ataxia/inflammation

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Method for treating spinocerebellar ataxias

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CROSS REFERENCE TO RELATED APPLICATION This application claims the benefits of the Taiwan Patent Application Serial Number 104121047, filed on Jun. 30, 2015, the subject matter of which is incorporated herein by reference. BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention

Human I.kappa.B-.beta.

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FIELD OF INVENTION This invention relates to newly identified polynucleotides, polypeptides encoded by them and to the use of such polynucleotides and polypeptides, and to their production. More particularly, the polynucleotides and polypeptides of the present invention relate to the I.kappa.B

Inhibitors of transcription factor-NF-.kappa.B

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FIELD OF THE INVENTION This invention relates in general to salicylanilide inhibitors of transcription factor NF-.kappa.B. Such compounds are particularly useful for treating diseases in which activation of NF-.kappa.B is implicated. More specifically, these compounds inhibit I.kappa.B

Squaric acid derivatives as inhibitors of the nicotinamide

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FIELD OF THE INVENTION This invention relates to squaric acid derivatives, and in particular derivatives of 3,4-diamino-cyclobut-3-ene-1,2-dione which are useful for the inhibiting of the enzyme nicotinamide phosphoribosyltransferase (NAMPRT), and to medical use of such squaric acid

Urea and thiourea derivatives

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FIELD OF THE INVENTION This invention relates to urea and thiourea derivatives, which are useful for the inhibiting of the enzyme nicotinamide phosphoribosyltransferase (NAMPRT), and to medical use of such derivatives. BACKGROUND OF THE INVENTION Inhibition of the enzyme nicotinamide

Method and compositions for treating diseases mediated by transglutaminase activity

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FIELD OF INVENTION The present invention is directed to methods and compositions for treating diseases mediated by transglutaminase activity, by inhibiting the activity of transglutaminase. BACKGROUND OF THE INVENTION Protein cross-linking resulting in the formation of aggregates is a common feature

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