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Journal of Clinical Psychopharmacology 2008-Apr

Photo-onycholysis caused by olanzapine and aripiprazole.

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Stamatis Gregoriou
Theodora Karagiorga
Alexander Stratigos
Kyriakos Volonakis
George Kontochristopoulos
Dimitris Rigopoulos

Keywords

Abstract

Photo-onycholysis associated with drugs is an uncommon disorder. We report the case of a woman who developed photo-onycholysis on multiple nails after uptake of olanzapine. Substitution of olanzapine with aripiprazole further exacerbated the problem. The possible mechanisms of photo-onycholysis development by modern atypical antipsychotics, modulating dopamine receptors, are discussed.

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