Rearranged neoclerodane diterpenoids from the aerial parts of Salvia hispanica L

Six new rearranged neoclerodane diterpenoids (1-6), as well as three known ones, were obtained from the aerial part of Salvia hispanica L. Their structures were elucidated by extensive analysis of spectroscopic data (1D, 2D NMR, and HRESIMS) and Mosher's method. The absolute configurations of 1, 2, and 4 were determined by single-crystal X-ray diffraction analysis. All isolated compounds were evaluated for their cardioprotective effects against H₂O₂-induced cardiomyocytes injury, and compound 5 showed statistically significant cardioprotective effect in vitro assays.

Keywords: Cardioprotective effects; Neo-clerodane diterpenoids; Salvia hispanica L..