Infection and Immunity 2004-Jan
Protection against anthrax toxemia by hexa-D-arginine in vitro and in vivo.
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Keywords
Abstract
The anthrax toxin protective antigen precursor is activated by proteolytic cleavage by furin or a furin-like protease. We present here data demonstrating that the small stable furin inhibitor hexa-D-arginine amide delays anthrax toxin-induced toxemia both in cells and in live animals, suggesting that furin inhibition may represent a reasonable avenue for therapeutic intervention in anthrax.