In recent years, hypersensitivity reactions to the Shuanghuanglian injection have attracted broad attention. However, the componential chief culprits inducing the reactions and the underlying mechanisms involved have not been completely defined. In this study, we used a combination of approaches
Temperature-sensitive and calcium-permeable transient receptor potential vanilloid 3 (TRPV3) channel abundantly expressed in the keratinocyte plays important functions in the skin physiology. Dysfunctional gain-of-function mutations of TRPV3 cause genetic Olmsted Syndrome (OS) characterized by
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