epiglottitis/polysaccharide

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Efficacy of Haemophilus influenzae type b capsular polysaccharide vaccine on the incidence of epiglottitis and meningitis.

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48,997 children of 3 months to 5 years were vaccinated with Haemophilus influenzae type b (Hib) capsular polysaccharide vaccine in a double blind study carried out in Finland in 1974. A clear-cut effect was obtained in the incidence of epiglottitis. The number of patients decreased 58% for three

Effect of previous infection on antibody response of children to vaccination with capsular polysaccharide of Haemophilus influenzae Type b.

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Children who had recovered from meningitis, orbital cellulitis, or epiglottitis caused by Haemophilus influenzae type b were immunized with capsular polysaccharide vaccine derived from that bacterium; some healthy siblings and adults who had not had H. influenzae infections were also vaccinated. Of

Antibody response to capsular polysaccharides of groups A and C neisseria meningitidis and Haemophilus influenzae type b during bacteremic disease.

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Levels of antibodies to the capsular polysaccharides of groups A and C Neisseria meningitidis and Haemophilus influenzae type b were determined by radioimmunoassay in acute- and convalescent-phase sera of 377 patients with meningitis, septicemia, or epiglottitis. Diagnostic criteria, based on a

Response to immunization with Haemophilus influenzae type b polysaccharide-pertussis vaccine and risk of Haemophilus meningitis in children with the Km(1) immunoglobulin allotype.

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In experimental animals, immune responses to certain antigens are regulated by immunoglobulin allotype-linked genes. In an effort to detect such genes in humans, we examined the antibody responses of 74 healthy children with different Km(1) or Gm(23) allotypes to a Haemophilus influenzae type b

Incidence and prognosis of acute epiglottitis in children in a Swedish region.

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Acute epiglottitis, which is almost exclusively caused by Haemophilus influenzae type b, was studied retrospectively in children 0 to 15 years old in a defined region of southwest Sweden from 1971 through 1980; 211 patients with clinically well-documented acute epiglottitis were found. The

Recurrent acute epiglottitis in adults: defective antibody response.

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BACKGROUND Recurrent acute epiglottitis is uncommon in adults. In the medical literature, very little is known about the immune status of this population. OBJECTIVE To evaluate the immune system of a group of four adult patients with recurrent acute epiglottitis, in what represents the largest

Aetiology of acute epiglottitis in adults.

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In order to determine the aetiology of acute epiglottitis in adults, blood cultures, paired sera and a urine sample were obtained from 54 patients with fever and epiglottitis visualized by indirect laryngoscopy or by direct fibreoptic nasolaryngoscopy. Antibodies were determined against the capsular

Host factors and antibody response Haemophilus influenza type b meningitis and epiglottitis.

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Levels of antibody in serum after infection with Haemophilus influenza type b or challenge with polysaccharide vaccine are highly variable. Convalescent-phase serum antibody to the capsular polysaccharide of H. influenzae type b was measured in two groups of patients with pathophysiologically

Epiglottitis and Haemophilus influenzae immunization: the Pittsburgh experience--a five-year review.

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OBJECTIVE Current trends in the clinical presentation and management of children with epiglottitis at Children's Hospital of Pittsburgh were reviewed for the years 1988 to 1993. METHODS The medical records of all patients diagnosed as having epiglottitis between July 1988 and June 1993 at the

Serum and salivary antibody responses to non-capsular Haemophilus influenzae antigens in children with meningitis and epiglottitis.

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Serum IgG, IgA and IgM antibody and salivary IgA antibody concentrations to non-capsular Haemophilus influenzae antigens were measured in 13 children with H. influenzae type b meningitis and in 15 children with epiglottitis. Most had detectable serum IgG and IgM antibody at presentation but

Correlation between G2m(n) immunoglobulin allotype and human antibody response and susceptibility to polysaccharide encapsulated bacteria.

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To determine whether genetic factors influence the human antibody response to polysaccharides, we correlated Ig allotypes with the concentrations of antibody to 14 bacterial capsular antigens in 130 actively immunized Caucasian adults. The 88 individuals possessing G2m(n), an allotype antigen of

Acute epiglottitis: epidemiology and Streptococcus pneumoniae serotype distribution in adults.

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OBJECTIVE We studied the incidence and bacterial epidemiology of acute epiglottitis presenting in the first 16 years following the introduction of general childhood vaccination against Haemophilus influenzae type b. Our main objectives were to analyse (1) the incidence of Streptococcus pneumoniae

Capsule and fimbriae modulate the invasion of Haemophilus influenzae in a human blood-cerebrospinal fluid barrier model.

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The Gram-negative bacterium Haemophilus influenzae (H. influenzae) can commensally colonize the upper respiratory tract, but also cause life threatening disease including epiglottitis, sepsis and meningitis. The H. influenzae capsule protects the bacteria against both phagocytosis and opsonization.

Interactive effect of genes associated with immunoglobulin allotypes and HLA specificities on susceptibility to Haemophilus influenzae disease.

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Genes associated with immunoglobulin (Ig) allotype determinants are important in regulation of immune responses to bacterial polysaccharides. Furthermore, loci associated with Ig allotypes have been reported to interact with those associated with the major histocompatibility complex and affect

Risk factors for invasive Haemophilus influenzae disease among children 2-16 years of age in the vaccine era, Switzerland 1991-1993. The Swiss H. Influenzae Study Group.

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BACKGROUND Continued surveillance, and detailed investigation of direct and indirect effects of conjugated vaccines and risk factors for invasive H.influenzae serotype B (Hib) disease in the vaccine era are important. METHODS 143 cases with invasive disease between 1991 and 1993 aged 2-16 years were

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