[Effect of hypoxic hypercapnia on expression of COX-2 mRNA in pulmonary arterioles].
Keywords
Abstract
OBJECTIVE
To study the effect of chronic hypoxic hypercapnia on expression of COX-2 mRNA in pulmonary arterioles.
METHODS
SD rats were randomly divided into two groups: control group and hypoxic hypercapnic group. COX-2 mRNA was observed in pulmonary arterioles by the technique of in situ hybridization.
RESULTS
mPAP, weight ratio of right ventricle (RV) to left ventricle plus septum (LV + S) and COX-2 mRNA in pulmonary arterioles were much higher in rats of hypoxic hypercapnic group than those of control group. Light microscopy showed that vessel smooth muscle cell hypertrophy and vessel cavity straightness were found in hypoxic hypercapnic group.
CONCLUSIONS
Changes of expressions of COX-2 mRNA may regulate hypoxic hypercapnic pulmonary hypertension.
