Journal of Pediatrics 2004-Mar
Effect of ibuprofen on bilirubin-albumin binding.
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Keywords
Abstract
Ibuprofen is used for closing the ductus arteriosus in premature newborn infants. Ibuprofen interferes with bilirubin-albumin binding and increases the unbound bilirubin in pooled newborn plasma to levels similar to those produced by sulfisoxazole, a drug that causes kernicterus in premature newborn infants.