anticancer/vomiting

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Method for the management of cancer and cancer treatment-related comorbidities

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TECHNICAL FIELD The invention concerns a method for the management of cancer and treatment cancer comorbidities, including but not limited to cancer-related fatigue, cachexia, anorexia, pain, anemia, asthenia, depression, impaired cognitive function, loss of appetite, muscle weakness, nausea,

Macrocyclic antagonists of the motilin receptor for treatment of gastrointestinal dysmotility disorders

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FIELD OF THE INVENTION The present invention relates to novel conformationally-defined macrocyclic compounds that bind to and/or are functional modulators of the motilin receptor including subtypes, isoforms and/or variants thereof. These macrocyclic compounds possess appropriate pharmacological

Ondansetron sublingual spray formulation

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FIELD OF THE INVENTION The invention is directed to sublingual spray formulations containing ondansetron or a pharmaceutically acceptable salt thereof. The invention is further directed to method for treating or preventing nausea and emesis associated with cancer treatments by administering

Imidazolyl benzisoquinolines useful as 5-HT.sub.3 receptor antagonists

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SUMMARY The present invention relates to novel benzisoquinoline derivatives. More particularly, the present invention relates to: i) A benzisoquinoline derivative of the formula: ##STR2## (wherein all of the symbols have the same meaning as defined hereafter) and non-toxic acid addition salts and

Supermolecular carboplatin derivatives, their preparation and pharmaceutical composition containing them as active ingredient and applications of the compositions

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CROSS REFERENCE TO RELATED APPLICATIONS This application is a 371 filing of PCT/CN01/01595 filed Nov. 30, 2001, which is herein incorporated by reference in its entirety. TECHNICAL FIELD The present invention relates to a novel class of supermolecular carboplatin derivatives, the preparation of such

Process for the preparation of 1,5--carboxylic acid derivatives

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FIELD OF THE INVENTION The present invention relates generally to processes for the preparation of pharmaceutical compounds and compositions useful in the treatment of disorders and diseases of the central nervous system (CNS). More specifically, the present invention relates to the preparation of

Heterocyclic carboxylic acid amides and esters of azabicyclic compounds as gastric prokinetic, antiemetic, anxiolytic and antiarrhythmic agents

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BACKGROUND OF THE INVENTION 1. Field of Invention Novel 5-aminomethyl- and 5-hydroxymethyl-1-azabicyclo[3.2.1]octanes and 5-aminomethyl- and 5-hydroxymethyl-1-azabicyclo[3.3.1]nonanes are coupled with aryl carboxylic acids to obtain the corresponding amides and esters. These novel amides and esters,

Carbocyclic carboxylic acid amides and esters of azabicyclic compounds as gastric prokinetic, antiemetic, anxiolytic and antiarrhythmic agents

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BACKGROUND OF THE INVENTION 1. Field of Invention Novel 5-aminomethyl- and 5-hydroxymethyl-1-azabicyclo[3.2.1]octanes and 5-aminomethyl-and 5 -hydroxymethyl-1-azabicyclo[3.3.1]nonanes are coupled with aryl carboxylic acids to obtain the corresponding amides and esters. These novel amides and esters,

Cinnoline-3-carboxylic acid derivatives

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FIELD OF THE INVENTION This invention relates to a cinnoline derivative which is pharmaceutically useful as an antagonist against serotonin 5-HT.sub.3 receptor, its pharmaceutically acceptable salts, its N-oxide derivatives or solvates thereof, and pharmaceutical compositions containing the

Cinnoline-3-carboxylic acid derivatives

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