Fifty-three patients with cluster headache, mean age 42.6 years, were examined by means of pupillometry. Pharmacological stimulation was carried out by the instillation of eye drops; the sympathomimetic agents hydroxyamphetamine (a norepinephrine releaser) and phenylephrine (an agent acting directly
Local pharmacological manipulations of both pupils in persons with cluster headache (CH) have shown a reduced pain-side sympathetic activity. It is difficult to determine if this sympathetic defect is localized in the nuclei of the CNS and/or in peripheral neurons that innervate the pupil. This
Acute non-traumatic headaches with neurological deficits alarm emergency department (ED) physicians. Typically, a sudden headache with oculomotor nerve palsy involving a pupil indicates the possibility of a subarachnoid hemorrhage (SAH) due to an aneurysm originating from the posterior communicating
A 42-year-old woman presents with headache and anisocoria. Gonioscopy suggested narrow angles. Ultrasound biomicroscopy confirmed the diagnosis. The patient underwent bilateral peripheral iridotomies with resolution of her symptoms. The differential diagnosis of headache and anisocoria are reviewed.
Headaches are common and are a frequent reason to seek medical attention. The general practitioner is often confronted with this problem and has to decide which investigations are to be ordered. Simple but careful history and examination are mandatory as the presence of a red eye, exophthalmos,
BACKGROUND
ITP can give rise to bleeding episodes in different parts of the body including the central nervous system with various systemic manifestations.
METHODS
An eight-year old female child, diagnosed as a case of chronic ITP for last two years, developed intense headache and vomiting for a few
Tyramine pupillometry was performed in 27 cluster headache patients and in 45 healthy controls. Asymmetry variables, i.e. symptomatic(S)-nonsymptomatic(NS) side diameter difference and the ratios (S/NS, log NS/S or S/S+NS) displayed higher sensitivities than variables which express the function of
The case of a patient suffering from strictly unilateral continuous headache, absolutely responsive to indomethacin is reported. This is the first Hemicrania continua case to be documented in Spain. The tyramine test resulted in anisocoria with the smaller pupil on the symptomatic side. A second
Various autonomic parameters have been studied in two patients with "hemicrania continua", a newly described unilateral headache which is aborted by indomethacin. Striking findings were made on pupillometry: In both patients, isocoria was present when untreated. Bilateral instillation of tyramine in
For seventeen years, a young man suffered from headaches of one to three days duration occurring once every six or seven days and totally disappearing between episodes. These were strictly unilateral (always on the left side), and were absolutely responsive to indomethacin. They differ clinically
Eleven female patients with cervicogenic headache (mean age, 43 years; range, 25-59 years) have been examined with the pupillometer. The pupillary diameter was examined in the basal state (that is, the status before pharmacologic stimulation) and after topically administered tyramine (2%),
A 50-year-old white Caucasian woman with previously diagnosed migraine was admitted with unilateral headache and anisocoria. An initial assessment revealed no cause for this abnormality and she was thought to have mydriasis in the context of migraine. However, failure of her symptoms and signs to
Pupillary autonomic dysfunction and right-left differences were investigated in muscle contraction headache (MCH) and migraine, by means of biocular infrared videopupillography (biocular Iriscorder). The study was performed on 36 patients with MCH or migraine and on 23 healthy controls. The
A case of an 11-year-old boy with recurrent migraine auras without headache is reported. Aura was preceded by an anisocoria and was characterized, besides other brain-stem signs, by confusional state. Ictal EEG recordings showed fast activity. Recognition of this finding may prevent an inappropriate
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