butyl acetate/atrophy

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Evaluation of subchronic toxicity of n-butyl acetate vapor.

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The subchronic toxicity of n-butyl acetate (nBA), a common industrial solvent, was tested in rats in a 13-week inhalation study. Male and female Sprague-Dawley (SD) rats were exposed to concentrations of 0, 500, 1500 or 3000 ppm nBA for 6 h per day, 5 days per week for 13 consecutive weeks.

Renal polycystosis in the rat induced by prednisolone tertiary butyl acetate.

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A single i.m. injection of 66 mg/kg prednisolone tertiary butyl acetate given on the 1st day of life produced glomerular degeneration and collecting duct and proximal tubule cysts in rat kidneys. There was evidence of delayed nephrogenesis leading to persistance of the neogenic zone.

Psychological test performance during experimental challenge to toluene and n-butyl acetate in cases of solvent-induced toxic encephalopathy.

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OBJECTIVE This study determined whether performance in neurobehavioral tests deteriorates during subjectively annoying chemical challenge below known neurotoxic thresholds among persons with toxic encephalopathy with subjective hypersensitivity to chemicals. METHODS Subjects with symptoms and

Degeneration and regeneration of the olfactory epithelium after olfactory bulb ablation in the pig: a morphological and electrophysiological study.

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The olfactory bulbs were removed surgically from Large White male and female pigs, 10--12 weeks of age. At intervals of 3, 7, 14, 42 and 84 d after bulbectomy, the pigs were sacrificed and portions of olfactory mucosa were removed from the ethmoturbinate and septum regions of the nasal cavity;

Comparative toxicity of two-dexamethasone derivatives following topical ocular instillation to rabbits. II. Systemic histopathological changes.

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Dexamethasone-21-tertiary butyl acetate (dexamethasone TBA) and dexamethasone alcohol at concentrations of 0.2, 0.1, 0.01, and 0.001% were topically instilled into the right eyes of groups of 10 rabbits for 21 consecutive days. Vehicle control and untreated control groups were used for comparative

Spray drying from organic solvents to prepare nanoporous/nanoparticulate microparticles of protein: excipient composites designed for oral inhalation.

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OBJECTIVE The aim of this study was to determine if spray-drying could successfully produce microparticles containing the model protein trypsin in a form suitable for inhalation. METHODS Trypsin was spray-dried with raffinose from a methanol : n-butyl acetate solvent system (MeOH : BA). The solvent

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