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breast neoplasms/tyrosine
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Tyrosine kinase receptor antagonists and methods of treatment for breast cancer
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BACKGROUND OF THE INVENTION
Many tumor cells depend on the activity of tyrosine kinases, which act, among other functions, to depress apoptosis in the cell. The tyrosine kinases are usually overproduced in malignant cells, which contributes to the cell's ability to resist apoptosis. Modulating the
Method of treatment of breast cancers over-expressing the SHP2 signature genes
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FIELD OF THE INVENTION
The present invention relates to methods for treating cancer.
BACKGROUND OF THE INVENTION
Each year 1.1 million new cases of breast cancer occur among women worldwide and 400,000 women will die from this disease (www.uicc.org, www.who.int). Although progress has been made in
Methods of using EPHA2 for predicting activity of compounds that interact with and/or modulate protein tyrosine kinases and/or protein tyrosine kinase pathways in breast cells
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FIELD OF THE INVENTION
The present invention relates generally to the field of pharmacogenomics, and more specifically to new and alternative methods and procedures to determine drug sensitivity in patients, and particularly in patients with breast cancer. This invention allows the development of
Tyrosine-phosphorylated WBP2, a novel cancer target and biomarker
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CROSS-REFERENCE TO RELATED APPLICATION
This application is a national stage filing under 35 U.S.C. .sctn.371 of international application PCT/SG2011/000293, filed Aug. 25, 2011, which was published under PCT Article 21(2) in English, and claims the benefit of Singapore Patent Application No.
Antibodies to HER4, human receptor tyrosine kinase
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1. INTRODUCTION
The present invention is generally directed to a novel receptor tyrosine kinase related to the epidermal growth factor receptor, termed HER4/p180.sup.erbB4 ("HER4"), and to novel diagnostic and therapeutic compositions comprising HER4-derived or HER4-related biological components.
Altered intracellular localization of BRK/Sik protein tyrosine kinase in human prostate tumors
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FIELD OF THE INVENTION
The invention relates to methods for detecting an abnormal prostate condition in an animal. Specifically, the invention relates to methods of detecting an abnormal prostate condition in an animal by detecting the amount of Breast Tumor Kinase (BRK) protein present in the
Inhibitors of the EGF-receptor tyrosine kinase and methods for their use
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The excellent technical assistance of Suzy Downes and Ellse Sudbeck in the studies related to this invention is gratefully acknowledged.
BACKGROUND OF THE INVENTION
Breast cancer is the most common form of malignancy in women, representing 32% of all new cancer cases and causing 18% of the cancer
Inhibitors of the EGF-receptor tyrosine kinase and methods for their use
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BACKGROUND OF THE INVENTION
Breast cancer is the most common form of malignancy in women, representing 32% of all new cancer cases and causing 18% of the cancer related deaths among women in the USA. Although the majority of patients with metastatic breast cancer will experience an initial response,
Long-acting oxytocin analogues for the treatment and prevention of breast cancer and psychiatric disorders
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BACKGROUND OF THE INVENTION
Breast cancer is the most common form of cancer in women, resulting in approximately 180,000 new cancer cases annually and causing 18% of cancer-related deaths of women in the United States. It is the second leading cause of cancer-related deaths in humans. Despite recent
Bruton's tyrosine kinase as anti-cancer drug target
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FIELD
Embodiments of the invention find application in the field of cancer therapy.
BACKGROUND
Protein tyrosine kinases (PTKs) mediate the reversible process of tyrosine phosphorylation, providing the signals that activate or block signal transduction pathways that govern cell survival decisions and
Bruton's tyrosine kinase as anti-cancer drug target
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FIELD
Embodiments of the invention find application in the field of cancer therapy.
BACKGROUND
Protein tyrosine kinases (PTKs) mediate the reversible process of tyrosine phosphorylation, providing the signals that activate or block signal transduction pathways that govern cell survival decisions and
Bruton's tyrosine kinase as anti-cancer drug target
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FIELD
Embodiments of the invention find application in the field of cancer therapy.
BACKGROUND
Protein tyrosine kinases (PTKs) mediate the reversible process of tyrosine phosphorylation, providing the signals that activate or block signal transduction pathways that govern cell survival decisions and
Therapeutic compositions and methods useful in modulating protein tyrosine phosphatases
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BACKGROUND OF THE INVENTION
Intercellular protein tyrosine phosphorylation is regulated by extracellular stimuli, such as cytokines, to control cell growth, differentiation and functional activities. This signaling mechanism depends on the interplay of protein tyrosine kinases, which initiate
Therapeutic compositions and methods useful in modulating protein tyrosine phosphatases
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BACKGROUND OF THE INVENTION
Intercellular protein tyrosine phosphorylation is regulated by extracellular stimuli, such as cytokines, to control cell growth, differentiation and functional activities. This signaling mechanism depends on the interplay of protein tyrosine kinases, which initiate
DEP-1 receptor protein tyrosine phosphatase interacting proteins and related methods
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BACKGROUND OF THE INVENTION
1. Field of the Invention
The present invention relates generally to biomolecules that mediate biological signal transduction in cells, which signals are communicated by phosphorylation and dephosphorylation of cellular proteins for processes such as cellular
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