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echitamine/fibrosarcoma

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Antitumor effect of echitamine chloride on methylcholonthrene induced fibrosarcoma in rats.

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Echitamine chloride a plant alkaloid from Alstonia scholaris has been used to examine the anticancer effects on methylcholanthrene-induced fibrosarcoma. Echitamine chloride dissolved in saline (10 mg/kg body weight) and injected subcutaneously for 20 days in fibrosarcoma rats has exhibited

Inhibition of glycolysis and respiration of sarcoma-180 cells by echitamine chloride.

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Malignant tumors are known to exhibit high rates of glycolytic activity leading to high production of lactic acid. Hence, neoplastic cells have elevated activity of enzymes responsible for glycolysis. Echitamine chloride, an indole alkaloid extracted from the bark of Alstonia scholaris, has been
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