Postgraduate Medical Journal 2004-Jun
Dramatic levodopa responsiveness of dystonia in a sporadic case of spinocerebellar ataxia type 3.
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Keywords
Abstract
A genetically confirmed case of spinocerebellar ataxia type 3 (SCA 3), presenting with disabling foot dystonia, peripheral neuropathy, and minimal cerebellar signs is reported. The dystonia improved dramatically with levodopa treatment in the absence of additional parkinsonian feature. A trial of levodopa for dystonia in SCA 3 may be of therapeutic benefit, at least in the initial stage of the disease.