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2 results
[Effects of intrathecal escin and clonidine in the treatment of neuropathic pain in rats].
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OBJECTIVE
To investigate the effects of intrathecal escin and clonidine, used alone or in combination, in the treatment of neuropathic pain in rats and the possible mechanism.
METHODS
Ninety-six male SD rats weighing 250-300 g were chronically implanted with lumbar intrathecal catheters. One week
Gabapentin decreases membrane calcium currents in injured as well as in control mammalian primary afferent neurons.
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OBJECTIVE
Neuropathic pain following injury to peripheral sensory neurons is a common clinical problem and frequently difficult to treat. Gabapentin (GBP), a novel anticonvulsant, has significant analgesic effects in clinical neuropathic states and in relevant preclinical models, but its mechanism
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