1% TFA) for 10 cycles. The load procedure, followed by the wash procedure was carried out a total of five times to ensure maximum protein binding. Bound proteins were eluted in 5 .mu.L of ACN (0.1% TFA) for 20 cycles into a clean tube. The ACN (0.1% TFA) was removed using an eppendorf vacufuge plus for 10 minutes at 45.degree. C. Samples were then reconstituted in 5 .mu.L ddH.sub.2O (0.1% TFA) and spotted onto a ground steel MALDI target. Each sample was spotted a total of three times at 1 .mu.L each time, allowing complete drying of the spot before more material was added. After the final spotting was completely dry, 1 .mu.L of a saturated solution of 40 mgs of Sinapinic Acid matrix prepared in 1 mL of 50:50 solution of ACN/ddH.sub.2O (0.1% TFA) was spotted onto each sample and all samples were allowed to dry completely on the bench top prior to data collection. One microliter of protein standard was added to several locations on the MALDI target as well. The protein standard was spotted only once and followed by addition of the sinapinic acid matrix used for the OW samples.

Data was collected on a Bruker Reflex III MALDI-IOF mass spectrometer in its linear positive mode, as linear mode increases the sensitivity. Acquisition of all spectra was performed both manually and automatically (user unbiased acquisition) using Bruker Daltonics flex Control software. For each spot, MALDI-TOF mass spectra were acquired at least three times, with a total of 200 laser shots accumulated for each run. Shot accumulation was programmed using a fuzzy logic operator to only consider spectra with S/N better than 20 in between m/z 2000-45,000. Sample integrity was evaluated by visual inspection of the generated MALDI-TOF spectrum. High mass peak splitting together with increased quantity of low mass peaks suggest protein degredation has occurred and the sample was not used further.

Total protein content of each pool was determined using a bicinchoninic acid protein assay kit with a 1:20 (v/v) ratio of standard and unknown to working reagent and an incubation time of 30 min at 37.degree. C. To ensure reliable total protein content calculation, a series of dilutions were made for each sample (i.e. 1:2, 1:4, 1:6) and all dilutions were plated in triplicate. A standard curve using diluted albumin (2 mg/ml, 1.5 mg/ml, 1 m/ml, 0.75 mg/ml, 0.5 mg/ml, 0.25 mg/ml 0.125 mg/ml 0.025 mg/ml and 0 mg/ml) was generated and blank subtraction was applied to all standards and unknowns. The protein concentration for each unknown was calculated using a four-parameter fit of the standard curve. Concentrations were multiplied by the dilution factor and averaged to give an accurate total protein content calculation. Assays were only considered valid if the coefficient of variation (% CV) was 15% or below.

Using the total protein content determined by BCA, 25 .mu.g of protein from each pool was loaded onto a NuPAGE Bis-Tris 4-12% gradient separation gel and run using methods standard for an individual skilled in the art as shown in FIG. 1. Following separation of the ocular proteome, between 20-22 slices were cut for each lane and subjected to disulfide reduction using Dithiothreitol, followed by sulfhydryl aklyation using iodoacetemide, and finally trypsin digestion. Specific slice counts for each sample were as follows: Lane 1=20 slices, Lane 2=21 slices, Lane 3=22 slices, Lane 4=21 slices, Lane 5=20 slices, Lane 6=20 slices, Lane 7=21 slices, Lane 8=21 slices.

Example 3: Methods and Results for Label Free Quantitation by LC MS/MS

Twenty .mu.L from each trypsin digestion reaction was loaded onto a nanoAcquity UPLC (Waters) and eluted using a gradient from 3-99% 0.1% formic acid, 75% acetonitrile over 30 minutes. A LTQ Orbitrap Velos (Thermo Scientific) was used for detection of the peptides produced by proteolytic cleavage. Raw data files from the LC-MS/MS analysis were uploaded into the MASCOT database for protein identification using the UniProtKB database, 2 ppm peptide mass tolerance, and 0.5 Da fragment mass tolerance. The output from MASCOT was then uploaded into the software packages Scaffold and MaxQuant for analysis.

Greater than 700 protein hits were identified using this method. In order to isolate potential biomarker candidates, peak intensities for each group (cancer and control) were averaged for each protein and fold change was determined with respect to cancer. In addition a student's T-test was applied to each protein providing a p-value. All proteins with a fold change of greater than 1.5 and a p-value <0.05 were, considered as possible biomarker candidates. P-values and fold changes were assessed on a case by case basis and some proteins with higher p-values were included in the candidate biomarkers list. The list was then narrowed based on biological relevance to breast cancer, other cancer subtypes, and cancer processes. The complete list of candidate biomarkers is given in Tables 2A and 2B and shown in graphic form in FIGS. 2 and 3.

TABLE-US-00002 TABLE 2A Biomarkers with an increase expression in cancer as compared to control samples. Protein ID P-Value Fold Change CLEC3B 0.067 No expression in control KLK8 0.07 No expression in control C8A 0.149 No expression in control HRC 0.17 No expression in control KLK13 0.178 No expression in control C7 0.207 No expression in control ALDH1A1 0.24 No expression in control APOL1 0.32 No expression in control MUC-1 0.27 40.6 BLMH 0.212 38.1 SPRR1B 0.117 35.1 SERPINB2 0.11 16.1 Putative uncharacterized 0.165 11.7 protein RAB-30 0.153 11.3 C4A 0.099 9.6 PRDX6 0.14 7.6 CFHR1 0.169 7.4 A1BG 0.11 7.2 GGH 0.14 7.1 EZR 0.066 6.3 SERPINF2 0.16 5.9 HPX 0.1 5.5 CRISP3 0.0238 5.2 CPA4 0.14 4.8 PGLYRP2 0.06 3.9 CASP14 0.068 3.3 Ig Kappa Chain V-III region 0.001 2.6 POM ALB 0.014 2.4 CFH 0.042 2.1 SLC34A2 0.105 29.3

TABLE-US-00003 TABLE 2B Biomarkers with a decrease in expression in cancer samples as compared to controls Protein ID P-value Fold Change GAS6 0.045 3.5 CTSL1 0.051 3.4 SFRP1 0.059 3.4 BPI 0.045 2.5 CHID1 0.0546 2.2 MSN 0.0545 2.06 ERAP1 0.014 1.6 QPCT 0.045 1.6 ATRN 0.062 1.6 LTF 0.051 1.5

To further confirm protein identity, the peptide sequences produced by trypsin digestion were mapped back to the original protein sequence. Trypsin products unique to particular proteins were noted, as these sequences have the potential to be used as diagnostic peptides as well as isotopically labeled standards in the final CLIA triple quadrupole mass spectrometry assay. The sequences of the trypsin products and the full-length proteins markers identified in Tables 2A and 2B are provided in Appendix I and Appendix II, respectively.

Example 4: Methods for Schirmer Strip Collections and Processing

Institutional review board approval was obtained for the collection of tears using Schirmer strips. For collection, the rounded tip of the Schirmer strip was folded over at the 0 mm line forming a lip. The folded portion was placed in the lower eyelid of the participant and they were asked to close their eye and keep it in the closed position for a period of 5 minutes. After five minutes the strip was removed and placed in a sterile 1.5 mL pre-labeled snap top tube and placed at -20.degree. C. or -80.degree. C. depending on availability. Collection criteria stated that if the 35 mm mark was reached prior to the five minute time, the strip could be removed.

Data collected from participants included the following, age, sex, race, currently taking birth control or on hormone replacement therapy, ophthamological infections, current or recent chemotherapy treatments, family history of cancer, genetic testing (BRAC1/2) if available, cancer stage, cancer type, hormone receptor status, size of mass, tumor grad, previous history of cancer. A spreadsheet was constructed to house this information and allow for sample stratification based on desired characteristics. Sample total protein content was also entered into the database.

To elute the proteins bound to the Schirmer strip, the strips were first diced and placed in a clean sterile 1.5 mL snap top tube. 200 .mu.L of 1.times.PBS was added to the diced strip and the sample was incubated at 4.degree. C. with mild shaking overnight. Following elution, the samples were spun briefly to collect the strip fragments at the bottom of the tube, and the supernatant was transferred to a new clean 1.5 mL snap top tube. Total protein content was determined using BCA assay, as described above, and the samples were stored at -80.degree. C. until further use.

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TABLE-US-00004 Protein Name Uniprot IPI Gene Name: Complement C4A POCOL4 IPI00032258 C4A_Human Trypsin Fragments 1. AEFQDALEK 2. DHAVDLIQK 3. DKGQAGLQR (SEQ ID NO: 1) (SEQ ID NO: 2) (SEQ ID NO: 3) 4. EMSGSPASG 5. FACYYPR 6. FGLLDEDGK IPVK (SEQ ID NO: 5) K (SEQ ID NO: 4) (SEQ ID NO: 6) 7. GHLFLQTDQ 8. GLCVATPVQ 9. GIQDEDGYR PIYNPGQR LR (SEQ ID NO: 9) (SEQ ID NO: 7) (SEQ ID NO: 8) 10. GPEVQUVAH 11. GSFEFPVGD 12. HLVPGAPFL SPWLK AVSK LQALVR (SEQ ID NO: 10) (SEQ ID NO: 11) (SEQ ID NO: 12) 13. LLATLCSAE 14. LNMGITDLQ 15. ITQVLHFTK VCQCAEGK GLR (SEQ ID NO: 15) (SEQ ID NO: 13) (SEQ ID NO: 14) 16. NVNFQK 17. QGSFQGGFR 18. SCGLHQLLR (SEQ ID NO: 16) (SEQ ID NO: 17) (SEQ ID NO: 18) 19. VDFTLSSER 20. VDVQAGACE 21. VFALDQK (SEQ ID NO: 19) GK (SEQ ID NO: 21) (SEQ ID NO: 20) 22. VGDTININI 23. VLSLAQEQV 24. VTASDPLDT R GGSPEK LGSEGALSP (SEQ ID NO: 22) (SEQ ID NO: 23) GGVASLLR (SEQ ID NO: 24) 25. YLDKTEQWS TLPPETK (SEQ ID NO: 25) 10 20 30 40 (SEQ ID NO: 26) MRLLWGLIWA SSFFTLSLQK PRLLLFSPSV VHLGVPLSVG 50 60 70 80 VQLQDVPRGQ VVKGSVFLRN PSRNNVPCSP K.sup.(15)VDFTLSSER 90 100 110 120 DFALLSLQVP LKDAK.sup.(18)SCGLH QLLR.sup.(10)GPEVQL VAHSPWLKDS 130 140 150 160 LSRTTNIQGI NLLFSSRR.sup.(7)GH LFLQTDQPIY NPGQRVRYR.sup.(21)V 170 180 190 200 FALDQKMRPS TDTITVMVEN SHGLRVRKKE VYMPSSIFQD 210 220 230 240 DFVIPDISEP GTWKISARFS DGLESNSSTQ FEVKKYVLPN 250 260 270 280 FEVKITPGKP YILTVPGHLD EMQLDIQARY IYGKPVQGVA 290 300 310 320 YVR.sup.(6)FGLLDED GKKTFFRGLE SQTKLVNGQS HISLSK(2)AEFQ 330 340 350 360 DALEK.sup.(14)LNMGI TDLQGLRLYV AAAIIESPGG EMEEAELTSW 370 380 390 400 YFVSSPFSLD LSKTKR.sup.(12)HLVP GAPFLLQALV R.sup.(4)EMSGSPASG 410 420 430 440 IPVKVSATVS SPGSVPEVQD IQQNTDGSGQ VSIPIIIPQT 450 460 470 480 ISELQLSVSA GSPHPAIARL TVAAPPSGGP GFLSIERPDS 490 500 510 520 RPPR.sup.(22)VGDTLN LNLRAVGSGA TFSHYYMIL SRGQIVFMNR 530 540 550 560 EPKRTLTSVS VFVDHHLAPS FYFVAFYYHG DHPVANSLR.sup.(20)V 570 580 590 600 DVQAGACEGK LELSVDGAKQ YRNGESVKLH LETDSLALVA 610 620 630 640 LGALDTALYA AGSKSHKPLN MGKVFEAMNS YDLGCGPGGG 650 660 670 680 DSALQVFQAA GLAFSDGDQW TLSRKRLSCP KEKTTRKKR.sup.(16)N 690 700 710 720 VNFQKAINEK LGQYASPTAK RCCQDGVTRL PMMRSCEQRA 730 740 750 760 ARVQQPDCRE PFLSCCQFAE SLRKKSR.sup.(3)DKG QAGLQRALEI 770 780 790 800 LQEEDLIDED DIPVRSFFFE NWLWRVETVD RFQILTLWLP 810 820 830 840 DSLTTWEIHG LSLSKTK.sup.(8)GLC VATPVQLRVF REFHLHLRLP 850 860 870 880 MSVRRFEQLE LRPVLYNYLD KNLTVSVHVS PVEGLCLAGG 890 900 910 920 GGLAQQVLVP AGSARPVAFS VVPTAAAAVS LKVVAR.sup.(11)GSFE 930 940 950 960 FPVGDAVSKV LQIEKEGAIH REELVYELNP LDHRGRTLEI 970 980 990 1000 PGNSDPNMIP DGDFNSYVR.sup.(24)V TASDPLDTLG SEGALSPGGV 1010 1020 1030 1040 ASLLRLPRGC GEQTMIYLAP TLAASR.sup.(25)YLDK TEQWSTLPPE 1050 1060 1070 1080 TK.sup.(2)DHAVDLIQ KGYMRIQQFR KADGSYAAWL SRDSSTWLTA 1090 1100 1110 1120 FVLK.sup.(23)VLSLAQ EQVGGSPEKL QETSNWLLSQ QQADGSFQDP 1130 1140 1150 1160 CPVLDRSMQG GLVGNDETVA LTAFVTIALH HGLAVFQDEG 1170 1180 1190 1200 AEPLKQRVEA SISKANSFLG EKASAGLLGA HAAAITAYAL 1210 1220 1230 1240 TLTKAPVDLL GVAHNNLMAM AQETGDNLYW GSVTGSQSNA 1250 1260 1270 1280 VSPTPAPRNP SDPMPQAPAL WIETTAYALL HLLLHEGKAE 1290 1300 1310 1320 MADQASAWLT R.sup.(17)QGSFQGGFR STQDTVIALD ALSAYWIASH 1330 1340 1350 1360 TTEERGLNVT LSSTGRNGFK SHALQLNNRQ IRGLEEELQF 1370 1380 1390 1400 SLGSKINVKV GGNSKGTLKV LRTYNVLDMK NTTCQDLQIE 1410 1420 1430 1440 VTVKGHVEYT MEANEDYEDY EYDELPAKDD PDAPLQPVTP 1450 1460 1470 1480 LQLFEGRRNR RRREAPKVVE EQESRVHYTV CIWRNGKVGL 1490 1500 1510 1520 SGMAIADVTL LSGFHALRAD LEKLTSLSDR YVSHFETEGP 1530 1540 1550 1560 HVLLYFDSVP TSRECVGFEA VQEVPVGLVQ PASATLYDYY 1570 1580 1590 1600 NPERRCSVFY GAPSKSR.sup.(13)LLA TLCSAEVCQC AEGKCPRQRR 1610 1620 1630 1640 ALER.sup.(9)GLQDED GYRMK.sup.(5)FACYY PRVEYGFQVK VLREDSRAAF 1650 1660 1670 1680 RLFETK.sup.(18)ITQV LHFTKDVKAA ANQMRNFLVR ASCRLRLEPG 1690 1700 1710 1720 KEYLIMGLDG ATYDLEGHPQ YLLDSNSWIE EMPSERLCRS 1730 1740 TRQRAACAQL NDFLQEYGTQ GCQV Protein Name Uniprot IPI Gene Name Histidine Rich Protein P04196 IPI00022371 HRG_Human Trypsin fragments 1. YKEENDDFASFR 2. ADLFYDVEALDLESPK (SEQ ID NO: 27) (SEQ ID NO: 28) MKALIAALLL ITLQYSCAVS PTDCSAVEPE AEKALDLINK (SEQ ID NO: 29) 70 80 RRRDGYLFQL LRIADAHLDR VENTTVYYLV LDVQESDCSV 90 100 110 120 LSRKYWNDCE PPDSRRPSEI VIGQCKVIAT RHSHESQDLR 130 140 150 160 VIDFNCTTSS VSSALANTKD SPVLIDFFED TERYRKQANK 170 180 190 200 ALEK.sup.(1)YKEEND DFASFRVDRI ERVARVRGGE GTGYFVDFSV 210 220 230 240 RNCPRHHFPR HPNVFGFCR.sup.(2)A DLFYDVEALD LESPKNLVIN 250 260 270 280 CEVFDPQEHE NINGVPPHLG HPFHWGGHER SSTTKPPFKP 290 300 310 320 HGSRDHHHPH KPHEHGPPPP PDERDHSHGP PLPQGPPPLL 330 340 350 360 PMSCSSCQHA TFGTNGAQRH SHNNNSSDLH PHKHHSHEQH 370 380 390 400 PHGHHPHAHH PHEHDTHRQH PHGHHPHGHH PHGHHPHGHH 410 420 430 440 PHGHHPHCHD FQDYGPCDPP PHNQGHCCHG HGPPPGHLRR 450 460 470 480 RGPGKGPRPF HCRQIGSVYR LPPLRKGEVL PLPEANPPSF 490 500 510 520 PLPHHKHPLK PDNQPFPQSV SESCPGKFKS GFPQVSMFFT HTFPK Protein Name Uniprot IPI Gene Name C-type lectin domain P05452 IPI00009028.2 CLEC3B_Human family 3, member B (Tetranectin) Trypsin fragments 1. EQQALQTVCLK 2. TFHEASEDCISR (SEQ ID NO: 30) (SEQ ID NO: 31) 10 20 30 40 (SEQ ID NO: 32) MELWGAYLLL CLFSLLTQVT TEPPTQKPKK IVNAKKDVVN 50 60 70 80 TKMFEELKSR LDTLAQEVAL L.sup.1KEQQALQTV CLKGTKVHMK 90 100 110 120 CFLALTQTK.sup.2T FHEASEDCIS RGGTLGTPQT GSENDALYEY 130 140 150 160 LRQSVGNEAE IWLGLNDMAA EGTWVDMTGA RIAYKNWETE 170 180 190 200 ITAQPDGGKT ENCAVLSGAA NGKWFDKRCR DQLPYICQFG IV

Protein Name Uniprot IPI Gene Name Kallikrein-8 O60259-2 IPI00219892 KLK8_Human isoform 2 Trypsin fragments 1. ENFPDTLNCAEVK (SEQ ID NO: 33) 10 20 30 40 (SEQ ID NO: 34) MGRPRPRAAK TWMFLLLLGG AWAGHSRAQE DKVLGGHECQ 50 60 70 80 PHSQPWQAAL FQGQQLLCGG VLVGGNWVLT AAHCKKPKYT 90 100 110 120 VRLGDHSLQN KDGPEQEIPV VQSIPHPCYN SSDVEDHNHD 130 140 150 160 LMLLQLRDQA SLGSKVKPIS LADHCTQPGQ KCTVSGWGTV 170 180 190 200 TSPR.sup.(3)ENFPDT LNCAEVKIFP QKKCEDAYPG QITDGMVCAG 210 220 230 240 SSKGADTCQG DSGGPLVCDG ALQGITSWGS DPCGRSDKPG 250 260 VYTNICRYLD WIKKIIGSKG Protein Name Uniprot IPI Gene Name Complement Component P07357 IPI00011252 C8A_Human 8 alpha Trypsin fragments 1. AIDEDCSQY 2. LGSLGAACE 3. QAQCGQDFQ EPIPGSQK QTQTEGAK CK (SEQ ID NO: 35) (SEQ ID NO: 36) (SEQ ID NO: 37) 10 20 30 40 (SEQ ID NO: 38) MFAVVFFILS LMTCQPGVTA QEKVNQRVRR AATPAAVTCQ 50 60 70 80 LSNWSEWTDC FPCQDKKYRH RSLLQPNKFG GTICSGDIWD 90 100 110 120 QASCSSSTTC VR.sup.(3)QAQCGQDF QCKETGRCLK RHLVCNGDQD 130 140 150 160 CLDGSDEDDC EDVR.sup.(1)AIDEDC SQYEPIPGSQ KAALGYNILT 170 180 190 200 QEDAQSVYDA SYYGGQCETV YNGEWRELRY DSTCERLYYG 210 220 230 240 DDEKYFRKPY NFLKYHFEAL ADTGISSEFY DNANDLLSKV 250 260 270 280 KKDKSDSFGV TIGIGPAGSP LLVGVGVSHS QDTSFLNELN 290 300 310 320 WYNEKKFIFT RIFTKVQTAH FKMRKDDIML DEGMLQSLME 330 340 350 360 LPDQYNYGMY AKFINDYGTH YITSGSMGGI YEYILVIDKA 370 380 390 400 KMESLGITSR DITTCFGGSL GIQYEDKINV GGGLSGDHCK 410 420 430 440 KFGGGKTERA RKAMAVEDII SRVRGGSSGW SGGLAQNRST 450 460 470 480 ITYRSWGRSL KYNPVVIDFE MQPIHEVLRH TSLGPLEAKR 490 500 510 520 QNLRRALDQY LMEFNACRCG PCFNNGVPIL EGTSCRCQCR 530 540 550 560 .sup.(2)LGSLGAACEQ TQTEGAKADG SWSCWSSWSV CRAGIQERRR 570 580 ECDNPAPQNG GASCPGRKVQ TQAC Protein Name Uniprot IPI Gene Name Kallikrein-13 Q9UKR3 IPI00007726 KLK13_Human Trypsin fragments 1. TLQCANIQLR 2. ITDNMLCAGTK (SEQ ID NO: 39) 10 20 30 40 (SEQ ID NO: 41) MWPLALVIAS LTLALSGGVS QESSKVLNTN GTSGFLPGGY 50 60 70 80 TCFPHSQPWQ AALLVQGRLL CGGVLVHPKW VLTAAHCLKE 90 100 110 120 GLKVYLGKHA LGRVEAGEQV REVVHSIPHP EYRRSPTHLM 130 140 150 160 HDHDIMLLEL QSPVQLTGYI QTLPLSHNNR LTPGTTCRVS 170 180 190 200 GWGTTTSPQV NYPR.sup.(1)TLQCAN IQLRSDEECR QVYPGK.sup.(2)ITDN 210 220 230 240 MLCAGTKEGG KDSCEGDSGG PLVCNRTLYG IVSWGDFPCG 250 260 270 QPDRPGVYTR VSRYVLWIRE TIRKYETQQQ KWLKGPQ Protein Name Uniprot IPI Gene Name Complement P10643 IPI00296608 C7_Human Component 7 Trypsin fragments 1. AASGTQNNVLR 2. DSCTLPASAEK (SEQ ID NO: 42) (SEQ ID NO: 43) 10 20 30 40 (SEQ ID NO: 44) MKVISLFILV GFIGEFQSFS SASSPVNCQW DFYAPWSECN 50 60 70 80 GCTKTQTRRR SVAVYGQYGG QPCVGNAFET QSCEPTRGCP 90 100 110 120 TEEGCGERFR CFSGQCISKS LVCNGDSDCD EDSADEDRCE 130 140 150 160 DSERRPSCDI DKPPPNIELT GNGYNELTGQ FRNRVINTKS 170 180 190 200 FGGQCRKVFS GDGKDFYRLS GNVLSYTFQV KINNDFNYEF 210 220 230 240 YNSTWSYVKH TSTEHTSSSR KRSFFRSSSS SSRSYTSHTN 250 260 270 280 EIHKGKSYQL LVVENTVEVA QFINNNPEFL QLAEPFWKEL 290 300 310 320 SHLPSLYDYS AYRRLIDQYG THYLQSGSLG GEYRVLFYVD 330 340 350 360 SEKLKENDFN SVEEKKCKSS GWHFVVKFSS HGCKELENAL 370 380 390 400 K.sup.(1)AASGTQNNV LRGEPFIRGG GAGFISGLSY LELDNPAGNK 410 420 430 440 RRYSAWAESV TNLPQVIKQK LTPLYELVKE VPCASVKKLY 450 460 470 480 LKWALEEYLD EFDPCHCRPC QNGGLATVEG THCLCHCKPY 490 500 510 520 TFGAACEQGV LVGNQAGGVD GGWSCWSSWS PCVQGKKTRS 530 540 550 560 RECNNPPPSG GGRSCVGETT ESTQCEDEEL EHLRLLEPHC 570 580 590 600 FPLSLVPTEF CPSPPALKDG FVQDEGTMFP VGKNVVYTCN 610 620 630 640 EGYSLIGNPV ARCGEDLRWL VGEMHCQKIA CVLPVLMDGI 650 660 670 680 QSHPQKPFYT VGEKVTVSCS GGMSLEGPSA FLCGSSLKWS 690 700 710 720 PEMKNARCVQ KENPLTQAVP KCQRWEKLQN SRCVCKMPYE 730 740 750 760 CGPSLDVCAQ DERSKRILPL TVCKMHVLHC QGRNYTLTGR 770 780 790 800 .sup.(2)DSCTLPASAE KACGACPLWG KCDAESSKCV CREASECEEE 810 820 830 840 GFSICVEVNG KEQTMSECEA GALRCRGQSI SVTSIRPCAA ETQ Protein Name Uniprot IPI Gene Name Retinal P00352 IPI00218914 ALDH1A1_Human Dehydrogenase Trypsin fragments 1. SSSGTPDLP 2. YILGNPLTPGVTQG VLLTDLK PQIDKEQYDK (SEQ ID NO: 45) (SEQ ID NO: 46) 10 20 30 40 (SEQ ID NO: 47) M.sup.(1)SSSGTPDLP VLLTDLKIQY TKIFINNEWH DSVSGKKFPV 50 60 70 80 FNPATEEELC QVEEGDKEDV DKAVKAARQA FQIGSPWRTM 90 100 110 120 DASERGRLLY KLADLIERDR LLLATMESMN GGKLYSNAYL 130 140 150 160 NDLAGCIKTL RYCAGWADKI QGRTIPIDGN FFTYTRHEPI 170 180 190 200 GVCGQIIPWN FPLVMLIWKI GPALSCGNTV VVKPAEQTPL 210 220 230 240 TALHVASLIK EAGFPPGVVN IVPGYGPTAG AAISSHMDID 250 260 270 280 KVAFTGSTEV GKLIKEAAGK SNLKRVTLEL GGKSPCIVLA 290 300 310 320 DADLDNAVEF AHHGVFYHQG QCCIAASRIF VEESIYDEFV 330 340 350 360 RRSVERAKK.sup.(2)Y ILGNPLTPGV TQGPQIDKEQ YDKILDLIES 370 380 390 400 GKKEGAKLEC GGGPWGNKGY FVQPTVFSNV TDEMRIAKEE 410 420 430 440 IFGPVQQIMK FKSLDDVIKR ANNTFYGLSA GVFTKDIDKA 450 460 470 480 ITISSALQAG TVWVNCYGVV SAQCPFGGFK MSGNGRELGE 490 500 YGFHEYTEVK TVTVKISQKN S Protein Name Uniprot IPI Gene Name ApoLipoprotein L1 Q9UKR3 IPI00I86903 APOL1_Human isoform 2

Trypsin fragments 1. VTEPISAESGEQVER (SEQ ID NO: 48) 10 20 30 40 (SEQ ID NO: 49) MEGAALLRVS VLCIWMSALF LGVGVRAEEA GARVQQNVPS 50 60 70 80 GTDTGDPQSK PLGDWAAGTM DPESSIFIED AIKYFKEKVS 90 100 110 120 TQNLLLLLTD NEAWNGFVAA AELPRNEADE LRKALDNLAR 130 140 150 160 QMIMKDKNWH DKGQQYRNWF LKEFPRLKSE LEDNIRRLRA 170 180 190 200 LADGVQKVHK GTTIANVVSG SLSISSGILT LVGMGLAPFT 210 220 230 240 EGGSLVLLEP GMELGITAAL TGITSSTMDY GKKWWTQAQA 250 260 270 280 HDLVIKSLDK LKEVREFLGE NISNFLSLAG NTYQLTRGIG 290 300 310 320 KDIRALRRAR ANLQSVPHAS ASRPRVTEPI SAESGEQVER 330 340 350 360 VNEPSILEMS RGVKLTDVAP VSFFLVLDVV YLVYESKHLH 370 380 390 EGAKSETAEE LKKVAQELEE KLNILNNNYK ILQADQEL Protein Name Uniprot IPI Gene Name Mucin 1 P15941-2 IPI00218163 Muc1_Human isoform 2 Trypsin fragments 1. DISEMFIQLYK 2. QGGFLGLSNIK (SEQ ID NO: 50) (SEQ ID NO: 51) 10 20 30 40 (SEQ ID NO: 52) MTPGTQSPFF LLLLLTVLTV VTGSGHASST PGGEKETSAT 50 60 70 80 QRSSVPSSTE KNAVSMTSSV LSSHSPGSGS STTQGQDVTL 90 100 110 120 APATEPASGS AATWGQDVTS VPVTRPALGS TTPPAHDVTS 130 140 150 160 APDNKPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS 170 180 190 200 APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS 210 220 230 240 APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS 250 260 270 280 APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS 290 300 310 320 APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS 330 340 350 360 APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS 370 380 390 400 APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS 410 420 430 440 APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS 450 460 470 480 APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS 490 500 510 520 APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS 530 540 550 560 APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS 570 580 590 600 APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS 610 620 630 640 APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS 650 660 670 680 APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS 690 700 710 720 APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS 730 740 750 760 APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS 770 780 790 800 APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS 810 820 830 840 APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS 850 860 870 880 APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS 890 900 910 920 APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS 930 940 950 960 APDTRPAPGS TAPPAHGVTS APDTRPAPGS TAPPAHGVTS 970 980 990 1000 ASGSASGSAS TLVHNGTSAR ATTTPASKST PFSIPSHHSD 1010 1020 1030 1040 TPTTLASHST KTDASSTHHS SVPPLTSSNH STSPQLSTGV 1050 1060 1070 1080 SFFFLSFHIS NLQFNSSLED PSTDYYQELQ R.sup.(1)DISEMFLQI 1090 1100 1110 1120 YK.sup.(2)QGGFLGLS NIKFRPGSVV VQLTLAFREG TINVHDVETQ 1130 1140 1150 1160 FNQYKTEAAS RYNLTISDVS VSDVPFPFSA QSGAGVPGWG 1170 1180 1190 1200 IALLVLVCVL VALAIVYLIA LAVCQCRRKN YGQLDIFPAR 1210 1220 1230 1240 DTYHPMSEYP TYHTHGRYVP PSSTDRSPYE KVSAGNGGSS 1250 LSYTNPAVAA TSANL Protein Name Uniprot IPI Gene Name Bleomycin Q13867 IPI00219575 BLMH_Human Hydrolase Trypsin fragments 1. AQHVFQHAV 2. SSSGLNSEK PQEGKPITNQK VAALIQK (SEQ ID NO: 53) (SEQ ID NO: 54) 10 20 30 40 (SEQ ID NO: 55) M.sup.(2)SSSGLNSEK VAALIQKLNS DPQFVLAQNV GTTHDLLDIC 50 60 70 80 LKRATVQR.sup.(1)AQ HVFQHAVPQE GKPITNQKSS GRCWIFSCLN 90 100 110 120 VMRLPFMKKL NIEEFEFSQS YLFFWDKVER CYFFLSAFVD 130 140 150 160 TAQRKEPEDG RLVQFLLMNP ANDGGQWDML VNIVEKYGVI 170 180 190 200 PKKCFPESYT TEATRRMNDI LNHKMRERCI RLRNLVHSGA 210 220 230 240 TKGEISATQD VMMEEIFRVV CICLGNPPET FTWEYRDKDK 250 260 270 280 NYQKIGPITP LEFYREHVKP LFNMEDKICL VNDPRPQHKY 290 300 310 320 NKLYTVEYLS NMVGGRKTLY NNQPIDFLKK MVAASIKDGE 330 340 350 360 AVWFGCDVGK HFNSKLGLSD MNLYDHELVF GVSLKNMNKA 370 380 390 400 ERLTFGESLM THAMTFTAVS EKDDQDGAFT KWRVENSWGE 410 420 430 440 DHGHKGYLCM TDEWFSEYVY EVVVDRKHVP EEVLAVLEQE 450 PIILPAWDPM GALAE Protein Name Uniprot IPI Gene Name Cornifin-B P22528 IPI00304903 SPRRIB_Human Trypsin fragments 1. QPCTPPPQLQQQQVK 2. VPEPCPSIVTPAPAQQK (SEQ ID NO: 56) (SEQ ID NO: 57) 10 20 30 40 (SEQ ID NO: 58) MSSQQQK.sup.(1)QPC TPPPQLQQQQ VKQPCQPPPQ EPCIPKTKEP 50 60 70 80 CHPKVPEPCH PKVPEPCQPK VPEPCHPK.sup.(2)VP EPCPSIVTPA PAQQKTKQK Protein Name Uniprot IPI Gene Name Plasminogen activator P05120 IPI00007117 SERPINB2_Human inhibitor-2 Trypsin fragments 1. GKIPNLLPEGSVDGDTR (SEQ ID NO: 59) 10 20 30 40 (SEQ ID NO: 60) MEDLCVANTL FALNLFKHLA KASPTQNLFL SPWSISSTMA 50 60 70 80 MVYMGSRGST EDQMAKVLQF NEVGANAVTP MTPENFTSCG 90 100 110 120 FMQQIQKGSY PDAILQAQAA DKIHSSFRSL SSAINASTGN 130 140 150 160 YLLESVNKLF GEKSASFREE YIRLCQKYYS SEPQAVDFLE 170 180 190 200 CAEEARKKIN SWVKTQTKGK IPNLLPEGSV DGDTRMVLVN 210 220 230 240 AVYFKGKWKT PFEKKLNGLY PFRVNSAQRT PVQMMYLREK 250 260 270 280 LNIGYIEDLK AQILELPYAG DVSMFLLLPD EIADVSTGLE 290 300 310 320 LLESEITYDK LNKWTSKDKM AEDEVEVYIP QFKLEEHYEL 330 340 350 360 RSILRSMGME DAFNKGRANF SGMSERNDLF LSEVFHQAMV 370 380 390 400 DVNEEGTEAA AGTGGVMTGR TGHGGPQFVA DHPFLFLIMA

410 KITNCILFFG RFSSP Protein Name Uniprot IPI Gene Name Peroxiredoxin-6 P30041 IPI00220301 PRDX6_Human Trypsin fragments 1. DINAYNCEEPTEK 2. NFDEILR (SEQ ID NO: 61) (SEQ ID NO: 62) 10 20 30 40 (SEQ ID NO: 63) MPGGLLLGDV APNFEANTTV GRIRFHDFLG DSWGILFSHP 50 60 70 80 RDFTPVCTTE LGRAAKLAPE FAKRNVKLIA LSIDSVEDHL 90 100 110 120 AWSK.sup.(1)DINAYN CEEPTEKLPF PIIDDRNREL AILLGMLDPA 130 140 150 160 EKDEKGMPVT ARVVFVFGPD KKLKLSILYP ATTGR.sup.(2)NFDEI 170 180 190 200 LRVVISLQLT AEKRVATPVD WKDGDSVMVL PTIPEEEAKK 210 220 LFPKGVFTKE LPSGKKYLRY TPQP Protein Name Uniprot IPI Gene Name Complement Q03591 IPI00011264 CFHR1_Human factor-H Trypsin Fragments 1. ITCTEEGWSPTPK 2. STDTSCVNPPTVQ 3. TGESAEFVCK (SEQ ID NO: 64) NAHILSR (SEQ ID NO: 66) (SEQ ID NO: 65) 10 20 30 40 (SEQ ID NO: 67) MWLLVSVILI SRISSVGGEA TFCDFPKINH GILYDEEKYK 50 60 70 80 PFSQVPTGEV FYYSCEYNFV SPSKSFWTR.sup.(1)I TCTEEGWSPT 90 100 110 120 PKCLRLCFFP FVENGRSESS GQTHLEGDTV QIICNTGYRL 130 140 150 160 QNNENNISCV ERGWSTPPKC R.sup.(2)STDTSCVNP PTVQNAHILS 170 180 190 200 RQMSKYPSGE RVRYECRSPY EMFGDEEVMC LNGNWTEPPQ 210 220 230 240 CKDSTGKCGP PPPIDNGDIT SFPLSVYAPA SSVEYQCQNL 250 260 270 280 YQLEGNKRIT CRNGQWSEPP KCLHPCVISR EIMENYNIAL 290 300 310 320 RWTAKQKLYL R.sup.(3)TGESAEFVC KRGYRLSSRS HTLRTTCWDG 330 KLEYPTCAKR Protein Name Uniprot IPI Gene Name Isoform 1 of P04217 IPI00022895 A1BG_Human Alpha-1B- glycoprotein Trypsin Fragments 1. ATWSGAVLAGR 2. CLAPLEGAR 3. GVTFLLR (SEQ ID NO: 68) (SEQ ID NO: 69) (SEQ ID NO: 70) 4. HQFLLTGDTQGR 5. LLELTGPK 6. SGLSTGWTQLSK (SEQ ID NO: 71) (SEQ ID NO: 72) (SEQ ID NO: 73) 10 20 30 40 (SEQ ID NO: 74) MSMLVVFLLL WGVTWGPVTE AAIFYETQPS LWAESESLLK 50 60 70 80 PLANVTLTCQ AHLETPDFQL FKNGVAQEPV HLDSPAIK.sup.(4)HQ 90 100 110 120 FLLTGDTQGR YRCR.sup.(8)SGLSTG WTQLSK.sup.(5)LLEL TGPKSLPAPW 130 140 150 160 LSMAPVSWIT PGLKTTAVCR GVLR.sup.(4)GVTFLL RREGDHEFLE 170 180 190 200 VPEAQEDVEA TFPVHQPGNY SCSYRTDGEG ALSEPSATVT 210 220 230 240 IEELAAPPPP VLMHHGESSQ VLHPGNKVTL TCVAPLSGVD 250 260 270 280 FQLRRGEKEL LVPRSSTSPD RIFFHLNAVA LGDGGHYTCR 290 300 310 320 YRLHDNQNGW SGDSAPVELI LSDETLPAPE FSPEPESGRA 330 340 350 360 LRLR.sup.(2)CLAPLE GARFALVRED RGGRRVHRFQ SPAGTEALFE 370 380 390 400 LHNISVADSA NYSCVYVDLK PPFGGSAPSE RLELHVDGPP 410 420 430 440 PRPQLR.sup.(1)ATWS GAVLAGRDAV LRCEGPIPDV TFELLREGET 450 460 470 480 KAVKTVRTPG AAANLELIFV GPQHAGNYRC RYRSWVPHTF 490 ESELSDPVEL LVAES Protein Name Uniprot IPI Gene Name Gamma-glutamyl Q92820 IPI00023728 GGH_Human hydrolase Trypsin Fragments 1. NLDGISHAPNAVK (SEQ ID NO: 75) 10 20 30 40 (SEQ ID NO: 76) MASPGCLLCV LGLLLCGAAS LELSRPHGDT AKKPIIGILM 50 60 70 80 QKCRNKVMKN YGRYYIAASY VKYLESAGAR VVPVRLDLTE 90 100 110 120 KDYEILFKSI NGILFPGGSV DLRRSDYAKV AKIFYNLSIQ 130 140 150 160 SFDDGDYDPV WGTCLGFEEL SLLISGECLL TATDTVDVAM 170 180 190 200 PLNFTGGQLH SRMFQNFPTE LLLSLAVEPL TANFHKWSLS 210 220 230 240 VKNFTMNEKL KKFFNVLTTN TDGKIEFIST MEGYKYPVYG 250 260 270 280 VQWHPEKAPY EWKNLDGISH APNAVKTAFY LAEFFVNEAR 290 300 310 KNNHHFKSES EEERALIYQF SPIYTGHISS FQQCYIFD Protein Name Uniprot IPI Gene Name Ezrin P15311 IPI00843975 EZR_Human Trypsin Fragments 1. ALQLEEER 2. APDFVFYAPR 3. ELSEQIQR (SEQ ID NO: 77) (SEQ ID NO: 78) (SEQ ID NO: 89) 4. IALLEEAR 5. IGFPWSEIR 6. QRIDEFEAL (SEQ ID NO: 80) (SEQ ID NO: 81) (SEQ ID NO: 82) 7. SGYLSSER 8. SQEQLAAELAEYTAK 9. VSAQEVRK (SEQ ID NO: 83) (SEQ ID NO: 84) (SEQ ID NO: 85) 10 20 30 40 (SEQ ID NO: 86) MPKPINVRVT TMDAELEFAI QPNTTGKQLF DQVVKTIGLR 50 60 70 80 EVWYFGLHYV DNKGFPTWLK LDKK.sup.(3)VSAQEV RKENPLQFKF 90 100 110 120 RAKFYPEDVA EELIQDITQK LFFLQVKEGI LSDEIYCPPE 130 140 150 160 TAVLLGSYAV QAKFGDYNKE VHK.sup.(7)SGYLSSE RLIPQRVMDQ 170 180 190 200 HKLTRDQWED RIQVWHAEHR GMLKDNAMLE YLKIAQDLEM 210 220 230 240 YGINYFEIKN KKGTDLWLGV DALGLNIYEK DDKLTPK.sup.(5)IGF 250 260 270 280 PWSEIRNISF NDKKFVIKPI DKK.sup.(2)APDFVFY APRLRINKRI 290 300 310 320 LQLCMGNHEL YMRRRKPDTI EVQQMKAQAR EEKHQKQLER 330 340 350 360 QQLETEKKRR ETVEREKEQM MREKEELMLR LQDYEEKTKK 370 380 390 400 AER.sup.(3)ELSEQIQ R.sup.(1)ALQLEEERK RAQEEAERLE ADRMAALRAK 410 420 430 440 EELERQAVDQ IK.sup.(11)SQEQLAAE LAEYTAK.sup.(4)IAL LEEARRRKED 450 460 470 480 EVEEWQHRAK EAQDDLVKTK EELHLVMTAP PPPPPPVYEP 490 500 510 520 VSYHVQESLQ DEGAEPTGYS AELSSEGIRD DRNEEKRITE 530 540 550 560 AEKNERVQRQ LLTLSSELSQ ARDENKRTHN DIIHNENMRQ 570 580 GRDKYKTLRQ IRQGNTK.sup.(6)QRI DEFEAL Protein Name Uniprot IPI Gene Name Alpha-2- P08697 IPI00879231 SERPINF2_Human antiplasmin Trypsin Fragments 1. LGNQEPGGQTALK (SEQ ID NO: 87) 10 20 30 40 (SEQ ID NO: 88) MALLWGLLVL SWSCLQGPCS VFSPVSAMEP LGRQLTSGPN 50 60 70 80 QEQVSPLTLL KLGNQEPGGQ TALKSPPGVC SRDPTPEQTH 90 100 110 120 RLARAMMAFT ADLFSLVAQT STCPNLILSP LSVALALSHL 130 140 150 160 ALGAQNHTLQ RLQQVLHAGS GPCLPHLLSR LCQDLGPGAF 170 180 190 200 RLAARMYLQK GFPIKEDFLE QSEQLFGAKP VSLTGKQEDD 210 220 230 240 LANINQWVKE ATEGKIQEFL SGLPEDTVLL LLNAIHFQGF 250 260 270 280 WRNKFDPSLT QRDSFHLDEQ FTVPVEMMQA RTYPLRWFLL

290 300 310 320 EQPEIQVAHF PFKNNMSFVV LVPTHFEWNV SQVLANLSWD 330 340 350 360 TLHPPLVWER PTKVRLPKLY LKHQMDLVAT LSQLGLQELF 370 380 390 400 QAPDLRGISE QSLVVSGVQH QSTLELSEVG VEAAAATSIA 410 420 430 440 MSRMSLSSFS VNRPFLFFIF EDTTGLPLFV GSVRNPNPSA 450 460 470 480 PRELKEQQDS PGNKDFLQSL KGFPRGDKLF GPDLKLVPPM 490 EEDYPQFGSP K Protein Name Uniprot IPI Gene Name Hemopexin P02790 IPI00022488 HPX_Human Trypsin Fragments 1. DVRDYFMPCPGR 2. DYFMPCPGR 3. EVGTPHGIILDSVD (SEQ ID NO: 89) (SEQ ID NO: 90) AAFICPGSSR (SEQ ID NO: 91) 4. GECQAEGVLFFQGDR 5. GEFVWK 6. GGYTLVSGYPK (SEQ ID NO: 92) (SEQ ID NO: 93) (SEQ ID NO: 94) 7. LLQDEFPGI 8. NFPSPVDAAFR 9. QGHNSVFLIK PSPIDAAVECHR (SEQ ID NO: 96) (SEQ ID NO: 97) (SEQ ID NO: 95) 10. SGAQATWTELPWPHEK 11. VDGALCMEK 12. WKNFPSPVDAAFR (SEQ ID NO: 98) (SEQ ID NO: 99) (SEQ ID NO: 100) 10 20 30 40 (SEQ ID NO: 101) MARVLGAPVA LGLWSLCWSL AIATPLPPTS AHGNVAEGET 50 60 70 80 KPDPDVTERC SDGWSFDATT LDDNGTMLFF K.sup.(5)GEFVWKSHK 90 100 110 120 WDRELISERW K.sup.(8)NFPSPVDAA FR.sup.(9)QGHNSVFL IKGDKVWVYP 130 140 150 160 PEKKEKGYPK .sup.(7)LLQDEFPGIP SPLDAAVECH R.sup.(4)GECQAEGVL 170 180 190 200 FFQGDREWFW DLATGTMKER SWPAVGNCSS ALRWLGRYYC 210 220 230 240 FQGNQFLRFD PVRGEVPPRY PR.sup.(1)DVR.sup.(2)DYFMP CPGRGHGHRN 250 260 270 280 GTGHGNSTHH GPEYMRCSPH LVLSALTSDN HGATYAFSGT 290 300 310 320 HYWRLDTSRD GWHSWPIAHQ WPQGPSAVDA AFSWEEKLYL 330 340 350 360 VQGTQVYVFL TK.sup.(6)GGYTLVSG YPKRLEK.sup.(3)EVG TPHGIILDSV 370 380 390 400 DAAFICPGSS RLHIMAGRRL WWLDLK.sup.(10)SGAQ ATWTELPWPH 410 420 430 440 EK.sup.(11)VDGALCME KSLGPNSCSA NGPGLYLIHG PNLYCYSDVE 450 460 KLNAAKALPQ PQNVTSLLGC TH Protein Name Uniprot IPI Gene Name Cysteine Rich P54108 IPI00974055 Crisp3_Human Secretory Protein 3 Trypsin Fragments 1. WANQCNYR (SEQ ID NO: 102) 10 20 30 40 (SEQ ID NO: 103) MTLFPVLLFL VAGLLPSFPA NEDKDPAFTA LLTTQTQVQR 50 60 70 80 EIVNKHNELR RAVSPPARNM LKMEWNKEAA ANAQKWANQC 90 100 110 120 NYRHSNPKDR MTSLKCGENL YMSSASSSWS QAIQSWFDEY 130 140 150 160 NDFDFGVGPK TPNAVVGHYT QVVWYSSYLV GCGNAYCPNQ 170 180 190 200 KVLKYYYVCQ YCPAGNWANR LYVPYEQGAP CASCPDNCDD 210 220 230 240 GLCTNGCKYE DLYSNCKSLK LTLTCKHQLV RDSCKASCNC Protein Name Uniprot IPI Gene Name Carboxypeptidase A4 Q9UI42 IPI00008894 CP4A_Human Trypsin Fragments 1. DPAITSILEK 2. SRNPGSSCIGADPNR 3. GASDNPCSEVYHGPH (SEQ ID NO: 104) (SEQ ID NO: 105) ANSEVEVK (SEQ ID NO: 106) 4. SVVDFIQK 5. NPGSSCIGADPNR (SEQ ID NO: 107) (SEQ ID NO: 108) 10 20 30 40 (SEQ ID NO: 109) MRWILFIGAL IGSSICGQEK FFGDQVLRIN VRNGDEISKL 50 60 70 80 SQLVNSNNLK LNFWKSPSSF NRPVDVLVPS VSLQAFKSFL 90 100 110 120 RSQGLEYAVT IEDLQALLDN EDDEMQHNEG QERSSNNFNY 130 140 150 160 GAYHSLEAIY HEMDNIAADF PDLARRVKIG HSFENRPMYV 170 180 190 200 LKFSTGKGVR RPAVWLNAGI HSREWISQAT AIWTARKIVS 210 220 230 240 DYQR.sup.(1)DPAITS ILEKMDIFLL PVANPDGYVY TQTQNRLWRK 250 260 270 280 TR.sup.(2)SR.sup.(5)NPGSSC IGADPNRNWN ASFAGK.sup.(3)GASD NPCSEVYHGP 290 300 310 320 HANSEVEVK.sup.(4)SVVDFIQKHGN FKGFIDLHSY SQLLMYPYGY 330 340 350 360 SVKKAPDAEE LDKVARLAAK ALASVSGTEY QVGPTCTTVY 370 380 390 400 PASGSSIDWA YDNGIKFAFT FELRDTGTYG FLLPANQIIP 410 420 TAEETWLGLK TIMEHVRDNL Protein Name Uniprot IPI Gene Name N-acetylmuramyl- Q96PD5-2 IPI00394992 PGLYRP2_Human L-alanine amidase Trypsin Fragments 1. GSQTQSHPDLGTEG 2. TFTLLDPK CWDQLSAPR (SEQ ID NO: 111) (SEQ ID NO: 110) 10 20 30 40 (SEQ ID NO: 112) MAQGVLWILL GLLLWSDPGT ASLPLLMDSV IQALAELEQK 50 60 70 80 VPAAKTRHTA SAWLMSAPNS GPHNRLYHFL LGAWSLNATE 90 100 110 120 LDPCPLSPEL LGLTKEVARH DVREGKEYGV VLAPDGSTVA 130 140 150 160 VEPLLAGLEA GLQGRRVINL PLDSMAAPWE TGDTFPDVVA 170 180 190 200 IAPDVRATSS PGLRDGSPDV TTADIGANTP DATKGCPDVQ 210 220 230 240 ASLPDAKAKS PPTMVDSLLA VTLAGNLGLT FLR.sup.(1)GSQTQSH 250 260 270 280 PDLGTEGCWD QLSAPR.sup.(2)TFTL LDPKASLLTM AFLNGALDGV 290 300 310 320 ILGDYLSRTP EPRPSLSHLL SQYYGAGVAR DPGFRSNFRR 330 340 350 360 QNGAALTSAS ILAQQVWGTL VLLQRLEPVH LQLQCMSQEQ 370 380 390 400 LAQVAANATK EFTEAFLGCP ATHPRCRWGA APYRGRPKLL 410 420 430 440 QLPLGFLYVH HTYVPAPPCT DFTRCAANMR SMQRYHQDTQ 450 460 470 480 GWGDIGYSFV VGSDGYVYEG RGWHWVGAHT LGHNSRGFGV 490 500 510 520 AIVGNYTAAL PTEAALRTVR DTLPSCAVRA GLLRPDYALL 530 540 550 560 GHRQLVRTDC PGDALFDLLR TWPHFTATVK PRPARSVSKR 570 SRREPPPRTL PATDLQ Protein Name Uniprot Gene Name Caspase-14 P31944 CASP14_Human Trypsin Fragments 1. AREGSEEDLDALEHMFR 2. DPTAEQFQEELEK 3. FQQAIDSR (SEQ ID NO: 113) (SEQ ID NO: 114) (SEQ ID NO: 115) 4. KTNPEIQSTLR 5. MAEAELVQEGK 6. RDPTAEQFQEELEK (SEQ ID NO: 116) (SEQ ID NO: 117) (SEQ ID NO: 118) 7. RMAEAELVQEGK 8. SLEEEKYDMSGAR 9. TNPEIQSTLR (SEQ ID NO: 119) (SEQ ID NO: 120) (SEQ ID NO: 121) 10. VYIIQACR (SEQ ID NO: 122) 10 20 30 40 (SEQ ID NO: 123) MSNPR.sup.(8)SLEEE KYDMSGARLA LILCVTK.sup.(1)ARE GSEEDLDALE 50 60 70 80 HMFRQLRFES TMK.sup.(6)R.sup.(2)DPTAEQ FQEELEK.sup.(3)FQQ AIDSREDPVS 90 100 110 120 CAFVVLMAHG REGFLKGEDG EMVKLENLFE ALNNKNCQAL 130 140 150 160 RAKPKV.sup.(10)YIIQ ACRGEQRDPG ETVGGDEIVM VIKDSPQTIP 170 180 190 200 TYTDALHVYS TVEGYIAYRH DQKGSCFIQT LVDVFTKRKG 210 220 230 240 HILELLTEVT R.sup.(7)R.sup.(5)MAEAELVQ EGKAR.sup.(4)K.sup.(9)TNPE IQSTLRKRLY LQ Protein Name Uniprot IPI Gene Name

Ig Kappa chain P04207 IPI00385253 KV308_Human V-III region POM Trypsin Fragments 1. LLIYGASTR (SEQ ID NO: 124) 10 20 30 40 (SEQ ID NO: 125) MEAPAQLLFL LLLWLPDTTG SIVMTQSPAT LSVSPGERAT 50 60 70 80 LSCRASQSVS NNLAWYQQKP GQPPRLLIYG ASTRATGIPA 90 100 110 120 RFSGSGSGTE FTLTISRLQS EDFAVYYCQQ YNNWPPWTFG QGTRVEIKR Protein Name Uniprot IPI Gene Name Ig Kappa chain P01624 IPI00387119 KV306_Human V-III region POM Trypsin Fragments 1. EIVMTQSPVTLSVSPGER (SEQ ID NO: 126) 10 20 30 40 (SEQ ID NO: 127) EIVMTQSPVT LSVSPGERAT LSCRASQSIS NSYLAWYQQK 50 60 70 80 PSGSPRLLIY GASTRATGIP ARFSGSGSGT EFTLTISSLQ 90 100 SEDFAVYYCQ QYNNWPPTFG QGTRVEIKR Protein Name Uniprot IPI Gene Name Isoform 1 P02768-1 IPI00387119 ALB_Human Serum Albumin Trypsin Fragments 1. AACLLPK 2. AAFTECCQAADK 3. AAFTECCQAADKAACLLPK (SEQ ID NO: 128) (SEQ ID NO: 129) (SEQ ID NO: 130) 4. ADDKETCFAEEGK 5. ADDKETCFAEEGKK 6. AEFAEVSK (SEQ ID NO: 131) (SEQ ID NO: 132) (SEQ ID NO: 133) 7. AEFAEVSKLVTDLTK 8. ATKEQIK 9. ATKEQIKAVMDDFAAFVEK (SEQ ID NO: 134) (SEQ ID NO: 135) (SEQ ID NO: 136) 11. AVMDDFAAFVEK 12. CASIQKFGER 13. CCAAADPHECYAK (SEQ ID NO: 137) (SEQ ID NO: 138) (SEQ ID NO: 139) 14. CCKADDKETCFAEEGK 15. CCKHPEAK 16. CCTESLVNR (SEQ ID NO: 140) (SEQ ID NO: 141) (SEQ ID NO: 142) 17. CCTESLVNRRPCFSALEV 18. DDNPNLPR 19. DAHKSEVAHR DETYVPK (SEQ ID NO: 144) (SEQ ID NO: 145) (SEQ ID NO: 143) 20. DLGEENFK 21. DVCKNYAEAK 22. DVFLGMFLYEYAR (SEQ ID NO: 146) (SEQ ID NO: 147) (SEQ ID NO: 148) 23. ECCEKPLLEK 24. EFNAETFTFHADICTLSEK 25. EFNAETFTFHADICTLSE (SEQ ID NO: 149) (SEQ ID NO: 150) KER (SEQ ID NO: 151) 26. EQLKAVMDDFAAFVEK 27. ETCFAEGK 28. ETCFAEEGKK (SEQ ID NO: 152) (SEQ ID NO: 153) (SEQ ID NO: 154) 29. ETYGEMADCCAK 30. FKDLGEENFK 31. FPKAEFAEVSK (SEQ ID NO: 155) (SEQ ID NO: 156) (SEQ ID NO: 157) 32. FQNALLVR 33. HPDYSVVLLLR 34. HPYFYAPELLFFAK (SEQ ID NO: 158) (SEQ ID NO: 159) (SEQ ID NO: 160) 35. LAKTYETTLEK 36. LCTVATLR 37. LCTVATLRETYGEMADCCAK (SEQ ID NO: 161) (SEQ ID NO: 162) (SEQ ID NO: 163) 38. LDELRDEGK 39. LDELRDEGKASSAK 40. LKCASLQK (SEQ ID NO: 164) (SEQ ID NO: 165) (SEQ ID NO: 166) 41. LKECCEKPLLEK 42. LSQRFPK 43. LFSQRFPKAEFAEVSK (SEQ ID NO: 167) (SEQ ID NO: 168) (SEQ ID NO: 169) 44. LVAASQAALGL 45. LVNEVTEFAK 46. IVNEVTEFA (SEQ ID NO: 170) (SEQ ID NO: 171) KTCVADESAENCDK (SEQ ID NO: 172) 47. LVRPEVDVM 48. LVRPEVDVM 49. LVTDLTK CTAFHDNEETFLK CTAFHDNEETFLKK (SEQ ID NO: 175) (SEQ ID NO: 173) (SEQ ID NO: 174) 50. KLVAASQAALGL 51. KQTALVELVK 52. KVPQVSTPTLLVEVSR (SEQ ID NO: 176) (SEQ ID NO: 177) (SEQ ID NO: 178) 53. KYLYEIAR 54. MPCAEDYIL 55. NECFIQHK (SEQ ID NO: 179) SVVILNQILCVILHEK (SEQ ID NO: 181) (SEQ ID NO: 180) 56. NECFLQHKDDNPNLPR 57. NIGKVGSK 58. NYAEAK (SEQ ID NO: 182) (SEQ ID NO: 183) (SEQ ID NO: 184) 59. NYAEAKDVF 60. PLVEEPQNL 61. QEPERNECF IGMFIYEYAR IK LQHK (SEQ ID NO: 185) (SEQ ID NO: 186) (SEQ ID NO: 187) 62. QEPERNECF 63. QNCELFEQL 64. QNCELFEQL LQHKDDNPNLPR GEYK GEYKFQNAIIVR (SEQ ID NO: 188) (SEQ ID NO: 189) (SEQ ID NO: 190) 65. QTAIVEIVK 66. RHPDYSVVLLLR 67. RMPCAEDYL (SEQ ID NO: 191) (SEQ ID NO: 192) SVVLKNQLCVLHEK (SEQ ID NO: 193) 68. RPCFSALEV 69. SHCIAEVEN 70. SHCIAEVEN DETYVPK DEMPADLPS DEMPADLPS (SEQ ID NO: 194) LAADFVESK LAADFVESK DVCKNYAEAK (SEQ ID NO: 196) (SEQ ID NO: 195) 71. SHCIAEVEN 72. SLHTLFGDK 73. SLHTLFGDK DEMPADLPS (SEQ ID NO: 198) LCTVATLR LAADFVESKDVCK (SEQ ID NO: 199) (SEQ ID NO: 197) 74. TCVADESAE 75. TCVADESAE 76. TCVADESAE NCDK NCDKSLHTLFGDK NCDKSLHTL (SEQ ID NO: 200) (SEQ ID NO: 201) FGDKLCTVATLR (SEQ ID NO: 202) 77. TPVSDRVTK 78. TYETTLEK 79. TYETTIEKC (SEQ ID NO: 203) (SEQ ID NO: 204) CAAADPHECYAK (SEQ ID NO: 205) 80. VFDEFKPLV 81. VHTECCHGD 82. VHTECCHGD EEPQNLIK LLECADDR LLECADDRADLAK (SEQ ID NO: 206) (SEQ ID NO: 207) (SEQ ID NO: 208) 83. VHTECCHGDLLE 84. VPQVSTPTL 85. YICENQDSI CADDRADLAK VEVSR SSK YICENQDSISSK (SEQ ID NO: 210) (SEQ ID NO: 211) (SEQ ID NO: 209) 86. YICENQDSISSKLK 87. YLYEIAR 88. YLYEIARR (SEQ ID NO: 212) (SEQ ID NO: 213) (SEQ ID NO: 214) 89. YKAAFTECC 90. YKAAFTECC QAADK QAADKAACLLPK (SEQ ID NO: 215) (SEQ ID NO: 216) MKWVTFISLL FLFSSAYSRG VFRR.sup.(10)DAHKSE VAHR.sup.(30)FK.sup.(20)DLGE ENFK (SEQ ID NO: 217) ALVLIA FAQYLQQCPFEDHVK.sup.(45)LVNEV TEFAK.sup.(74,75,76)TCVAD ESAENCDK.sup.(72,73)SL HTLFGD K.sup.(37,36)LCTVATLR.sup.(23)ETYGE MADCCAK.sup.(61)(62)QEP ER.sup.(55)(56)NECFLQHK .sup.(18)DDNPNLPR.sup.(47)(48)LV RPEVDVMCTA FHDNEETFLK .sup.(53)K.sup.(87,88)YLYEIARR.sup.(24)H PYFYAPELLF FAKR.sup.(89,90)YK.sup.(2)(3)AAFT ECCQAADK.sup.(1)AA CLLPK.sup.(39)(38)LDELR DEGKASSAKQ R.sup.(49)LK.sup.(12)CASLQKFGERAFKAWAV AR.sup.(43)(48)LSQR.sup.(31)FPK.sup.(4)A EFAEV.sup.(7)SK.sup.(49)LVT DLTK.sup.(81,82,83)VHTECC HGDLLECADD RADLAK.sup.(85,86)YICE NQDSISSK.sup.(41)LK .sup.(23)ECCEKPLLEK .sup.(69,70,71)SHCIAEVEND EMPADLPSLA ADFVESK.sup.(21)DVC K.sup.(58)(59)NYAEAK.sup.(22)DVFLGMFLYEYAR .sup.(68)R.sup.(33)HPDYSVVLL LR.sup.(35)LAK.sup.(78,79)TYETT LEK.sup.(12)CCAAADP HECYAK.sup.(80)VFDE FK.sup.(40)PLVEEPQN LIK.sup.(63)(64)QNCELFE QLGEYK.sup.(32)FQNA LLVRYTK.sup.(52)K.sup.(54)VP QVSTPTLVEV SR.sup.(57)NLGKVGSK .sup.(15)CCKHPEAK.sup.(67)R.sup.(64)M PCAEDYLSVV LNQLCVLHEK .sup.(77)TPVSDRVTK.sup.(17)(16)C CTESLVNR.sup.(68)RP CFSALEVDET YVPK.sup.(25)(24)EFNAETFTF HADICTL SEKERQIK.sup.(51)K.sup.(65)Q TALVELVKHK PK.sup.(10)(9)ATK.sup.(26)EQLK.sup.(11)A VMDDFAAFVEK.sup.(14)CCK.sup.(4)ADDK.sup.(28)(27)ET CFAEEGK.sup.(5)(56)K.sup.(44)LV AASQAALGL Protein Name Uniprot IPI Gene Name Isoform 1 of P08603 IPI00029739 CFH_Human Complement factor H Trypsin Fragments 1. *AGEQVTYTCATYYK 2. CLHPCVISR 3. *DGWSAQPTCIK (SEQ ID NO: 218) (SEQ ID NO: 219) (SEQ ID NO: 220) 4. *DTSCVNPP 5. *EFDHNSNIR 6. EIMENYNIALR TVQNAYIVSR (SEQ ID NO: 222) (SEQ ID NO: 223) (SEQ ID NO: 221) 7. GDAVCTESGWR 8. GDAVCTESG 9. *IDVHLVPDR (SEQ ID NO: 224) WRPLPSCEEK (SEQ ID NO: 226) (SEQ ID NO: 225) 10. *LSYTCEGGFR 11. IVSSAMEPD 12. NTEILTGSW (SEQ ID NO: 227) REYHFGQAVR SDQTYPEGTQAIYK (SEQ ID NO: 228) (SEQ ID NO: 229) 13. RPYFPVAVGK 14. *SCDIPVFMNAR 15. SIDVACHPGYALPK (SEQ ID NO: 230) (SEQ ID NO: 231) (SEQ ID NO: 232) 16. SLGNVIMVCR 17. *SSNLIILEEHLK 18. *SSQESYAHGTK (SEQ ID NO: 233) (SEQ ID NO: 234) (SEQ ID NO: 235) 19. TGDEITYQCR 20. TGESVEFVCK 21. *TKNDFTWFK (SEQ ID NO: 236) (SEQ ID NO: 237) (SEQ ID NO: 238) 22. TTCWDGKLE 23. *VSVLCQEN 24. *WQSIPLCVEK YPTCAK YLIQEGEELTCKDGR (SEQ ID NO: 241) (SEQ ID NO: 239) (SEQ ID NO: 240) 25. *WSSPPQCEGLPCK (SEQ ID NO: 242) 10 20 30 40 (SEQ ID NO: 243) MRLLAKIICL MLWAICVAED CNELPPRR.sup.(12)NT EILTGSWSDQ 50 60 70 80 TYPEGTQAIY KCRPGYR.sup.(16)SLG NVIMVCRKGE WVALNPLRKC 90 100 110 120 QKRPCGHPGD TPEGTFTLTG GNVFEYGVKA VYTCNEGYQL

130 140 150 160 LGEINYRECD TDGWTNDIPI CEVVKCLPVT APENGK.sup.(11)IVSS 170 180 190 200 AMEPDREYHF GQAVRFVCNS GYKIEGDEEM HCSDDGFWSK 210 220 230 240 EKPKCVEISC KSPDVINGSP ISQKIIYKEN ERFQYKCNMG 250 260 270 280 YEYSER.sup.(7)GDAV CTESGWR.sup.(8)PLP SCEEKSCDNP YIPNGDYSPL 290 300 310 320 RIKHR.sup.(19)TGDEI TYQCRNGFYP ATRGNTAKCT STGWIPAPRC 330 340 350 360 TLKPCDYPDI KHGGLYHENM R.sup.(13)RPYFPVAVG KYYSYYCDEH 370 380 390 400 FETPSGSYWD HIHCTQDGWS PAVPCLRKCY FPYLENGYNQ 410 420 430 440 NYGRKFVQGK .sup.(15)SIDVACHPGY ALPKAQTTVT CMENGWSPTP 450 460 470 480 RCIRVKTCSK SSIDIENGFI SESQYTYALK EKAKYQCKLG 490 500 510 520 YVTADGETSG SITCGK.sup.(3)DGWS AQPTCIK.sup.(14)SCD IPVFMNAR.sup.(21)TK 530 540 550 560 NDFTWFKLND TLDYECHDGY ESNTGSTTGS IVCGYNGWSD 570 580 590 600 LPICYERECE LPK.sup.(9)IDVHLVP DRKKDQYKVG EVLKFSCKPG 610 620 630 640 FTIVGPNSVQ CYHFGLSPDL PICKEQVQSC GPPPELLNGN 650 660 670 680 VKEKTKEEYG HSEVVEYYCN PRFLMKGPNK IQCVDGEWTT 690 700 710 720 LPVCIVEEST CGDIPELEHG WAQLSSPPYY YGDSVEFNCS 730 740 750 760 ESFTMIGHRS ITCIHGVWTQ LPQCVAIDKL KKCK.sup.(17)SSNLII 770 780 790 800 LEEHLKNKK.sup.(5)E FDHNSNIRYR CRGKEGWIHT VCINGRWDPE 810 820 830 840 VNCSMAQIQL CPPPPQIPNS HNMTTTLNYR DGEK.sup.(23)VSVLCQ 850 860 870 880 ENYLIQEGEE ITCKDGR.sup.(24)WQS IPLCVEKIPC SQPPQIEHGT 890 900 910 920 INSSR.sup.(18)SSQES YAHGTK.sup.(10)LSYT CEGGFRISEE NETTCYMGK.sup.(25)W 930 940 950 960 SSPPQCEGLP CKSPPEISHG VVAHMSDSYQ YGEEVTYKCF 970 980 990 1000 EGFGIDGPAI AKCLGEKWSH PPSCIKTDCL SLPSFENAIP 1010 1020 1030 1040 MGEKKDVYK.sup.(1)A GEQVTYTCAT YYKMDGASNV TCINSRWTGR 1050 1060 1070 1080 PTCR.sup.(4)DTSCVN PPTVQNAYIV SRQMSKYPSG ERVRYQCRSP 1090 1100 1110 1120 YEMFGDEEVM CLNGNWTEPP QCKDSTGKCG PPPPIDNGDI 1130 1140 1150 1160 TSFPLSVYAP ASSVEYQCQN LYQLEGNKRI TCRNGQWSEP 1170 1180 1190 1200 PK.sup.(2)CLHPCVIS R.sup.(6)EIMENYNIA LRNTAKQKLY SR.sup.(20)TGESVEFV 1210 1220 1230 CKRGYRLSSR SHTLR.sup.(22)TTCWD GKLEYPTCAK R Protein Name Uniprot IPI Gene Name Isoform 1 of Sodium- O95436-1 IPI00007910 SLC34A2_Human dependent phosphate transport protein Trypsin Fragments 1. EAQGEVPASDSKTECTAL 2. VISQIAMNDEK (SEQ ID NO: 244) (SEQ ID NO: 245) 10 20 30 40 (SEQ ID NO: 246) MAPWPELGDA QPNPDKYLEG AAGQQPTAPD KGKETNKTDN 50 60 70 80 TEAPVTKIEL LPSYSTATLI DEPTEVDDPW NLPTLQDSGI 90 100 110 120 KWSERDTKGK ILCFFQGIGR LILLLGFLYF FVCSLDILSS 130 140 150 160 AFQLVGGKMA GQFFSNSSIM SNPLLGLVIG VLVTVLVQSS 170 180 190 200 STSTSIVVSM VSSSLLTVRA AIPIIMGANI GTSITNTIVA 210 220 230 240 LMQVGDRSEF RRAFAGATVH DEFNWLSVLC LLPVEVATHY 250 260 270 280 LEIITQLIVE SFHFKNGEDA PDLLKVITKP FTKLIVQLDK 290 300 310 320 K.sup.(2)VISQIAMND EKAKNKSLVK IWCKTFTNKT QINVTVPSTA 330 340 350 360 NCTSPSLCWT DGIQNWTMKN VTYKENIAKC QHIFVNFHLP 370 380 390 400 DLAVGTILLI LSLLVLCGCL IMIVKILGSV LKGQVALVIK 410 420 430 440 KTINTDFPFP FAWLTGYLAI LVGAGMTFIV QSSSVFTSAL 450 460 470 480 TPLIGIGVIT IERAYPLTLG SNIGTTTTAI LAALASPGNA 490 500 510 520 LRSSLQIALC HFFFNISGIL LWYPIPFTRL PIRMAKGLGN 530 540 550 560 ISAKYRWFAV FYLIIFFFLI PLTVFGLSLA GWRVLVGVGV 570 580 590 600 PVVFIIILVL CLRLLQSRCP RVLPKKLQNW NFLPLWMRSL 610 620 630 640 KPWDAVVSKF TGCFQMRCCC CCRVCCRACC LLCDCPKCCR 650 660 670 680 CSKCCEDLEE AQEGQDVPVK APETFDNITI SR.sup.(1)EAQGEVPA 690 SDSKTECTAL Protein Name Uniprot IPI Gene Name Putative IPI00152189 Uncharacterized protein Trypsin Fragments 1. FSVLGSGLNR MAWAPLLLTLLSLLTGSLSQPVLTQPPSASASLGASVTLTCTLSSGYSNYKVD (SEQ ID NO: 248) WYQQRPGKGPRFVMRVGTGGIVGSKGDGIPDRFSVLGSGLNRYLTIKNIQEEDESDYHCGADHGSGS NFV Protein Name Uniprot IPI Gene Name Ras Related Protein Q15771 IPI00302030 RAB_30_Human Rab-30 Trypsin Fragments 1. LQIWDTAGQER 2. SMEDYDFLFK (SEQ ID NO: 249) (SEQ ID NO: 250) 10 20 30 40 (SEQ ID NO: 251) M.sup.(2)SMEDYDFLF KIVLIGNAGV GKTCLVRRFT QGLFPPGQGA 50 60 70 80 TIGVDFMIKT VEINGEKVK.sup.(2)L QIWDTAGQER FRSITQSYYR 90 100 110 120 SANALILTYD ITCEESFRCL PEWLREIEQY ASNKVITVLV 130 140 150 160 GNKIDLAERR EVSQQRAEEF SEAQDMYYLE TSAKESDNVE 170 180 190 200 KLFLDLACRL ISEAPQNTLV NHVSSPLPGE GKSISYLTCC NFN

TABLE-US-00005 Protein Name Uniprot IPI Gene Name Isoform 1 of growth Q14393 IPI00412410 GAS6_Human arrest-specific protein 6 Trypsin Fragments 1. CEQVCVNSP 2. GQSEVSAAQ 3. IAVAGDLFQ GSYTCHCDGR LQER PER (SEQ ID NO: 252) (SEQ ID NO: 253) (SEQ ID NO: 254) 4. MFSGTPVIR 5. MQCFSVTER 6. NSGFATCVQ (SEQ ID NO: 255) (SEQ ID NO: 256) NLPDQCTPNPCDR (SEQ ID NO: 257) 10 20 30 40 (SEQ ID NO: 258) MAPSLSPGPA ALRRAPQLLL LLLAAECALA ALLPAREATQ 50 60 70 80 FLRPRQRRAF QVFEEAKQGH LERECVEELC SREEAREVFE 90 100 110 120 NDPETDYFYP RYLDCINKYG SPYTK.sup.(8)NSGFA TCVQNLPDQC 130 140 150 160 TPNPCDRKGT QACQDLMGNF FCLCKAGWGG RLCDKDVNEC 170 180 190 200 SQENGGCLQI CHNKPGSFHC SCHSGFELSS DGRTCQDIDE 210 220 230 240 CADSEACGEA RCKNLPGSYS CLCDEGFAYS SQEKACRDVD 250 260 270 280 ECLQGR.sup.(1)CEQV CVNSPGSYTC HCDGRGGLKL SQDMDTCELE 290 300 310 320 AGWPCPRHRR DGSPAARPGR GAQGSRSEGH IPDRRGPRPW 330 340 350 360 QDILPCVPFS VAKSVKSLYL GR.sup.(4)MFSGTPVI RLRFKRLQPT 370 380 390 400 RLVAEFDFRT FDPEGILLFA GGHQDSTWIV LALRAGRLEL 410 420 430 440 QLRYNGVGRV TSSGPVINHG MWQTISVEEL ARNLVIKVNR 450 460 470 480 DAVMK.sup.(3)IAVAG DLFQPERGLY HLNLTVGGIP FHEKDLVQPI 490 500 510 520 NPRLDGCMRS WNWLNGEDTT IQETVKVNTR .sup.(5)MQCFSVTERG 530 540 550 560 SFYPGSGFAF YSLDYMRTPL DVGTESTWEV EVVAHIRPAA 570 580 590 600 DTGVLFALWA PDLRAVPLSV ALVDYHSTKK LKKQLVVLAV 610 620 630 640 EHTALALMEI KVCDGQEHVV TVSLRDGEAT LEVDGTR.sup.(2)GQS 650 660 670 680 EVSAAQLQER LAVLERHLRS PVLTFAGGLP DVPVTSAPVT 690 700 710 720 AFYRGCMTLE VNRRLLDLDE AAYKHSDITA KSCPPVEPAA Protein Name Uniprot IPI Gene Name Cathepsin L1 P07711 IPI00012887 CTSL1_Human Trypsin Fragments 1. HSFTMAMNA 2. LYGMNEEGWR 3. NHCGIASAASYPV FGDMTSEEFR (SEQ ID NO: 260) (SEQ ID NO: 261) (SEQ ID NO: 259) 4. NSWGEEWGMGGYVK (SEQ ID NO: 262) 10 20 30 40 (SEQ ID NO: 263) MNPTLILAAF CLGIASATLT FDHSLEAQWT KWKAMGNR.sup.(2)LY 50 60 70 80 GMNEEGWRRA VWEKNMKMIE LHNQEYREGK .sup.(1)HSFTMAMNAF 90 100 110 120 GDMTSEEFRQ VMNGFQNRKP RKGKVFQEPL FYEAPRSVDW 130 140 150 160 REKGYVTPVK NQGQCGSCWA FSATGALEGQ MFRKTGRLIS 170 180 190 200 LSEQNLVDCS GPQGNEGCNG GLMDYAFQYV QDNGGLDSEE 210 220 230 240 SYPYEATEES CKYNPKYSVA NDTGFVDIPK QEKALMKAVA 250 260 270 280 TVGPISVAID AGHESFLFYK EGIYFEPDCS SEDMDHGVLV 290 300 310 320 VGYGFESTES DNNKYWLVK.sup.(4)N SWGEEWGMGG YVKMAKDRR.sup.(3)N 330 HCGIASAASY PTV Protein Name Uniprot IPI Gene Name Secreted frizzled- Q8N474 IPI00749245 SFRP1_Human related protein 1 Trypsin Fragments 1. FYTKPPQCVDIPADLR 2. LCHNVGYK 3. LCHNVGYKK (SEQ ID NO: 264) (SEQ ID NO: 265) (SEQ ID NO: 266) 4. MVLPNLLEHETMAEVK 5. PQGTTVCPPCDNELK 6. QQASSWVPLLNK (SEQ ID NO: 267) (SEQ ID NO: 268) (SEQ ID NO: 269) 7. SEAIIEHLCASEFALR 8. SQYLLTAIHK (SEQ ID NO: 270) (SEQ ID NO: 271) 10 20 30 40 (SEQ ID NO: 272) MGIGRSEGGR RGAALGVLLA LGAALLAVGS ASEYDYVSFQ 50 60 70 80 SDIGPYQSGR .sup.(1)FYTKPPQCVD IPADLR.sup.(2,3)LCHN VGYKK.sup.(4)MVLPN 90 100 110 120 LLEHETMAEV K.sup.(6)QQASSWVPL LNKNCHAGTQ VFLCSLFAPV 130 140 150 160 CLDRPIYPCR WLCEAVRDSC EPVMQFFGFY WPEMLKCDKF 170 180 190 200 PEGDVCIAMT PPNATEASK.sup.(5)P QGTTVCPPCD NELK.sup.(7)SEAIIE 210 220 230 240 HLCASEFALR MKIKEVKKEN GDKKIVPKKK KPLKLGPIKK 250 260 270 280 KDLKKLVLYL KNGADCPCHQ LDNLSHHFLI MGRKVK.sup.(8)SQYL 290 300 310 LTAIHKWDKK NKEFKNFMKK MKNHECPTFQ SVFK Protein Name Uniprot IPI Gene Name Bactericidal P17213 IPI00827847 BPI_Human permeability- increasing protein Trypsin Fragments 1. GLDYASQQGTAALQK 2. IKIPDYSDSFK (SEQ ID NO: 273) (SEQ ID NO: 274) 10 20 30 40 (SEQ ID NO: 275) MRENMARGFC NAPRWASLMV LVAIGTAVTA AVNPGVVVRI 50 60 70 80 SQK.sup.(2)GLDYASQ QGTAALQKEL KR.sup.(2)IKIPDYSD SFKIKHLGKG 90 100 110 120 HYSFYSMDIR EFQLPSSQIS MVPNVGLKFS ISNANIKISG 130 140 150 160 KWKAQKRFLK MSGNFDLSIE GMSISADLKL GSNPTSGKPT 170 180 190 200 ITCSSCSSHI NSVHVHISKS KVGWLIQLFH KKIESALRNK 210 220 230 240 MNSQVCEKVT NSVSSELQPY FQTLPVMTKI DSVAGINYGL 250 260 270 280 VAPPATTAET LDVQMKGEFY SENHHNPPPF APPVMEFPAA 290 300 310 320 HDRMVYLGLS DYFFNTAGLV YQEAGVLKMT LRDDMIPKES 330 340 350 360 KFRLTTKFFG TFLPEVAKKF PNMKIQIHVS ASTPPHLSVQ 370 380 390 400 PTGLTFYPAV DVQAFAVLPN SSLASLFLIG MHTTGSMEVS 410 420 430 440 AESNRLVGEL KLDRLLLELK HSNIGPFPVE LLQDIMNYIV 450 460 470 480 PILVLPRVNE KLQKGFPLPT PARVQLYNVV LQPHQNFLLF GADVVYK Protein Name Uniprot IPI Gene Name Chitinase domain Q9BWS9-2 IPI00306719 CHID1_Human containing protein 1 Trypsin Fragments 1. GLHIVPR 2. GLVVTDLK 3. NVLDSEDEIEELSK (SEQ ID NO: 276) (SEQ ID NO: 277) (SEQ ID NO: 278) 4. SQFSDKPVQDR 5. YIQTLK (SEQ ID NO: 279) (SEQ ID NO: 280) 10 20 30 40 (SEQ ID NO: 281) MRTLFNLLWL ALACSPVHTT LSKSDAKKAA SKTLLEK.sup.(4)SQF 50 60 70 80 SDKPVQDR.sup.(2)GL VVTDLKAESV VLEHRSYCSA KARDRHFAGD 90 100 110 120 VLGYVTPWNS HGYDVTKVFG SKFTQISPVW LQLKRRGREM 130 140 150 160 FEVTGLHDVD QGWMRAVRKH AK.sup.(1)GLHIVPRL LFEDWTYDDF 170 180 190 200 R.sup.(3)NVLDSEDEI EELSKTVVQV AKNQHFDGFV VEVWNQLLSQ 210 220 230 240 KRVGLIHMLT HLAEALHQAR LLALLVIPPA ITPGTDQLGM 250 260 270 280 FTHKEFEQLA PVLDGFSLMT YDYSTAHQPG PNAPLSWVRA 290 300 310 320 CVQVLDPKSK WRSKILLGLN FYGMDYATSK DAREPVVGAR 330 340 350 360 .sup.(5)YIQTLKDHRP RMVWDSQASE HFFEYKKSRS GRHVVFYPTL 370 380 390 KSLQVRLELA RELGVGVSIW ELGQGLDYFY DLL Protein Name Uniprot IPI Gene Name

Moesin P26038 IPI00219365 MSN_Human Trypsin Fragments 1. ALELEQER 2. ALTSELANAR 3. AQMVQEDLEK (SEQ ID NO: 282) (SEQ ID NO: 283) (SEQ ID NO: 284) 4. ESEAVEWQQK 5. ISQLEMAR 6. IGFPWSEIR (SEQ ID NO: 285) (SEQ ID NO: 286) (SEQ ID NO: 287) 10 20 30 40 (SEQ ID NO: 288) MPKTISVRVT TMDAELEFAI QPNTTGKQLF DQVVKTIGLR 50 60 70 80 EVWFFGLQYQ DTKGFSTWLK LNKKVTAQDV RKESPLLFKF 90 100 110 120 RAKFYPEDVS EELIQDITQR LFFLQVKEGI LNDDIYCPPE 130 140 150 160 TAVLLASYAV QSKYGDFNKE VHKSGYLAGD KLLPQRVLEQ 170 180 190 200 HKLNKDQWEE RIQVWHEEHR GMLREDAVLE YLKIAQDLEM 210 220 230 240 YGVNYFSIKN KKGSELWLGV DALGLNIYEQ NDRLTPK.sup.(5)IGF 250 260 270 280 PWSEIRNISF NDKKFVIKPI DKKAPDFVFY APRLRINKRI 290 300 310 320 LALCMGNHEL YMRRRKPDTI EVQQMKAQAR EEKHQKQMER 330 340 350 360 AMLENEKKKR EMAEKEKEKI EREKEELMER LKQIEEQTKK 370 380 390 400 AQQELEEQTR R.sup.(1)ALLEQERK RAQSEAEKLA KERQEAEEAK 410 420 430 440 EALLQASRDQ KKTQEQLALE MAELTAR.sup.(5)ISQ LEMARQKK.sup.(4)ES 450 460 470 480 EAVEWQQK.sup.(3)AQ MVQEDLEKTR AELKTAMSTP HVAEPAENEQ 490 500 510 520 DEQDENGAEA SADLRADAMA KDRSEEERTT EAEKNERVQK 530 540 550 560 HLK.sup.(2)ALTSELA NARDESKKTA NDMIHAENMR LGRDKYKTLR 570 QIRQGNTKQR IDEFESM Protein Name Uniprot IPI Gene Name Isoform 2 of Q9NZ08-2 IPI00165949 ERAP1_Human Endoplasmic reticulum aminopeptidase 1 Trypsin Fragments 1. GACILNMLR 2. ILASTQFEPTAAR 3. SQIEFALCR (SEQ ID NO: 289) (SEQ ID NO: 290) (SEQ ID NO: 291) 10 20 30 40 (SEQ ID NO: 292) MVFLPLKWSL ATMSFLLSSL LALLTVSTPS WCQSTEASPK 50 60 70 80 RSDGTPFPWN KIRLPEYVIP VHYDLLIHAN LTTLTFWGTT 90 100 110 120 KVEITASQPT STIILHSHHL QISRATLRKG AGERLSEEPL 130 140 150 160 QVLEHPRQEQ IALLAPEPLL VGLPYTVVIH YAGNLSETFH 170 180 190 200 GFYKSTYRTK EGELR.sup.(2)ILAST QFEPTAARMA FPCFDEPAFK 210 220 230 240 ASFSIKIRRE PRHLAISNMP LVKSVTVAEG LIEDHFDVTV 250 260 270 280 KMSTYLVAFI ISDFESVSKI TKSGVKVSVY AVPDKINQAD 290 300 310 320 YALDAAVTLL EFYEDYFSIP YPLPKQDLAA IPDFQSGAME 330 340 350 360 NWGLTTYRES ALLFDAEKSS ASSKLGITMT VAHELAHQWF 370 380 390 400 GNLVTMEWWN DLWLNEGFAK FMEFVSVSVT HPELKVGDYP 410 420 430 440 FGKCFDAMEV DALNSSHPVS TPVENPAQIR EMFDDVSYDK 450 460 470 480 .sup.(1)GACILNMLRE YLSADAFKSG IVQYLQKHSY KNTKNEDLWD 490 500 510 520 SMASICPTDG VKGMDGFCSR SQHSSSSSHW HQEGVDVKTM 530 540 550 560 MNTWTLQKGF PLITITVRGR NVHMKQEHYM KGSDGAPDTG 570 580 590 600 YLWHVPLTFI TSKSDMVHRF LLKTKTDVLI LPEEVEWIKF 610 620 630 640 NVGMNGYYIV HYEDDGWDSL TGLLKGTHTA VSSNDRASLI 650 660 670 680 NNAFQLVSIG KLSIEKALDL SLYLKHETEI MPVFQGLNEL 690 700 710 720 IPMYKLMEKR DMNEVETQFK AFLIRLLRDL IDKQTWTDEG 730 740 750 760 SVSERMLRSQ LLLLACVHNY QPCVQRAEGY FRKWKESNGN 770 780 790 800 LSLPVDVTLA VFAVGAQSTE GWDFLYSKYQ FSLSSTEK.sup.(3)SQ 810 820 830 840 IEFALCRTQN KEKLQWLLDE SFKGDKIKTQ EFPQILTLIG 850 860 870 880 RNPVGYPLAW QFLRKNWNKL VQKFELGSSS IAHMNMGTTN 890 900 910 920 QFSTRTRLEE VKGFFSSLKE NGSQLRCVQQ TIETIEENIG 930 940 WMDKNFDKIR VWLQSEKLER M Protein Name Uniprot IPI Gene Name Isoform 1 of QPCT IPI00003919 Q16769-1 glutaminyl-peptide Trypsin Fragments 1. MASTPHPPGAR 2. YPGSPGSYAAR (SEQ ID NO: 293) (SEQ ID NO: 294) 10 20 30 40 (SEQ ID NO: 295) MAGGRHRRVV GTLHLLLLVA ALPWASRGVS PSASAWPEEK 50 60 70 80 NYHQPAILNS SALRQIAEGT SISEMWQNDL QPLLIER.sup.2YPG 90 100 110 120 SPGSYAARQH IMQRIQRLQA DWVLEIDTFL SQTPYGYRSF 130 140 150 160 SNIISTLNPT AKRHLVLACH YDSKYFSHWN NRVFVGATDS 170 180 190 200 AVPCAMMLEL ARALDKKLLS LKTVSDSKPD LSLQLIFFDG 210 220 230 240 EEAFLHWSPQ DSLYGSRHLA AK.sup.1MASTPHPP GARGTSQLHG 250 260 270 280 MDLLVLLDLI GAPNPTFPNF FPNSARWFER LQAIEHELHE 290 300 310 320 LGLLKDHSLE GRYFQNYSYG GVIQDDHIPF LRRGVPVLHL 330 340 350 360 IPSPFPEVWH TMDDNEENLD ESTIDNLKNI LQVFVLEYLH L Protein Name Uniprot IPI Gene Name Isoform 1 of O75882 IPI00027235 ATRN_Human Attraction Trypsin Fragments 1. CTWLIEGQPNR 2. GDECQLCEVENR 3. GVKGDECQLCEVENR (SEQ ID NO: 296) (SEQ ID NO: 297) (SEQ ID NO: 298) 4. LADDLYR 5. IMQSSQSMSK 6. LTGSSGFVTDGPGNYK (SEQ ID NO: 299) (SEQ ID NO: 300) (SEQ ID NO: 301) 7. SCALDQNCQWEPR (SEQ ID NO: 302) 10 20 30 40 (SEQ ID NO: 303) MVAAAAATEA RLRRRTAATA ALAGRSGGPH WDWDVTRAGR 50 60 70 80 PGLGAGLRLP RLLSPPLRPR LLLLLLLLSP PLLLLLLPCE 90 100 110 120 AEAAAAAAAV SGSAAAEAKE CDRPCVNGGR CNPGTGQCVC 130 140 150 160 PAGWVGEQCQ HCGGRFR.sup.(6)LTG SSGFVTDGPG NYKYKTK.sup.(1)CTW 170 180 190 200 LIEGQPNRIM RLRFNHFATE CSWDHLYVYD GDSIYAPLVA 210 220 230 240 AFSGLIVPER DGNETVPEVV ATSGYALLHF FSDAAYNLTG 250 260 270 280 FNITYSFDMC PNNCSGRGEC KISNSSDTVE CECSENWKGE 290 300 310 320 ACDIPHCTDN CGFPHRGICN SSDVRGCSCF SDWQGPGCSV 330 340 350 360 PVPANQSFWT REEYSNLKLP RASHKAVVNG NIMWVVGGYM 370 380 390 400 FNHSDYNMVL AYDLASREWL PLNRSVNNVV VRYGHSLALY 410 420 430 440 KDKIYMYGGK IDSTGNVTNE LRVFHIHNES WVLLTPKAKE 450 460 470 480 QYAVVGHSAH IVTLKNGRVV MLVIFGHCPL YGYISNVQEY 490 500 510 520 DLDKNTWSIL HTQGALVQGG YGHSSVYDHR TRALYVHGGY 530 540 550 560 KAFSANKYR.sup.(6)L ADDLYRYDVD TQMWTILKDS RFFRYLHTAV 570 580 590 600 IVSGTMLVFG GNTHNDTSMS HGAKCFSSDF MAYDIACDRW 610 620 630 640 SVLPRPDLHH DVNRFGHSAV LHNSTMYVFG GFNSLLLSDI 650 660 670 680 LVFTSEQCDA HRSEAACLAA GPGIRCVWNT GSSQCISWAL 690 700 710 720 ATDEQEEKLK SECFSKRTLD HDRCDQHTDC YSCTANTNDC

730 740 750 760 HWCNDHCVPR NHSCSEGQIS IFRYENCPKD NPMYYCNKKT 770 780 790 800 SCR.sup.(7)SCALDQN CQWEPRNQEC IALPENICGI GWHLVGNSCL 810 820 830 840 KITTAKENYD NAKLFCRNHN ALLASLTTQK KVEFVLKQLR 850 860 870 880 .sup.(5)IMQSSQSMSK LTLTPWVGLR KINVSYWCWE DMSPFTNSLL 890 900 910 920 QWMPSEPSDA GFCGILSEPS TRGLKAATCI NPLNGSVCER 930 940 950 960 PANHSAKQCR TPCALRTACG SCTSGSSECM WCSNMKQCVD 970 980 990 1000 SNAYVASFPF GQCMEWYTMS TCPPENCSGY CTCSHCLEQP 1010 1020 1030 1040 GCGWCTDPSN TGKGKCIEGS YKGPVKMPSQ APTGNFYPQP 1050 1060 1070 1080 LLNSSMCLED SRYNWSFIHC PACQCNGHSK CINQSICEKC 1090 1100 1110 1120 ENLTTGKHCE TCISGFYGDP TNGGKCQPCK CNGHASLCNT 1130 1140 1150 1160 NTGKCFCTTK .sup.(9)GVK.sup.(2)GDECQLC EVENRYQGNP LRGTCYYTLL 1170 1180 1190 1200 IDYQFTFSLS QEDDRYYTAI NFVATPDEQN RDLDMFINAS 1210 1220 1230 1240 KNFNLNITWA ASFSAGTQAG EEMPVVSKTN IKEYKDSFSN 1250 1260 1270 1280 EKFDFRNHPN ITFFVYVSNF TWPIKIQIAF SQHSNFMDLV 1290 1300 1310 1320 QFFVTFFSCF LSLLLVAAVV WKIKQSCWAS RRREQLLREM 1330 1340 1350 1360 QQMASRPFAS VNVALETDEE PPDLIGGSIK TVPKPIALEP 1370 1380 1390 1400 CFGNKAAVLS VFVRLPRGLG GIPPPGQSGL AVASALVDIS 1410 1420 QQMPIVYKEK SGAVRNRKQQ PPAQPGTC Protein Name Uniprot IPI Gene Name Uncharacterized IPI00925547 LTF_Human protein Trypsin Fragments 1. ADAVTLDGG 2. ARVVWCAVG 3. ARVVWCAVG FIYEAGLAPYK EQELR EQELRK (SEQ ID NO: 304) (SEQ ID NO: 305) (SEQ ID NO: 306) 4. CAFSSQEPYFSYSGAFK 5. CFQWQR 6. CGLVPVLAENYK (SEQ ID NO: 307) (SEQ ID NO: 308) (SEQ ID NO: 309) 7. CLAENAGDVAFVK 8. CLRDGAGDVAFIR 9. CSTSPLLEACEFLRK (SEQ ID NO: 310) (SEQ ID NO: 311) (SEQ ID NO: 312) 10. CSTSPLLEACEFLR 11. CVPNSNER 12. CVPNSNERYYGYTGAFR (SEQ ID NO: 313) (SEQ ID NO: 314) (SEQ ID NO: 315) 13. DCHLAR 14. DEYELLCPDNTR 15. DGAGDVAFIR (SEQ ID NO: 316) (SEQ ID NO: 317) (SEQ ID NO: 318) 16. DGAGDVAFIRESTV 17. DLLFKDSAI 18. DLKLADFAL FEDLSDEAERDEY GFSR LCLDGK ELLCPDNTR (SEQ ID NO: 320) (SEQ ID NO: 321) (SEQ ID NO: 319) 19. DLKLADFALLCLDGKR 20. DKSPKFQLFGSPSGQK 21. DSAIGFSR (SEQ ID NO: 322) (SEQ ID NO: 323) (SEQ ID NO: 324) 22. DSAIGFSRV 23. DSPIQCIQA 24. DSPIQCIQAIAENRA PPR IAENR DAVTLDGGFIYE (SEQ ID NO: 325) (SEQ ID NO: 326) AGLAPYK (SEQ ID NO: 327) 25. DVTVLQNTD 26. DVTVLQNTD 27. GEADAMSLD GNNNEAWAK GNNNEAWAKDIK GGYVYTAGK (SEQ ID NO: 328) (SEQ ID NO: 329) (SEQ ID NO: 330) 28. GGSFQLNELQGLK 29. GPPVSCIK 30. GPPVSCIKR (SEQ ID NO: 331) (SEQ ID NO: 332) (SEQ ID NO: 333) 31. GQFPNLCR (SEQ ID NO: 334) (SEQ ID NO: 335) MKLVFLVLLF LGALGLCLAG RRRSVQWCA VSQPEATK.sup.(5)CF QWQRNMRK VR.sup.(29,30)GPPV SCIKR.sup.(23,24)DS PIQCIQAIAE NR.sup.(1)ADAVTLDG GFIYEAGLAP YKLRPVAAE VYGTERQPR THYYAV AVVKK.sup.(28)G GSFQLNELQG LKSCHTGLRR TAGWNVPIGT LRPFLNWTG PPEPIEAAV ARFFSA SCVPGA DK.sup.(31)GQFPNLCR LCAGTGENK.sup.(8)C AFSSQEPYFS YSGAFK.sup.(8)CLR .sup.(15,16)DGAGDVAFI RESTVFE DLSDE AER.sup.(14)DEYELL CPDNTRKPVDK FK.sup.(13)DCHLARVP SHAVVARSV NGKEDAIWN LLRQAQE KFGK.sup.(20)D KSPKFQLFG SPSGQK.sup.(17)DLLFK .sup.(21,22)DSAIGFSRVP PRIDSGLYL GSGYFTAIQ NLRKSEE EVAAR R.sup.(2,3)ARVVWCAV GEQELRKCNQW SGLSEGSVTC SSASTTEDC IALK.sup.(23)GEADA MSLDGGY VYTAG K.sup.(6)CGLVPVLA ENYKSQQSSDP DPNCVDRPVE GYLAVAVVR RSDTSLTWN SVKGKKS CHTAV DRTAGWNIP MGLLFNQTGSC KFDEYFSQSC APGSDPRSN LCALCIGDE QGENK.sup.(11,12)CV PNSNE RYYGYTGAF R.sup.(7)CLAENAGDVA FVK.sup.(25,26)DVTVLQN TDGNNNEAW AK.sup.(18,19)DLKLADF ALLCLDG KRKPV TEARSCHLA MAPNHAVVSRM DKVERLKQVL LHQQAKFGR NGSDCPDKF CLFQSET KNLLF NDNTECLAR LHGKTTYEKYL GPQYVAGITN LKK.sup.(9,10)CSTSPL LEACEFLRK

SEQUENCE LISTINGS

1

33519PRTHomo sapiens 1Ala Glu Phe Gln Asp Ala Leu Glu Lys1 529PRTHomo sapiens 2Asp His Ala Val Asp Leu Ile Gln Lys1 539PRTHomo sapiens 3Asp Lys Gly Gln Ala Gly Leu Gln Arg1 5413PRTHomo sapiens 4Glu Met Ser Gly Ser Pro Ala Ser Gly Ile Pro Val Lys1 5 1057PRTHomo sapiens 5Phe Ala Cys Tyr Tyr Pro Arg1 5610PRTHomo sapiens 6Phe Gly Leu Leu Asp Glu Asp Gly Lys Lys1 5 10717PRTHomo sapiens 7Gly His Leu Phe Leu Gln Thr Asp Gln Pro Ile Tyr Asn Pro Gly Gln1 5 10 15Arg811PRTHomo sapiens 8Gly Leu Cys Val Ala Thr Pro Val Gln Leu Arg1 5 1099PRTHomo sapiens 9Gly Ile Gln Asp Glu Asp Gly Tyr Arg1 51014PRTHomo sapiens 10Gly Pro Glu Val Gln Leu Val Ala His Ser Pro Trp Leu Lys1 5 101113PRTHomo sapiens 11Gly Ser Phe Glu Phe Pro Val Gly Asp Ala Val Ser Lys1 5 101215PRTHomo sapiens 12His Leu Val Pro Gly Ala Pro Phe Leu Leu Gln Ala Leu Val Arg1 5 10 151317PRTHomo sapiens 13Leu Leu Ala Thr Leu Cys Ser Ala Glu Val Cys Gln Cys Ala Glu Gly1 5 10 15Lys1412PRTHomo sapiens 14Leu Asn Met Gly Ile Thr Asp Leu Gln Gly Leu Arg1 5 10159PRTHomo sapiens 15Ile Thr Gln Val Leu His Phe Thr Lys1 5166PRTHomo sapiens 16Asn Val Asn Phe Gln Lys1 5179PRTHomo sapiens 17Gln Gly Ser Phe Gln Gly Gly Phe Arg1 5189PRTHomo sapiens 18Ser Cys Gly Leu His Gln Leu Leu Arg1 5199PRTHomo sapiens 19Val Asp Phe Thr Leu Ser Ser Glu Arg1 52011PRTHomo sapiens 20Val Asp Val Gln Ala Gly Ala Cys Glu Gly Lys1 5 10217PRTHomo sapiens 21Val Phe Ala Leu Asp Gln Lys1 52210PRTHomo sapiens 22Val Gly Asp Thr Ile Asn Ile Asn Ile Arg1 5 102315PRTHomo sapiens 23Val Leu Ser Leu Ala Gln Glu Gln Val Gly Gly Ser Pro Glu Lys1 5 10 152426PRTHomo sapiens 24Val Thr Ala Ser Asp Pro Leu Asp Thr Leu Gly Ser Glu Gly Ala Leu1 5 10 15Ser Pro Gly Gly Val Ala Ser Leu Leu Arg 20 252516PRTHomo sapiens 25Tyr Leu Asp Lys Thr Glu Gln Trp Ser Thr Leu Pro Pro Glu Thr Lys1 5 10 15261744PRTHomo sapiens 26Met Arg Leu Leu Trp Gly Leu Ile Trp Ala Ser Ser Phe Phe Thr Leu1 5 10 15Ser Leu Gln Lys Pro Arg Leu Leu Leu Phe Ser Pro Ser Val Val His 20 25 30Leu Gly Val Pro Leu Ser Val Gly Val Gln Leu Gln Asp Val Pro Arg 35 40 45Gly Gln Val Val Lys Gly Ser Val Phe Leu Arg Asn Pro Ser Arg Asn 50 55 60Asn Val Pro Cys Ser Pro Lys Val Asp Phe Thr Leu Ser Ser Glu Arg65 70 75 80Asp Phe Ala Leu Leu Ser Leu Gln Val Pro Leu Lys Asp Ala Lys Ser 85 90 95Cys Gly Leu His Gln Leu Leu Arg Gly Pro Glu Val Gln Leu Val Ala 100 105 110His Ser Pro Trp Leu Lys Asp Ser Leu Ser Arg Thr Thr Asn Ile Gln 115 120 125Gly Ile Asn Leu Leu Phe Ser Ser Arg Arg Gly His Leu Phe Leu Gln 130 135 140Thr Asp Gln Pro Ile Tyr Asn Pro Gly Gln Arg Val Arg Tyr Arg Val145 150 155 160Phe Ala Leu Asp Gln Lys Met Arg Pro Ser Thr Asp Thr Ile Thr Val 165 170 175Met Val Glu Asn Ser His Gly Leu Arg Val Arg Lys Lys Glu Val Tyr 180 185 190Met Pro Ser Ser Ile Phe Gln Asp Asp Phe Val Ile Pro Asp Ile Ser 195 200 205Glu Pro Gly Thr Trp Lys Ile Ser Ala Arg Phe Ser Asp Gly Leu Glu 210 215 220Ser Asn Ser Ser Thr Gln Phe Glu Val Lys Lys Tyr Val Leu Pro Asn225 230 235 240Phe Glu Val Lys Ile Thr Pro Gly Lys Pro Tyr Ile Leu Thr Val Pro 245 250 255Gly His Leu Asp Glu Met Gln Leu Asp Ile Gln Ala Arg Tyr Ile Tyr 260 265 270Gly Lys Pro Val Gln Gly Val Ala Tyr Val Arg Phe Gly Leu Leu Asp 275 280 285Glu Asp Gly Lys Lys Thr Phe Phe Arg Gly Leu Glu Ser Gln Thr Lys 290 295 300Leu Val Asn Gly Gln Ser His Ile Ser Leu Ser Lys Ala Glu Phe Gln305 310 315 320Asp Ala Leu Glu Lys Leu Asn Met Gly Ile Thr Asp Leu Gln Gly Leu 325 330 335Arg Leu Tyr Val Ala Ala Ala Ile Ile Glu Ser Pro Gly Gly Glu Met 340 345 350Glu Glu Ala Glu Leu Thr Ser Trp Tyr Phe Val Ser Ser Pro Phe Ser 355 360 365Leu Asp Leu Ser Lys Thr Lys Arg His Leu Val Pro Gly Ala Pro Phe 370 375 380Leu Leu Gln Ala Leu Val Arg Glu Met Ser Gly Ser Pro Ala Ser Gly385 390 395 400Ile Pro Val Lys Val Ser Ala Thr Val Ser Ser Pro Gly Ser Val Pro 405 410 415Glu Val Gln Asp Ile Gln Gln Asn Thr Asp Gly Ser Gly Gln Val Ser 420 425 430Ile Pro Ile Ile Ile Pro Gln Thr Ile Ser Glu Leu Gln Leu Ser Val 435 440 445Ser Ala Gly Ser Pro His Pro Ala Ile Ala Arg Leu Thr Val Ala Ala 450 455 460Pro Pro Ser Gly Gly Pro Gly Phe Leu Ser Ile Glu Arg Pro Asp Ser465 470 475 480Arg Pro Pro Arg Val Gly Asp Thr Leu Asn Leu Asn Leu Arg Ala Val 485 490 495Gly Ser Gly Ala Thr Phe Ser His Tyr Tyr Tyr Met Ile Leu Ser Arg 500 505 510Gly Gln Ile Val Phe Met Asn Arg Glu Pro Lys Arg Thr Leu Thr Ser 515 520 525Val Ser Val Phe Val Asp His His Leu Ala Pro Ser Phe Tyr Phe Val 530 535 540Ala Phe Tyr Tyr His Gly Asp His Pro Val Ala Asn Ser Leu Arg Val545 550 555 560Asp Val Gln Ala Gly Ala Cys Glu Gly Lys Leu Glu Leu Ser Val Asp 565 570 575Gly Ala Lys Gln Tyr Arg Asn Gly Glu Ser Val Lys Leu His Leu Glu 580 585 590Thr Asp Ser Leu Ala Leu Val Ala Leu Gly Ala Leu Asp Thr Ala Leu 595 600 605Tyr Ala Ala Gly Ser Lys Ser His Lys Pro Leu Asn Met Gly Lys Val 610 615 620Phe Glu Ala Met Asn Ser Tyr Asp Leu Gly Cys Gly Pro Gly Gly Gly625 630 635 640Asp Ser Ala Leu Gln Val Phe Gln Ala Ala Gly Leu Ala Phe Ser Asp 645 650 655Gly Asp Gln Trp Thr Leu Ser Arg Lys Arg Leu Ser Cys Pro Lys Glu 660 665 670Lys Thr Thr Arg Lys Lys Arg Asn Val Asn Phe Gln Lys Ala Ile Asn 675 680 685Glu Lys Leu Gly Gln Tyr Ala Ser Pro Thr Ala Lys Arg Cys Cys Gln 690 695 700Asp Gly Val Thr Arg Leu Pro Met Met Arg Ser Cys Glu Gln Arg Ala705 710 715 720Ala Arg Val Gln Gln Pro Asp Cys Arg Glu Pro Phe Leu Ser Cys Cys 725 730 735Gln Phe Ala Glu Ser Leu Arg Lys Lys Ser Arg Asp Lys Gly Gln Ala 740 745 750Gly Leu Gln Arg Ala Leu Glu Ile Leu Gln Glu Glu Asp Leu Ile Asp 755 760 765Glu Asp Asp Ile Pro Val Arg Ser Phe Phe Pro Glu Asn Trp Leu Trp 770 775 780Arg Val Glu Thr Val Asp Arg Phe Gln Ile Leu Thr Leu Trp Leu Pro785 790 795 800Asp Ser Leu Thr Thr Trp Glu Ile His Gly Leu Ser Leu Ser Lys Thr 805 810 815Lys Gly Leu Cys Val Ala Thr Pro Val Gln Leu Arg Val Phe Arg Glu 820 825 830Phe His Leu His Leu Arg Leu Pro Met Ser Val Arg Arg Phe Glu Gln 835 840 845Leu Glu Leu Arg Pro Val Leu Tyr Asn Tyr Leu Asp Lys Asn Leu Thr 850 855 860Val Ser Val His Val Ser Pro Val Glu Gly Leu Cys Leu Ala Gly Gly865 870 875 880Gly Gly Leu Ala Gln Gln Val Leu Val Pro Ala Gly Ser Ala Arg Pro 885 890 895Val Ala Phe Ser Val Val Pro Thr Ala Ala Ala Ala Val Ser Leu Lys 900 905 910Val Val Ala Arg Gly Ser Phe Glu Phe Pro Val Gly Asp Ala Val Ser 915 920 925Lys Val Leu Gln Ile Glu Lys Glu Gly Ala Ile His Arg Glu Glu Leu 930 935 940Val Tyr Glu Leu Asn Pro Leu Asp His Arg Gly Arg Thr Leu Glu Ile945 950 955 960Pro Gly Asn Ser Asp Pro Asn Met Ile Pro Asp Gly Asp Phe Asn Ser 965 970 975Tyr Val Arg Val Thr Ala Ser Asp Pro Leu Asp Thr Leu Gly Ser Glu 980 985 990Gly Ala Leu Ser Pro Gly Gly Val Ala Ser Leu Leu Arg Leu Pro Arg 995 1000 1005Gly Cys Gly Glu Gln Thr Met Ile Tyr Leu Ala Pro Thr Leu Ala 1010 1015 1020Ala Ser Arg Tyr Leu Asp Lys Thr Glu Gln Trp Ser Thr Leu Pro 1025 1030 1035Pro Glu Thr Lys Asp His Ala Val Asp Leu Ile Gln Lys Gly Tyr 1040 1045 1050Met Arg Ile Gln Gln Phe Arg Lys Ala Asp Gly Ser Tyr Ala Ala 1055 1060 1065Trp Leu Ser Arg Asp Ser Ser Thr Trp Leu Thr Ala Phe Val Leu 1070 1075 1080Lys Val Leu Ser Leu Ala Gln Glu Gln Val Gly Gly Ser Pro Glu 1085 1090 1095Lys Leu Gln Glu Thr Ser Asn Trp Leu Leu Ser Gln Gln Gln Ala 1100 1105 1110Asp Gly Ser Phe Gln Asp Pro Cys Pro Val Leu Asp Arg Ser Met 1115 1120 1125Gln Gly Gly Leu Val Gly Asn Asp Glu Thr Val Ala Leu Thr Ala 1130 1135 1140Phe Val Thr Ile Ala Leu His His Gly Leu Ala Val Phe Gln Asp 1145 1150 1155Glu Gly Ala Glu Pro Leu Lys Gln Arg Val Glu Ala Ser Ile Ser 1160 1165 1170Lys Ala Asn Ser Phe Leu Gly Glu Lys Ala Ser Ala Gly Leu Leu 1175 1180 1185Gly Ala His Ala Ala Ala Ile Thr Ala Tyr Ala Leu Thr Leu Thr 1190 1195 1200Lys Ala Pro Val Asp Leu Leu Gly Val Ala His Asn Asn Leu Met 1205 1210 1215Ala Met Ala Gln Glu Thr Gly Asp Asn Leu Tyr Trp Gly Ser Val 1220 1225 1230Thr Gly Ser Gln Ser Asn Ala Val Ser Pro Thr Pro Ala Pro Arg 1235 1240 1245Asn Pro Ser Asp Pro Met Pro Gln Ala Pro Ala Leu Trp Ile Glu 1250 1255 1260Thr Thr Ala Tyr Ala Leu Leu His Leu Leu Leu His Glu Gly Lys 1265 1270 1275Ala Glu Met Ala Asp Gln Ala Ser Ala Trp Leu Thr Arg Gln Gly 1280 1285 1290Ser Phe Gln Gly Gly Phe Arg Ser Thr Gln Asp Thr Val Ile Ala 1295 1300 1305Leu Asp Ala Leu Ser Ala Tyr Trp Ile Ala Ser His Thr Thr Glu 1310 1315 1320Glu Arg Gly Leu Asn Val Thr Leu Ser Ser Thr Gly Arg Asn Gly 1325 1330 1335Phe Lys Ser His Ala Leu Gln Leu Asn Asn Arg Gln Ile Arg Gly 1340 1345 1350Leu Glu Glu Glu Leu Gln Phe Ser Leu Gly Ser Lys Ile Asn Val 1355 1360 1365Lys Val Gly Gly Asn Ser Lys Gly Thr Leu Lys Val Leu Arg Thr 1370 1375 1380Tyr Asn Val Leu Asp Met Lys Asn Thr Thr Cys Gln Asp Leu Gln 1385 1390 1395Ile Glu Val Thr Val Lys Gly His Val Glu Tyr Thr Met Glu Ala 1400 1405 1410Asn Glu Asp Tyr Glu Asp Tyr Glu Tyr Asp Glu Leu Pro Ala Lys 1415 1420 1425Asp Asp Pro Asp Ala Pro Leu Gln Pro Val Thr Pro Leu Gln Leu 1430 1435 1440Phe Glu Gly Arg Arg Asn Arg Arg Arg Arg Glu Ala Pro Lys Val 1445 1450 1455Val Glu Glu Gln Glu Ser Arg Val His Tyr Thr Val Cys Ile Trp 1460 1465 1470Arg Asn Gly Lys Val Gly Leu Ser Gly Met Ala Ile Ala Asp Val 1475 1480 1485Thr Leu Leu Ser Gly Phe His Ala Leu Arg Ala Asp Leu Glu Lys 1490 1495 1500Leu Thr Ser Leu Ser Asp Arg Tyr Val Ser His Phe Glu Thr Glu 1505 1510 1515Gly Pro His Val Leu Leu Tyr Phe Asp Ser Val Pro Thr Ser Arg 1520 1525 1530Glu Cys Val Gly Phe Glu Ala Val Gln Glu Val Pro Val Gly Leu 1535 1540 1545Val Gln Pro Ala Ser Ala Thr Leu Tyr Asp Tyr Tyr Asn Pro Glu 1550 1555 1560Arg Arg Cys Ser Val Phe Tyr Gly Ala Pro Ser Lys Ser Arg Leu 1565 1570 1575Leu Ala Thr Leu Cys Ser Ala Glu Val Cys Gln Cys Ala Glu Gly 1580 1585 1590Lys Cys Pro Arg Gln Arg Arg Ala Leu Glu Arg Gly Leu Gln Asp 1595 1600 1605Glu Asp Gly Tyr Arg Met Lys Phe Ala Cys Tyr Tyr Pro Arg Val 1610 1615 1620Glu Tyr Gly Phe Gln Val Lys Val Leu Arg Glu Asp Ser Arg Ala 1625 1630 1635Ala Phe Arg Leu Phe Glu Thr Lys Ile Thr Gln Val Leu His Phe 1640 1645 1650Thr Lys Asp Val Lys Ala Ala Ala Asn Gln Met Arg Asn Phe Leu 1655 1660 1665Val Arg Ala Ser Cys Arg Leu Arg Leu Glu Pro Gly Lys Glu Tyr 1670 1675 1680Leu Ile Met Gly Leu Asp Gly Ala Thr Tyr Asp Leu Glu Gly His 1685 1690 1695Pro Gln Tyr Leu Leu Asp Ser Asn Ser Trp Ile Glu Glu Met Pro 1700 1705 1710Ser Glu Arg Leu Cys Arg Ser Thr Arg Gln Arg Ala Ala Cys Ala 1715 1720 1725Gln Leu Asn Asp Phe Leu Gln Glu Tyr Gly Thr Gln Gly Cys Gln 1730 1735 1740Val2712PRTHomo sapiens 27Tyr Lys Glu Glu Asn Asp Asp Phe Ala Ser Phe Arg1 5 102816PRTHomo sapiens 28Ala Asp Leu Phe Tyr Asp Val Glu Ala Leu Asp Leu Glu Ser Pro Lys1 5 10 1529525PRTHomo sapiens 29Met Lys Ala Leu Ile Ala Ala Leu Leu Leu Ile Thr Leu Gln Tyr Ser1 5 10 15Cys Ala Val Ser Pro Thr Asp Cys Ser Ala Val Glu Pro Glu Ala Glu 20 25 30Lys Ala Leu Asp Leu Ile Asn Lys Arg Arg Arg Asp Gly Tyr Leu Phe 35 40 45Gln Leu Leu Arg Ile Ala Asp Ala His Leu Asp Arg Val Glu Asn Thr 50 55 60Thr Val Tyr Tyr Leu Val Leu Asp Val Gln Glu Ser Asp Cys Ser Val65 70 75 80Leu Ser Arg Lys Tyr Trp Asn Asp Cys Glu Pro Pro Asp Ser Arg Arg 85 90 95Pro Ser Glu Ile Val Ile Gly Gln Cys Lys Val Ile Ala Thr Arg His 100 105 110Ser His Glu Ser Gln Asp Leu Arg Val Ile Asp Phe Asn Cys Thr Thr 115 120 125Ser Ser Val Ser Ser Ala Leu Ala Asn Thr Lys Asp Ser Pro Val Leu 130 135 140Ile Asp Phe Phe Glu Asp Thr Glu Arg Tyr Arg Lys Gln Ala Asn Lys145 150 155 160Ala Leu Glu Lys Tyr Lys Glu Glu Asn Asp Asp Phe Ala Ser Phe Arg 165 170 175Val Asp Arg Ile Glu Arg Val Ala Arg Val Arg Gly Gly Glu Gly Thr 180 185 190Gly Tyr Phe Val Asp Phe Ser Val Arg Asn Cys Pro Arg His His Phe 195 200 205Pro Arg His Pro Asn Val Phe Gly Phe Cys Arg Ala Asp Leu Phe Tyr 210 215 220Asp Val Glu Ala Leu Asp Leu Glu Ser Pro Lys Asn Leu Val Ile Asn225 230 235 240Cys Glu Val Phe Asp Pro Gln Glu His Glu Asn Ile Asn Gly Val Pro 245 250 255Pro His Leu Gly His Pro Phe His Trp Gly Gly His Glu Arg Ser Ser 260 265 270Thr Thr Lys Pro Pro Phe Lys Pro His Gly Ser Arg Asp His His His 275 280 285Pro His Lys Pro His Glu His Gly Pro Pro Pro Pro Pro Asp Glu Arg 290 295 300Asp His Ser His Gly Pro Pro Leu Pro Gln Gly Pro Pro Pro Leu Leu305 310 315 320Pro Met Ser Cys Ser Ser Cys Gln His Ala Thr Phe Gly Thr Asn Gly 325

330 335Ala Gln Arg His Ser His Asn Asn Asn Ser Ser Asp Leu His Pro His 340 345 350Lys His His Ser His Glu Gln His Pro His Gly His His Pro His Ala 355 360 365His His Pro His Glu His Asp Thr His Arg Gln His Pro His Gly His 370 375 380His Pro His Gly His His Pro His Gly His His Pro His Gly His His385 390 395 400Pro His Gly His His Pro His Cys His Asp Phe Gln Asp Tyr Gly Pro 405 410 415Cys Asp Pro Pro Pro His Asn Gln Gly His Cys Cys His Gly His Gly 420 425 430Pro Pro Pro Gly His Leu Arg Arg Arg Gly Pro Gly Lys Gly Pro Arg 435 440 445Pro Phe His Cys Arg Gln Ile Gly Ser Val Tyr Arg Leu Pro Pro Leu 450 455 460Arg Lys Gly Glu Val Leu Pro Leu Pro Glu Ala Asn Phe Pro Ser Phe465 470 475 480Pro Leu Pro His His Lys His Pro Leu Lys Pro Asp Asn Gln Pro Phe 485 490 495Pro Gln Ser Val Ser Glu Ser Cys Pro Gly Lys Phe Lys Ser Gly Phe 500 505 510Pro Gln Val Ser Met Phe Phe Thr His Thr Phe Pro Lys 515 520 5253011PRTHomo sapiens 30Glu Gln Gln Ala Leu Gln Thr Val Cys Leu Lys1 5 103112PRTHomo sapiens 31Thr Phe His Glu Ala Ser Glu Asp Cys Ile Ser Arg1 5 1032202PRTHomo sapiens 32Met Glu Leu Trp Gly Ala Tyr Leu Leu Leu Cys Leu Phe Ser Leu Leu1 5 10 15Thr Gln Val Thr Thr Glu Pro Pro Thr Gln Lys Pro Lys Lys Ile Val 20 25 30Asn Ala Lys Lys Asp Val Val Asn Thr Lys Met Phe Glu Glu Leu Lys 35 40 45Ser Arg Leu Asp Thr Leu Ala Gln Glu Val Ala Leu Leu Lys Glu Gln 50 55 60Gln Ala Leu Gln Thr Val Cys Leu Lys Gly Thr Lys Val His Met Lys65 70 75 80Cys Phe Leu Ala Phe Thr Gln Thr Lys Thr Phe His Glu Ala Ser Glu 85 90 95Asp Cys Ile Ser Arg Gly Gly Thr Leu Gly Thr Pro Gln Thr Gly Ser 100 105 110Glu Asn Asp Ala Leu Tyr Glu Tyr Leu Arg Gln Ser Val Gly Asn Glu 115 120 125Ala Glu Ile Trp Leu Gly Leu Asn Asp Met Ala Ala Glu Gly Thr Trp 130 135 140Val Asp Met Thr Gly Ala Arg Ile Ala Tyr Lys Asn Trp Glu Thr Glu145 150 155 160Ile Thr Ala Gln Pro Asp Gly Gly Lys Thr Glu Asn Cys Ala Val Leu 165 170 175Ser Gly Ala Ala Asn Gly Lys Trp Phe Asp Lys Arg Cys Arg Asp Gln 180 185 190Leu Pro Tyr Ile Cys Gln Phe Gly Ile Val 195 2003313PRTHomo sapiens 33Glu Asn Phe Pro Asp Thr Leu Asn Cys Ala Glu Val Lys1 5 1034260PRTHomo sapiens 34Met Gly Arg Pro Arg Pro Arg Ala Ala Lys Thr Trp Met Phe Leu Leu1 5 10 15Leu Leu Gly Gly Ala Trp Ala Gly His Ser Arg Ala Gln Glu Asp Lys 20 25 30Val Leu Gly Gly His Glu Cys Gln Pro His Ser Gln Pro Trp Gln Ala 35 40 45Ala Leu Phe Gln Gly Gln Gln Leu Leu Cys Gly Gly Val Leu Val Gly 50 55 60Gly Asn Trp Val Leu Thr Ala Ala His Cys Lys Lys Pro Lys Tyr Thr65 70 75 80Val Arg Leu Gly Asp His Ser Leu Gln Asn Lys Asp Gly Pro Glu Gln 85 90 95Glu Ile Pro Val Val Gln Ser Ile Pro His Pro Cys Tyr Asn Ser Ser 100 105 110Asp Val Glu Asp His Asn His Asp Leu Met Leu Leu Gln Leu Arg Asp 115 120 125Gln Ala Ser Leu Gly Ser Lys Val Lys Pro Ile Ser Leu Ala Asp His 130 135 140Cys Thr Gln Pro Gly Gln Lys Cys Thr Val Ser Gly Trp Gly Thr Val145 150 155 160Thr Ser Pro Arg Glu Asn Phe Pro Asp Thr Leu Asn Cys Ala Glu Val 165 170 175Lys Ile Phe Pro Gln Lys Lys Cys Glu Asp Ala Tyr Pro Gly Gln Ile 180 185 190Thr Asp Gly Met Val Cys Ala Gly Ser Ser Lys Gly Ala Asp Thr Cys 195 200 205Gln Gly Asp Ser Gly Gly Pro Leu Val Cys Asp Gly Ala Leu Gln Gly 210 215 220Ile Thr Ser Trp Gly Ser Asp Pro Cys Gly Arg Ser Asp Lys Pro Gly225 230 235 240Val Tyr Thr Asn Ile Cys Arg Tyr Leu Asp Trp Ile Lys Lys Ile Ile 245 250 255Gly Ser Lys Gly 2603517PRTHomo sapiens 35Ala Ile Asp Glu Asp Cys Ser Gln Tyr Glu Pro Ile Pro Gly Ser Gln1 5 10 15Lys3617PRTHomo sapiens 36Leu Gly Ser Leu Gly Ala Ala Cys Glu Gln Thr Gln Thr Glu Gly Ala1 5 10 15Lys3711PRTHomo sapiens 37Gln Ala Gln Cys Gly Gln Asp Phe Gln Cys Lys1 5 1038584PRTHomo sapiens 38Met Phe Ala Val Val Phe Phe Ile Leu Ser Leu Met Thr Cys Gln Pro1 5 10 15Gly Val Thr Ala Gln Glu Lys Val Asn Gln Arg Val Arg Arg Ala Ala 20 25 30Thr Pro Ala Ala Val Thr Cys Gln Leu Ser Asn Trp Ser Glu Trp Thr 35 40 45Asp Cys Phe Pro Cys Gln Asp Lys Lys Tyr Arg His Arg Ser Leu Leu 50 55 60Gln Pro Asn Lys Phe Gly Gly Thr Ile Cys Ser Gly Asp Ile Trp Asp65 70 75 80Gln Ala Ser Cys Ser Ser Ser Thr Thr Cys Val Arg Gln Ala Gln Cys 85 90 95Gly Gln Asp Phe Gln Cys Lys Glu Thr Gly Arg Cys Leu Lys Arg His 100 105 110Leu Val Cys Asn Gly Asp Gln Asp Cys Leu Asp Gly Ser Asp Glu Asp 115 120 125Asp Cys Glu Asp Val Arg Ala Ile Asp Glu Asp Cys Ser Gln Tyr Glu 130 135 140Pro Ile Pro Gly Ser Gln Lys Ala Ala Leu Gly Tyr Asn Ile Leu Thr145 150 155 160Gln Glu Asp Ala Gln Ser Val Tyr Asp Ala Ser Tyr Tyr Gly Gly Gln 165 170 175Cys Glu Thr Val Tyr Asn Gly Glu Trp Arg Glu Leu Arg Tyr Asp Ser 180 185 190Thr Cys Glu Arg Leu Tyr Tyr Gly Asp Asp Glu Lys Tyr Phe Arg Lys 195 200 205Pro Tyr Asn Phe Leu Lys Tyr His Phe Glu Ala Leu Ala Asp Thr Gly 210 215 220Ile Ser Ser Glu Phe Tyr Asp Asn Ala Asn Asp Leu Leu Ser Lys Val225 230 235 240Lys Lys Asp Lys Ser Asp Ser Phe Gly Val Thr Ile Gly Ile Gly Pro 245 250 255Ala Gly Ser Pro Leu Leu Val Gly Val Gly Val Ser His Ser Gln Asp 260 265 270Thr Ser Phe Leu Asn Glu Leu Asn Lys Tyr Asn Glu Lys Lys Phe Ile 275 280 285Phe Thr Arg Ile Phe Thr Lys Val Gln Thr Ala His Phe Lys Met Arg 290 295 300Lys Asp Asp Ile Met Leu Asp Glu Gly Met Leu Gln Ser Leu Met Glu305 310 315 320Leu Pro Asp Gln Tyr Asn Tyr Gly Met Tyr Ala Lys Phe Ile Asn Asp 325 330 335Tyr Gly Thr His Tyr Ile Thr Ser Gly Ser Met Gly Gly Ile Tyr Glu 340 345 350Tyr Ile Leu Val Ile Asp Lys Ala Lys Met Glu Ser Leu Gly Ile Thr 355 360 365Ser Arg Asp Ile Thr Thr Cys Phe Gly Gly Ser Leu Gly Ile Gln Tyr 370 375 380Glu Asp Lys Ile Asn Val Gly Gly Gly Leu Ser Gly Asp His Cys Lys385 390 395 400Lys Phe Gly Gly Gly Lys Thr Glu Arg Ala Arg Lys Ala Met Ala Val 405 410 415Glu Asp Ile Ile Ser Arg Val Arg Gly Gly Ser Ser Gly Trp Ser Gly 420 425 430Gly Leu Ala Gln Asn Arg Ser Thr Ile Thr Tyr Arg Ser Trp Gly Arg 435 440 445Ser Leu Lys Tyr Asn Pro Val Val Ile Asp Phe Glu Met Gln Pro Ile 450 455 460His Glu Val Leu Arg His Thr Ser Leu Gly Pro Leu Glu Ala Lys Arg465 470 475 480Gln Asn Leu Arg Arg Ala Leu Asp Gln Tyr Leu Met Glu Phe Asn Ala 485 490 495Cys Arg Cys Gly Pro Cys Phe Asn Asn Gly Val Pro Ile Leu Glu Gly 500 505 510Thr Ser Cys Arg Cys Gln Cys Arg Leu Gly Ser Leu Gly Ala Ala Cys 515 520 525Glu Gln Thr Gln Thr Glu Gly Ala Lys Ala Asp Gly Ser Trp Ser Cys 530 535 540Trp Ser Ser Trp Ser Val Cys Arg Ala Gly Ile Gln Glu Arg Arg Arg545 550 555 560Glu Cys Asp Asn Pro Ala Pro Gln Asn Gly Gly Ala Ser Cys Pro Gly 565 570 575Arg Lys Val Gln Thr Gln Ala Cys 5803910PRTHomo sapiens 39Thr Leu Gln Cys Ala Asn Ile Gln Leu Arg1 5 104011PRTHomo sapiens 40Ile Thr Asp Asn Met Leu Cys Ala Gly Thr Lys1 5 1041277PRTHomo sapiens 41Met Trp Pro Leu Ala Leu Val Ile Ala Ser Leu Thr Leu Ala Leu Ser1 5 10 15Gly Gly Val Ser Gln Glu Ser Ser Lys Val Leu Asn Thr Asn Gly Thr 20 25 30Ser Gly Phe Leu Pro Gly Gly Tyr Thr Cys Phe Pro His Ser Gln Pro 35 40 45Trp Gln Ala Ala Leu Leu Val Gln Gly Arg Leu Leu Cys Gly Gly Val 50 55 60Leu Val His Pro Lys Trp Val Leu Thr Ala Ala His Cys Leu Lys Glu65 70 75 80Gly Leu Lys Val Tyr Leu Gly Lys His Ala Leu Gly Arg Val Glu Ala 85 90 95Gly Glu Gln Val Arg Glu Val Val His Ser Ile Pro His Pro Glu Tyr 100 105 110Arg Arg Ser Pro Thr His Leu Asn His Asp His Asp Ile Met Leu Leu 115 120 125Glu Leu Gln Ser Pro Val Gln Leu Thr Gly Tyr Ile Gln Thr Leu Pro 130 135 140Leu Ser His Asn Asn Arg Leu Thr Pro Gly Thr Thr Cys Arg Val Ser145 150 155 160Gly Trp Gly Thr Thr Thr Ser Pro Gln Val Asn Tyr Pro Lys Thr Leu 165 170 175Gln Cys Ala Asn Ile Gln Leu Arg Ser Asp Glu Glu Cys Arg Gln Val 180 185 190Tyr Pro Gly Lys Ile Thr Asp Asn Met Leu Cys Ala Gly Thr Lys Glu 195 200 205Gly Gly Lys Asp Ser Cys Glu Gly Asp Ser Gly Gly Pro Leu Val Cys 210 215 220Asn Arg Thr Leu Tyr Gly Ile Val Ser Trp Gly Asp Phe Pro Cys Gly225 230 235 240Gln Pro Asp Arg Pro Gly Val Tyr Thr Arg Val Ser Arg Tyr Val Leu 245 250 255Trp Ile Arg Glu Thr Ile Arg Lys Tyr Glu Thr Gln Gln Gln Lys Trp 260 265 270Leu Lys Gly Pro Gln 2754211PRTHomo sapiens 42Ala Ala Ser Gly Thr Gln Asn Asn Val Leu Arg1 5 104311PRTHomo sapiens 43Asp Ser Cys Thr Leu Pro Ala Ser Ala Glu Lys1 5 1044843PRTHomo sapiens 44Met Lys Val Ile Ser Leu Phe Ile Leu Val Gly Phe Ile Gly Glu Phe1 5 10 15Gln Ser Phe Ser Ser Ala Ser Ser Pro Val Asn Cys Gln Trp Asp Phe 20 25 30Tyr Ala Pro Trp Ser Glu Cys Asn Gly Cys Thr Lys Thr Gln Thr Arg 35 40 45Arg Arg Ser Val Ala Val Tyr Gly Gln Tyr Gly Gly Gln Pro Cys Val 50 55 60Gly Asn Ala Phe Glu Thr Gln Ser Cys Glu Pro Thr Arg Gly Cys Pro65 70 75 80Thr Glu Glu Gly Cys Gly Glu Arg Phe Arg Cys Phe Ser Gly Gln Cys 85 90 95Ile Ser Lys Ser Leu Val Cys Asn Gly Asp Ser Asp Cys Asp Glu Asp 100 105 110Ser Ala Asp Glu Asp Arg Cys Glu Asp Ser Glu Arg Arg Pro Ser Cys 115 120 125Asp Ile Asp Lys Pro Pro Pro Asn Ile Glu Leu Thr Gly Asn Gly Tyr 130 135 140Asn Glu Leu Thr Gly Gln Phe Arg Asn Arg Val Ile Asn Thr Lys Ser145 150 155 160Phe Gly Gly Gln Cys Arg Lys Val Phe Ser Gly Asp Gly Lys Asp Phe 165 170 175Tyr Arg Leu Ser Gly Asn Val Leu Ser Tyr Thr Phe Gln Val Lys Ile 180 185 190Asn Asn Asp Phe Asn Tyr Glu Phe Tyr Asn Ser Thr Trp Ser Tyr Val 195 200 205Lys His Thr Ser Thr Glu His Thr Ser Ser Ser Arg Lys Arg Ser Phe 210 215 220Phe Arg Ser Ser Ser Ser Ser Ser Arg Ser Tyr Thr Ser His Thr Asn225 230 235 240Glu Ile His Lys Gly Lys Ser Tyr Gln Leu Leu Val Val Glu Asn Thr 245 250 255Val Glu Val Ala Gln Phe Ile Asn Asn Asn Pro Glu Phe Leu Gln Leu 260 265 270Ala Glu Pro Phe Trp Lys Glu Leu Ser His Leu Pro Ser Leu Tyr Asp 275 280 285Tyr Ser Ala Tyr Arg Arg Leu Ile Asp Gln Tyr Gly Thr His Tyr Leu 290 295 300Gln Ser Gly Ser Leu Gly Gly Glu Tyr Arg Val Leu Phe Tyr Val Asp305 310 315 320Ser Glu Lys Leu Lys Gln Asn Asp Phe Asn Ser Val Glu Glu Lys Lys 325 330 335Cys Lys Ser Ser Gly Trp His Phe Val Val Lys Phe Ser Ser His Gly 340 345 350Cys Lys Glu Leu Glu Asn Ala Leu Lys Ala Ala Ser Gly Thr Gln Asn 355 360 365Asn Val Leu Arg Gly Glu Pro Phe Ile Arg Gly Gly Gly Ala Gly Phe 370 375 380Ile Ser Gly Leu Ser Tyr Leu Glu Leu Asp Asn Pro Ala Gly Asn Lys385 390 395 400Arg Arg Tyr Ser Ala Trp Ala Glu Ser Val Thr Asn Leu Pro Gln Val 405 410 415Ile Lys Gln Lys Leu Thr Pro Leu Tyr Glu Leu Val Lys Glu Val Pro 420 425 430Cys Ala Ser Val Lys Lys Leu Tyr Leu Lys Trp Ala Leu Glu Glu Tyr 435 440 445Leu Asp Glu Phe Asp Pro Cys His Cys Arg Pro Cys Gln Asn Gly Gly 450 455 460Leu Ala Thr Val Glu Gly Thr His Cys Leu Cys His Cys Lys Pro Tyr465 470 475 480Thr Phe Gly Ala Ala Cys Glu Gln Gly Val Leu Val Gly Asn Gln Ala 485 490 495Gly Gly Val Asp Gly Gly Trp Ser Cys Trp Ser Ser Trp Ser Pro Cys 500 505 510Val Gln Gly Lys Lys Thr Arg Ser Arg Glu Cys Asn Asn Pro Pro Pro 515 520 525Ser Gly Gly Gly Arg Ser Cys Val Gly Glu Thr Thr Glu Ser Thr Gln 530 535 540Cys Glu Asp Glu Glu Leu Glu His Leu Arg Leu Leu Glu Pro His Cys545 550 555 560Phe Pro Leu Ser Leu Val Pro Thr Glu Phe Cys Pro Ser Pro Pro Ala 565 570 575Leu Lys Asp Gly Phe Val Gln Asp Glu Gly Thr Met Phe Pro Val Gly 580 585 590Lys Asn Val Val Tyr Thr Cys Asn Glu Gly Tyr Ser Leu Ile Gly Asn 595 600 605Pro Val Ala Arg Cys Gly Glu Asp Leu Arg Trp Leu Val Gly Glu Met 610 615 620His Cys Gln Lys Ile Ala Cys Val Leu Pro Val Leu Met Asp Gly Ile625 630 635 640Gln Ser His Pro Gln Lys Pro Phe Tyr Thr Val Gly Glu Lys Val Thr 645 650 655Val Ser Cys Ser Gly Gly Met Ser Leu Glu Gly Pro Ser Ala Phe Leu 660 665 670Cys Gly Ser Ser Leu Lys Trp Ser Pro Glu Met Lys Asn Ala Arg Cys 675 680 685Val Gln Lys Glu Asn Pro Leu Thr Gln Ala Val Pro Lys Cys Gln Arg 690 695 700Trp Glu Lys Leu Gln Asn Ser Arg Cys Val Cys Lys Met Pro Tyr Glu705 710 715 720Cys Gly Pro Ser Leu Asp Val Cys Ala Gln Asp Glu Arg Ser Lys Arg 725 730 735Ile Leu Pro Leu Thr Val Cys Lys Met His Val Leu His Cys Gln Gly 740 745 750Arg Asn Tyr Thr Leu Thr Gly Arg Asp Ser Cys Thr Leu Pro Ala Ser 755 760 765Ala Glu Lys Ala Cys Gly Ala Cys Pro Leu Trp Gly Lys Cys Asp Ala 770 775 780Glu Ser Ser Lys Cys Val Cys Arg Glu Ala Ser Glu Cys Glu Glu Glu785 790

795 800Gly Phe Ser Ile Cys Val Glu Val Asn Gly Lys Glu Gln Thr Met Ser 805 810 815Glu Cys Glu Ala Gly Ala Leu Arg Cys Arg Gly Gln Ser Ile Ser Val 820 825 830Thr Ser Ile Arg Pro Cys Ala Ala Glu Thr Gln 835 8404516PRTHomo sapiens 45Ser Ser Ser Gly Thr Pro Asp Leu Pro Val Leu Leu Thr Asp Leu Lys1 5 10 154624PRTHomo sapiens 46Tyr Ile Leu Gly Asn Pro Leu Thr Pro Gly Val Thr Gln Gly Pro Gln1 5 10 15Ile Asp Lys Glu Gln Tyr Asp Lys 2047501PRTHomo sapiens 47Met Ser Ser Ser Gly Thr Pro Asp Leu Pro Val Leu Leu Thr Asp Leu1 5 10 15Lys Ile Gln Tyr Thr Lys Ile Phe Ile Asn Asn Glu Trp His Asp Ser 20 25 30Val Ser Gly Lys Lys Phe Pro Val Phe Asn Pro Ala Thr Glu Glu Glu 35 40 45Leu Cys Gln Val Glu Glu Gly Asp Lys Glu Asp Val Asp Lys Ala Val 50 55 60Lys Ala Ala Arg Gln Ala Phe Gln Ile Gly Ser Pro Trp Arg Thr Met65 70 75 80Asp Ala Ser Glu Arg Gly Arg Leu Leu Tyr Lys Leu Ala Asp Leu Ile 85 90 95Glu Arg Asp Arg Leu Leu Leu Ala Thr Met Glu Ser Met Asn Gly Gly 100 105 110Lys Leu Tyr Ser Asn Ala Tyr Leu Asn Asp Leu Ala Gly Cys Ile Lys 115 120 125Thr Leu Arg Tyr Cys Ala Gly Trp Ala Asp Lys Ile Gln Gly Arg Thr 130 135 140Ile Pro Ile Asp Gly Asn Phe Phe Thr Tyr Thr Arg His Glu Pro Ile145 150 155 160Gly Val Cys Gly Gln Ile Ile Pro Trp Asn Phe Pro Leu Val Met Leu 165 170 175Ile Trp Lys Ile Gly Pro Ala Leu Ser Cys Gly Asn Thr Val Val Val 180 185 190Lys Pro Ala Glu Gln Thr Pro Leu Thr Ala Leu His Val Ala Ser Leu 195 200 205Ile Lys Glu Ala Gly Phe Pro Pro Gly Val Val Asn Ile Val Pro Gly 210 215 220Tyr Gly Pro Thr Ala Gly Ala Ala Ile Ser Ser His Met Asp Ile Asp225 230 235 240Lys Val Ala Phe Thr Gly Ser Thr Glu Val Gly Lys Leu Ile Lys Glu 245 250 255Ala Ala Gly Lys Ser Asn Leu Lys Arg Val Thr Leu Glu Leu Gly Gly 260 265 270Lys Ser Pro Cys Ile Val Leu Ala Asp Ala Asp Leu Asp Asn Ala Val 275 280 285Glu Phe Ala His His Gly Val Phe Tyr His Gln Gly Gln Cys Cys Ile 290 295 300Ala Ala Ser Arg Ile Phe Val Glu Glu Ser Ile Tyr Asp Glu Phe Val305 310 315 320Arg Arg Ser Val Glu Arg Ala Lys Lys Tyr Ile Leu Gly Asn Pro Leu 325 330 335Thr Pro Gly Val Thr Gln Gly Pro Gln Ile Asp Lys Glu Gln Tyr Asp 340 345 350Lys Ile Leu Asp Leu Ile Glu Ser Gly Lys Lys Glu Gly Ala Lys Leu 355 360 365Glu Cys Gly Gly Gly Pro Trp Gly Asn Lys Gly Tyr Phe Val Gln Pro 370 375 380Thr Val Phe Ser Asn Val Thr Asp Glu Met Arg Ile Ala Lys Glu Glu385 390 395 400Ile Phe Gly Pro Val Gln Gln Ile Met Lys Phe Lys Ser Leu Asp Asp 405 410 415Val Ile Lys Arg Ala Asn Asn Thr Phe Tyr Gly Leu Ser Ala Gly Val 420 425 430Phe Thr Lys Asp Ile Asp Lys Ala Ile Thr Ile Ser Ser Ala Leu Gln 435 440 445Ala Gly Thr Val Trp Val Asn Cys Tyr Gly Val Val Ser Ala Gln Cys 450 455 460Pro Phe Gly Gly Phe Lys Met Ser Gly Asn Gly Arg Glu Leu Gly Glu465 470 475 480Tyr Gly Phe His Glu Tyr Thr Glu Val Lys Thr Val Thr Val Lys Ile 485 490 495Ser Gln Lys Asn Ser 5004815PRTHomo sapiens 48Val Thr Glu Pro Ile Ser Ala Glu Ser Gly Glu Gln Val Glu Arg1 5 10 1549398PRTHomo sapiens 49Met Glu Gly Ala Ala Leu Leu Arg Val Ser Val Leu Cys Ile Trp Met1 5 10 15Ser Ala Leu Phe Leu Gly Val Gly Val Arg Ala Glu Glu Ala Gly Ala 20 25 30Arg Val Gln Gln Asn Val Pro Ser Gly Thr Asp Thr Gly Asp Pro Gln 35 40 45Ser Lys Pro Leu Gly Asp Trp Ala Ala Gly Thr Met Asp Pro Glu Ser 50 55 60Ser Ile Phe Ile Glu Asp Ala Ile Lys Tyr Phe Lys Glu Lys Val Ser65 70 75 80Thr Gln Asn Leu Leu Leu Leu Leu Thr Asp Asn Glu Ala Trp Asn Gly 85 90 95Phe Val Ala Ala Ala Glu Leu Pro Arg Asn Glu Ala Asp Glu Leu Arg 100 105 110Lys Ala Leu Asp Asn Leu Ala Arg Gln Met Ile Met Lys Asp Lys Asn 115 120 125Trp His Asp Lys Gly Gln Gln Tyr Arg Asn Trp Phe Leu Lys Glu Phe 130 135 140Pro Arg Leu Lys Ser Glu Leu Glu Asp Asn Ile Arg Arg Leu Arg Ala145 150 155 160Leu Ala Asp Gly Val Gln Lys Val His Lys Gly Thr Thr Ile Ala Asn 165 170 175Val Val Ser Gly Ser Leu Ser Ile Ser Ser Gly Ile Leu Thr Leu Val 180 185 190Gly Met Gly Leu Ala Pro Phe Thr Glu Gly Gly Ser Leu Val Leu Leu 195 200 205Glu Pro Gly Met Glu Leu Gly Ile Thr Ala Ala Leu Thr Gly Ile Thr 210 215 220Ser Ser Thr Met Asp Tyr Gly Lys Lys Trp Trp Thr Gln Ala Gln Ala225 230 235 240His Asp Leu Val Ile Lys Ser Leu Asp Lys Leu Lys Glu Val Arg Glu 245 250 255Phe Leu Gly Glu Asn Ile Ser Asn Phe Leu Ser Leu Ala Gly Asn Thr 260 265 270Tyr Gln Leu Thr Arg Gly Ile Gly Lys Asp Ile Arg Ala Leu Arg Arg 275 280 285Ala Arg Ala Asn Leu Gln Ser Val Pro His Ala Ser Ala Ser Arg Pro 290 295 300Arg Val Thr Glu Pro Ile Ser Ala Glu Ser Gly Glu Gln Val Glu Arg305 310 315 320Val Asn Glu Pro Ser Ile Leu Glu Met Ser Arg Gly Val Lys Leu Thr 325 330 335Asp Val Ala Pro Val Ser Phe Phe Leu Val Leu Asp Val Val Tyr Leu 340 345 350Val Tyr Glu Ser Lys His Leu His Glu Gly Ala Lys Ser Glu Thr Ala 355 360 365Glu Glu Leu Lys Lys Val Ala Gln Glu Leu Glu Glu Lys Leu Asn Ile 370 375 380Leu Asn Asn Asn Tyr Lys Ile Leu Gln Ala Asp Gln Glu Leu385 390 3955011PRTHomo sapiens 50Asp Ile Ser Glu Met Phe Ile Gln Leu Tyr Lys1 5 105111PRTHomo sapiens 51Gln Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys1 5 10521255PRTHomo sapiens 52Met Thr Pro Gly Thr Gln Ser Pro Phe Phe Leu Leu Leu Leu Leu Thr1 5 10 15Val Leu Thr Val Val Thr Gly Ser Gly His Ala Ser Ser Thr Pro Gly 20 25 30Gly Glu Lys Glu Thr Ser Ala Thr Gln Arg Ser Ser Val Pro Ser Ser 35 40 45Thr Glu Lys Asn Ala Val Ser Met Thr Ser Ser Val Leu Ser Ser His 50 55 60Ser Pro Gly Ser Gly Ser Ser Thr Thr Gln Gly Gln Asp Val Thr Leu65 70 75 80Ala Pro Ala Thr Glu Pro Ala Ser Gly Ser Ala Ala Thr Trp Gly Gln 85 90 95Asp Val Thr Ser Val Pro Val Thr Arg Pro Ala Leu Gly Ser Thr Thr 100 105 110Pro Pro Ala His Asp Val Thr Ser Ala Pro Asp Asn Lys Pro Ala Pro 115 120 125Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 130 135 140Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser145 150 155 160Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 165 170 175Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 180 185 190Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 195 200 205Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 210 215 220Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser225 230 235 240Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 245 250 255Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 260 265 270Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 275 280 285Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 290 295 300Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser305 310 315 320Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 325 330 335Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 340 345 350Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 355 360 365Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 370 375 380Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser385 390 395 400Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 405 410 415Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 420 425 430Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 435 440 445Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 450 455 460Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser465 470 475 480Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 485 490 495Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 500 505 510Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 515 520 525Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 530 535 540Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser545 550 555 560Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 565 570 575Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 580 585 590Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 595 600 605Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 610 615 620Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser625 630 635 640Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 645 650 655Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 660 665 670Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 675 680 685Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 690 695 700Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser705 710 715 720Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 725 730 735Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 740 745 750Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 755 760 765Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 770 775 780Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser785 790 795 800Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 805 810 815Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 820 825 830Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 835 840 845Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr 850 855 860Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser865 870 875 880Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala Pro Pro Ala His 885 890 895Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro Gly Ser Thr Ala 900 905 910Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Thr Arg Pro Ala Pro 915 920 925Gly Ser Thr Ala Pro Pro Ala His Gly Val Thr Ser Ala Pro Asp Asn 930 935 940Arg Pro Ala Leu Gly Ser Thr Ala Pro Pro Val His Asn Val Thr Ser945 950 955 960Ala Ser Gly Ser Ala Ser Gly Ser Ala Ser Thr Leu Val His Asn Gly 965 970 975Thr Ser Ala Arg Ala Thr Thr Thr Pro Ala Ser Lys Ser Thr Pro Phe 980 985 990Ser Ile Pro Ser His His Ser Asp Thr Pro Thr Thr Leu Ala Ser His 995 1000 1005Ser Thr Lys Thr Asp Ala Ser Ser Thr His His Ser Ser Val Pro 1010 1015 1020Pro Leu Thr Ser Ser Asn His Ser Thr Ser Pro Gln Leu Ser Thr 1025 1030 1035Gly Val Ser Phe Phe Phe Leu Ser Phe His Ile Ser Asn Leu Gln 1040 1045 1050Phe Asn Ser Ser Leu Glu Asp Pro Ser Thr Asp Tyr Tyr Gln Glu 1055 1060 1065Leu Gln Arg Asp Ile Ser Glu Met Phe Leu Gln Ile Tyr Lys Gln 1070 1075 1080Gly Gly Phe Leu Gly Leu Ser Asn Ile Lys Phe Arg Pro Gly Ser 1085 1090 1095Val Val Val Gln Leu Thr Leu Ala Phe Arg Glu Gly Thr Ile Asn 1100 1105 1110Val His Asp Val Glu Thr Gln Phe Asn Gln Tyr Lys Thr Glu Ala 1115 1120 1125Ala Ser Arg Tyr Asn Leu Thr Ile Ser Asp Val Ser Val Ser Asp 1130 1135 1140Val Pro Phe Pro Phe Ser Ala Gln Ser Gly Ala Gly Val Pro Gly 1145 1150 1155Trp Gly Ile Ala Leu Leu Val Leu Val Cys Val Leu Val Ala Leu 1160 1165 1170Ala Ile Val Tyr Leu Ile Ala Leu Ala Val Cys Gln Cys Arg Arg 1175 1180 1185Lys Asn Tyr Gly Gln Leu Asp Ile Phe Pro Ala Arg Asp Thr Tyr 1190 1195 1200His Pro Met Ser Glu Tyr Pro Thr Tyr His Thr His Gly Arg Tyr 1205 1210 1215Val Pro Pro Ser Ser Thr Asp Arg Ser Pro Tyr Glu Lys Val Ser 1220 1225 1230Ala Gly Asn Gly Gly Ser Ser Leu Ser Tyr Thr Asn Pro Ala Val 1235 1240 1245Ala Ala Thr Ser Ala Asn Leu 1250 12555320PRTHomo sapiens 53Ala Gln His Val Phe Gln His Ala Val Pro Gln Glu Gly Lys Pro Ile1 5 10 15Thr Asn Gln Lys 205416PRTHomo sapiens 54Ser Ser Ser Gly Leu Asn Ser Glu Lys Val Ala Ala Leu Ile Gln Lys1 5 10 1555455PRTHomo sapiens 55Met Ser Ser Ser Gly Leu Asn Ser Glu Lys Val Ala Ala Leu Ile Gln1 5 10 15Lys Leu Asn Ser Asp Pro Gln Phe Val Leu Ala Gln Asn Val Gly Thr 20 25 30Thr His Asp Leu Leu Asp Ile Cys Leu Lys Arg Ala Thr Val Gln Arg 35 40 45Ala Gln His Val Phe Gln His Ala Val Pro Gln Glu Gly Lys Pro Ile 50 55 60Thr Asn Gln Lys Ser Ser Gly Arg Cys Trp Ile Phe Ser Cys Leu Asn65 70 75 80Val Met Arg Leu Pro Phe Met Lys Lys Leu Asn Ile Glu Glu Phe Glu 85 90 95Phe Ser Gln Ser Tyr Leu Phe Phe Trp Asp Lys Val Glu Arg Cys Tyr 100 105 110Phe Phe Leu Ser Ala Phe Val Asp Thr Ala Gln Arg Lys Glu Pro Glu 115 120

125Asp Gly Arg Leu Val Gln Phe Leu Leu Met Asn Pro Ala Asn Asp Gly 130 135 140Gly Gln Trp Asp Met Leu Val Asn Ile Val Glu Lys Tyr Gly Val Ile145 150 155 160Pro Lys Lys Cys Phe Pro Glu Ser Tyr Thr Thr Glu Ala Thr Arg Arg 165 170 175Met Asn Asp Ile Leu Asn His Lys Met Arg Glu Phe Cys Ile Arg Leu 180 185 190Arg Asn Leu Val His Ser Gly Ala Thr Lys Gly Glu Ile Ser Ala Thr 195 200 205Gln Asp Val Met Met Glu Glu Ile Phe Arg Val Val Cys Ile Cys Leu 210 215 220Gly Asn Pro Pro Glu Thr Phe Thr Trp Glu Tyr Arg Asp Lys Asp Lys225 230 235 240Asn Tyr Gln Lys Ile Gly Pro Ile Thr Pro Leu Glu Phe Tyr Arg Glu 245 250 255His Val Lys Pro Leu Phe Asn Met Glu Asp Lys Ile Cys Leu Val Asn 260 265 270Asp Pro Arg Pro Gln His Lys Tyr Asn Lys Leu Tyr Thr Val Glu Tyr 275 280 285Leu Ser Asn Met Val Gly Gly Arg Lys Thr Leu Tyr Asn Asn Gln Pro 290 295 300Ile Asp Phe Leu Lys Lys Met Val Ala Ala Ser Ile Lys Asp Gly Glu305 310 315 320Ala Val Trp Phe Gly Cys Asp Val Gly Lys His Phe Asn Ser Lys Leu 325 330 335Gly Leu Ser Asp Met Asn Leu Tyr Asp His Glu Leu Val Phe Gly Val 340 345 350Ser Leu Lys Asn Met Asn Lys Ala Glu Arg Leu Thr Phe Gly Glu Ser 355 360 365Leu Met Thr His Ala Met Thr Phe Thr Ala Val Ser Glu Lys Asp Asp 370 375 380Gln Asp Gly Ala Phe Thr Lys Trp Arg Val Glu Asn Ser Trp Gly Glu385 390 395 400Asp His Gly His Lys Gly Tyr Leu Cys Met Thr Asp Glu Trp Phe Ser 405 410 415Glu Tyr Val Tyr Glu Val Val Val Asp Arg Lys His Val Pro Glu Glu 420 425 430Val Leu Ala Val Leu Glu Gln Glu Pro Ile Ile Leu Pro Ala Trp Asp 435 440 445Pro Met Gly Ala Leu Ala Glu 450 4555615PRTHomo sapiens 56Gln Pro Cys Thr Pro Pro Pro Gln Leu Gln Gln Gln Gln Val Lys1 5 10 155717PRTHomo sapiens 57Val Pro Glu Pro Cys Pro Ser Ile Val Thr Pro Ala Pro Ala Gln Gln1 5 10 15Lys5889PRTHomo sapiens 58Met Ser Ser Gln Gln Gln Lys Gln Pro Cys Thr Pro Pro Pro Gln Leu1 5 10 15Gln Gln Gln Gln Val Lys Gln Pro Cys Gln Pro Pro Pro Gln Glu Pro 20 25 30Cys Ile Pro Lys Thr Lys Glu Pro Cys His Pro Lys Val Pro Glu Pro 35 40 45Cys His Pro Lys Val Pro Glu Pro Cys Gln Pro Lys Val Pro Glu Pro 50 55 60Cys His Pro Lys Val Pro Glu Pro Cys Pro Ser Ile Val Thr Pro Ala65 70 75 80Pro Ala Gln Gln Lys Thr Lys Gln Lys 855917PRTHomo sapiens 59Gly Lys Ile Pro Asn Leu Leu Pro Glu Gly Ser Val Asp Gly Asp Thr1 5 10 15Arg60415PRTHomo sapiens 60Met Glu Asp Leu Cys Val Ala Asn Thr Leu Phe Ala Leu Asn Leu Phe1 5 10 15Lys His Leu Ala Lys Ala Ser Pro Thr Gln Asn Leu Phe Leu Ser Pro 20 25 30Trp Ser Ile Ser Ser Thr Met Ala Met Val Tyr Met Gly Ser Arg Gly 35 40 45Ser Thr Glu Asp Gln Met Ala Lys Val Leu Gln Phe Asn Glu Val Gly 50 55 60Ala Asn Ala Val Thr Pro Met Thr Pro Glu Asn Phe Thr Ser Cys Gly65 70 75 80Phe Met Gln Gln Ile Gln Lys Gly Ser Tyr Pro Asp Ala Ile Leu Gln 85 90 95Ala Gln Ala Ala Asp Lys Ile His Ser Ser Phe Arg Ser Leu Ser Ser 100 105 110Ala Ile Asn Ala Ser Thr Gly Asn Tyr Leu Leu Glu Ser Val Asn Lys 115 120 125Leu Phe Gly Glu Lys Ser Ala Ser Phe Arg Glu Glu Tyr Ile Arg Leu 130 135 140Cys Gln Lys Tyr Tyr Ser Ser Glu Pro Gln Ala Val Asp Phe Leu Glu145 150 155 160Cys Ala Glu Glu Ala Arg Lys Lys Ile Asn Ser Trp Val Lys Thr Gln 165 170 175Thr Lys Gly Lys Ile Pro Asn Leu Leu Pro Glu Gly Ser Val Asp Gly 180 185 190Asp Thr Arg Met Val Leu Val Asn Ala Val Tyr Phe Lys Gly Lys Trp 195 200 205Lys Thr Pro Phe Glu Lys Lys Leu Asn Gly Leu Tyr Pro Phe Arg Val 210 215 220Asn Ser Ala Gln Arg Thr Pro Val Gln Met Met Tyr Leu Arg Glu Lys225 230 235 240Leu Asn Ile Gly Tyr Ile Glu Asp Leu Lys Ala Gln Ile Leu Glu Leu 245 250 255Pro Tyr Ala Gly Asp Val Ser Met Phe Leu Leu Leu Pro Asp Glu Ile 260 265 270Ala Asp Val Ser Thr Gly Leu Glu Leu Leu Glu Ser Glu Ile Thr Tyr 275 280 285Asp Lys Leu Asn Lys Trp Thr Ser Lys Asp Lys Met Ala Glu Asp Glu 290 295 300Val Glu Val Tyr Ile Pro Gln Phe Lys Leu Glu Glu His Tyr Glu Leu305 310 315 320Arg Ser Ile Leu Arg Ser Met Gly Met Glu Asp Ala Phe Asn Lys Gly 325 330 335Arg Ala Asn Phe Ser Gly Met Ser Glu Arg Asn Asp Leu Phe Leu Ser 340 345 350Glu Val Phe His Gln Ala Met Val Asp Val Asn Glu Glu Gly Thr Glu 355 360 365Ala Ala Ala Gly Thr Gly Gly Val Met Thr Gly Arg Thr Gly His Gly 370 375 380Gly Pro Gln Phe Val Ala Asp His Pro Phe Leu Phe Leu Ile Met His385 390 395 400Lys Ile Thr Asn Cys Ile Leu Phe Phe Gly Arg Phe Ser Ser Pro 405 410 4156113PRTHomo sapiens 61Asp Ile Asn Ala Tyr Asn Cys Glu Glu Pro Thr Glu Lys1 5 10627PRTHomo sapiens 62Asn Phe Asp Glu Ile Leu Arg1 563224PRTHomo sapiens 63Met Pro Gly Gly Leu Leu Leu Gly Asp Val Ala Pro Asn Phe Glu Ala1 5 10 15Asn Thr Thr Val Gly Arg Ile Arg Phe His Asp Phe Leu Gly Asp Ser 20 25 30Trp Gly Ile Leu Phe Ser His Pro Arg Asp Phe Thr Pro Val Cys Thr 35 40 45Thr Glu Leu Gly Arg Ala Ala Lys Leu Ala Pro Glu Phe Ala Lys Arg 50 55 60Asn Val Lys Leu Ile Ala Leu Ser Ile Asp Ser Val Glu Asp His Leu65 70 75 80Ala Trp Ser Lys Asp Ile Asn Ala Tyr Asn Cys Glu Glu Pro Thr Glu 85 90 95Lys Leu Pro Phe Pro Ile Ile Asp Asp Arg Asn Arg Glu Leu Ala Ile 100 105 110Leu Leu Gly Met Leu Asp Pro Ala Glu Lys Asp Glu Lys Gly Met Pro 115 120 125Val Thr Ala Arg Val Val Phe Val Phe Gly Pro Asp Lys Lys Leu Lys 130 135 140Leu Ser Ile Leu Tyr Pro Ala Thr Thr Gly Arg Asn Phe Asp Glu Ile145 150 155 160Leu Arg Val Val Ile Ser Leu Gln Leu Thr Ala Glu Lys Arg Val Ala 165 170 175Thr Pro Val Asp Trp Lys Asp Gly Asp Ser Val Met Val Leu Pro Thr 180 185 190Ile Pro Glu Glu Glu Ala Lys Lys Leu Phe Pro Lys Gly Val Phe Thr 195 200 205Lys Glu Leu Pro Ser Gly Lys Lys Tyr Leu Arg Tyr Thr Pro Gln Pro 210 215 2206413PRTHomo sapiens 64Ile Thr Cys Thr Glu Glu Gly Trp Ser Pro Thr Pro Lys1 5 106510PRTHomo sapiens 65Thr Gly Glu Ser Ala Glu Phe Val Cys Lys1 5 106620PRTHomo sapiens 66Ser Thr Asp Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala His1 5 10 15Ile Leu Ser Arg 2067330PRTHomo sapiens 67Met Trp Leu Leu Val Ser Val Ile Leu Ile Ser Arg Ile Ser Ser Val1 5 10 15Gly Gly Glu Ala Thr Phe Cys Asp Phe Pro Lys Ile Asn His Gly Ile 20 25 30Leu Tyr Asp Glu Glu Lys Tyr Lys Pro Phe Ser Gln Val Pro Thr Gly 35 40 45Glu Val Phe Tyr Tyr Ser Cys Glu Tyr Asn Phe Val Ser Pro Ser Lys 50 55 60Ser Phe Trp Thr Arg Ile Thr Cys Thr Glu Glu Gly Trp Ser Pro Thr65 70 75 80Pro Lys Cys Leu Arg Leu Cys Phe Phe Pro Phe Val Glu Asn Gly His 85 90 95Ser Glu Ser Ser Gly Gln Thr His Leu Glu Gly Asp Thr Val Gln Ile 100 105 110Ile Cys Asn Thr Gly Tyr Arg Leu Gln Asn Asn Glu Asn Asn Ile Ser 115 120 125Cys Val Glu Arg Gly Trp Ser Thr Pro Pro Lys Cys Arg Ser Thr Asp 130 135 140Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala His Ile Leu Ser145 150 155 160Arg Gln Met Ser Lys Tyr Pro Ser Gly Glu Arg Val Arg Tyr Glu Cys 165 170 175Arg Ser Pro Tyr Glu Met Phe Gly Asp Glu Glu Val Met Cys Leu Asn 180 185 190Gly Asn Trp Thr Glu Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys 195 200 205Gly Pro Pro Pro Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu 210 215 220Ser Val Tyr Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu225 230 235 240Tyr Gln Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp 245 250 255Ser Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile 260 265 270Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys Leu 275 280 285Tyr Leu Arg Thr Gly Glu Ser Ala Glu Phe Val Cys Lys Arg Gly Tyr 290 295 300Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys Trp Asp Gly305 310 315 320Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg 325 3306811PRTHomo sapiens 68Ala Thr Trp Ser Gly Ala Val Leu Ala Gly Arg1 5 10699PRTHomo sapiens 69Cys Leu Ala Pro Leu Glu Gly Ala Arg1 5707PRTHomo sapiens 70Gly Val Thr Phe Leu Leu Arg1 57112PRTHomo sapiens 71His Gln Phe Leu Leu Thr Gly Asp Thr Gln Gly Arg1 5 10728PRTHomo sapiens 72Leu Leu Glu Leu Thr Gly Pro Lys1 57312PRTHomo sapiens 73Ser Gly Leu Ser Thr Gly Trp Thr Gln Leu Ser Lys1 5 1074495PRTHomo sapiens 74Met Ser Met Leu Val Val Phe Leu Leu Leu Trp Gly Val Thr Trp Gly1 5 10 15Pro Val Thr Glu Ala Ala Ile Phe Tyr Glu Thr Gln Pro Ser Leu Trp 20 25 30Ala Glu Ser Glu Ser Leu Leu Lys Pro Leu Ala Asn Val Thr Leu Thr 35 40 45Cys Gln Ala His Leu Glu Thr Pro Asp Phe Gln Leu Phe Lys Asn Gly 50 55 60Val Ala Gln Glu Pro Val His Leu Asp Ser Pro Ala Ile Lys His Gln65 70 75 80Phe Leu Leu Thr Gly Asp Thr Gln Gly Arg Tyr Arg Cys Arg Ser Gly 85 90 95Leu Ser Thr Gly Trp Thr Gln Leu Ser Lys Leu Leu Glu Leu Thr Gly 100 105 110Pro Lys Ser Leu Pro Ala Pro Trp Leu Ser Met Ala Pro Val Ser Trp 115 120 125Ile Thr Pro Gly Leu Lys Thr Thr Ala Val Cys Arg Gly Val Leu Arg 130 135 140Gly Val Thr Phe Leu Leu Arg Arg Glu Gly Asp His Glu Phe Leu Glu145 150 155 160Val Pro Glu Ala Gln Glu Asp Val Glu Ala Thr Phe Pro Val His Gln 165 170 175Pro Gly Asn Tyr Ser Cys Ser Tyr Arg Thr Asp Gly Glu Gly Ala Leu 180 185 190Ser Glu Pro Ser Ala Thr Val Thr Ile Glu Glu Leu Ala Ala Pro Pro 195 200 205Pro Pro Val Leu Met His His Gly Glu Ser Ser Gln Val Leu His Pro 210 215 220Gly Asn Lys Val Thr Leu Thr Cys Val Ala Pro Leu Ser Gly Val Asp225 230 235 240Phe Gln Leu Arg Arg Gly Glu Lys Glu Leu Leu Val Pro Arg Ser Ser 245 250 255Thr Ser Pro Asp Arg Ile Phe Phe His Leu Asn Ala Val Ala Leu Gly 260 265 270Asp Gly Gly His Tyr Thr Cys Arg Tyr Arg Leu His Asp Asn Gln Asn 275 280 285Gly Trp Ser Gly Asp Ser Ala Pro Val Glu Leu Ile Leu Ser Asp Glu 290 295 300Thr Leu Pro Ala Pro Glu Phe Ser Pro Glu Pro Glu Ser Gly Arg Ala305 310 315 320Leu Arg Leu Arg Cys Leu Ala Pro Leu Glu Gly Ala Arg Phe Ala Leu 325 330 335Val Arg Glu Asp Arg Gly Gly Arg Arg Val His Arg Phe Gln Ser Pro 340 345 350Ala Gly Thr Glu Ala Leu Phe Glu Leu His Asn Ile Ser Val Ala Asp 355 360 365Ser Ala Asn Tyr Ser Cys Val Tyr Val Asp Leu Lys Pro Pro Phe Gly 370 375 380Gly Ser Ala Pro Ser Glu Arg Leu Glu Leu His Val Asp Gly Pro Pro385 390 395 400Pro Arg Pro Gln Leu Arg Ala Thr Trp Ser Gly Ala Val Leu Ala Gly 405 410 415Arg Asp Ala Val Leu Arg Cys Glu Gly Pro Ile Pro Asp Val Thr Phe 420 425 430Glu Leu Leu Arg Glu Gly Glu Thr Lys Ala Val Lys Thr Val Arg Thr 435 440 445Pro Gly Ala Ala Ala Asn Leu Glu Leu Ile Phe Val Gly Pro Gln His 450 455 460Ala Gly Asn Tyr Arg Cys Arg Tyr Arg Ser Trp Val Pro His Thr Phe465 470 475 480Glu Ser Glu Leu Ser Asp Pro Val Glu Leu Leu Val Ala Glu Ser 485 490 4957513PRTHomo sapiens 75Asn Leu Asp Gly Ile Ser His Ala Pro Asn Ala Val Lys1 5 1076318PRTHomo sapiens 76Met Ala Ser Pro Gly Cys Leu Leu Cys Val Leu Gly Leu Leu Leu Cys1 5 10 15Gly Ala Ala Ser Leu Glu Leu Ser Arg Pro His Gly Asp Thr Ala Lys 20 25 30Lys Pro Ile Ile Gly Ile Leu Met Gln Lys Cys Arg Asn Lys Val Met 35 40 45Lys Asn Tyr Gly Arg Tyr Tyr Ile Ala Ala Ser Tyr Val Lys Tyr Leu 50 55 60Glu Ser Ala Gly Ala Arg Val Val Pro Val Arg Leu Asp Leu Thr Glu65 70 75 80Lys Asp Tyr Glu Ile Leu Phe Lys Ser Ile Asn Gly Ile Leu Phe Pro 85 90 95Gly Gly Ser Val Asp Leu Arg Arg Ser Asp Tyr Ala Lys Val Ala Lys 100 105 110Ile Phe Tyr Asn Leu Ser Ile Gln Ser Phe Asp Asp Gly Asp Tyr Phe 115 120 125Pro Val Trp Gly Thr Cys Leu Gly Phe Glu Glu Leu Ser Leu Leu Ile 130 135 140Ser Gly Glu Cys Leu Leu Thr Ala Thr Asp Thr Val Asp Val Ala Met145 150 155 160Pro Leu Asn Phe Thr Gly Gly Gln Leu His Ser Arg Met Phe Gln Asn 165 170 175Phe Pro Thr Glu Leu Leu Leu Ser Leu Ala Val Glu Pro Leu Thr Ala 180 185 190Asn Phe His Lys Trp Ser Leu Ser Val Lys Asn Phe Thr Met Asn Glu 195 200 205Lys Leu Lys Lys Phe Phe Asn Val Leu Thr Thr Asn Thr Asp Gly Lys 210 215 220Ile Glu Phe Ile Ser Thr Met Glu Gly Tyr Lys Tyr Pro Val Tyr Gly225 230 235 240Val Gln Trp His Pro Glu Lys Ala Pro Tyr Glu Trp Lys Asn Leu Asp 245 250 255Gly Ile Ser His Ala Pro Asn Ala Val Lys Thr Ala Phe Tyr Leu Ala 260 265 270Glu Phe Phe Val Asn Glu Ala Arg Lys Asn Asn His His Phe Lys Ser 275 280 285Glu Ser Glu Glu Glu Lys Ala Leu Ile Tyr Gln Phe Ser Pro Ile Tyr 290 295 300Thr Gly Asn Ile Ser Ser Phe Gln Gln Cys Tyr Ile Phe Asp305 310 315778PRTHomo sapiens 77Ala Leu Gln Leu Glu Glu Glu Arg1 57810PRTHomo sapiens 78Ala Pro Asp Phe Val Phe Tyr Ala Pro Arg1 5 10798PRTHomo sapiens 79Glu Leu Ser Glu Gln Ile Gln Arg1 5808PRTHomo sapiens 80Ile Ala Leu Leu Glu Glu Ala Arg1

5819PRTHomo sapiens 81Ile Gly Phe Pro Trp Ser Glu Ile Arg1 5829PRTHomo sapiens 82Gln Arg Ile Asp Glu Phe Glu Ala Leu1 5838PRTHomo sapiens 83Ser Gly Tyr Leu Ser Ser Glu Arg1 58415PRTHomo sapiens 84Ser Gln Glu Gln Leu Ala Ala Glu Leu Ala Glu Tyr Thr Ala Lys1 5 10 15858PRTHomo sapiens 85Val Ser Ala Gln Glu Val Arg Lys1 586586PRTHomo sapiens 86Met Pro Lys Pro Ile Asn Val Arg Val Thr Thr Met Asp Ala Glu Leu1 5 10 15Glu Phe Ala Ile Gln Pro Asn Thr Thr Gly Lys Gln Leu Phe Asp Gln 20 25 30Val Val Lys Thr Ile Gly Leu Arg Glu Val Trp Tyr Phe Gly Leu His 35 40 45Tyr Val Asp Asn Lys Gly Phe Pro Thr Trp Leu Lys Leu Asp Lys Lys 50 55 60Val Ser Ala Gln Glu Val Arg Lys Glu Asn Pro Leu Gln Phe Lys Phe65 70 75 80Arg Ala Lys Phe Tyr Pro Glu Asp Val Ala Glu Glu Leu Ile Gln Asp 85 90 95Ile Thr Gln Lys Leu Phe Phe Leu Gln Val Lys Glu Gly Ile Leu Ser 100 105 110Asp Glu Ile Tyr Cys Pro Pro Glu Thr Ala Val Leu Leu Gly Ser Tyr 115 120 125Ala Val Gln Ala Lys Phe Gly Asp Tyr Asn Lys Glu Val His Lys Ser 130 135 140Gly Tyr Leu Ser Ser Glu Arg Leu Ile Pro Gln Arg Val Met Asp Gln145 150 155 160His Lys Leu Thr Arg Asp Gln Trp Glu Asp Arg Ile Gln Val Trp His 165 170 175Ala Glu His Arg Gly Met Leu Lys Asp Asn Ala Met Leu Glu Tyr Leu 180 185 190Lys Ile Ala Gln Asp Leu Glu Met Tyr Gly Ile Asn Tyr Phe Glu Ile 195 200 205Lys Asn Lys Lys Gly Thr Asp Leu Trp Leu Gly Val Asp Ala Leu Gly 210 215 220Leu Asn Ile Tyr Glu Lys Asp Asp Lys Leu Thr Pro Lys Ile Gly Phe225 230 235 240Pro Trp Ser Glu Ile Arg Asn Ile Ser Phe Asn Asp Lys Lys Phe Val 245 250 255Ile Lys Pro Ile Asp Lys Lys Ala Pro Asp Phe Val Phe Tyr Ala Pro 260 265 270Arg Leu Arg Ile Asn Lys Arg Ile Leu Gln Leu Cys Met Gly Asn His 275 280 285Glu Leu Tyr Met Arg Arg Arg Lys Pro Asp Thr Ile Glu Val Gln Gln 290 295 300Met Lys Ala Gln Ala Arg Glu Glu Lys His Gln Lys Gln Leu Glu Arg305 310 315 320Gln Gln Leu Glu Thr Glu Lys Lys Arg Arg Glu Thr Val Glu Arg Glu 325 330 335Lys Glu Gln Met Met Arg Glu Lys Glu Glu Leu Met Leu Arg Leu Gln 340 345 350Asp Tyr Glu Glu Lys Thr Lys Lys Ala Glu Arg Glu Leu Ser Glu Gln 355 360 365Ile Gln Arg Ala Leu Gln Leu Glu Glu Glu Arg Lys Arg Ala Gln Glu 370 375 380Glu Ala Glu Arg Leu Glu Ala Asp Arg Met Ala Ala Leu Arg Ala Lys385 390 395 400Glu Glu Leu Glu Arg Gln Ala Val Asp Gln Ile Lys Ser Gln Glu Gln 405 410 415Leu Ala Ala Glu Leu Ala Glu Tyr Thr Ala Lys Ile Ala Leu Leu Glu 420 425 430Glu Ala Arg Arg Arg Lys Glu Asp Glu Val Glu Glu Trp Gln His Arg 435 440 445Ala Lys Glu Ala Gln Asp Asp Leu Val Lys Thr Lys Glu Glu Leu His 450 455 460Leu Val Met Thr Ala Pro Pro Pro Pro Pro Pro Pro Val Tyr Glu Pro465 470 475 480Val Ser Tyr His Val Gln Glu Ser Leu Gln Asp Glu Gly Ala Glu Pro 485 490 495Thr Gly Tyr Ser Ala Glu Leu Ser Ser Glu Gly Ile Arg Asp Asp Arg 500 505 510Asn Glu Glu Lys Arg Ile Thr Glu Ala Glu Lys Asn Glu Arg Val Gln 515 520 525Arg Gln Leu Leu Thr Leu Ser Ser Glu Leu Ser Gln Ala Arg Asp Glu 530 535 540Asn Lys Arg Thr His Asn Asp Ile Ile His Asn Glu Asn Met Arg Gln545 550 555 560Gly Arg Asp Lys Tyr Lys Thr Leu Arg Gln Ile Arg Gln Gly Asn Thr 565 570 575Lys Gln Arg Ile Asp Glu Phe Glu Ala Leu 580 5858713PRTHomo sapiens 87Leu Gly Asn Gln Glu Pro Gly Gly Gln Thr Ala Leu Lys1 5 1088491PRTHomo sapiens 88Met Ala Leu Leu Trp Gly Leu Leu Val Leu Ser Trp Ser Cys Leu Gln1 5 10 15Gly Pro Cys Ser Val Phe Ser Pro Val Ser Ala Met Glu Pro Leu Gly 20 25 30Arg Gln Leu Thr Ser Gly Pro Asn Gln Glu Gln Val Ser Pro Leu Thr 35 40 45Leu Leu Lys Leu Gly Asn Gln Glu Pro Gly Gly Gln Thr Ala Leu Lys 50 55 60Ser Pro Pro Gly Val Cys Ser Arg Asp Pro Thr Pro Glu Gln Thr His65 70 75 80Arg Leu Ala Arg Ala Met Met Ala Phe Thr Ala Asp Leu Phe Ser Leu 85 90 95Val Ala Gln Thr Ser Thr Cys Pro Asn Leu Ile Leu Ser Pro Leu Ser 100 105 110Val Ala Leu Ala Leu Ser His Leu Ala Leu Gly Ala Gln Asn His Thr 115 120 125Leu Gln Arg Leu Gln Gln Val Leu His Ala Gly Ser Gly Pro Cys Leu 130 135 140Pro His Leu Leu Ser Arg Leu Cys Gln Asp Leu Gly Pro Gly Ala Phe145 150 155 160Arg Leu Ala Ala Arg Met Tyr Leu Gln Lys Gly Phe Pro Ile Lys Glu 165 170 175Asp Phe Leu Glu Gln Ser Glu Gln Leu Phe Gly Ala Lys Pro Val Ser 180 185 190Leu Thr Gly Lys Gln Glu Asp Asp Leu Ala Asn Ile Asn Gln Trp Val 195 200 205Lys Glu Ala Thr Glu Gly Lys Ile Gln Glu Phe Leu Ser Gly Leu Pro 210 215 220Glu Asp Thr Val Leu Leu Leu Leu Asn Ala Ile His Phe Gln Gly Phe225 230 235 240Trp Arg Asn Lys Phe Asp Pro Ser Leu Thr Gln Arg Asp Ser Phe His 245 250 255Leu Asp Glu Gln Phe Thr Val Pro Val Glu Met Met Gln Ala Arg Thr 260 265 270Tyr Pro Leu Arg Trp Phe Leu Leu Glu Gln Pro Glu Ile Gln Val Ala 275 280 285His Phe Pro Phe Lys Asn Asn Met Ser Phe Val Val Leu Val Pro Thr 290 295 300His Phe Glu Trp Asn Val Ser Gln Val Leu Ala Asn Leu Ser Trp Asp305 310 315 320Thr Leu His Pro Pro Leu Val Trp Glu Arg Pro Thr Lys Val Arg Leu 325 330 335Pro Lys Leu Tyr Leu Lys His Gln Met Asp Leu Val Ala Thr Leu Ser 340 345 350Gln Leu Gly Leu Gln Glu Leu Phe Gln Ala Pro Asp Leu Arg Gly Ile 355 360 365Ser Glu Gln Ser Leu Val Val Ser Gly Val Gln His Gln Ser Thr Leu 370 375 380Glu Leu Ser Glu Val Gly Val Glu Ala Ala Ala Ala Thr Ser Ile Ala385 390 395 400Met Ser Arg Met Ser Leu Ser Ser Phe Ser Val Asn Arg Pro Phe Leu 405 410 415Phe Phe Ile Phe Glu Asp Thr Thr Gly Leu Pro Leu Phe Val Gly Ser 420 425 430Val Arg Asn Pro Asn Pro Ser Ala Pro Arg Glu Leu Lys Glu Gln Gln 435 440 445Asp Ser Pro Gly Asn Lys Asp Phe Leu Gln Ser Leu Lys Gly Phe Pro 450 455 460Arg Gly Asp Lys Leu Phe Gly Pro Asp Leu Lys Leu Val Pro Pro Met465 470 475 480Glu Glu Asp Tyr Pro Gln Phe Gly Ser Pro Lys 485 4908912PRTHomo sapiens 89Asp Val Arg Asp Tyr Phe Met Pro Cys Pro Gly Arg1 5 10909PRTHomo sapiens 90Asp Tyr Phe Met Pro Cys Pro Gly Arg1 59124PRTHomo sapiens 91Glu Val Gly Thr Pro His Gly Ile Ile Leu Asp Ser Val Asp Ala Ala1 5 10 15Phe Ile Cys Pro Gly Ser Ser Arg 209215PRTHomo sapiens 92Gly Glu Cys Gln Ala Glu Gly Val Leu Phe Phe Gln Gly Asp Arg1 5 10 15936PRTHomo sapiens 93Gly Glu Phe Val Trp Lys1 59411PRTHomo sapiens 94Gly Gly Tyr Thr Leu Val Ser Gly Tyr Pro Lys1 5 109521PRTHomo sapiens 95Leu Leu Gln Asp Glu Phe Pro Gly Ile Pro Ser Pro Ile Asp Ala Ala1 5 10 15Val Glu Cys His Arg 209611PRTHomo sapiens 96Asn Phe Pro Ser Pro Val Asp Ala Ala Phe Arg1 5 109710PRTHomo sapiens 97Gln Gly His Asn Ser Val Phe Leu Ile Lys1 5 109816PRTHomo sapiens 98Ser Gly Ala Gln Ala Thr Trp Thr Glu Leu Pro Trp Pro His Glu Lys1 5 10 15999PRTHomo sapiens 99Val Asp Gly Ala Leu Cys Met Glu Lys1 510013PRTHomo sapiens 100Trp Lys Asn Phe Pro Ser Pro Val Asp Ala Ala Phe Arg1 5 10101462PRTHomo sapiens 101Met Ala Arg Val Leu Gly Ala Pro Val Ala Leu Gly Leu Trp Ser Leu1 5 10 15Cys Trp Ser Leu Ala Ile Ala Thr Pro Leu Pro Pro Thr Ser Ala His 20 25 30Gly Asn Val Ala Glu Gly Glu Thr Lys Pro Asp Pro Asp Val Thr Glu 35 40 45Arg Cys Ser Asp Gly Trp Ser Phe Asp Ala Thr Thr Leu Asp Asp Asn 50 55 60Gly Thr Met Leu Phe Phe Lys Gly Glu Phe Val Trp Lys Ser His Lys65 70 75 80Trp Asp Arg Glu Leu Ile Ser Glu Arg Trp Lys Asn Phe Pro Ser Pro 85 90 95Val Asp Ala Ala Phe Arg Gln Gly His Asn Ser Val Phe Leu Ile Lys 100 105 110Gly Asp Lys Val Trp Val Tyr Pro Pro Glu Lys Lys Glu Lys Gly Tyr 115 120 125Pro Lys Leu Leu Gln Asp Glu Phe Pro Gly Ile Pro Ser Pro Leu Asp 130 135 140Ala Ala Val Glu Cys His Arg Gly Glu Cys Gln Ala Glu Gly Val Leu145 150 155 160Phe Phe Gln Gly Asp Arg Glu Trp Phe Trp Asp Leu Ala Thr Gly Thr 165 170 175Met Lys Glu Arg Ser Trp Pro Ala Val Gly Asn Cys Ser Ser Ala Leu 180 185 190Arg Trp Leu Gly Arg Tyr Tyr Cys Phe Gln Gly Asn Gln Phe Leu Arg 195 200 205Phe Asp Pro Val Arg Gly Glu Val Pro Pro Arg Tyr Pro Arg Asp Val 210 215 220Arg Asp Tyr Phe Met Pro Cys Pro Gly Arg Gly His Gly His Arg Asn225 230 235 240Gly Thr Gly His Gly Asn Ser Thr His His Gly Pro Glu Tyr Met Arg 245 250 255Cys Ser Pro His Leu Val Leu Ser Ala Leu Thr Ser Asp Asn His Gly 260 265 270Ala Thr Tyr Ala Phe Ser Gly Thr His Tyr Trp Arg Leu Asp Thr Ser 275 280 285Arg Asp Gly Trp His Ser Trp Pro Ile Ala His Gln Trp Pro Gln Gly 290 295 300Pro Ser Ala Val Asp Ala Ala Phe Ser Trp Glu Glu Lys Leu Tyr Leu305 310 315 320Val Gln Gly Thr Gln Val Tyr Val Phe Leu Thr Lys Gly Gly Tyr Thr 325 330 335Leu Val Ser Gly Tyr Pro Lys Arg Leu Glu Lys Glu Val Gly Thr Pro 340 345 350His Gly Ile Ile Leu Asp Ser Val Asp Ala Ala Phe Ile Cys Pro Gly 355 360 365Ser Ser Arg Leu His Ile Met Ala Gly Arg Arg Leu Trp Trp Leu Asp 370 375 380Leu Lys Ser Gly Ala Gln Ala Thr Trp Thr Glu Leu Pro Trp Pro His385 390 395 400Glu Lys Val Asp Gly Ala Leu Cys Met Glu Lys Ser Leu Gly Pro Asn 405 410 415Ser Cys Ser Ala Asn Gly Pro Gly Leu Tyr Leu Ile His Gly Pro Asn 420 425 430Leu Tyr Cys Tyr Ser Asp Val Glu Lys Leu Asn Ala Ala Lys Ala Leu 435 440 445Pro Gln Pro Gln Asn Val Thr Ser Leu Leu Gly Cys Thr His 450 455 4601028PRTHomo sapiens 102Trp Ala Asn Gln Cys Asn Tyr Arg1 5103240PRTHomo sapiens 103Met Thr Leu Phe Pro Val Leu Leu Phe Leu Val Ala Gly Leu Leu Pro1 5 10 15Ser Phe Pro Ala Asn Glu Asp Lys Asp Pro Ala Phe Thr Ala Leu Leu 20 25 30Thr Thr Gln Thr Gln Val Gln Arg Glu Ile Val Asn Lys His Asn Glu 35 40 45Leu Arg Arg Ala Val Ser Pro Pro Ala Arg Asn Met Leu Lys Met Glu 50 55 60Trp Asn Lys Glu Ala Ala Ala Asn Ala Gln Lys Trp Ala Asn Gln Cys65 70 75 80Asn Tyr Arg His Ser Asn Pro Lys Asp Arg Met Thr Ser Leu Lys Cys 85 90 95Gly Glu Asn Leu Tyr Met Ser Ser Ala Ser Ser Ser Trp Ser Gln Ala 100 105 110Ile Gln Ser Trp Phe Asp Glu Tyr Asn Asp Phe Asp Phe Gly Val Gly 115 120 125Pro Lys Thr Pro Asn Ala Val Val Gly His Tyr Thr Gln Val Val Trp 130 135 140Tyr Ser Ser Tyr Leu Val Gly Cys Gly Asn Ala Tyr Cys Pro Asn Gln145 150 155 160Lys Val Leu Lys Tyr Tyr Tyr Val Cys Gln Tyr Cys Pro Ala Gly Asn 165 170 175Trp Ala Asn Arg Leu Tyr Val Pro Tyr Glu Gln Gly Ala Pro Cys Ala 180 185 190Ser Cys Pro Asp Asn Cys Asp Asp Gly Leu Cys Thr Asn Gly Cys Lys 195 200 205Tyr Glu Asp Leu Tyr Ser Asn Cys Lys Ser Leu Lys Leu Thr Leu Thr 210 215 220Cys Lys His Gln Leu Val Arg Asp Ser Cys Lys Ala Ser Cys Asn Cys225 230 235 24010410PRTHomo sapiens 104Asp Pro Ala Ile Thr Ser Ile Leu Glu Lys1 5 1010515PRTHomo sapiens 105Ser Arg Asn Pro Gly Ser Ser Cys Ile Gly Ala Asp Pro Asn Arg1 5 10 1510623PRTHomo sapiens 106Gly Ala Ser Asp Asn Pro Cys Ser Glu Val Tyr His Gly Pro His Ala1 5 10 15Asn Ser Glu Val Glu Val Lys 201078PRTHomo sapiens 107Ser Val Val Asp Phe Ile Gln Lys1 510813PRTHomo sapiens 108Asn Pro Gly Ser Ser Cys Ile Gly Ala Asp Pro Asn Arg1 5 10109420PRTHomo sapiens 109Met Arg Trp Ile Leu Phe Ile Gly Ala Leu Ile Gly Ser Ser Ile Cys1 5 10 15Gly Gln Glu Lys Phe Phe Gly Asp Gln Val Leu Arg Ile Asn Val Arg 20 25 30Asn Gly Asp Glu Ile Ser Lys Leu Ser Gln Leu Val Asn Ser Asn Asn 35 40 45Leu Lys Leu Asn Phe Trp Lys Ser Pro Ser Ser Phe Asn Arg Pro Val 50 55 60Asp Val Leu Val Pro Ser Val Ser Leu Gln Ala Phe Lys Ser Phe Leu65 70 75 80Arg Ser Gln Gly Leu Glu Tyr Ala Val Thr Ile Glu Asp Leu Gln Ala 85 90 95Leu Leu Asp Asn Glu Asp Asp Glu Met Gln His Asn Glu Gly Gln Glu 100 105 110Arg Ser Ser Asn Asn Phe Asn Tyr Gly Ala Tyr His Ser Leu Glu Ala 115 120 125Ile Tyr His Glu Met Asp Asn Ile Ala Ala Asp Phe Pro Asp Leu Ala 130 135 140Arg Arg Val Lys Ile Gly His Ser Phe Glu Asn Arg Pro Met Tyr Val145 150 155 160Leu Lys Phe Ser Thr Gly Lys Gly Val Arg Arg Pro Ala Val Trp Leu 165 170 175Asn Ala Gly Ile His Ser Arg Glu Trp Ile Ser Gln Ala Thr Ala Ile 180 185 190Trp Thr Ala Arg Lys Ile Val Ser Asp Tyr Gln Arg Asp Pro Ala Ile 195 200 205Thr Ser Ile Leu Glu Lys Met Asp Ile Phe Leu Leu Pro Val Ala Asn 210 215 220Pro Asp Gly Tyr Val Tyr Thr Gln Thr Gln Asn Arg Leu Trp Arg Lys225 230 235 240Thr Arg Ser Arg Asn Pro Gly Ser Ser Cys Ile Gly Ala Asp Pro Asn 245 250 255Arg Asn Trp Asn Ala Ser Phe Ala Gly Lys Gly Ala Ser Asp Asn Pro 260 265 270Cys Ser Glu Val Tyr His Gly Pro His Ala Asn Ser Glu Val Glu Val 275 280 285Lys Ser Val Val Asp Phe Ile Gln Lys His Gly Asn Phe Lys Gly Phe 290 295 300Ile Asp Leu His Ser Tyr Ser Gln Leu Leu Met Tyr Pro Tyr Gly Tyr305 310 315 320Ser Val Lys Lys Ala Pro Asp Ala Glu Glu Leu Asp Lys Val Ala

Arg 325 330 335Leu Ala Ala Lys Ala Leu Ala Ser Val Ser Gly Thr Glu Tyr Gln Val 340 345 350Gly Pro Thr Cys Thr Thr Val Tyr Pro Ala Ser Gly Ser Ser Ile Asp 355 360 365Trp Ala Tyr Asp Asn Gly Ile Lys Phe Ala Phe Thr Phe Glu Leu Arg 370 375 380Asp Thr Gly Thr Tyr Gly Phe Leu Leu Pro Ala Asn Gln Ile Ile Pro385 390 395 400Thr Ala Glu Glu Thr Trp Leu Gly Leu Lys Thr Ile Met Glu His Val 405 410 415Arg Asp Asn Leu 42011023PRTHomo sapiens 110Gly Ser Gln Thr Gln Ser His Pro Asp Leu Gly Thr Glu Gly Cys Trp1 5 10 15Asp Gln Leu Ser Ala Pro Arg 201118PRTHomo sapiens 111Thr Phe Thr Leu Leu Asp Pro Lys1 5112576PRTHomo sapiens 112Met Ala Gln Gly Val Leu Trp Ile Leu Leu Gly Leu Leu Leu Trp Ser1 5 10 15Asp Pro Gly Thr Ala Ser Leu Pro Leu Leu Met Asp Ser Val Ile Gln 20 25 30Ala Leu Ala Glu Leu Glu Gln Lys Val Pro Ala Ala Lys Thr Arg His 35 40 45Thr Ala Ser Ala Trp Leu Met Ser Ala Pro Asn Ser Gly Pro His Asn 50 55 60Arg Leu Tyr His Phe Leu Leu Gly Ala Trp Ser Leu Asn Ala Thr Glu65 70 75 80Leu Asp Pro Cys Pro Leu Ser Pro Glu Leu Leu Gly Leu Thr Lys Glu 85 90 95Val Ala Arg His Asp Val Arg Glu Gly Lys Glu Tyr Gly Val Val Leu 100 105 110Ala Pro Asp Gly Ser Thr Val Ala Val Glu Pro Leu Leu Ala Gly Leu 115 120 125Glu Ala Gly Leu Gln Gly Arg Arg Val Ile Asn Leu Pro Leu Asp Ser 130 135 140Met Ala Ala Pro Trp Glu Thr Gly Asp Thr Phe Pro Asp Val Val Ala145 150 155 160Ile Ala Pro Asp Val Arg Ala Thr Ser Ser Pro Gly Leu Arg Asp Gly 165 170 175Ser Pro Asp Val Thr Thr Ala Asp Ile Gly Ala Asn Thr Pro Asp Ala 180 185 190Thr Lys Gly Cys Pro Asp Val Gln Ala Ser Leu Pro Asp Ala Lys Ala 195 200 205Lys Ser Pro Pro Thr Met Val Asp Ser Leu Leu Ala Val Thr Leu Ala 210 215 220Gly Asn Leu Gly Leu Thr Phe Leu Arg Gly Ser Gln Thr Gln Ser His225 230 235 240Pro Asp Leu Gly Thr Glu Gly Cys Trp Asp Gln Leu Ser Ala Pro Arg 245 250 255Thr Phe Thr Leu Leu Asp Pro Lys Ala Ser Leu Leu Thr Met Ala Phe 260 265 270Leu Asn Gly Ala Leu Asp Gly Val Ile Leu Gly Asp Tyr Leu Ser Arg 275 280 285Thr Pro Glu Pro Arg Pro Ser Leu Ser His Leu Leu Ser Gln Tyr Tyr 290 295 300Gly Ala Gly Val Ala Arg Asp Pro Gly Phe Arg Ser Asn Phe Arg Arg305 310 315 320Gln Asn Gly Ala Ala Leu Thr Ser Ala Ser Ile Leu Ala Gln Gln Val 325 330 335Trp Gly Thr Leu Val Leu Leu Gln Arg Leu Glu Pro Val His Leu Gln 340 345 350Leu Gln Cys Met Ser Gln Glu Gln Leu Ala Gln Val Ala Ala Asn Ala 355 360 365Thr Lys Glu Phe Thr Glu Ala Phe Leu Gly Cys Pro Ala Ile His Pro 370 375 380Arg Cys Arg Trp Gly Ala Ala Pro Tyr Arg Gly Arg Pro Lys Leu Leu385 390 395 400Gln Leu Pro Leu Gly Phe Leu Tyr Val His His Thr Tyr Val Pro Ala 405 410 415Pro Pro Cys Thr Asp Phe Thr Arg Cys Ala Ala Asn Met Arg Ser Met 420 425 430Gln Arg Tyr His Gln Asp Thr Gln Gly Trp Gly Asp Ile Gly Tyr Ser 435 440 445Phe Val Val Gly Ser Asp Gly Tyr Val Tyr Glu Gly Arg Gly Trp His 450 455 460Trp Val Gly Ala His Thr Leu Gly His Asn Ser Arg Gly Phe Gly Val465 470 475 480Ala Ile Val Gly Asn Tyr Thr Ala Ala Leu Pro Thr Glu Ala Ala Leu 485 490 495Arg Thr Val Arg Asp Thr Leu Pro Ser Cys Ala Val Arg Ala Gly Leu 500 505 510Leu Arg Pro Asp Tyr Ala Leu Leu Gly His Arg Gln Leu Val Arg Thr 515 520 525Asp Cys Pro Gly Asp Ala Leu Phe Asp Leu Leu Arg Thr Trp Pro His 530 535 540Phe Thr Ala Thr Val Lys Pro Arg Pro Ala Arg Ser Val Ser Lys Arg545 550 555 560Ser Arg Arg Glu Pro Pro Pro Arg Thr Leu Pro Ala Thr Asp Leu Gln 565 570 57511317PRTHomo sapiens 113Ala Arg Glu Gly Ser Glu Glu Asp Leu Asp Ala Leu Glu His Met Phe1 5 10 15Arg11413PRTHomo sapiens 114Asp Pro Thr Ala Glu Gln Phe Gln Glu Glu Leu Glu Lys1 5 101158PRTHomo sapiens 115Phe Gln Gln Ala Ile Asp Ser Arg1 511611PRTHomo sapiens 116Lys Thr Asn Pro Glu Ile Gln Ser Thr Leu Arg1 5 1011711PRTHomo sapiens 117Met Ala Glu Ala Glu Leu Val Gln Glu Gly Lys1 5 1011814PRTHomo sapiens 118Arg Asp Pro Thr Ala Glu Gln Phe Gln Glu Glu Leu Glu Lys1 5 1011912PRTHomo sapiens 119Arg Met Ala Glu Ala Glu Leu Val Gln Glu Gly Lys1 5 1012013PRTHomo sapiens 120Ser Leu Glu Glu Glu Lys Tyr Asp Met Ser Gly Ala Arg1 5 1012110PRTHomo sapiens 121Thr Asn Pro Glu Ile Gln Ser Thr Leu Arg1 5 101228PRTHomo sapiens 122Val Tyr Ile Ile Gln Ala Cys Arg1 5123242PRTHomo sapiens 123Met Ser Asn Pro Arg Ser Leu Glu Glu Glu Lys Tyr Asp Met Ser Gly1 5 10 15Ala Arg Leu Ala Leu Ile Leu Cys Val Thr Lys Ala Arg Glu Gly Ser 20 25 30Glu Glu Asp Leu Asp Ala Leu Glu His Met Phe Arg Gln Leu Arg Phe 35 40 45Glu Ser Thr Met Lys Arg Asp Pro Thr Ala Glu Gln Phe Gln Glu Glu 50 55 60Leu Glu Lys Phe Gln Gln Ala Ile Asp Ser Arg Glu Asp Pro Val Ser65 70 75 80Cys Ala Phe Val Val Leu Met Ala His Gly Arg Glu Gly Phe Leu Lys 85 90 95Gly Glu Asp Gly Glu Met Val Lys Leu Glu Asn Leu Phe Glu Ala Leu 100 105 110Asn Asn Lys Asn Cys Gln Ala Leu Arg Ala Lys Pro Lys Val Tyr Ile 115 120 125Ile Gln Ala Cys Arg Gly Glu Gln Arg Asp Pro Gly Glu Thr Val Gly 130 135 140Gly Asp Glu Ile Val Met Val Ile Lys Asp Ser Pro Gln Thr Ile Pro145 150 155 160Thr Tyr Thr Asp Ala Leu His Val Tyr Ser Thr Val Glu Gly Tyr Ile 165 170 175Ala Tyr Arg His Asp Gln Lys Gly Ser Cys Phe Ile Gln Thr Leu Val 180 185 190Asp Val Phe Thr Lys Arg Lys Gly His Ile Leu Glu Leu Leu Thr Glu 195 200 205Val Thr Arg Arg Met Ala Glu Ala Glu Leu Val Gln Glu Gly Lys Ala 210 215 220Arg Lys Thr Asn Pro Glu Ile Gln Ser Thr Leu Arg Lys Arg Leu Tyr225 230 235 240Leu Gln1249PRTHomo sapiens 124Leu Leu Ile Tyr Gly Ala Ser Thr Arg1 5125129PRTHomo sapiens 125Met Glu Ala Pro Ala Gln Leu Leu Phe Leu Leu Leu Leu Trp Leu Pro1 5 10 15Asp Thr Thr Gly Glu Ile Val Met Thr Gln Ser Pro Ala Thr Leu Ser 20 25 30Val Ser Pro Gly Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser 35 40 45Val Ser Asn Asn Leu Ala Trp Tyr Gln Gln Lys Pro Gly Gln Pro Pro 50 55 60Arg Leu Leu Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala65 70 75 80Arg Phe Ser Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser 85 90 95Arg Leu Gln Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn 100 105 110Asn Trp Pro Pro Trp Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys 115 120 125Arg12618PRTHomo sapiens 126Glu Ile Val Met Thr Gln Ser Pro Val Thr Leu Ser Val Ser Pro Gly1 5 10 15Glu Arg127109PRTHomo sapiens 127Glu Ile Val Met Thr Gln Ser Pro Val Thr Leu Ser Val Ser Pro Gly1 5 10 15Glu Arg Ala Thr Leu Ser Cys Arg Ala Ser Gln Ser Ile Ser Asn Ser 20 25 30Tyr Leu Ala Trp Tyr Gln Gln Lys Pro Ser Gly Ser Pro Arg Leu Leu 35 40 45Ile Tyr Gly Ala Ser Thr Arg Ala Thr Gly Ile Pro Ala Arg Phe Ser 50 55 60Gly Ser Gly Ser Gly Thr Glu Phe Thr Leu Thr Ile Ser Ser Leu Gln65 70 75 80Ser Glu Asp Phe Ala Val Tyr Tyr Cys Gln Gln Tyr Asn Asn Trp Pro 85 90 95Pro Thr Phe Gly Gln Gly Thr Arg Val Glu Ile Lys Arg 100 1051287PRTHomo sapiens 128Ala Ala Cys Leu Leu Pro Lys1 512912PRTHomo sapiens 129Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys1 5 1013019PRTHomo sapiens 130Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu1 5 10 15Leu Pro Lys13113PRTHomo sapiens 131Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys1 5 1013214PRTHomo sapiens 132Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys1 5 101338PRTHomo sapiens 133Ala Glu Phe Ala Glu Val Ser Lys1 513415PRTHomo sapiens 134Ala Glu Phe Ala Glu Val Ser Lys Leu Val Thr Asp Leu Thr Lys1 5 10 151357PRTHomo sapiens 135Ala Thr Lys Glu Gln Ile Lys1 513619PRTHomo sapiens 136Ala Thr Lys Glu Gln Ile Lys Ala Val Met Asp Asp Phe Ala Ala Phe1 5 10 15Val Glu Lys13712PRTHomo sapiens 137Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys1 5 1013810PRTHomo sapiens 138Cys Ala Ser Ile Gln Lys Phe Gly Glu Arg1 5 1013913PRTHomo sapiens 139Cys Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys1 5 1014016PRTHomo sapiens 140Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe Ala Glu Glu Gly Lys1 5 10 151418PRTHomo sapiens 141Cys Cys Lys His Pro Glu Ala Lys1 51429PRTHomo sapiens 142Cys Cys Thr Glu Ser Leu Val Asn Arg1 514325PRTHomo sapiens 143Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe Ser Ala Leu1 5 10 15Glu Val Asp Glu Thr Tyr Val Pro Lys 20 251448PRTHomo sapiens 144Asp Asp Asn Pro Asn Leu Pro Arg1 514510PRTHomo sapiens 145Asp Ala His Lys Ser Glu Val Ala His Arg1 5 101468PRTHomo sapiens 146Asp Leu Gly Glu Glu Asn Phe Lys1 514710PRTHomo sapiens 147Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys1 5 1014813PRTHomo sapiens 148Asp Val Phe Leu Gly Met Phe Leu Tyr Glu Tyr Ala Arg1 5 1014910PRTHomo sapiens 149Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys1 5 1015019PRTHomo sapiens 150Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu1 5 10 15Ser Glu Lys15121PRTHomo sapiens 151Glu Phe Asn Ala Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu1 5 10 15Ser Glu Lys Glu Arg 2015216PRTHomo sapiens 152Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala Ala Phe Val Glu Lys1 5 10 151539PRTHomo sapiens 153Glu Thr Cys Phe Ala Glu Glu Gly Lys1 515410PRTHomo sapiens 154Glu Thr Cys Phe Ala Glu Glu Gly Lys Lys1 5 1015512PRTHomo sapiens 155Glu Thr Tyr Gly Glu Met Ala Asp Cys Cys Ala Lys1 5 1015610PRTHomo sapiens 156Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys1 5 1015711PRTHomo sapiens 157Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys1 5 101588PRTHomo sapiens 158Phe Gln Asn Ala Leu Leu Val Arg1 515911PRTHomo sapiens 159His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg1 5 1016014PRTHomo sapiens 160His Pro Tyr Phe Tyr Ala Pro Glu Leu Leu Phe Phe Ala Lys1 5 1016111PRTHomo sapiens 161Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys1 5 101628PRTHomo sapiens 162Leu Cys Thr Val Ala Thr Leu Arg1 516320PRTHomo sapiens 163Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala Asp1 5 10 15Cys Cys Ala Lys 201649PRTHomo sapiens 164Leu Asp Glu Leu Arg Asp Glu Gly Lys1 516514PRTHomo sapiens 165Leu Asp Glu Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys1 5 101668PRTHomo sapiens 166Leu Lys Cys Ala Ser Leu Gln Lys1 516712PRTHomo sapiens 167Leu Lys Glu Cys Cys Glu Lys Pro Leu Leu Glu Lys1 5 101687PRTHomo sapiens 168Leu Ser Gln Arg Phe Pro Lys1 516916PRTHomo sapiens 169Leu Phe Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser Lys1 5 10 1517011PRTHomo sapiens 170Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu1 5 1017110PRTHomo sapiens 171Leu Val Asn Glu Val Thr Glu Phe Ala Lys1 5 1017223PRTHomo sapiens 172Ile Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp Glu1 5 10 15Ser Ala Glu Asn Cys Asp Lys 2017322PRTHomo sapiens 173Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn1 5 10 15Glu Glu Thr Phe Leu Lys 2017423PRTHomo sapiens 174Leu Val Arg Pro Glu Val Asp Val Met Cys Thr Ala Phe His Asp Asn1 5 10 15Glu Glu Thr Phe Leu Lys Lys 201757PRTHomo sapiens 175Leu Val Thr Asp Leu Thr Lys1 517612PRTHomo sapiens 176Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly Leu1 5 1017710PRTHomo sapiens 177Lys Gln Thr Ala Leu Val Glu Leu Val Lys1 5 1017816PRTHomo sapiens 178Lys Val Pro Gln Val Ser Thr Pro Thr Leu Leu Val Glu Val Ser Arg1 5 10 151798PRTHomo sapiens 179Lys Tyr Leu Tyr Glu Ile Ala Arg1 518025PRTHomo sapiens 180Met Pro Cys Ala Glu Asp Tyr Ile Leu Ser Val Val Ile Leu Asn Gln1 5 10 15Ile Leu Cys Val Ile Leu His Glu Lys 20 251818PRTHomo sapiens 181Asn Glu Cys Phe Ile Gln His Lys1 518216PRTHomo sapiens 182Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn Pro Asn Leu Pro Arg1 5 10 151838PRTHomo sapiens 183Asn Ile Gly Lys Val Gly Ser Lys1 51846PRTHomo sapiens 184Asn Tyr Ala Glu Ala Lys1 518519PRTHomo sapiens 185Asn Tyr Ala Glu Ala Lys Asp Val Phe Ile Gly Met Phe Ile Tyr Glu1 5 10 15Tyr Ala Arg18611PRTHomo sapiens 186Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys1 5 1018713PRTHomo sapiens 187Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys1 5 1018821PRTHomo sapiens 188Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln His Lys Asp Asp Asn1 5 10 15Pro Asn Leu Pro Arg 2018913PRTHomo sapiens 189Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys1 5 1019021PRTHomo sapiens 190Gln Asn Cys Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn1 5 10 15Ala Ile Ile Val Arg 201919PRTHomo sapiens 191Gln Thr Ala Ile Val Glu Ile Val Lys1 519212PRTHomo sapiens 192Arg His Pro Asp Tyr Ser Val Val Leu Leu Leu Arg1 5 1019323PRTHomo sapiens 193Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val Leu Lys Asn Gln1 5 10 15Leu Cys Val Leu His Glu Lys 2019416PRTHomo sapiens 194Arg Pro Cys Phe Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys1 5 10 1519537PRTHomo sapiens 195Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu1 5 10 15Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys Asn 20 25 30Tyr Ala Glu Ala Lys 3519627PRTHomo sapiens 196Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu1

5 10 15Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys 20 2519731PRTHomo sapiens 197Ser His Cys Ile Ala Glu Val Glu Asn Asp Glu Met Pro Ala Asp Leu1 5 10 15Pro Ser Leu Ala Ala Asp Phe Val Glu Ser Lys Asp Val Cys Lys 20 25 301989PRTHomo sapiens 198Ser Leu His Thr Leu Phe Gly Asp Lys1 519917PRTHomo sapiens 199Ser Leu His Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu1 5 10 15Arg20013PRTHomo sapiens 200Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys1 5 1020122PRTHomo sapiens 201Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His1 5 10 15Thr Leu Phe Gly Asp Lys 2020230PRTHomo sapiens 202Thr Cys Val Ala Asp Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His1 5 10 15Thr Leu Phe Gly Asp Lys Leu Cys Thr Val Ala Thr Leu Arg 20 25 302039PRTHomo sapiens 203Thr Pro Val Ser Asp Arg Val Thr Lys1 52048PRTHomo sapiens 204Thr Tyr Glu Thr Thr Leu Glu Lys1 520521PRTHomo sapiens 205Thr Tyr Glu Thr Thr Ile Glu Lys Cys Cys Ala Ala Ala Asp Pro His1 5 10 15Glu Cys Tyr Ala Lys 2020617PRTHomo sapiens 206Val Phe Asp Glu Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile1 5 10 15Lys20717PRTHomo sapiens 207Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp1 5 10 15Arg20822PRTHomo sapiens 208Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp1 5 10 15Arg Ala Asp Leu Ala Lys 2020934PRTHomo sapiens 209Val His Thr Glu Cys Cys His Gly Asp Leu Leu Glu Cys Ala Asp Asp1 5 10 15Arg Ala Asp Leu Ala Lys Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser 20 25 30Ser Lys21014PRTHomo sapiens 210Val Pro Gln Val Ser Thr Pro Thr Leu Val Glu Val Ser Arg1 5 1021112PRTHomo sapiens 211Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys1 5 1021214PRTHomo sapiens 212Tyr Ile Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys1 5 102137PRTHomo sapiens 213Tyr Leu Tyr Glu Ile Ala Arg1 52148PRTHomo sapiens 214Tyr Leu Tyr Glu Ile Ala Arg Arg1 521514PRTHomo sapiens 215Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys1 5 1021621PRTHomo sapiens 216Tyr Lys Ala Ala Phe Thr Glu Cys Cys Gln Ala Ala Asp Lys Ala Ala1 5 10 15Cys Leu Leu Pro Lys 20217609PRTHomo sapiens 217Met Lys Trp Val Thr Phe Ile Ser Leu Leu Phe Leu Phe Ser Ser Ala1 5 10 15Tyr Ser Arg Gly Val Phe Arg Arg Asp Ala His Lys Ser Glu Val Ala 20 25 30His Arg Phe Lys Asp Leu Gly Glu Glu Asn Phe Lys Ala Leu Val Leu 35 40 45Ile Ala Phe Ala Gln Tyr Leu Gln Gln Cys Pro Phe Glu Asp His Val 50 55 60Lys Leu Val Asn Glu Val Thr Glu Phe Ala Lys Thr Cys Val Ala Asp65 70 75 80Glu Ser Ala Glu Asn Cys Asp Lys Ser Leu His Thr Leu Phe Gly Asp 85 90 95Lys Leu Cys Thr Val Ala Thr Leu Arg Glu Thr Tyr Gly Glu Met Ala 100 105 110Asp Cys Cys Ala Lys Gln Glu Pro Glu Arg Asn Glu Cys Phe Leu Gln 115 120 125His Lys Asp Asp Asn Pro Asn Leu Pro Arg Leu Val Arg Pro Glu Val 130 135 140Asp Val Met Cys Thr Ala Phe His Asp Asn Glu Glu Thr Phe Leu Lys145 150 155 160Lys Tyr Leu Tyr Glu Ile Ala Arg Arg His Pro Tyr Phe Tyr Ala Pro 165 170 175Glu Leu Leu Phe Phe Ala Lys Arg Tyr Lys Ala Ala Phe Thr Glu Cys 180 185 190Cys Gln Ala Ala Asp Lys Ala Ala Cys Leu Leu Pro Lys Leu Asp Glu 195 200 205Leu Arg Asp Glu Gly Lys Ala Ser Ser Ala Lys Gln Arg Leu Lys Cys 210 215 220Ala Ser Leu Gln Lys Phe Gly Glu Arg Ala Phe Lys Ala Trp Ala Val225 230 235 240Ala Arg Leu Ser Gln Arg Phe Pro Lys Ala Glu Phe Ala Glu Val Ser 245 250 255Lys Leu Val Thr Asp Leu Thr Lys Val His Thr Glu Cys Cys His Gly 260 265 270Asp Leu Leu Glu Cys Ala Asp Asp Arg Ala Asp Leu Ala Lys Tyr Ile 275 280 285Cys Glu Asn Gln Asp Ser Ile Ser Ser Lys Leu Lys Glu Cys Cys Glu 290 295 300Lys Pro Leu Leu Glu Lys Ser His Cys Ile Ala Glu Val Glu Asn Asp305 310 315 320Glu Met Pro Ala Asp Leu Pro Ser Leu Ala Ala Asp Phe Val Glu Ser 325 330 335Lys Asp Val Cys Lys Asn Tyr Ala Glu Ala Lys Asp Val Phe Leu Gly 340 345 350Met Phe Leu Tyr Glu Tyr Ala Arg Arg His Pro Asp Tyr Ser Val Val 355 360 365Leu Leu Leu Arg Leu Ala Lys Thr Tyr Glu Thr Thr Leu Glu Lys Cys 370 375 380Cys Ala Ala Ala Asp Pro His Glu Cys Tyr Ala Lys Val Phe Asp Glu385 390 395 400Phe Lys Pro Leu Val Glu Glu Pro Gln Asn Leu Ile Lys Gln Asn Cys 405 410 415Glu Leu Phe Glu Gln Leu Gly Glu Tyr Lys Phe Gln Asn Ala Leu Leu 420 425 430Val Arg Tyr Thr Lys Lys Val Pro Gln Val Ser Thr Pro Thr Leu Val 435 440 445Glu Val Ser Arg Asn Leu Gly Lys Val Gly Ser Lys Cys Cys Lys His 450 455 460Pro Glu Ala Lys Arg Met Pro Cys Ala Glu Asp Tyr Leu Ser Val Val465 470 475 480Leu Asn Gln Leu Cys Val Leu His Glu Lys Thr Pro Val Ser Asp Arg 485 490 495Val Thr Lys Cys Cys Thr Glu Ser Leu Val Asn Arg Arg Pro Cys Phe 500 505 510Ser Ala Leu Glu Val Asp Glu Thr Tyr Val Pro Lys Glu Phe Asn Ala 515 520 525Glu Thr Phe Thr Phe His Ala Asp Ile Cys Thr Leu Ser Glu Lys Glu 530 535 540Arg Gln Ile Lys Lys Gln Thr Ala Leu Val Glu Leu Val Lys His Lys545 550 555 560Pro Lys Ala Thr Lys Glu Gln Leu Lys Ala Val Met Asp Asp Phe Ala 565 570 575Ala Phe Val Glu Lys Cys Cys Lys Ala Asp Asp Lys Glu Thr Cys Phe 580 585 590Ala Glu Glu Gly Lys Lys Leu Val Ala Ala Ser Gln Ala Ala Leu Gly 595 600 605Leu21814PRTHomo sapiens 218Ala Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr Tyr Tyr Lys1 5 102199PRTHomo sapiens 219Cys Leu His Pro Cys Val Ile Ser Arg1 522011PRTHomo sapiens 220Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys1 5 1022118PRTHomo sapiens 221Asp Thr Ser Cys Val Asn Pro Pro Thr Val Gln Asn Ala Tyr Ile Val1 5 10 15Ser Arg2229PRTHomo sapiens 222Glu Phe Asp His Asn Ser Asn Ile Arg1 522311PRTHomo sapiens 223Glu Ile Met Glu Asn Tyr Asn Ile Ala Leu Arg1 5 1022411PRTHomo sapiens 224Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg1 5 1022519PRTHomo sapiens 225Gly Asp Ala Val Cys Thr Glu Ser Gly Trp Arg Pro Leu Pro Ser Cys1 5 10 15Glu Glu Lys2269PRTHomo sapiens 226Ile Asp Val His Leu Val Pro Asp Arg1 522710PRTHomo sapiens 227Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg1 5 1022819PRTHomo sapiens 228Ile Val Ser Ser Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln1 5 10 15Ala Val Arg22923PRTHomo sapiens 229Asn Thr Glu Ile Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu1 5 10 15Gly Thr Gln Ala Ile Tyr Lys 2023010PRTHomo sapiens 230Arg Pro Tyr Phe Pro Val Ala Val Gly Lys1 5 1023111PRTHomo sapiens 231Ser Cys Asp Ile Pro Val Phe Met Asn Ala Arg1 5 1023214PRTHomo sapiens 232Ser Ile Asp Val Ala Cys His Pro Gly Tyr Ala Leu Pro Lys1 5 1023310PRTHomo sapiens 233Ser Leu Gly Asn Val Ile Met Val Cys Arg1 5 1023412PRTHomo sapiens 234Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys1 5 1023511PRTHomo sapiens 235Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys1 5 1023610PRTHomo sapiens 236Thr Gly Asp Glu Ile Thr Tyr Gln Cys Arg1 5 1023710PRTHomo sapiens 237Thr Gly Glu Ser Val Glu Phe Val Cys Lys1 5 102389PRTHomo sapiens 238Thr Lys Asn Asp Phe Thr Trp Phe Lys1 523915PRTHomo sapiens 239Thr Thr Cys Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys1 5 10 1524023PRTHomo sapiens 240Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly Glu Glu1 5 10 15Leu Thr Cys Lys Asp Gly Arg 2024110PRTHomo sapiens 241Trp Gln Ser Ile Pro Leu Cys Val Glu Lys1 5 1024213PRTHomo sapiens 242Trp Ser Ser Pro Pro Gln Cys Glu Gly Leu Pro Cys Lys1 5 102431231PRTHomo sapiens 243Met Arg Leu Leu Ala Lys Ile Ile Cys Leu Met Leu Trp Ala Ile Cys1 5 10 15Val Ala Glu Asp Cys Asn Glu Leu Pro Pro Arg Arg Asn Thr Glu Ile 20 25 30Leu Thr Gly Ser Trp Ser Asp Gln Thr Tyr Pro Glu Gly Thr Gln Ala 35 40 45Ile Tyr Lys Cys Arg Pro Gly Tyr Arg Ser Leu Gly Asn Val Ile Met 50 55 60Val Cys Arg Lys Gly Glu Trp Val Ala Leu Asn Pro Leu Arg Lys Cys65 70 75 80Gln Lys Arg Pro Cys Gly His Pro Gly Asp Thr Pro Phe Gly Thr Phe 85 90 95Thr Leu Thr Gly Gly Asn Val Phe Glu Tyr Gly Val Lys Ala Val Tyr 100 105 110Thr Cys Asn Glu Gly Tyr Gln Leu Leu Gly Glu Ile Asn Tyr Arg Glu 115 120 125Cys Asp Thr Asp Gly Trp Thr Asn Asp Ile Pro Ile Cys Glu Val Val 130 135 140Lys Cys Leu Pro Val Thr Ala Pro Glu Asn Gly Lys Ile Val Ser Ser145 150 155 160Ala Met Glu Pro Asp Arg Glu Tyr His Phe Gly Gln Ala Val Arg Phe 165 170 175Val Cys Asn Ser Gly Tyr Lys Ile Glu Gly Asp Glu Glu Met His Cys 180 185 190Ser Asp Asp Gly Phe Trp Ser Lys Glu Lys Pro Lys Cys Val Glu Ile 195 200 205Ser Cys Lys Ser Pro Asp Val Ile Asn Gly Ser Pro Ile Ser Gln Lys 210 215 220Ile Ile Tyr Lys Glu Asn Glu Arg Phe Gln Tyr Lys Cys Asn Met Gly225 230 235 240Tyr Glu Tyr Ser Glu Arg Gly Asp Ala Val Cys Thr Glu Ser Gly Trp 245 250 255Arg Pro Leu Pro Ser Cys Glu Glu Lys Ser Cys Asp Asn Pro Tyr Ile 260 265 270Pro Asn Gly Asp Tyr Ser Pro Leu Arg Ile Lys His Arg Thr Gly Asp 275 280 285Glu Ile Thr Tyr Gln Cys Arg Asn Gly Phe Tyr Pro Ala Thr Arg Gly 290 295 300Asn Thr Ala Lys Cys Thr Ser Thr Gly Trp Ile Pro Ala Pro Arg Cys305 310 315 320Thr Leu Lys Pro Cys Asp Tyr Pro Asp Ile Lys His Gly Gly Leu Tyr 325 330 335His Glu Asn Met Arg Arg Pro Tyr Phe Pro Val Ala Val Gly Lys Tyr 340 345 350Tyr Ser Tyr Tyr Cys Asp Glu His Phe Glu Thr Pro Ser Gly Ser Tyr 355 360 365Trp Asp His Ile His Cys Thr Gln Asp Gly Trp Ser Pro Ala Val Pro 370 375 380Cys Leu Arg Lys Cys Tyr Phe Pro Tyr Leu Glu Asn Gly Tyr Asn Gln385 390 395 400Asn Tyr Gly Arg Lys Phe Val Gln Gly Lys Ser Ile Asp Val Ala Cys 405 410 415His Pro Gly Tyr Ala Leu Pro Lys Ala Gln Thr Thr Val Thr Cys Met 420 425 430Glu Asn Gly Trp Ser Pro Thr Pro Arg Cys Ile Arg Val Lys Thr Cys 435 440 445Ser Lys Ser Ser Ile Asp Ile Glu Asn Gly Phe Ile Ser Glu Ser Gln 450 455 460Tyr Thr Tyr Ala Leu Lys Glu Lys Ala Lys Tyr Gln Cys Lys Leu Gly465 470 475 480Tyr Val Thr Ala Asp Gly Glu Thr Ser Gly Ser Ile Thr Cys Gly Lys 485 490 495Asp Gly Trp Ser Ala Gln Pro Thr Cys Ile Lys Ser Cys Asp Ile Pro 500 505 510Val Phe Met Asn Ala Arg Thr Lys Asn Asp Phe Thr Trp Phe Lys Leu 515 520 525Asn Asp Thr Leu Asp Tyr Glu Cys His Asp Gly Tyr Glu Ser Asn Thr 530 535 540Gly Ser Thr Thr Gly Ser Ile Val Cys Gly Tyr Asn Gly Trp Ser Asp545 550 555 560Leu Pro Ile Cys Tyr Glu Arg Glu Cys Glu Leu Pro Lys Ile Asp Val 565 570 575His Leu Val Pro Asp Arg Lys Lys Asp Gln Tyr Lys Val Gly Glu Val 580 585 590Leu Lys Phe Ser Cys Lys Pro Gly Phe Thr Ile Val Gly Pro Asn Ser 595 600 605Val Gln Cys Tyr His Phe Gly Leu Ser Pro Asp Leu Pro Ile Cys Lys 610 615 620Glu Gln Val Gln Ser Cys Gly Pro Pro Pro Glu Leu Leu Asn Gly Asn625 630 635 640Val Lys Glu Lys Thr Lys Glu Glu Tyr Gly His Ser Glu Val Val Glu 645 650 655Tyr Tyr Cys Asn Pro Arg Phe Leu Met Lys Gly Pro Asn Lys Ile Gln 660 665 670Cys Val Asp Gly Glu Trp Thr Thr Leu Pro Val Cys Ile Val Glu Glu 675 680 685Ser Thr Cys Gly Asp Ile Pro Glu Leu Glu His Gly Trp Ala Gln Leu 690 695 700Ser Ser Pro Pro Tyr Tyr Tyr Gly Asp Ser Val Glu Phe Asn Cys Ser705 710 715 720Glu Ser Phe Thr Met Ile Gly His Arg Ser Ile Thr Cys Ile His Gly 725 730 735Val Trp Thr Gln Leu Pro Gln Cys Val Ala Ile Asp Lys Leu Lys Lys 740 745 750Cys Lys Ser Ser Asn Leu Ile Ile Leu Glu Glu His Leu Lys Asn Lys 755 760 765Lys Glu Phe Asp His Asn Ser Asn Ile Arg Tyr Arg Cys Arg Gly Lys 770 775 780Glu Gly Trp Ile His Thr Val Cys Ile Asn Gly Arg Trp Asp Pro Glu785 790 795 800Val Asn Cys Ser Met Ala Gln Ile Gln Leu Cys Pro Pro Pro Pro Gln 805 810 815Ile Pro Asn Ser His Asn Met Thr Thr Thr Leu Asn Tyr Arg Asp Gly 820 825 830Glu Lys Val Ser Val Leu Cys Gln Glu Asn Tyr Leu Ile Gln Glu Gly 835 840 845Glu Glu Ile Thr Cys Lys Asp Gly Arg Trp Gln Ser Ile Pro Leu Cys 850 855 860Val Glu Lys Ile Pro Cys Ser Gln Pro Pro Gln Ile Glu His Gly Thr865 870 875 880Ile Asn Ser Ser Arg Ser Ser Gln Glu Ser Tyr Ala His Gly Thr Lys 885 890 895Leu Ser Tyr Thr Cys Glu Gly Gly Phe Arg Ile Ser Glu Glu Asn Glu 900 905 910Thr Thr Cys Tyr Met Gly Lys Trp Ser Ser Pro Pro Gln Cys Glu Gly 915 920 925Leu Pro Cys Lys Ser Pro Pro Glu Ile Ser His Gly Val Val Ala His 930 935 940Met Ser Asp Ser Tyr Gln Tyr Gly Glu Glu Val Thr Tyr Lys Cys Phe945 950 955 960Glu Gly Phe Gly Ile Asp Gly Pro Ala Ile Ala Lys Cys Leu Gly Glu 965 970 975Lys Trp Ser His Pro Pro Ser Cys Ile Lys Thr Asp Cys Leu Ser Leu 980 985 990Pro Ser Phe Glu Asn Ala Ile Pro Met Gly Glu Lys Lys Asp Val Tyr 995 1000 1005Lys Ala Gly Glu Gln Val Thr Tyr Thr Cys Ala Thr Tyr Tyr Lys 1010 1015 1020Met Asp Gly Ala Ser Asn Val Thr Cys Ile Asn Ser Arg Trp Thr 1025 1030 1035Gly Arg Pro Thr Cys Arg Asp Thr Ser Cys Val Asn Pro Pro Thr 1040 1045 1050Val Gln Asn Ala Tyr Ile Val Ser Arg Gln Met Ser Lys Tyr Pro 1055

1060 1065Ser Gly Glu Arg Val Arg Tyr Gln Cys Arg Ser Pro Tyr Glu Met 1070 1075 1080Phe Gly Asp Glu Glu Val Met Cys Leu Asn Gly Asn Trp Thr Glu 1085 1090 1095Pro Pro Gln Cys Lys Asp Ser Thr Gly Lys Cys Gly Pro Pro Pro 1100 1105 1110Pro Ile Asp Asn Gly Asp Ile Thr Ser Phe Pro Leu Ser Val Tyr 1115 1120 1125Ala Pro Ala Ser Ser Val Glu Tyr Gln Cys Gln Asn Leu Tyr Gln 1130 1135 1140Leu Glu Gly Asn Lys Arg Ile Thr Cys Arg Asn Gly Gln Trp Ser 1145 1150 1155Glu Pro Pro Lys Cys Leu His Pro Cys Val Ile Ser Arg Glu Ile 1160 1165 1170Met Glu Asn Tyr Asn Ile Ala Leu Arg Trp Thr Ala Lys Gln Lys 1175 1180 1185Leu Tyr Ser Arg Thr Gly Glu Ser Val Glu Phe Val Cys Lys Arg 1190 1195 1200Gly Tyr Arg Leu Ser Ser Arg Ser His Thr Leu Arg Thr Thr Cys 1205 1210 1215Trp Asp Gly Lys Leu Glu Tyr Pro Thr Cys Ala Lys Arg 1220 1225 123024418PRTHomo sapiens 244Glu Ala Gln Gly Glu Val Pro Ala Ser Asp Ser Lys Thr Glu Cys Thr1 5 10 15Ala Leu24511PRTHomo sapiens 245Val Ile Ser Gln Ile Ala Met Asn Asp Glu Lys1 5 10246690PRTHomo sapiens 246Met Ala Pro Trp Pro Glu Leu Gly Asp Ala Gln Pro Asn Pro Asp Lys1 5 10 15Tyr Leu Glu Gly Ala Ala Gly Gln Gln Pro Thr Ala Pro Asp Lys Ser 20 25 30Lys Glu Thr Asn Lys Thr Asp Asn Thr Glu Ala Pro Val Thr Lys Ile 35 40 45Glu Leu Leu Pro Ser Tyr Ser Thr Ala Thr Leu Ile Asp Glu Pro Thr 50 55 60Glu Val Asp Asp Pro Trp Asn Leu Pro Thr Leu Gln Asp Ser Gly Ile65 70 75 80Lys Trp Ser Glu Arg Asp Thr Lys Gly Lys Ile Leu Cys Phe Phe Gln 85 90 95Gly Ile Gly Arg Leu Ile Leu Leu Leu Gly Phe Leu Tyr Phe Phe Val 100 105 110Cys Ser Leu Asp Ile Leu Ser Ser Ala Phe Gln Leu Val Gly Gly Lys 115 120 125Met Ala Gly Gln Phe Phe Ser Asn Ser Ser Ile Met Ser Asn Pro Leu 130 135 140Leu Gly Leu Val Ile Gly Val Leu Val Thr Val Leu Val Gln Ser Ser145 150 155 160Ser Thr Ser Thr Ser Ile Val Val Ser Met Val Ser Ser Ser Leu Leu 165 170 175Thr Val Arg Ala Ala Ile Pro Ile Ile Met Gly Ala Asn Ile Gly Thr 180 185 190Ser Ile Thr Asn Thr Ile Val Ala Leu Met Gln Val Gly Asp Arg Ser 195 200 205Glu Phe Arg Arg Ala Phe Ala Gly Ala Thr Val His Asp Phe Phe Asn 210 215 220Trp Leu Ser Val Leu Val Leu Leu Pro Val Glu Val Ala Thr His Tyr225 230 235 240Leu Glu Ile Ile Thr Gln Leu Ile Val Glu Ser Phe His Phe Lys Asn 245 250 255Gly Glu Asp Ala Pro Asp Leu Leu Lys Val Ile Thr Lys Pro Phe Thr 260 265 270Lys Leu Ile Val Gln Leu Asp Lys Lys Val Ile Ser Gln Ile Ala Met 275 280 285Asn Asp Glu Lys Ala Lys Asn Lys Ser Leu Val Lys Ile Trp Cys Lys 290 295 300Thr Phe Thr Asn Lys Thr Gln Ile Asn Val Thr Val Pro Ser Thr Ala305 310 315 320Asn Cys Thr Ser Pro Ser Leu Cys Trp Thr Asp Gly Ile Gln Asn Trp 325 330 335Thr Met Lys Asn Val Thr Tyr Lys Glu Asn Ile Ala Lys Cys Gln His 340 345 350Ile Phe Val Asn Phe His Leu Pro Asp Leu Ala Val Gly Thr Ile Leu 355 360 365Leu Ile Leu Ser Leu Leu Val Leu Cys Gly Cys Leu Ile Met Ile Val 370 375 380Lys Ile Leu Gly Ser Val Leu Lys Gly Gln Val Ala Thr Val Ile Lys385 390 395 400Lys Thr Ile Asn Thr Asp Phe Pro Phe Pro Phe Ala Trp Leu Thr Gly 405 410 415Tyr Leu Ala Ile Leu Val Gly Ala Gly Met Thr Phe Ile Val Gln Ser 420 425 430Ser Ser Val Phe Thr Ser Ala Leu Thr Pro Leu Ile Gly Ile Gly Val 435 440 445Ile Thr Ile Glu Arg Ala Tyr Pro Leu Thr Leu Gly Ser Asn Ile Gly 450 455 460Thr Thr Thr Thr Ala Ile Leu Ala Ala Leu Ala Ser Pro Gly Asn Ala465 470 475 480Leu Arg Ser Ser Leu Gln Ile Ala Leu Cys His Phe Phe Phe Asn Ile 485 490 495Ser Gly Ile Leu Leu Trp Tyr Pro Ile Pro Phe Thr Arg Leu Pro Ile 500 505 510Arg Met Ala Lys Gly Leu Gly Asn Ile Ser Ala Lys Tyr Arg Trp Phe 515 520 525Ala Val Phe Tyr Leu Ile Ile Phe Phe Phe Leu Ile Pro Leu Thr Val 530 535 540Phe Gly Leu Ser Leu Ala Gly Trp Arg Val Leu Val Gly Val Gly Val545 550 555 560Pro Val Val Phe Ile Ile Ile Leu Val Leu Cys Leu Arg Leu Leu Gln 565 570 575Ser Arg Cys Pro Arg Val Leu Pro Lys Lys Leu Gln Asn Trp Asn Phe 580 585 590Leu Pro Leu Trp Met Arg Ser Leu Lys Pro Trp Asp Ala Val Val Ser 595 600 605Lys Phe Thr Gly Cys Phe Gln Met Arg Cys Cys Cys Cys Cys Arg Val 610 615 620Cys Cys Arg Ala Cys Cys Leu Leu Cys Asp Cys Pro Lys Cys Cys Arg625 630 635 640Cys Ser Lys Cys Cys Glu Asp Leu Glu Glu Ala Gln Glu Gly Gln Asp 645 650 655Val Pro Val Lys Ala Pro Glu Thr Phe Asp Asn Ile Thr Ile Ser Arg 660 665 670Glu Ala Gln Gly Glu Val Pro Ala Ser Asp Ser Lys Thr Glu Cys Thr 675 680 685Ala Leu 69024710PRTHomo sapiens 247Phe Ser Val Leu Gly Ser Gly Leu Asn Arg1 5 10248123PRTHomo sapiens 248Met Ala Trp Ala Pro Leu Leu Leu Thr Leu Leu Ser Leu Leu Thr Gly1 5 10 15Ser Leu Ser Gln Pro Val Leu Thr Gln Pro Pro Ser Ala Ser Ala Ser 20 25 30Leu Gly Ala Ser Val Thr Leu Thr Cys Thr Leu Ser Ser Gly Tyr Ser 35 40 45Asn Tyr Lys Val Asp Trp Tyr Gln Gln Arg Pro Gly Lys Gly Pro Arg 50 55 60Phe Val Met Arg Val Gly Thr Gly Gly Ile Val Gly Ser Lys Gly Asp65 70 75 80Gly Ile Pro Asp Arg Phe Ser Val Leu Gly Ser Gly Leu Asn Arg Tyr 85 90 95Leu Thr Ile Lys Asn Ile Gln Glu Glu Asp Glu Ser Asp Tyr His Cys 100 105 110Gly Ala Asp His Gly Ser Gly Ser Asn Phe Val 115 12024911PRTHomo sapiens 249Leu Gln Ile Trp Asp Thr Ala Gly Gln Glu Arg1 5 1025010PRTHomo sapiens 250Ser Met Glu Asp Tyr Asp Phe Leu Phe Lys1 5 10251203PRTHomo sapiens 251Met Ser Met Glu Asp Tyr Asp Phe Leu Phe Lys Ile Val Leu Ile Gly1 5 10 15Asn Ala Gly Val Gly Lys Thr Cys Leu Val Arg Arg Phe Thr Gln Gly 20 25 30Leu Phe Pro Pro Gly Gln Gly Ala Thr Ile Gly Val Asp Phe Met Ile 35 40 45Lys Thr Val Glu Ile Asn Gly Glu Lys Val Lys Leu Gln Ile Trp Asp 50 55 60Thr Ala Gly Gln Glu Arg Phe Arg Ser Ile Thr Gln Ser Tyr Tyr Arg65 70 75 80Ser Ala Asn Ala Leu Ile Leu Thr Tyr Asp Ile Thr Cys Glu Glu Ser 85 90 95Phe Arg Cys Leu Pro Glu Trp Leu Arg Glu Ile Glu Gln Tyr Ala Ser 100 105 110Asn Lys Val Ile Thr Val Leu Val Gly Asn Lys Ile Asp Leu Ala Glu 115 120 125Arg Arg Glu Val Ser Gln Gln Arg Ala Glu Glu Phe Ser Glu Ala Gln 130 135 140Asp Met Tyr Tyr Leu Glu Thr Ser Ala Lys Glu Ser Asp Asn Val Glu145 150 155 160Lys Leu Phe Leu Asp Leu Ala Cys Arg Leu Ile Ser Glu Ala Arg Gln 165 170 175Asn Thr Leu Val Asn Asn Val Ser Ser Pro Leu Pro Gly Glu Gly Lys 180 185 190Ser Ile Ser Tyr Leu Thr Cys Cys Asn Phe Asn 195 20025219PRTHomo sapiens 252Cys Glu Gln Val Cys Val Asn Ser Pro Gly Ser Tyr Thr Cys His Cys1 5 10 15Asp Gly Arg25313PRTHomo sapiens 253Gly Gln Ser Glu Val Ser Ala Ala Gln Leu Gln Glu Arg1 5 1025412PRTHomo sapiens 254Ile Ala Val Ala Gly Asp Leu Phe Gln Pro Glu Arg1 5 102559PRTHomo sapiens 255Met Phe Ser Gly Thr Pro Val Ile Arg1 52569PRTHomo sapiens 256Met Gln Cys Phe Ser Val Thr Glu Arg1 525722PRTHomo sapiens 257Asn Ser Gly Phe Ala Thr Cys Val Gln Asn Leu Pro Asp Gln Cys Thr1 5 10 15Pro Asn Pro Cys Asp Arg 20258720PRTHomo sapiens 258Met Ala Pro Ser Leu Ser Pro Gly Pro Ala Ala Leu Arg Arg Ala Pro1 5 10 15Gln Leu Leu Leu Leu Leu Leu Ala Ala Glu Cys Ala Leu Ala Ala Leu 20 25 30Leu Pro Ala Arg Glu Ala Thr Gln Phe Leu Arg Pro Arg Gln Arg Arg 35 40 45Ala Phe Gln Val Phe Glu Glu Ala Lys Gln Gly His Leu Glu Arg Glu 50 55 60Cys Val Glu Glu Leu Cys Ser Arg Glu Glu Ala Arg Glu Val Phe Glu65 70 75 80Asn Asp Pro Glu Thr Asp Tyr Phe Tyr Pro Arg Tyr Leu Asp Cys Ile 85 90 95Asn Lys Tyr Gly Ser Pro Tyr Thr Lys Asn Ser Gly Phe Ala Thr Cys 100 105 110Val Gln Asn Leu Pro Asp Gln Cys Thr Pro Asn Pro Cys Asp Arg Lys 115 120 125Gly Thr Gln Ala Cys Gln Asp Leu Met Gly Asn Phe Phe Cys Leu Cys 130 135 140Lys Ala Gly Trp Gly Gly Arg Leu Cys Asp Lys Asp Val Asn Glu Cys145 150 155 160Ser Gln Glu Asn Gly Gly Cys Leu Gln Ile Cys His Asn Lys Pro Gly 165 170 175Ser Phe His Cys Ser Cys His Ser Gly Phe Glu Leu Ser Ser Asp Gly 180 185 190Arg Thr Cys Gln Asp Ile Asp Glu Cys Ala Asp Ser Glu Ala Cys Gly 195 200 205Glu Ala Arg Cys Lys Asn Leu Pro Gly Ser Tyr Ser Cys Leu Cys Asp 210 215 220Glu Gly Phe Ala Tyr Ser Ser Gln Glu Lys Ala Cys Arg Asp Val Asp225 230 235 240Glu Cys Leu Gln Gly Arg Cys Glu Gln Val Cys Val Asn Ser Pro Gly 245 250 255Ser Tyr Thr Cys His Cys Asp Gly Arg Gly Gly Leu Lys Leu Ser Gln 260 265 270Asp Met Asp Thr Cys Glu Leu Glu Ala Gly Trp Pro Cys Pro Arg His 275 280 285Arg Arg Asp Gly Ser Pro Ala Ala Arg Pro Gly Arg Gly Ala Gln Gly 290 295 300Ser Arg Ser Glu Gly His Ile Pro Asp Arg Arg Gly Pro Arg Pro Trp305 310 315 320Gln Asp Ile Leu Pro Cys Val Pro Phe Ser Val Ala Lys Ser Val Lys 325 330 335Ser Leu Tyr Leu Gly Arg Met Phe Ser Gly Thr Pro Val Ile Arg Leu 340 345 350Arg Phe Lys Arg Leu Gln Pro Thr Arg Leu Val Ala Glu Phe Asp Phe 355 360 365Arg Thr Phe Asp Pro Glu Gly Ile Leu Leu Phe Ala Gly Gly His Gln 370 375 380Asp Ser Thr Trp Ile Val Leu Ala Leu Arg Ala Gly Arg Leu Glu Leu385 390 395 400Gln Leu Arg Tyr Asn Gly Val Gly Arg Val Thr Ser Ser Gly Pro Val 405 410 415Ile Asn His Gly Met Trp Gln Thr Ile Ser Val Glu Glu Leu Ala Arg 420 425 430Asn Leu Val Ile Lys Val Asn Arg Asp Ala Val Met Lys Ile Ala Val 435 440 445Ala Gly Asp Leu Phe Gln Pro Glu Arg Gly Leu Tyr His Leu Asn Leu 450 455 460Thr Val Gly Gly Ile Pro Phe His Glu Lys Asp Leu Val Gln Pro Ile465 470 475 480Asn Pro Arg Leu Asp Gly Cys Met Arg Ser Trp Asn Trp Leu Asn Gly 485 490 495Glu Asp Thr Thr Ile Gln Glu Thr Val Lys Val Asn Thr Arg Met Gln 500 505 510Cys Phe Ser Val Thr Glu Arg Gly Ser Phe Tyr Pro Gly Ser Gly Phe 515 520 525Ala Phe Tyr Ser Leu Asp Tyr Met Arg Thr Pro Leu Asp Val Gly Thr 530 535 540Glu Ser Thr Trp Glu Val Glu Val Val Ala His Ile Arg Pro Ala Ala545 550 555 560Asp Thr Gly Val Leu Phe Ala Leu Trp Ala Pro Asp Leu Arg Ala Val 565 570 575Pro Leu Ser Val Ala Leu Val Asp Tyr His Ser Thr Lys Lys Leu Lys 580 585 590Lys Gln Leu Val Val Leu Ala Val Glu His Thr Ala Leu Ala Leu Met 595 600 605Glu Ile Lys Val Cys Asp Gly Gln Glu His Val Val Thr Val Ser Leu 610 615 620Arg Asp Gly Glu Ala Thr Leu Glu Val Asp Gly Thr Arg Gly Gln Ser625 630 635 640Glu Val Ser Ala Ala Gln Leu Gln Glu Arg Leu Ala Val Leu Glu Arg 645 650 655His Leu Arg Ser Pro Val Leu Thr Phe Ala Gly Gly Leu Pro Asp Val 660 665 670Pro Val Thr Ser Ala Pro Val Thr Ala Phe Tyr Arg Gly Cys Met Thr 675 680 685Leu Glu Val Asn Arg Arg Leu Leu Asp Leu Asp Glu Ala Ala Tyr Lys 690 695 700His Ser Asp Ile Thr Ala His Ser Cys Pro Pro Val Glu Pro Ala Ala705 710 715 72025919PRTHomo sapiens 259His Ser Phe Thr Met Ala Met Asn Ala Phe Gly Asp Met Thr Ser Glu1 5 10 15Glu Phe Arg26010PRTHomo sapiens 260Leu Tyr Gly Met Asn Glu Glu Gly Trp Arg1 5 1026113PRTHomo sapiens 261Asn His Cys Gly Ile Ala Ser Ala Ala Ser Tyr Pro Val1 5 1026214PRTHomo sapiens 262Asn Ser Trp Gly Glu Glu Trp Gly Met Gly Gly Tyr Val Lys1 5 10263333PRTHomo sapiens 263Met Asn Pro Thr Leu Ile Leu Ala Ala Phe Cys Leu Gly Ile Ala Ser1 5 10 15Ala Thr Leu Thr Phe Asp His Ser Leu Glu Ala Gln Trp Thr Lys Trp 20 25 30Lys Ala Met His Asn Arg Leu Tyr Gly Met Asn Glu Glu Gly Trp Arg 35 40 45Arg Ala Val Trp Glu Lys Asn Met Lys Met Ile Glu Leu His Asn Gln 50 55 60Glu Tyr Arg Glu Gly Lys His Ser Phe Thr Met Ala Met Asn Ala Phe65 70 75 80Gly Asp Met Thr Ser Glu Glu Phe Arg Gln Val Met Asn Gly Phe Gln 85 90 95Asn Arg Lys Pro Arg Lys Gly Lys Val Phe Gln Glu Pro Leu Phe Tyr 100 105 110Glu Ala Pro Arg Ser Val Asp Trp Arg Glu Lys Gly Tyr Val Thr Pro 115 120 125Val Lys Asn Gln Gly Gln Cys Gly Ser Cys Trp Ala Phe Ser Ala Thr 130 135 140Gly Ala Leu Glu Gly Gln Met Phe Arg Lys Thr Gly Arg Leu Ile Ser145 150 155 160Leu Ser Glu Gln Asn Leu Val Asp Cys Ser Gly Pro Gln Gly Asn Glu 165 170 175Gly Cys Asn Gly Gly Leu Met Asp Tyr Ala Phe Gln Tyr Val Gln Asp 180 185 190Asn Gly Gly Leu Asp Ser Glu Glu Ser Tyr Pro Tyr Glu Ala Thr Glu 195 200 205Glu Ser Cys Lys Tyr Asn Pro Lys Tyr Ser Val Ala Asn Asp Thr Gly 210 215 220Phe Val Asp Ile Pro Lys Gln Glu Lys Ala Leu Met Lys Ala Val Ala225 230 235 240Thr Val Gly Pro Ile Ser Val Ala Ile Asp Ala Gly His Glu Ser Phe 245 250 255Leu Phe Tyr Lys Glu Gly Ile Tyr Phe Glu Pro Asp Cys Ser Ser Glu 260 265 270Asp Met Asp His Gly Val Leu Val Val Gly Tyr Gly Phe Glu Ser Thr 275 280 285Glu Ser Asp Asn Asn Lys Tyr Trp Leu Val Lys Asn Ser Trp Gly Glu 290 295 300Glu Trp Gly Met Gly Gly Tyr Val Lys Met Ala Lys Asp Arg Arg Asn305

310 315 320His Cys Gly Ile Ala Ser Ala Ala Ser Tyr Pro Thr Val 325 33026416PRTHomo sapiens 264Phe Tyr Thr Lys Pro Pro Gln Cys Val Asp Ile Pro Ala Asp Leu Arg1 5 10 152658PRTHomo sapiens 265Leu Cys His Asn Val Gly Tyr Lys1 52669PRTHomo sapiens 266Leu Cys His Asn Val Gly Tyr Lys Lys1 526716PRTHomo sapiens 267Met Val Leu Pro Asn Leu Leu Glu His Glu Thr Met Ala Glu Val Lys1 5 10 1526815PRTHomo sapiens 268Pro Gln Gly Thr Thr Val Cys Pro Pro Cys Asp Asn Glu Leu Lys1 5 10 1526912PRTHomo sapiens 269Gln Gln Ala Ser Ser Trp Val Pro Leu Leu Asn Lys1 5 1027016PRTHomo sapiens 270Ser Glu Ala Ile Ile Glu His Leu Cys Ala Ser Glu Phe Ala Leu Arg1 5 10 1527110PRTHomo sapiens 271Ser Gln Tyr Leu Leu Thr Ala Ile His Lys1 5 10272314PRTHomo sapiens 272Met Gly Ile Gly Arg Ser Glu Gly Gly Arg Arg Gly Ala Ala Leu Gly1 5 10 15Val Leu Leu Ala Leu Gly Ala Ala Leu Leu Ala Val Gly Ser Ala Ser 20 25 30Glu Tyr Asp Tyr Val Ser Phe Gln Ser Asp Ile Gly Pro Tyr Gln Ser 35 40 45Gly Arg Phe Tyr Thr Lys Pro Pro Gln Cys Val Asp Ile Pro Ala Asp 50 55 60Leu Arg Leu Cys His Asn Val Gly Tyr Lys Lys Met Val Leu Pro Asn65 70 75 80Leu Leu Glu His Glu Thr Met Ala Glu Val Lys Gln Gln Ala Ser Ser 85 90 95Trp Val Pro Leu Leu Asn Lys Asn Cys His Ala Gly Thr Gln Val Phe 100 105 110Leu Cys Ser Leu Phe Ala Pro Val Cys Leu Asp Arg Pro Ile Tyr Pro 115 120 125Cys Arg Trp Leu Cys Glu Ala Val Arg Asp Ser Cys Glu Pro Val Met 130 135 140Gln Phe Phe Gly Phe Tyr Trp Pro Glu Met Leu Lys Cys Asp Lys Phe145 150 155 160Pro Glu Gly Asp Val Cys Ile Ala Met Thr Pro Pro Asn Ala Thr Glu 165 170 175Ala Ser Lys Pro Gln Gly Thr Thr Val Cys Pro Pro Cys Asp Asn Glu 180 185 190Leu Lys Ser Glu Ala Ile Ile Glu His Leu Cys Ala Ser Glu Phe Ala 195 200 205Leu Arg Met Lys Ile Lys Glu Val Lys Lys Glu Asn Gly Asp Lys Lys 210 215 220Ile Val Pro Lys Lys Lys Lys Pro Leu Lys Leu Gly Pro Ile Lys Lys225 230 235 240Lys Asp Leu Lys Lys Leu Val Leu Tyr Leu Lys Asn Gly Ala Asp Cys 245 250 255Pro Cys His Gln Leu Asp Asn Leu Ser His His Phe Leu Ile Met Gly 260 265 270Arg Lys Val Lys Ser Gln Tyr Leu Leu Thr Ala Ile His Lys Trp Asp 275 280 285Lys Lys Asn Lys Glu Phe Lys Asn Phe Met Lys Lys Met Lys Asn His 290 295 300Glu Cys Pro Thr Phe Gln Ser Val Phe Lys305 31027315PRTHomo sapiens 273Gly Leu Asp Tyr Ala Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys1 5 10 1527411PRTHomo sapiens 274Ile Lys Ile Pro Asp Tyr Ser Asp Ser Phe Lys1 5 10275487PRTHomo sapiens 275Met Arg Glu Asn Met Ala Arg Gly Pro Cys Asn Ala Pro Arg Trp Ala1 5 10 15Ser Leu Met Val Leu Val Ala Ile Gly Thr Ala Val Thr Ala Ala Val 20 25 30Asn Pro Gly Val Val Val Arg Ile Ser Gln Lys Gly Leu Asp Tyr Ala 35 40 45Ser Gln Gln Gly Thr Ala Ala Leu Gln Lys Glu Leu Lys Arg Ile Lys 50 55 60Ile Pro Asp Tyr Ser Asp Ser Phe Lys Ile Lys His Leu Gly Lys Gly65 70 75 80His Tyr Ser Phe Tyr Ser Met Asp Ile Arg Glu Phe Gln Leu Pro Ser 85 90 95Ser Gln Ile Ser Met Val Pro Asn Val Gly Leu Lys Phe Ser Ile Ser 100 105 110Asn Ala Asn Ile Lys Ile Ser Gly Lys Trp Lys Ala Gln Lys Arg Phe 115 120 125Leu Lys Met Ser Gly Asn Phe Asp Leu Ser Ile Glu Gly Met Ser Ile 130 135 140Ser Ala Asp Leu Lys Leu Gly Ser Asn Pro Thr Ser Gly Lys Pro Thr145 150 155 160Ile Thr Cys Ser Ser Cys Ser Ser His Ile Asn Ser Val His Val His 165 170 175Ile Ser Lys Ser Lys Val Gly Trp Leu Ile Gln Leu Phe His Lys Lys 180 185 190Ile Glu Ser Ala Leu Arg Asn Lys Met Asn Ser Gln Val Cys Glu Lys 195 200 205Val Thr Asn Ser Val Ser Ser Glu Leu Gln Pro Tyr Phe Gln Thr Leu 210 215 220Pro Val Met Thr Lys Ile Asp Ser Val Ala Gly Ile Asn Tyr Gly Leu225 230 235 240Val Ala Pro Pro Ala Thr Thr Ala Glu Thr Leu Asp Val Gln Met Lys 245 250 255Gly Glu Phe Tyr Ser Glu Asn His His Asn Pro Pro Pro Phe Ala Pro 260 265 270Pro Val Met Glu Phe Pro Ala Ala His Asp Arg Met Val Tyr Leu Gly 275 280 285Leu Ser Asp Tyr Phe Phe Asn Thr Ala Gly Leu Val Tyr Gln Glu Ala 290 295 300Gly Val Leu Lys Met Thr Leu Arg Asp Asp Met Ile Pro Lys Glu Ser305 310 315 320Lys Phe Arg Leu Thr Thr Lys Phe Phe Gly Thr Phe Leu Pro Glu Val 325 330 335Ala Lys Lys Phe Pro Asn Met Lys Ile Gln Ile His Val Ser Ala Ser 340 345 350Thr Pro Pro His Leu Ser Val Gln Pro Thr Gly Leu Thr Phe Tyr Pro 355 360 365Ala Val Asp Val Gln Ala Phe Ala Val Leu Pro Asn Ser Ser Leu Ala 370 375 380Ser Leu Phe Leu Ile Gly Met His Thr Thr Gly Ser Met Glu Val Ser385 390 395 400Ala Glu Ser Asn Arg Leu Val Gly Glu Leu Lys Leu Asp Arg Leu Leu 405 410 415Leu Glu Leu Lys His Ser Asn Ile Gly Pro Phe Pro Val Glu Leu Leu 420 425 430Gln Asp Ile Met Asn Tyr Ile Val Pro Ile Leu Val Leu Pro Arg Val 435 440 445Asn Glu Lys Leu Gln Lys Gly Phe Pro Leu Pro Thr Pro Ala Arg Val 450 455 460Gln Leu Tyr Asn Val Val Leu Gln Pro His Gln Asn Phe Leu Leu Phe465 470 475 480Gly Ala Asp Val Val Tyr Lys 4852767PRTHomo sapiens 276Gly Leu His Ile Val Pro Arg1 52778PRTHomo sapiens 277Gly Leu Val Val Thr Asp Leu Lys1 527814PRTHomo sapiens 278Asn Val Leu Asp Ser Glu Asp Glu Ile Glu Glu Leu Ser Lys1 5 1027911PRTHomo sapiens 279Ser Gln Phe Ser Asp Lys Pro Val Gln Asp Arg1 5 102806PRTHomo sapiens 280Tyr Ile Gln Thr Leu Lys1 5281393PRTHomo sapiens 281Met Arg Thr Leu Phe Asn Leu Leu Trp Leu Ala Leu Ala Cys Ser Pro1 5 10 15Val His Thr Thr Leu Ser Lys Ser Asp Ala Lys Lys Ala Ala Ser Lys 20 25 30Thr Leu Leu Glu Lys Ser Gln Phe Ser Asp Lys Pro Val Gln Asp Arg 35 40 45Gly Leu Val Val Thr Asp Leu Lys Ala Glu Ser Val Val Leu Glu His 50 55 60Arg Ser Tyr Cys Ser Ala Lys Ala Arg Asp Arg His Phe Ala Gly Asp65 70 75 80Val Leu Gly Tyr Val Thr Pro Trp Asn Ser His Gly Tyr Asp Val Thr 85 90 95Lys Val Phe Gly Ser Lys Phe Thr Gln Ile Ser Pro Val Trp Leu Gln 100 105 110Leu Lys Arg Arg Gly Arg Glu Met Phe Glu Val Thr Gly Leu His Asp 115 120 125Val Asp Gln Gly Trp Met Arg Ala Val Arg Lys His Ala Lys Gly Leu 130 135 140His Ile Val Pro Arg Leu Leu Phe Glu Asp Trp Thr Tyr Asp Asp Phe145 150 155 160Arg Asn Val Leu Asp Ser Glu Asp Glu Ile Glu Glu Leu Ser Lys Thr 165 170 175Val Val Gln Val Ala Lys Asn Gln His Phe Asp Gly Phe Val Val Glu 180 185 190Val Trp Asn Gln Leu Leu Ser Gln Lys Arg Val Gly Leu Ile His Met 195 200 205Leu Thr His Leu Ala Glu Ala Leu His Gln Ala Arg Leu Leu Ala Leu 210 215 220Leu Val Ile Pro Pro Ala Ile Thr Pro Gly Thr Asp Gln Leu Gly Met225 230 235 240Phe Thr His Lys Glu Phe Glu Gln Leu Ala Pro Val Leu Asp Gly Phe 245 250 255Ser Leu Met Thr Tyr Asp Tyr Ser Thr Ala His Gln Pro Gly Pro Asn 260 265 270Ala Pro Leu Ser Trp Val Arg Ala Cys Val Gln Val Leu Asp Pro Lys 275 280 285Ser Lys Trp Arg Ser Lys Ile Leu Leu Gly Leu Asn Phe Tyr Gly Met 290 295 300Asp Tyr Ala Thr Ser Lys Asp Ala Arg Glu Pro Val Val Gly Ala Arg305 310 315 320Tyr Ile Gln Thr Leu Lys Asp His Arg Pro Arg Met Val Trp Asp Ser 325 330 335Gln Ala Ser Glu His Phe Phe Glu Tyr Lys Lys Ser Arg Ser Gly Arg 340 345 350His Val Val Phe Tyr Pro Thr Leu Lys Ser Leu Gln Val Arg Leu Glu 355 360 365Leu Ala Arg Glu Leu Gly Val Gly Val Ser Ile Trp Glu Leu Gly Gln 370 375 380Gly Leu Asp Tyr Phe Tyr Asp Leu Leu385 3902828PRTHomo sapiens 282Ala Leu Glu Leu Glu Gln Glu Arg1 528310PRTHomo sapiens 283Ala Leu Thr Ser Glu Leu Ala Asn Ala Arg1 5 1028410PRTHomo sapiens 284Ala Gln Met Val Gln Glu Asp Leu Glu Lys1 5 1028510PRTHomo sapiens 285Glu Ser Glu Ala Val Glu Trp Gln Gln Lys1 5 102868PRTHomo sapiens 286Ile Ser Gln Leu Glu Met Ala Arg1 52879PRTHomo sapiens 287Ile Gly Phe Pro Trp Ser Glu Ile Arg1 5288577PRTHomo sapiens 288Met Pro Lys Thr Ile Ser Val Arg Val Thr Thr Met Asp Ala Glu Leu1 5 10 15Glu Phe Ala Ile Gln Pro Asn Thr Thr Gly Lys Gln Leu Phe Asp Gln 20 25 30Val Val Lys Thr Ile Gly Leu Arg Glu Val Trp Phe Phe Gly Leu Gln 35 40 45Tyr Gln Asp Thr Lys Gly Phe Ser Thr Trp Leu Lys Leu Asn Lys Lys 50 55 60Val Thr Ala Gln Asp Val Arg Lys Glu Ser Pro Leu Leu Phe Lys Phe65 70 75 80Arg Ala Lys Phe Tyr Pro Glu Asp Val Ser Glu Glu Leu Ile Gln Asp 85 90 95Ile Thr Gln Arg Leu Phe Phe Leu Gln Val Lys Glu Gly Ile Leu Asn 100 105 110Asp Asp Ile Tyr Cys Pro Pro Glu Thr Ala Val Leu Leu Ala Ser Tyr 115 120 125Ala Val Gln Ser Lys Tyr Gly Asp Phe Asn Lys Glu Val His Lys Ser 130 135 140Gly Tyr Leu Ala Gly Asp Lys Leu Leu Pro Gln Arg Val Leu Glu Gln145 150 155 160His Lys Leu Asn Lys Asp Gln Trp Glu Glu Arg Ile Gln Val Trp His 165 170 175Glu Glu His Arg Gly Met Leu Arg Glu Asp Ala Val Leu Glu Tyr Leu 180 185 190Lys Ile Ala Gln Asp Leu Glu Met Tyr Gly Val Asn Tyr Phe Ser Ile 195 200 205Lys Asn Lys Lys Gly Ser Glu Leu Trp Leu Gly Val Asp Ala Leu Gly 210 215 220Leu Asn Ile Tyr Glu Gln Asn Asp Arg Leu Thr Pro Lys Ile Gly Phe225 230 235 240Pro Trp Ser Glu Ile Arg Asn Ile Ser Phe Asn Asp Lys Lys Phe Val 245 250 255Ile Lys Pro Ile Asp Lys Lys Ala Pro Asp Phe Val Phe Tyr Ala Pro 260 265 270Arg Leu Arg Ile Asn Lys Arg Ile Leu Ala Leu Cys Met Gly Asn His 275 280 285Glu Leu Tyr Met Arg Arg Arg Lys Pro Asp Thr Ile Glu Val Gln Gln 290 295 300Met Lys Ala Gln Ala Arg Glu Glu Lys His Gln Lys Gln Met Glu Arg305 310 315 320Ala Met Leu Glu Asn Glu Lys Lys Lys Arg Glu Met Ala Glu Lys Glu 325 330 335Lys Glu Lys Ile Glu Arg Glu Lys Glu Glu Leu Met Glu Arg Leu Lys 340 345 350Gln Ile Glu Glu Gln Thr Lys Lys Ala Gln Gln Glu Leu Glu Glu Gln 355 360 365Thr Arg Arg Ala Leu Glu Leu Glu Gln Glu Arg Lys Arg Ala Gln Ser 370 375 380Glu Ala Glu Lys Leu Ala Lys Glu Arg Gln Glu Ala Glu Glu Ala Lys385 390 395 400Glu Ala Leu Leu Gln Ala Ser Arg Asp Gln Lys Lys Thr Gln Glu Gln 405 410 415Leu Ala Leu Glu Met Ala Glu Leu Thr Ala Arg Ile Ser Gln Leu Glu 420 425 430Met Ala Arg Gln Lys Lys Glu Ser Glu Ala Val Glu Trp Gln Gln Lys 435 440 445Ala Gln Met Val Gln Glu Asp Leu Glu Lys Thr Arg Ala Glu Leu Lys 450 455 460Thr Ala Met Ser Thr Pro His Val Ala Glu Pro Ala Glu Asn Glu Gln465 470 475 480Asp Glu Gln Asp Glu Asn Gly Ala Glu Ala Ser Ala Asp Leu Arg Ala 485 490 495Asp Ala Met Ala Lys Asp Arg Ser Glu Glu Glu Arg Thr Thr Glu Ala 500 505 510Glu Lys Asn Glu Arg Val Gln Lys His Leu Lys Ala Leu Thr Ser Glu 515 520 525Leu Ala Asn Ala Arg Asp Glu Ser Lys Lys Thr Ala Asn Asp Met Ile 530 535 540His Ala Glu Asn Met Arg Leu Gly Arg Asp Lys Tyr Lys Thr Leu Arg545 550 555 560Gln Ile Arg Gln Gly Asn Thr Lys Gln Arg Ile Asp Glu Phe Glu Ser 565 570 575Met2899PRTHomo sapiens 289Gly Ala Cys Ile Leu Asn Met Leu Arg1 529013PRTHomo sapiens 290Ile Leu Ala Ser Thr Gln Phe Glu Pro Thr Ala Ala Arg1 5 102919PRTHomo sapiens 291Ser Gln Ile Glu Phe Ala Leu Cys Arg1 5292941PRTHomo sapiens 292Met Val Phe Leu Pro Leu Lys Trp Ser Leu Ala Thr Met Ser Phe Leu1 5 10 15Leu Ser Ser Leu Leu Ala Leu Leu Thr Val Ser Thr Pro Ser Trp Cys 20 25 30Gln Ser Thr Glu Ala Ser Pro Lys Arg Ser Asp Gly Thr Pro Phe Pro 35 40 45Trp Asn Lys Ile Arg Leu Pro Glu Tyr Val Ile Pro Val His Tyr Asp 50 55 60Leu Leu Ile His Ala Asn Leu Thr Thr Leu Thr Phe Trp Gly Thr Thr65 70 75 80Lys Val Glu Ile Thr Ala Ser Gln Pro Thr Ser Thr Ile Ile Leu His 85 90 95Ser His His Leu Gln Ile Ser Arg Ala Thr Leu Arg Lys Gly Ala Gly 100 105 110Glu Arg Leu Ser Glu Glu Pro Leu Gln Val Leu Glu His Pro Arg Gln 115 120 125Glu Gln Ile Ala Leu Leu Ala Pro Glu Pro Leu Leu Val Gly Leu Pro 130 135 140Tyr Thr Val Val Ile His Tyr Ala Gly Asn Leu Ser Glu Thr Phe His145 150 155 160Gly Phe Tyr Lys Ser Thr Tyr Arg Thr Lys Glu Gly Glu Leu Arg Ile 165 170 175Leu Ala Ser Thr Gln Phe Glu Pro Thr Ala Ala Arg Met Ala Phe Pro 180 185 190Cys Phe Asp Glu Pro Ala Phe Lys Ala Ser Phe Ser Ile Lys Ile Arg 195 200 205Arg Glu Pro Arg His Leu Ala Ile Ser Asn Met Pro Leu Val Lys Ser 210 215 220Val Thr Val Ala Glu Gly Leu Ile Glu Asp His Phe Asp Val Thr Val225 230 235 240Lys Met Ser Thr Tyr Leu Val Ala Phe Ile Ile Ser Asp Phe Glu Ser 245 250 255Val Ser Lys Ile Thr Lys Ser Gly Val Lys Val Ser Val Tyr Ala Val 260 265 270Pro Asp Lys Ile Asn Gln Ala Asp Tyr Ala Leu Asp Ala Ala Val Thr 275 280 285Leu Leu Glu Phe Tyr Glu Asp Tyr Phe Ser Ile Pro Tyr Pro Leu Pro 290 295 300Lys Gln Asp Leu Ala Ala Ile Pro Asp Phe Gln Ser Gly Ala Met Glu305 310 315 320Asn Trp Gly Leu Thr Thr Tyr Arg Glu Ser Ala Leu Leu Phe Asp Ala 325 330 335Glu Lys Ser Ser Ala Ser Ser Lys Leu Gly Ile Thr

Met Thr Val Ala 340 345 350His Glu Leu Ala His Gln Trp Phe Gly Asn Leu Val Thr Met Glu Trp 355 360 365Trp Asn Asp Leu Trp Leu Asn Glu Gly Phe Ala Lys Phe Met Glu Phe 370 375 380Val Ser Val Ser Val Thr His Pro Glu Leu Lys Val Gly Asp Tyr Phe385 390 395 400Phe Gly Lys Cys Phe Asp Ala Met Glu Val Asp Ala Leu Asn Ser Ser 405 410 415His Pro Val Ser Thr Pro Val Glu Asn Pro Ala Gln Ile Arg Glu Met 420 425 430Phe Asp Asp Val Ser Tyr Asp Lys Gly Ala Cys Ile Leu Asn Met Leu 435 440 445Arg Glu Tyr Leu Ser Ala Asp Ala Phe Lys Ser Gly Ile Val Gln Tyr 450 455 460Leu Gln Lys His Ser Tyr Lys Asn Thr Lys Asn Glu Asp Leu Trp Asp465 470 475 480Ser Met Ala Ser Ile Cys Pro Thr Asp Gly Val Lys Gly Met Asp Gly 485 490 495Phe Cys Ser Arg Ser Gln His Ser Ser Ser Ser Ser His Trp His Gln 500 505 510Glu Gly Val Asp Val Lys Thr Met Met Asn Thr Trp Thr Leu Gln Lys 515 520 525Gly Phe Pro Leu Ile Thr Ile Thr Val Arg Gly Arg Asn Val His Met 530 535 540Lys Gln Glu His Tyr Met Lys Gly Ser Asp Gly Ala Pro Asp Thr Gly545 550 555 560Tyr Leu Trp His Val Pro Leu Thr Phe Ile Thr Ser Lys Ser Asp Met 565 570 575Val His Arg Phe Leu Leu Lys Thr Lys Thr Asp Val Leu Ile Leu Pro 580 585 590Glu Glu Val Glu Trp Ile Lys Phe Asn Val Gly Met Asn Gly Tyr Tyr 595 600 605Ile Val His Tyr Glu Asp Asp Gly Trp Asp Ser Leu Thr Gly Leu Leu 610 615 620Lys Gly Thr His Thr Ala Val Ser Ser Asn Asp Arg Ala Ser Leu Ile625 630 635 640Asn Asn Ala Phe Gln Leu Val Ser Ile Gly Lys Leu Ser Ile Glu Lys 645 650 655Ala Leu Asp Leu Ser Leu Tyr Leu Lys His Glu Thr Glu Ile Met Pro 660 665 670Val Phe Gln Gly Leu Asn Glu Leu Ile Pro Met Tyr Lys Leu Met Glu 675 680 685Lys Arg Asp Met Asn Glu Val Glu Thr Gln Phe Lys Ala Phe Leu Ile 690 695 700Arg Leu Leu Arg Asp Leu Ile Asp Lys Gln Thr Trp Thr Asp Glu Gly705 710 715 720Ser Val Ser Glu Arg Met Leu Arg Ser Gln Leu Leu Leu Leu Ala Cys 725 730 735Val His Asn Tyr Gln Pro Cys Val Gln Arg Ala Glu Gly Tyr Phe Arg 740 745 750Lys Trp Lys Glu Ser Asn Gly Asn Leu Ser Leu Pro Val Asp Val Thr 755 760 765Leu Ala Val Phe Ala Val Gly Ala Gln Ser Thr Glu Gly Trp Asp Phe 770 775 780Leu Tyr Ser Lys Tyr Gln Phe Ser Leu Ser Ser Thr Glu Lys Ser Gln785 790 795 800Ile Glu Phe Ala Leu Cys Arg Thr Gln Asn Lys Glu Lys Leu Gln Trp 805 810 815Leu Leu Asp Glu Ser Phe Lys Gly Asp Lys Ile Lys Thr Gln Glu Phe 820 825 830Pro Gln Ile Leu Thr Leu Ile Gly Arg Asn Pro Val Gly Tyr Pro Leu 835 840 845Ala Trp Gln Phe Leu Arg Lys Asn Trp Asn Lys Leu Val Gln Lys Phe 850 855 860Glu Leu Gly Ser Ser Ser Ile Ala His Met Val Met Gly Thr Thr Asn865 870 875 880Gln Phe Ser Thr Arg Thr Arg Leu Glu Glu Val Lys Gly Phe Phe Ser 885 890 895Ser Leu Lys Glu Asn Gly Ser Gln Leu Arg Cys Val Gln Gln Thr Ile 900 905 910Glu Thr Ile Glu Glu Asn Ile Gly Trp Met Asp Lys Asn Phe Asp Lys 915 920 925Ile Arg Val Trp Leu Gln Ser Glu Lys Leu Glu Arg Met 930 935 94029311PRTHomo sapiens 293Met Ala Ser Thr Pro His Pro Pro Gly Ala Arg1 5 1029411PRTHomo sapiens 294Tyr Pro Gly Ser Pro Gly Ser Tyr Ala Ala Arg1 5 10295361PRTHomo sapiens 295Met Ala Gly Gly Arg His Arg Arg Val Val Gly Thr Leu His Leu Leu1 5 10 15Leu Leu Val Ala Ala Leu Pro Trp Ala Ser Arg Gly Val Ser Pro Ser 20 25 30Ala Ser Ala Trp Pro Glu Glu Lys Asn Tyr His Gln Pro Ala Ile Leu 35 40 45Asn Ser Ser Ala Leu Arg Gln Ile Ala Glu Gly Thr Ser Ile Ser Glu 50 55 60Met Trp Gln Asn Asp Leu Gln Pro Leu Leu Ile Glu Arg Tyr Pro Gly65 70 75 80Ser Pro Gly Ser Tyr Ala Ala Arg Gln His Ile Met Gln Arg Ile Gln 85 90 95Arg Leu Gln Ala Asp Trp Val Leu Glu Ile Asp Thr Phe Leu Ser Gln 100 105 110Thr Pro Tyr Gly Tyr Arg Ser Phe Ser Asn Ile Ile Ser Thr Leu Asn 115 120 125Pro Thr Ala Lys Arg His Leu Val Leu Ala Cys His Tyr Asp Ser Lys 130 135 140Tyr Phe Ser His Trp Asn Asn Arg Val Phe Val Gly Ala Thr Asp Ser145 150 155 160Ala Val Pro Cys Ala Met Met Leu Glu Leu Ala Arg Ala Leu Asp Lys 165 170 175Lys Leu Leu Ser Leu Lys Thr Val Ser Asp Ser Lys Pro Asp Leu Ser 180 185 190Leu Gln Leu Ile Phe Phe Asp Gly Glu Glu Ala Phe Leu His Trp Ser 195 200 205Pro Gln Asp Ser Leu Tyr Gly Ser Arg His Leu Ala Ala Lys Met Ala 210 215 220Ser Thr Pro His Pro Pro Gly Ala Arg Gly Thr Ser Gln Leu His Gly225 230 235 240Met Asp Leu Leu Val Leu Leu Asp Leu Ile Gly Ala Pro Asn Pro Thr 245 250 255Phe Pro Asn Phe Phe Pro Asn Ser Ala Arg Trp Phe Glu Arg Leu Gln 260 265 270Ala Ile Glu His Glu Leu His Glu Leu Gly Leu Leu Lys Asp His Ser 275 280 285Leu Glu Gly Arg Tyr Phe Gln Asn Tyr Ser Tyr Gly Gly Val Ile Gln 290 295 300Asp Asp His Ile Pro Phe Leu Arg Arg Gly Val Pro Val Leu His Leu305 310 315 320Ile Pro Ser Pro Phe Pro Glu Val Trp His Thr Met Asp Asp Asn Glu 325 330 335Glu Asn Leu Asp Glu Ser Thr Ile Asp Asn Leu Asn Lys Ile Leu Gln 340 345 350Val Phe Val Leu Glu Tyr Leu His Leu 355 36029611PRTHomo sapiens 296Cys Thr Trp Leu Ile Glu Gly Gln Pro Asn Arg1 5 1029712PRTHomo sapiens 297Gly Asp Glu Cys Gln Leu Cys Glu Val Glu Asn Arg1 5 1029815PRTHomo sapiens 298Gly Val Lys Gly Asp Glu Cys Gln Leu Cys Glu Val Glu Asn Arg1 5 10 152997PRTHomo sapiens 299Leu Ala Asp Asp Leu Tyr Arg1 530010PRTHomo sapiens 300Ile Met Gln Ser Ser Gln Ser Met Ser Lys1 5 1030116PRTHomo sapiens 301Leu Thr Gly Ser Ser Gly Phe Val Thr Asp Gly Pro Gly Asn Tyr Lys1 5 10 1530213PRTHomo sapiens 302Ser Cys Ala Leu Asp Gln Asn Cys Gln Trp Glu Pro Arg1 5 103031428PRTHomo sapiens 303Met Val Ala Ala Ala Ala Ala Thr Glu Ala Arg Leu Arg Arg Arg Thr1 5 10 15Ala Ala Thr Ala Ala Leu Ala Gly Arg Ser Gly Gly Pro His Trp Asp 20 25 30Trp Asp Val Thr Arg Ala Gly Arg Pro Gly Leu Gly Ala Gly Leu Arg 35 40 45Leu Pro Arg Leu Leu Ser Pro Pro Leu Arg Pro Arg Leu Leu Leu Leu 50 55 60Leu Leu Leu Leu Ser Pro Pro Leu Leu Leu Leu Leu Leu Pro Cys Glu65 70 75 80Ala Glu Ala Ala Ala Ala Ala Ala Ala Val Ser Gly Ser Ala Ala Ala 85 90 95Glu Ala Lys Glu Cys Asp Arg Pro Cys Val Asn Gly Gly Arg Cys Asn 100 105 110Pro Gly Thr Gly Gln Cys Val Cys Pro Ala Gly Trp Val Gly Glu Gln 115 120 125Cys Gln His Cys Gly Gly Arg Phe Arg Leu Thr Gly Ser Ser Gly Phe 130 135 140Val Thr Asp Gly Pro Gly Asn Tyr Lys Tyr Lys Thr Lys Cys Thr Trp145 150 155 160Leu Ile Glu Gly Gln Pro Asn Arg Ile Met Arg Leu Arg Phe Asn His 165 170 175Phe Ala Thr Glu Cys Ser Trp Asp His Leu Tyr Val Tyr Asp Gly Asp 180 185 190Ser Ile Tyr Ala Pro Leu Val Ala Ala Phe Ser Gly Leu Ile Val Pro 195 200 205Glu Arg Asp Gly Asn Glu Thr Val Pro Glu Val Val Ala Thr Ser Gly 210 215 220Tyr Ala Leu Leu His Phe Phe Ser Asp Ala Ala Tyr Asn Leu Thr Gly225 230 235 240Phe Asn Ile Thr Tyr Ser Phe Asp Met Cys Pro Asn Asn Cys Ser Gly 245 250 255Arg Gly Glu Cys Lys Ile Ser Asn Ser Ser Asp Thr Val Glu Cys Glu 260 265 270Cys Ser Glu Asn Trp Lys Gly Glu Ala Cys Asp Ile Pro His Cys Thr 275 280 285Asp Asn Cys Gly Phe Pro His Arg Gly Ile Cys Asn Ser Ser Asp Val 290 295 300Arg Gly Cys Ser Cys Phe Ser Asp Trp Gln Gly Pro Gly Cys Ser Val305 310 315 320Pro Val Pro Ala Asn Gln Ser Phe Trp Thr Arg Glu Glu Tyr Ser Asn 325 330 335Leu Lys Leu Pro Arg Ala Ser His Lys Ala Val Val Asn Gly Asn Ile 340 345 350Met Trp Val Val Gly Gly Tyr Met Phe Asn His Ser Asp Tyr Asn Met 355 360 365Val Leu Ala Tyr Asp Leu Ala Ser Arg Glu Trp Leu Pro Leu Asn Arg 370 375 380Ser Val Asn Asn Val Val Val Arg Tyr Gly His Ser Leu Ala Leu Tyr385 390 395 400Lys Asp Lys Ile Tyr Met Tyr Gly Gly Lys Ile Asp Ser Thr Gly Asn 405 410 415Val Thr Asn Glu Leu Arg Val Phe His Ile His Asn Glu Ser Trp Val 420 425 430Leu Leu Thr Pro Lys Ala Lys Glu Gln Tyr Ala Val Val Gly His Ser 435 440 445Ala His Ile Val Thr Leu Lys Asn Gly Arg Val Val Met Leu Val Ile 450 455 460Phe Gly His Cys Pro Leu Tyr Gly Tyr Ile Ser Asn Val Gln Glu Tyr465 470 475 480Asp Leu Asp Lys Asn Thr Trp Ser Ile Leu His Thr Gln Gly Ala Leu 485 490 495Val Gln Gly Gly Tyr Gly His Ser Ser Val Tyr Asp His Arg Thr Arg 500 505 510Ala Leu Tyr Val His Gly Gly Tyr Lys Ala Phe Ser Ala Asn Lys Tyr 515 520 525Arg Leu Ala Asp Asp Leu Tyr Arg Tyr Asp Val Asp Thr Gln Met Trp 530 535 540Thr Ile Leu Lys Asp Ser Arg Phe Phe Arg Tyr Leu His Thr Ala Val545 550 555 560Ile Val Ser Gly Thr Met Leu Val Phe Gly Gly Asn Thr His Asn Asp 565 570 575Thr Ser Met Ser His Gly Ala Lys Cys Phe Ser Ser Asp Phe Met Ala 580 585 590Tyr Asp Ile Ala Cys Asp Arg Trp Ser Val Leu Pro Arg Pro Asp Leu 595 600 605His His Asp Val Asn Arg Phe Gly His Ser Ala Val Leu His Asn Ser 610 615 620Thr Met Tyr Val Phe Gly Gly Phe Asn Ser Leu Leu Leu Ser Asp Ile625 630 635 640Leu Val Phe Thr Ser Glu Gln Cys Asp Ala His Arg Ser Glu Ala Ala 645 650 655Cys Leu Ala Ala Gly Pro Gly Ile Arg Cys Val Trp Asn Thr Gly Ser 660 665 670Ser Gln Cys Ile Ser Trp Ala Leu Ala Thr Asp Glu Gln Glu Glu Lys 675 680 685Leu Lys Ser Glu Cys Phe Ser Lys Arg Thr Leu Asp His Asp Arg Cys 690 695 700Asp Gln His Thr Asp Cys Tyr Ser Cys Thr Ala Asn Thr Asn Asp Cys705 710 715 720His Trp Cys Asn Asp His Cys Val Pro Arg Asn His Ser Cys Ser Glu 725 730 735Gly Gln Ile Ser Ile Phe Arg Tyr Glu Asn Cys Pro Lys Asp Asn Pro 740 745 750Met Tyr Tyr Cys Asn Lys Lys Thr Ser Cys Arg Ser Cys Ala Leu Asp 755 760 765Gln Asn Cys Gln Trp Glu Pro Arg Asn Gln Glu Cys Ile Ala Leu Pro 770 775 780Glu Asn Ile Cys Gly Ile Gly Trp His Leu Val Gly Asn Ser Cys Leu785 790 795 800Lys Ile Thr Thr Ala Lys Glu Asn Tyr Asp Asn Ala Lys Leu Phe Cys 805 810 815Arg Asn His Asn Ala Leu Leu Ala Ser Leu Thr Thr Gln Lys Lys Val 820 825 830Glu Phe Val Leu Lys Gln Leu Arg Ile Met Gln Ser Ser Gln Ser Met 835 840 845Ser Lys Leu Thr Leu Thr Pro Trp Val Gly Leu Arg Lys Ile Asn Val 850 855 860Ser Tyr Trp Cys Trp Glu Asp Met Ser Pro Phe Thr Asn Ser Leu Leu865 870 875 880Gln Trp Met Pro Ser Glu Pro Ser Asp Ala Gly Phe Cys Gly Ile Leu 885 890 895Ser Glu Pro Ser Thr Arg Gly Leu Lys Ala Ala Thr Cys Ile Asn Pro 900 905 910Leu Asn Gly Ser Val Cys Glu Arg Pro Ala Asn His Ser Ala Lys Gln 915 920 925Cys Arg Thr Pro Cys Ala Leu Arg Thr Ala Cys Gly Asp Cys Thr Ser 930 935 940Gly Ser Ser Glu Cys Met Trp Cys Ser Asn Met Lys Gln Cys Val Asp945 950 955 960Ser Asn Ala Tyr Val Ala Ser Phe Pro Phe Gly Gln Cys Met Glu Trp 965 970 975Tyr Thr Met Ser Thr Cys Pro Pro Glu Asn Cys Ser Gly Tyr Cys Thr 980 985 990Cys Ser His Cys Leu Glu Gln Pro Gly Cys Gly Trp Cys Thr Asp Pro 995 1000 1005Ser Asn Thr Gly Lys Gly Lys Cys Ile Glu Gly Ser Tyr Lys Gly 1010 1015 1020Pro Val Lys Met Pro Ser Gln Ala Pro Thr Gly Asn Phe Tyr Pro 1025 1030 1035Gln Pro Leu Leu Asn Ser Ser Met Cys Leu Glu Asp Ser Arg Tyr 1040 1045 1050Asn Trp Ser Phe Ile His Cys Pro Ala Cys Gln Cys Asn Gly His 1055 1060 1065Ser Lys Cys Ile Asn Gln Ser Ile Cys Glu Lys Cys Glu Asn Leu 1070 1075 1080Thr Thr Gly Lys His Cys Glu Thr Cys Ile Ser Gly Phe Tyr Gly 1085 1090 1095Asp Pro Thr Asn Gly Gly Lys Cys Gln Pro Cys Lys Cys Asn Gly 1100 1105 1110His Ala Ser Leu Cys Asn Thr Asn Thr Gly Lys Cys Phe Cys Thr 1115 1120 1125Thr Lys Gly Val Lys Gly Asp Glu Cys Gln Leu Cys Glu Val Glu 1130 1135 1140Asn Arg Tyr Gln Gly Asn Pro Leu Arg Gly Thr Cys Tyr Tyr Thr 1145 1150 1155Leu Leu Ile Asp Tyr Gln Phe Thr Phe Ser Leu Ser Gln Glu Asp 1160 1165 1170Asp Arg Tyr Tyr Thr Ala Ile Asn Phe Val Ala Thr Pro Asp Glu 1175 1180 1185Gln Asn Arg Asp Leu Asp Met Phe Ile Asn Ala Ser Lys Asn Phe 1190 1195 1200Asn Leu Asn Ile Thr Trp Ala Ala Ser Phe Ser Ala Gly Thr Gln 1205 1210 1215Ala Gly Glu Glu Met Pro Val Val Ser Lys Thr Asn Ile Lys Glu 1220 1225 1230Tyr Lys Asp Ser Phe Ser Asn Glu Lys Phe Asp Phe Arg Asn His 1235 1240 1245Pro Asn Ile Thr Phe Phe Val Tyr Val Ser Asn Phe Thr Trp Pro 1250 1255 1260Ile Lys Ile Gln Ile Ala Phe Ser Gln His Ser Asn Phe Met Asp 1265 1270 1275Leu Val Gln Phe Phe Val Thr Phe Phe Ser Cys Phe Leu Ser Leu 1280 1285 1290Leu Leu Val Ala Ala Val Val Trp Lys Ile Lys Gln Ser Cys Trp 1295 1300 1305Ala Ser Arg Arg Arg Glu Gln Leu Leu Arg Glu Met Gln Gln Met 1310 1315 1320Ala Ser Arg Pro Phe Ala Ser Val Asn Val Ala Leu Glu Thr Asp 1325 1330 1335Glu Glu Pro Pro Asp Leu Ile Gly Gly Ser Ile Lys Thr Val Pro 1340 1345 1350Lys Pro Ile Ala Leu Glu Pro Cys Phe Gly Asn Lys Ala Ala Val 1355 1360 1365Leu Ser Val Phe Val

Arg Leu Pro Arg Gly Leu Gly Gly Ile Pro 1370 1375 1380Pro Pro Gly Gln Ser Gly Leu Ala Val Ala Ser Ala Leu Val Asp 1385 1390 1395Ile Ser Gln Gln Met Pro Ile Val Tyr Lys Glu Lys Ser Gly Ala 1400 1405 1410Val Arg Asn Arg Lys Gln Gln Pro Pro Ala Gln Pro Gly Thr Cys 1415 1420 142530420PRTHomo sapiens 304Ala Asp Ala Val Thr Leu Asp Gly Gly Phe Ile Tyr Glu Ala Gly Leu1 5 10 15Ala Pro Tyr Lys 2030514PRTHomo sapiens 305Ala Arg Val Val Trp Cys Ala Val Gly Glu Gln Glu Leu Arg1 5 1030615PRTHomo sapiens 306Ala Arg Val Val Trp Cys Ala Val Gly Glu Gln Glu Leu Arg Lys1 5 10 1530717PRTHomo sapiens 307Cys Ala Phe Ser Ser Gln Glu Pro Tyr Phe Ser Tyr Ser Gly Ala Phe1 5 10 15Lys3086PRTHomo sapiens 308Cys Phe Gln Trp Gln Arg1 530912PRTHomo sapiens 309Cys Gly Leu Val Pro Val Leu Ala Glu Asn Tyr Lys1 5 1031013PRTHomo sapiens 310Cys Leu Ala Glu Asn Ala Gly Asp Val Ala Phe Val Lys1 5 1031113PRTHomo sapiens 311Cys Leu Arg Asp Gly Ala Gly Asp Val Ala Phe Ile Arg1 5 1031215PRTHomo sapiens 312Cys Ser Thr Ser Pro Leu Leu Glu Ala Cys Glu Phe Leu Arg Lys1 5 10 1531314PRTHomo sapiens 313Cys Ser Thr Ser Pro Leu Leu Glu Ala Cys Glu Phe Leu Arg1 5 103148PRTHomo sapiens 314Cys Val Pro Asn Ser Asn Glu Arg1 531517PRTHomo sapiens 315Cys Val Pro Asn Ser Asn Glu Arg Tyr Tyr Gly Tyr Thr Gly Ala Phe1 5 10 15Arg3166PRTHomo sapiens 316Asp Cys His Leu Ala Arg1 531712PRTHomo sapiens 317Asp Glu Tyr Glu Leu Leu Cys Pro Asp Asn Thr Arg1 5 1031810PRTHomo sapiens 318Asp Gly Ala Gly Asp Val Ala Phe Ile Arg1 5 1031936PRTHomo sapiens 319Asp Gly Ala Gly Asp Val Ala Phe Ile Arg Glu Ser Thr Val Phe Glu1 5 10 15Asp Leu Ser Asp Glu Ala Glu Arg Asp Glu Tyr Glu Leu Leu Cys Pro 20 25 30Asp Asn Thr Arg 3532013PRTHomo sapiens 320Asp Leu Leu Phe Lys Asp Ser Ala Ile Gly Phe Ser Arg1 5 1032115PRTHomo sapiens 321Asp Leu Lys Leu Ala Asp Phe Ala Leu Leu Cys Leu Asp Gly Lys1 5 10 1532216PRTHomo sapiens 322Asp Leu Lys Leu Ala Asp Phe Ala Leu Leu Cys Leu Asp Gly Lys Arg1 5 10 1532316PRTHomo sapiens 323Asp Lys Ser Pro Lys Phe Gln Leu Phe Gly Ser Pro Ser Gly Gln Lys1 5 10 153248PRTHomo sapiens 324Asp Ser Ala Ile Gly Phe Ser Arg1 532512PRTHomo sapiens 325Asp Ser Ala Ile Gly Phe Ser Arg Val Pro Pro Arg1 5 1032614PRTHomo sapiens 326Asp Ser Pro Ile Gln Cys Ile Gln Ala Ile Ala Glu Asn Arg1 5 1032734PRTHomo sapiens 327Asp Ser Pro Ile Gln Cys Ile Gln Ala Ile Ala Glu Asn Arg Ala Asp1 5 10 15Ala Val Thr Leu Asp Gly Gly Phe Ile Tyr Glu Ala Gly Leu Ala Pro 20 25 30Tyr Lys32818PRTHomo sapiens 328Asp Val Thr Val Leu Gln Asn Thr Asp Gly Asn Asn Asn Glu Ala Trp1 5 10 15Ala Lys32921PRTHomo sapiens 329Asp Val Thr Val Leu Gln Asn Thr Asp Gly Asn Asn Asn Glu Ala Trp1 5 10 15Ala Lys Asp Ile Lys 2033018PRTHomo sapiens 330Gly Glu Ala Asp Ala Met Ser Leu Asp Gly Gly Tyr Val Tyr Thr Ala1 5 10 15Gly Lys33113PRTHomo sapiens 331Gly Gly Ser Phe Gln Leu Asn Glu Leu Gln Gly Leu Lys1 5 103328PRTHomo sapiens 332Gly Pro Pro Val Ser Cys Ile Lys1 53339PRTHomo sapiens 333Gly Pro Pro Val Ser Cys Ile Lys Arg1 53348PRTHomo sapiens 334Gly Gln Phe Pro Asn Leu Cys Arg1 5335708PRTHomo sapiens 335Met Lys Leu Val Phe Leu Val Leu Leu Phe Leu Gly Ala Leu Gly Leu1 5 10 15Cys Leu Ala Gly Arg Arg Arg Ser Val Gln Trp Cys Ala Val Ser Gln 20 25 30Pro Glu Ala Thr Lys Cys Phe Gln Trp Gln Arg Asn Met Arg Lys Val 35 40 45Arg Gly Pro Pro Val Ser Cys Ile Lys Arg Asp Ser Pro Ile Gln Cys 50 55 60Ile Gln Ala Ile Ala Glu Asn Arg Ala Asp Ala Val Thr Leu Asp Gly65 70 75 80Gly Phe Ile Tyr Glu Ala Gly Leu Ala Pro Tyr Lys Leu Arg Pro Val 85 90 95Ala Ala Glu Val Tyr Gly Thr Glu Arg Gln Pro Arg Thr His Tyr Tyr 100 105 110Ala Val Ala Val Val Lys Lys Gly Gly Ser Phe Gln Leu Asn Glu Leu 115 120 125Gln Gly Leu Lys Ser Cys His Thr Gly Leu Arg Arg Thr Ala Gly Trp 130 135 140Asn Val Pro Ile Gly Thr Leu Arg Pro Phe Leu Asn Trp Thr Gly Pro145 150 155 160Pro Glu Pro Ile Glu Ala Ala Val Ala Arg Phe Phe Ser Ala Ser Cys 165 170 175Val Pro Gly Ala Asp Lys Gly Gln Phe Pro Asn Leu Cys Arg Leu Cys 180 185 190Ala Gly Thr Gly Glu Asn Lys Cys Ala Phe Ser Ser Gln Glu Pro Tyr 195 200 205Phe Ser Tyr Ser Gly Ala Phe Lys Cys Leu Arg Asp Gly Ala Gly Asp 210 215 220Val Ala Phe Ile Arg Glu Ser Thr Val Phe Glu Asp Leu Ser Asp Glu225 230 235 240Ala Glu Arg Asp Glu Tyr Glu Leu Leu Cys Pro Asp Asn Thr Arg Lys 245 250 255Pro Val Asp Lys Phe Lys Asp Cys His Leu Ala Arg Val Pro Ser His 260 265 270Ala Val Val Ala Arg Ser Val Asn Gly Lys Glu Asp Ala Ile Trp Asn 275 280 285Leu Leu Arg Gln Ala Gln Glu Lys Phe Gly Lys Asp Lys Ser Pro Lys 290 295 300Phe Gln Leu Phe Gly Ser Pro Ser Gly Gln Lys Asp Leu Leu Phe Lys305 310 315 320Asp Ser Ala Ile Gly Phe Ser Arg Val Pro Pro Arg Ile Asp Ser Gly 325 330 335Leu Tyr Leu Gly Ser Gly Tyr Phe Thr Ala Ile Gln Asn Leu Arg Lys 340 345 350Ser Glu Glu Glu Val Ala Ala Arg Arg Ala Arg Val Val Trp Cys Ala 355 360 365Val Gly Glu Gln Glu Leu Arg Lys Cys Asn Gln Trp Ser Gly Leu Ser 370 375 380Glu Gly Ser Val Thr Cys Ser Ser Ala Ser Thr Thr Glu Asp Cys Ile385 390 395 400Ala Leu Lys Gly Glu Ala Asp Ala Met Ser Leu Asp Gly Gly Tyr Val 405 410 415Tyr Thr Ala Gly Lys Cys Gly Leu Val Pro Val Leu Ala Glu Asn Tyr 420 425 430Lys Ser Gln Gln Ser Ser Asp Pro Asp Pro Asn Cys Val Asp Arg Pro 435 440 445Val Glu Gly Tyr Leu Ala Val Ala Val Val Arg Arg Ser Asp Thr Ser 450 455 460Leu Thr Trp Asn Ser Val Lys Gly Lys Lys Ser Cys His Thr Ala Val465 470 475 480Asp Arg Thr Ala Gly Trp Asn Ile Pro Met Gly Leu Leu Phe Asn Gln 485 490 495Thr Gly Ser Cys Lys Phe Asp Glu Tyr Phe Ser Gln Ser Cys Ala Pro 500 505 510Gly Ser Asp Pro Arg Ser Asn Leu Cys Ala Leu Cys Ile Gly Asp Glu 515 520 525Gln Gly Glu Asn Lys Cys Val Pro Asn Ser Asn Glu Arg Tyr Tyr Gly 530 535 540Tyr Thr Gly Ala Phe Arg Cys Leu Ala Glu Asn Ala Gly Asp Val Ala545 550 555 560Phe Val Lys Asp Val Thr Val Leu Gln Asn Thr Asp Gly Asn Asn Asn 565 570 575Glu Ala Trp Ala Lys Asp Leu Lys Leu Ala Asp Phe Ala Leu Leu Cys 580 585 590Leu Asp Gly Lys Arg Lys Pro Val Thr Glu Ala Arg Ser Cys His Leu 595 600 605Ala Met Ala Pro Asn His Ala Val Val Ser Arg Met Asp Lys Val Glu 610 615 620Arg Leu Lys Gln Val Leu Leu His Gln Gln Ala Lys Phe Gly Arg Asn625 630 635 640Gly Ser Asp Cys Pro Asp Lys Phe Cys Leu Phe Gln Ser Glu Thr Lys 645 650 655Asn Leu Leu Phe Asn Asp Asn Thr Glu Cys Leu Ala Arg Leu His Gly 660 665 670Lys Thr Thr Tyr Glu Lys Tyr Leu Gly Pro Gln Tyr Val Ala Gly Ile 675 680 685Thr Asn Leu Lys Lys Cys Ser Thr Ser Pro Leu Leu Glu Ala Cys Glu 690 695 700Phe Leu Arg Lys705