Journal of Natural Products 1997-Jun

Cytotoxic and antiplatelet aggregation principles from Aglaia elliptifolia.

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T S Wu

M J Liou

C S Kuoh

C M Teng

T Nagao

K H Lee

ARTICLE: 9214732

DOI: 10.1021/np970163+

BioSeek: 9214732

Keywords

Abstract

Two related 1H-2,3,3a,8b-tetrahydrocyclopenta[b]benzofurans, aglafolin (1a) and rocaglamide (2), isolated from the stems of Aglaia elliptifolia, showed significant cytotoxicity in six cancer cell lines. Aglafolin (1a) was also found to completely block platelet aggregation caused by arachidonic acid and platelet-activating factor at 100 microM and 2 ng/mL, respectively.

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Cytotoxic and antiplatelet aggregation principles from Aglaia elliptifolia.

Keywords

aglafolin

rocaglamide

2 3 benzofuran

neoplasms

aglaia

arachidonic acid

antiplatelet

Abstract

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