aloperine/sophora flavescens

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In vitro anti-tumour activities of quinolizidine alkaloids derived from Sophora flavescens Ait.

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The dry root of Sophora flavescens Ait. (SF) has long been used in a variety of Chinese herbal formulations to treat patients with cancer. Alkaloids are commonly known to present in SF as main active constituents. Here, we report that among the six characterized SF-derived quinolizidine alkaloids

Liquid chromatography of active principles in Sophora flavescens root.

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Herbal medicines were one of the major resources for healthcare in earlier stages, and some traditional herbal medicines have been in use for more than 2000 years. Currently, they are attracting more and more attention of the modern pharmaceutical industry, as scientists has become aware that herbs

[Constituents in the alkaloid fraction of Kushen decoction].

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OBJECTIVE To study the chemical constituents of the alkaloid fraction of Kushen decoction. METHODS Constituents were isolated by different kinds of column chromatography and their structures were elucidated with spectral methods. RESULTS Eight compounds were isolated and identified as matrine (I),

Determination of quinolizidine alkaloids in traditional Chinese herbal drugs by nonaqueous capillary electrophoresis.

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A rapid method for the determination of quinolizidine alkaloids by nonaqueous capillary electrophoresis was developed. A total of 10 alkaloids (matrine, sophocarpine, oxymatrine, oxysophocarpine, sophoridine, cytisine, sophoramine, aloperine, lehmannine and dauricine) could be easily separated

KCNQ5 activation is a unifying molecular mechanism shared by genetically and culturally diverse botanical hypotensive folk medicines.

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Botanical folk medicines have been used throughout human history to treat common disorders such as hypertension, often with unknown underlying mechanisms. Here, we discovered that hypotensive folk medicines from a genetically diverse range of plant species each selectively activated the

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