breast neoplasms/phosphatase

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Method of treatment of breast cancers over-expressing the SHP2 signature genes

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FIELD OF THE INVENTION The present invention relates to methods for treating cancer. BACKGROUND OF THE INVENTION Each year 1.1 million new cases of breast cancer occur among women worldwide and 400,000 women will die from this disease (www.uicc.org, www.who.int). Although progress has been made in

DEP-1 receptor protein tyrosine phosphatase interacting proteins and related methods

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BACKGROUND OF THE INVENTION 1. Field of the Invention The present invention relates generally to biomolecules that mediate biological signal transduction in cells, which signals are communicated by phosphorylation and dephosphorylation of cellular proteins for processes such as cellular

Therapeutic compositions and methods useful in modulating protein tyrosine phosphatases

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BACKGROUND OF THE INVENTION Intercellular protein tyrosine phosphorylation is regulated by extracellular stimuli, such as cytokines, to control cell growth, differentiation and functional activities. This signaling mechanism depends on the interplay of protein tyrosine kinases, which initiate

Therapeutic compositions and methods useful in modulating protein tyrosine phosphatases

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ARID1A and PPP2R1A mutations in cancer

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This application incorporates by reference the contents of a 200 kb text file created on Apr. 19, 2013 and named "13819933sequencelisting.txt," which is the sequence listing for this application. Each reference cited in this disclosure is incorporated herein by reference in its entirety. BRIEF

Methods, compositions and kits for high throughput kinase activity screening using mass spectrometry and stable isotopes

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TECHNICAL FIELD The invention relates to compositions, kits and methods for diagnosis, research and prognosis of cancer and other conditions, by analyzing the entire kinome of cells and tissues. BACKGROUND Most cellular signaling pathways are regulated by post-translational modification of proteins,

Substituted 1,2,3,4-tetrahydroisoquinoline derivatives for the treatment of hormone-dependent diseases

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FIELD OF THE INVENTION The invention relates generally to compounds for the treatment of medical conditions involving hormones. More specifically, the invention relates to compounds, their preparation and their use in the treatment of hormone-dependent diseases including hormone-dependent cancers. A

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