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Page 1 from 66 results
Objective Examination and Rehabilitation Treatment of Patients With BPPV
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Efficacy Of Oral Trehalose In Spinocerebellar Ataxia 3
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Spinocerebellar ataxia 3 (SCA3) is a rare form of inherited neurodegenerative disease involving progressive degeneration of spinocerebellar tract. SCA3 is characterised by increasingly worsening cerebellar function leading to gait abnormalities and poor coordination, dysarthria, and abnormal eye
Integrated Functional Evaluation of the Cerebellum
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Spinocerebellar ataxias (SCAs) are autosomal dominantly inherited neurological disorders, characterized by a predominant atrophy of the cerebellum and the brainstem. The most common forms are caused by abnormal CAG repeat expansions, encoding elongated polyglutamine (polyQ).
Nowadays, no preventive
Safety and Efficacy of Etravirine in Friedreich Ataxia Patients
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Friedreich ataxia is a rare progressive neurodegenerative disease presenting in childhood or late adolescence for which no treatment is currently available. The disease is caused by the defective synthesis of Frataxin, a mitochondrial protein synthesized by the FXN gene. Over 95% of patients carry a
The Effect of Hericium Erinaceus Mycelium in Non-motor Symptoms of Parkinson's Disease
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Inclusion criteria:
1. PD patients aged 50-79 years diagnosed by neurologist (should exclude vascular parkinsonism, secondary parkinsonism( including toxin, drug, heavy metal, CO intoxication), normal pressure hydrocephalus, multiple system atrophy, progressive supranuclear palsy, cortical basal
Cerebello-Spinal tDCS as Rehabilitative Intervention in Neurodegenerative Ataxia
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Neurodegenerative cerebellar ataxias represent a heterogeneous group of disabling disorders in which progressive ataxia of gait, limb dysmetria, oculomotor deficits, dysarthria and kinetic tremor are the prominent clinical manifestations. Both the hereditary and sporadic forms usually present in
C-Trelin Orally Disintegrated(OD) Tablet 5mg in Ataxia Due to Spinocerebellar Degeneration
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Taltirelin Hydrate, an active substance of C-Trelin OD tablet 5mg, is an analogue of Thyrotropin Releasing Hormone(TRH). TRH is distributed widely in the brain, and exerts variety of central nervous system effects as well as endocrine activity such as releasing of Thyroid Stimulating Hormone(TSH)
tDCS for Multiple System Atrophy With Cerebellar Feature
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Participants receive transcranial direct current stimulation (tDCS) over M1, cerebellar cortex or sham stimulation for 30 minutes. The type of stimulation depends on random assignment. The participants have a 1 week of wash out period between each stimulation.
The assessment will be done by
A Trial of Non-invasive Stimulation in Cervical Dystonia
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Cervical dystonia (CD) is the most common adult onset dystonia. Abnormal sensorimotor integration and maladaptive plasticity have been proposed as possible mechanisms. Currently, there is no definite way to assess and modify this dysfunctional network. Deep brain stimulation (DBS) is one possible
Hyperbaric Oxygen for Carbon Monoxide Induced Chronic Encephalopathy
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1. Project title Hyperbaric Oxygen for Carbon Monoxide induced Chronic Encephalopathy
2. Principle investigator(s) Jeffrey Cooper, MD Diego Torres-Russo, MD
3. Participating institution(s) UNMC, Departments of Emergency Medicine and Neurology
4. Study aims, hypotheses, methods (brief overview of
A Single Dose Pharmaco-Diagnostic for Peripheral Nerve Continuity After Trauma
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This proposal contains two distinct aims to be investigated in two similar but distinct groups of patients.
Aim 1: To examine the mechanistic effect of 4AP on the return of sensorimotor function and EDX sensitivity in the setting of nerve dysfunction from orthopaedic trauma. This aim tests the
The Role of Cerebellum in Speech
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This study will investigate the role of the cerebellum in speech, building upon prior work in understanding cerebellar function in reaching and walking. Neuroimaging and lesion studies have provided strong evidence that the cerebellum is an integral part of the speech production network, though its
The Natural History of Familial Dysautonomia
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Define the phenotypic characteristics, severity and clinical evolution of FD on a patient-by patient basis. Investigators will enroll patients with FD in a multi-center observational natural history study to evaluate their biochemical, neurological and autonomic phenotype. Investigators will follow
Tllsh2910 for Ataxia and Gut Microbiota Alteration in Patients of Multiple System Atrophy
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Open Trail of γIFN for Friedreich Ataxia
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Friedreich ataxia (FRDA) is a devastating neurodegenerative disease that affects children and young adults. Patients become progressively unable to coordinate movements and walking until severe disability ensues. Most patients develop dilated cardiomyopathy and congestive heart failure. The disease
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