cyanocobalamin/neoplasms

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[Influence of methylcobalamin and cyanocobalamin on the neoplastic process in rats].

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The effect of methylcobalamine (5.6-dimethylbenzimidazolyl-Co-methylcobamide, CH3-B12) and cyanocobalamine (5,6-dimethylbenzimidazolyly-Co-cyanocobamide, CN-B12) on the growth of Walker's carcinosarcoma and longevity of white noninbred rats with implanted Zajdela ascites hepatoma was studied. The

Vitamin B12-mediated transport: a potential tool for tumor targeting of antineoplastic drugs and imaging agents.

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The uptake of vitamin B12 (cyanocobalamin, Cbl/VB12) in mammalian cells is mediated by specific, high-affinity receptors for the vitamin B12-binding protein, transcobalamin II, which is expressed on the plasma membrane. The receptor for vitamin B12 is overexpressed on a number of human tumors,

The reaction of HOCl and cyanocobalamin: corrin destruction and the liberation of cyanogen chloride.

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Overproduction of hypochlorous acid (HOCl) has been associated with the development of a variety of disorders such as inflammation, heart disease, pulmonary fibrosis, and cancer through its ability to modify various biomolecules. HOCl is a potent oxidant generated by the myeloperoxidase-hydrogen

Influence of cobalamin on the survival of mice bearing ascites tumor.

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The effect of cobalamin (vitamin B12) on the survival time of mice bearing P388 leukemia has been examined. Among the three cobalamins studied, the enzymatically active derivatives, methylcobalamin and 5'-deoxyadenosylcobalamin, were able to significantly increase the survival time of mice implanted

Tumor-host metabolic relationships: total levels and chromatographic pattern of vitamin B12 in serum, liver and tumor of Yoshida sarcoma-bearing rats.

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Total content of cobalamins was estimated by an isotopic dilution technique in serum and liver of Yoshida sarcoma-bearing rats and in a group of control rats. Total levels of vitamin B12 were also measured in neoplastic tissue. Hydroxycobalamin, adenosylcobalamin, cyanocobalamin and methylcobalamin,

[Effect of cyanocobalamin, cobamide coenzyme and the cytostatic hispen on changes in cobalamin levels in healthy rats and rats with transplanted sarcoma M-1].

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The influence of cyanocobalamine (CN-B12), cobamide coenzyme (5'-deoxyadenosyl-B12, DBC) and the cytostatic hisphen on the level of cobalamines in the blood serum, liver, kidney, heart and in the tumor of healthy and sarcoma M-1 implanted rats was studied. In the above organs and tissues cobalamines

Transcobalamin II receptor imaging via radiolabeled diethylene-triaminepentaacetate cobalamin analogs.

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Rapidly dividing cells up-regulate the number of transcobalamin II receptors during DNA replication. We have developed diethylene-triaminepentaacetate (DTPA) cobalamin analogs for the purpose of imaging transcobalamin II receptors in malignant and nonmalignant tissue. METHODS Methyl-, adenosyl- and

Synthesis and characterization of nido-carborane-cobalamin conjugates.

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Three vitamin B12 (cyanocobalamin) conjugates bearing one nido-carborane molecule or two nido-carborane molecules linked to the propionamide side chains via a four carbon linker have been synthesized. Reaction of o-carboranoylchloride with 1,4-diaminobutane in pyridine produced

Slow-targeted release of a ruthenium anticancer agent from vitamin B12 functionalized marine diatom microalgae.

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Herein we report the synthesis of a new biomaterial designed for targeted delivery of poorly water-soluble inorganic anticancer drugs, with a focus on colorectal cancer. Diatomaceous earth microparticles derived from marine microalgae were coated with vitamin B12 (cyanocobalamin) as a tumor

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