European Journal of Pharmacology 1978-Oct
Nucleus accumbens lesions reduce amphetamine hyperthermia but not hyperactivity.
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Abstract
Electrolytic lesions of the nucleus accumbens were found to produce an increase in spontaneous locomotion; additionally, these lesions attenuated the hyperthermic, but not the hyperkinetic, actions of d-amphetamine. These results suggest that while dopamine release from the mesolimbic system may underlie amphetamine-induced hyperthermia, other structures must also be involved in amphetamine-induced hypermotility.