dysarthria/inflammation

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Evaluation of s100β, NSE and GFAP Levels in Renal Transplantation

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Encephalopathy, thiamine deficiency, uremia, hypertension, electrolyte imbalance after dialysis are clinical pictures with high incidences in case of renal failure. There are multifactor reasons in its pathophysiology such as hormonal imbalance, oxidative stress, accumulation of metabolites in time,

S100β and Neuron Specific Enolase Levels in Liver Transplantation

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Neurologic disorders that affect the liver transplantation candidates when they are on the waitlist not only significantly affect preoperative morbidity and even mortality but also present important predictive factors for post-op neurologic manifestations. Attentive neurological evaluation before

Prehospital Advanced Diagnostics and Treatment of Acute Stroke

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Treat-NASPP is a prospective controlled intervention study. The main aim of this study is to prospectively compare patients with ischemic stroke (IS) who are diagnosed and treated prehospitally in the MSU (intervention), with those who receive conventional pre- and inhospital diagnostics and

A Controlled Comparison of Two DBS Targets for Upper Extremity Action Tremor

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Tremor is defined as rhythmic and oscillating involuntary movements of a body part. Action tremor occurs when a body part is activated, and is clinically most frequently seen in Essential (idiopathic) Tremor (ET), with an overall prevalence of 0.9 %, and of 4.6 % in people over 65 years. But it can

PK Study of EXPAREL in Subjects Undergoing Open Spinal Fusion or Reconstructive Surgery

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This is a Phase 1, multi-center, open-label study designed to evaluate the safety and pharmacokinetics of EXPAREL when administered via local wound infiltration to subjects undergoing open cervical or thoracic spinal fusion or reconstructive surgery. Fifteen subjects are planned for enrollment.

Phase 4, Controlled Study in Adult Subjects Undergoing Primary, 1-2 Level, Open Lumbar Spinal Fusion Surgery

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This is a Phase 4, multicenter, randomized, double-blind, controlled study in approximately 220 adult subjects undergoing primary, 1-2 level, open lumbar spinal fusion surgery under general anesthesia. Subjects will be screened within 30 days prior to study drug administration and at least one day

Biomarker Validation for Niemann-Pick Disease, Type C: Safety and Efficacy of N-Acetyl Cysteine

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Niemann-Pick Disease, type C (NPC) is an autosomal recessive lysosomal storage disease with progressive neurodegeneration. It is characterized by intracellular accumulation of cholesterol and glycosphingolipids. The age of onset is variable with cases manifesting from infancy to adulthood.

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