[Clinical and biochemical characteristics of biliferous tract diseases in patients with diabetes mellitus].

The aim of the study was to investigate manifestations of biliferous tract diseases in patients with diabetes mellitus (DM) and to measure concentrations and the ratio of lipids in gall-bladder and liver bile in these patients. 125patients with DM and biliferous tract diseases were examined. Patients with chronic cholecystitis (CC), cholelithiasis, and biliary dyskinesia underwent clinical examination as well as biochemical and instrumental tests. The control group included 87 healthy individuals of comparable age and gender. CC was diagnosed in 35.2% of DM patients, cholelithiasis - in 17.6% patients. In liver and gall-bladder bile samples taken from patients with CC and cholelithiasis, fatty acids concentrations was not significantly different, cholesterol level was significantly higher, and phospholipids level was lower than in the control group. Thus, indices of cholesterol saturation in liver and gall-bladder bile portions were higher in patients with cholelithiasis than in the control group. The study revealed high biliferous tract diseases morbidity in patients with DM. Thomas-Hofmann index, which characterizes bile saturation with cholesterol, is significantly higher in patients with cholelithiasis and DM, then in healthy individuals.