echitamine/alstonia

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Development and validation of a new HPTLC-HRMS method for the quantification of a potent pancreatic lipase inhibitory lead Echitamine from Alstonia scholaris.

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Alstonia scholaris is an important indole alkaloid rich medicinal plant with diverse pharmacological activity. To understand the effect of extraction techniques, the stem bark sample of A. scholaris was subjected to continuous hot percolation, ultrasonic extraction, and cold maceration

Antitumor effect of echitamine chloride on methylcholonthrene induced fibrosarcoma in rats.

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Echitamine chloride a plant alkaloid from Alstonia scholaris has been used to examine the anticancer effects on methylcholanthrene-induced fibrosarcoma. Echitamine chloride dissolved in saline (10 mg/kg body weight) and injected subcutaneously for 20 days in fibrosarcoma rats has exhibited

Modulation of the impaired drug metabolism in sarcoma-180-bearing mice by echitamine chloride.

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Echitamine chloride (EC), an indole alkaloid, extracted from the bark of Alstonia scholaris has got highly promising anticancer effect. The effect of this drug on the microsomal drug detoxifying system was studied in sarcoma-180 induced mice. When given sub-cutaneously at a dosage of 5 mg/kg body

Inhibition of glycolysis and respiration of sarcoma-180 cells by echitamine chloride.

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Malignant tumors are known to exhibit high rates of glycolytic activity leading to high production of lactic acid. Hence, neoplastic cells have elevated activity of enzymes responsible for glycolysis. Echitamine chloride, an indole alkaloid extracted from the bark of Alstonia scholaris, has been

Alstonia scholaris Linn R Br in the treatment and prevention of cancer: past, present, and future.

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Alstonia scholaris, commonly known as devil's tree, is an important medicinal plant in the various folk and traditional systems of medicine in Asia, Australia, and Africa. The decoction, mostly prepared from the bark, is used to treat a variety of diseases of which the most important is malaria.

Indole Alkaloids from Alstonia angustifolia.

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From the stem bark of ALSTONIA ANGUSTIFOLIA, eleven alkaloids were isolated. Seven of them are known ones: echitamine ( 1), N(b)-demethylechitamine ( 2), pseudoakuammigine ( 3), tubotaiwine ( 5), akuammicine ( 6), N(b)-beta-methylantirhine ( 12), and N(b)-methylakuammidine ( 13). The four others,

In vitro and in vivo antiplasmodial activity of extracts and isolated constituents of Alstonia congensis root bark.

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An aqueous decoction of root bark of Alstonia congensis Engl. (Apocynaceae) is used in several African countries to treat various ailments including malaria.Extracts of different polarity and isolated constituents were tested in vitro for their

The effect of seasonal variation on the antineoplastic activity of Alstonia scholaris R. Br. in HeLa cells.

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In order to evaluate the seasonal variation as well as cytotoxicity of different fractions of Alstonia scholaris R. Br. (ASE), the HeLa cells were treated with different doses of various fractions of ASE collected in monsoon, winter and summer. The exposure of HeLa cells to different extracts

The evaluation of the acute toxicity and long term safety of hydroalcoholic extract of Sapthaparna (Alstonia scholaris) in mice and rats.

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The acute and sub-acute toxic effects of various doses of hydroalcoholic extract of Alstonia scholaris (ASE) was studied in mice and rats. The acute toxicity in mice depended on the season of collection of plant. The highest acute toxicity was observed in the ASE prepared from the summer collection

Alstonia species: are they effective in malaria treatment?

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A review of the literature on Alstonia species indicates that evidence in support of their effectiveness in the treatment of malaria is controversial. The antiprotozoal activity of the major alkaloid present in Alstonia species, echitamine, was assessed in vitro against Plasmodium falciparum and

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