diplopia/seizures

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Lacosamide: a review of its use as adjunctive therapy in the management of partial-onset seizures.

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Lacosamide (Vimpat(®)) is a functionalized amino acid available orally (as a syrup or tablet) and as an intravenous infusion. It is believed to exert its antiepileptic effect by selectively enhancing the slow inactivation of voltage-gated sodium channels. Lacosamide is approved in several countries

Lacosamide for the prevention of partial onset seizures in epileptic adults.

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Lacosamide is a newly registered antiepileptic drug with dual mechanisms of action. It selectively enhances slow inactivation of voltage-gated sodium channels, resulting in stabilization of hyperexcitable neuronal membranes and inhibition of repetitive neuronal firing. It also binds to a

Long-term adjunctive lacosamide treatment in patients with partial-onset seizures.

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OBJECTIVE To evaluate long-term (up to 5.5 years) safety, seizure reduction, and maintenance of efficacy of the antiepileptic drug (AED) lacosamide as adjunctive treatment in an open-label extension trial (SP774; ClinicalTrials.gov: NCT00515619). METHODS Three hundred and seventy-six adults with

Conversion from immediate-release to extended-release lamotrigine improves seizure control.

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BACKGROUND Immediate release lamotrigine (LTG-IR) dosing can be limited by peak toxicity. It is thought that peak levels are responsible for some adverse effects such as dizziness, blurred vision, double vision and unsteadiness. At the same time, trough levels may be associated with reduced seizure

Randomized, multicenter, dose-ranging trial of retigabine for partial-onset seizures.

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OBJECTIVE To evaluate the efficacy and safety of retigabine 600, 900, and 1,200 mg/day administered three times daily as adjunctive therapy in patients with partial-onset seizures. METHODS A multicenter, randomized, double-blind, placebo-controlled trial was performed. After an 8-week baseline

[Gabapentin used in 559 patients with partial seizures. A multicenter observation study. Spanish Gabapentin Work Group].

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BACKGROUND Gabapentin (GBP) is a new antiepileptic drug whose efficacy and tolerability have been evaluated in clinical trials, although there is little data on its use in everyday clinical practice. OBJECTIVE To evaluate the characteristics of GBP in an observational study when used in patients

Pilot study of fluzinamide (N-methyl-3-[3-(trifluoromethyl)phenoxy]-1-azetidinecarboxamide) in refractory partial seizures.

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We conducted a pilot study of fluzinamide in 15 adults with refractory partial seizures. After a baseline period, fluzinamide was added to the existing regimen of phenytoin and carbamazepine and increased to maximum tolerated dose. Common side effects included dizziness, diplopia, ataxia, headache,

Extended-release vinpocetine: a possible adjuvant treatment for focal onset epileptic seizures.

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Extended-release vinpocetine is effective to control focal onset epileptic seizures with a low rate of adverse events. A clinical study was performed to evaluate the efficacy and tolerability of vinpocetine as an adjuvant treatment in patients with this

Lamotrigine therapy for partial seizures: a multicenter, placebo-controlled, double-blind, cross-over trial.

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The efficacy and safety of lamotrigine (LTG), a new antiepileptic drug (AED), were evaluated in a multicenter, randomized, double-blind, placebo-controlled, cross-over study of 98 patients with refractory partial seizures. Each treatment period lasted 14 weeks. Most patients were titrated to a LTG

Acute comitant esotropia in a boy with head trauma and convulsions receiving carbamazepine.

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We examined an 11-year-old boy who complained of acute onset of diplopia. The patient had head trauma and postsurgical convulsions and had been treated with carbamazepine. Diplopia developed after the dose of carbamazepine was increased to 700 mg/day. On examination, comitant esotropia and lateral

Controlled trial of lamotrigine (Lamictal) for refractory partial seizures.

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The antiepileptic effect of lamotrigine (LTG) was assessed in a double-blind, placebo-controlled crossover trial in 24 adult patients with refractory partial seizures. LTG or placebo was added to existing antiepileptic drugs (AEDs). The dose of LTG varied from 75 to 400 mg daily. Three patients did

Cerebral venous sinus thrombosis presenting with diplopia in pregnancy: a case report.

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BACKGROUND Cerebral venous sinus thrombosis is a rare condition. The most frequent symptoms and signs are headache, focal seizures with or without secondary generalization, unilateral or bilateral paresis and papilledema. We report a case of transverse sinus and superior sagittal sinus thrombosis

Prospective analysis of diplopia after anterior temporal lobectomy for mesial temporal lobe sclerosis.

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OBJECTIVE In this prospective study the authors investigated the incidence and natural history of postoperative diplopia in patients undergoing anterior temporal lobectomy (ATL) and amygdalohippocampectomy for medically intractable mesial temporal lobe epilepsy. METHODS Forty-seven patients

Multiple sclerosis originating in childhood associated with seizures and hallucinations.

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Multiple sclerosis, is an idiopathic inflammatory disease of the central nervous system. Symptoms rarely begin before age 10 or after age 60.The presentation may vary from isolated motor or sensory impairment to seizures or psychotic disturbances. This case report presents a 7-year-old male who

Isolated diplopia associated with calcineurin inhibitor therapy in a patient with idiopathic membranous nephropathy: a case report.

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Neurotoxicity is a common side effect of treatment with calcineurin inhibitors. Tremors are frequently reported as the most common manifestation. Variable presentations can include headaches, seizures, visual hallucinations or blindness. Sixth nerve palsy has been reported in previous cases of bone

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