FIELD OF THE INVENTION
The present invention relates to transdermal devices and methods for controllable dispensing of a nutraceutical or an active substance such as a chemical substance, a medication, a drug, a stimulant or the like, to a human or other mammal for purposes of promoting longevity,
FIELD OF THE INVENTION
The present invention relates to transdermal devices and methods for controllable dispensing of a nutraceutical or an active substance such as a chemical substance, a medication, a drug, a stimulant or the like, to a human or other mammal for purposes of promoting longevity,
FIELD OF THE INVENTION
The present invention relates to transdermal devices and methods for controllable dispensing of a nutraceutical or an active substance such as a chemical substance, a medication, a drug, a stimulant or the like, to a human or other mammal for purposes of promoting longevity,
FIELD OF THE INVENTION
The present invention relates to transdermal devices and methods for controllable dispensing of a nutraceutical or an active substance such as a chemical substance, a medication, a drug, a stimulant or the like, to a human or other mammal for purposes of promoting longevity,
FIELD OF THE INVENTION
The present invention relates to transdermal devices and methods for controllable dispensing of a nutraceutical or an active substance such as a chemical substance, a medication, a drug, a stimulant or the like, to a human or other mammal for purposes of promoting longevity,
REFERENCE TO A "SEQUENCE LISTING," A TABLE, OR A COMPUTER PROGRAM LISTING APPENDIX SUBMITTED AS AN ASCII TEXT FILE
The Sequence Listing written in file 93331-853706_ST25.TXT, created on Oct. 26, 2012, 1,755 bytes, machine format IBM-PC, MS-Windows operating system, is hereby incorporated by
PRIORITY
The present application claims the benefit of Indian Provisional Patent Application No. 1857/CHE/2012 filed on 10 May 2012 and the International Application No. PCT/IB2013/051482 filed on 24 Feb. 2013, the entire disclosure of which is relied on for all purposes and is incorporated into
FIELD OF INVENTION
The present invention generally relates to the transdermal delivery of substances.
BACKGROUND
Local transdermal delivery of drugs, while desirable, is limited by current technologies. Few pharmaceutical entities have successfully been delivered transdermally in effective dosages.
BACKGROUND OF THE INVENTION
The disclosure generally relates to the compound (R)--N-(3-(7-methyl-1H-indazol-5-yl)-1-(4-(1-methylpiperidin-4-yl)piperaz- in-1-yl)-1-oxopropan-2-yl)-4-(2-oxo-1,2-dihydroquinolin-3-yl)piperidine-1-- carboxamide (Compound I or the compound of formula I), including
BACKGROUND
Manoalide is a compound isolated from a marine sponge [E. D. de Silva et al., Tetrahedron Letters 21:1611-1614 (1980)] which has anti-inflammatory, immunosuppressive and analgesic properties. Manoalide the structure of which is shown below, includes a 5-hydroxy-2(5H)-furanone moiety,
PRIORITY
The present application claims the benefit of Indian Provisional Patent Application No. 1838/CHE/2012 filed on 10 May 2012 and the International Application No. PCT/IB2013/050917 filed on 4 Feb. 2013, the entire disclosure of which is relied on for all purposes and is incorporated into this
CROSS-REFERENCE TO RELATED APPLICATIONS
This application is the National Stage of International Application No. PCT/GB2009/050033, filed on Jan. 16, 2009, which claims the priority date of United Kingdom Application No. 0800741.1, filed on Jan. 16, 2008 the contents of both being hereby incorporated
BACKGROUND OF THE INVENTION
1. Technical Field of the Invention
The present invention generally relates to a multi-parameter physiological conditioning method and apparatus, and particularly to an autogenic-feedback training exercise method for training people to gain better control of specific
TECHNICAL FIELD
The present invention relates to a pharmaceutical, particularly a novel 2-aminobenzamide derivative or a salt thereof useful as an inhibitor for the capsaicin receptor VR1 (Vanilloid Receptor 1) activation, and a pharmaceutical thereof.
BACKGROUND OF THE INVENTION
VR1 is a receptor
BRIEF SUMMARY
Embodiments of the present invention are directed toward novel compounds of the formula (I),
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and hydrates, solvates, enantiomers, diastereomers, pharmaceutically acceptable salts, prodrugs and complexes thereof, wherein:
X and Y are each independently CH and connected by a
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