Lymphangiosarcoma of the scalp.
Keywords
Abstract
BACKGROUND
Lymphangiosarcoma is a rare, aggressive malignancy that originates from the endothelial cells lining lymphatic vessels and carries an extremely poor prognosis. Its clinical and histologic features are often indistinguishable from angiosarcoma.
OBJECTIVE
We sought to better characterize the clinical and histologic features of lymphangiosarcoma.
METHODS
Case report and review of the literature.
RESULTS
A number of immunohistochemical markers, including Von Willebrand factor, Ulex europaeus agglutinin 1, CD31, VEGFR-3, D2-40, Prox-1, can be used to help differentiate lymphatic from vascular tissue.
CONCLUSIONS
Recent characterization of several new biologic markers has allowed greater differentiation between these tumors and may provide new therapeutic targets for treatment.
