Journal of Pharmaceutical Sciences 1991-Apr
Cytotoxic principles of Securinega virosa: virosecurinine and viroallosecurinine and related derivatives.
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Keywords
Abstract
Virosecurinine (1) and viroallosecurinine (2) were isolated as two cytotoxic alkaloids from the leaves of Securinega virosa. A comparison of the cytotoxicity of 1 and several of its derivatives indicates that an alpha,beta- and a gamma,delta-unsaturated lactone located in a strained ring system, such as rings -B, -C, and -D of 1, is structurally required for significant cytotoxicity.