hypercapnia/atrophy

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Diaphragm Training Ultrasound

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PRedictOrs, PHEnotypes and Timing of Obstructive Sleep Apnea in Acute Coronary Syndrome

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Obstructive Sleep Apnea (OSA) is a well-known disorder of upper airways collapse during sleep time leading to oxygen desaturation, sleep fragmentation, tissue suffering and hypercapnia. The repeated airways collapse leads to a fall of blood saturation levels during sleep time and it is linked to

Sildenafil Treatment for Mild TBI

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In this study, 100 professional boxers that experience a concussion will be enrolled, randomized to either placebo or sildenafil (60mg) drug treatment, and arterial spin labeling and BOLD-MRI with hypercapnia will used to assess CBF and CVR, respectively. Symptom reporting, blood biomarkers, and

The PROtective Ventilation Using Open Lung Approach Or Not Trial

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1. Sample size calculation, randomization and patients safety. The required sample size is calculated from previous studies on the incidence of postoperative pulmonary complications. A two group chi-square test with a 0.05 two-sided significance level will have 80% power to detect the difference (in

UTLight-transcranial Doppler Assessment of Regional Cerebral Autoregulation

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Cerebral autoregulation (CA) is a complex mechanism that serves the essential and vital purpose of controlling cerebral blood flow and metabolism. A stable and optimal brain blood flow is imperative for normal brain function; therefore normal function of CA is crucial for brain health. Diabetes

E-23596 - Use of NCPAP Cycling to Wean Preterm Infants

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Randomized Controlled Trial to Study the Effect of Nasal Continuous Positive Airway Pressure (NCPAP) Cycling on Successful Weaning when Compared with Continuous Nasal Positive Airway Pressure (NCPAP) in Premature Infants of 25-28 weeks gestations Background: In Canada, preterm babies of < 28 weeks

Physiological Study of Low-frequency HFO/HFO-TGI and High-frequency HFO

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Rationale of the study Acute Respiratory Distress Syndrome (ARDS) is an acute inflammatory state of the pulmonary parenchyma that causes hypoxemia, atelectasis, pulmonary congestion, and reduction in pulmonary compliance. Mechanical ventilation is actually life-saving, but it may traumatize the

High Frequency Oscillatory Ventilation for Acute Respiratory Distress Syndrome (ARDS)

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BACKGROUND AND RATIONALE Recent two-center results (1) support a beneficial effect of combined high-frequency oscillation (HFO), recruitment maneuvers (RMs) and tracheal gas insufflation (TGI) on the survival of patients with severe acute respiratory distress syndrome (ARDS). The addition of TGI to

Effect of Obstructive Sleep Apnea on Central Blood Pressure and Kidney and Endothelial Function

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Obstructive sleep apnea (OSA) is a frequently underdiagnosed condition that has emerged as an increasing medical problem with important social and financial implications worldwide. Its prevalence may reach 25% in middle-aged men and 11% in women. The most important risk factor for OSA is obesity -

The Obesity-hypoventilation Syndrome Study of Clinical Characteristics and Predictive Factors of Response to Treatment

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HYPOTHESIS: Patients with OHS may be characterized and differentiated from obese patients without associated respiratory pathology on the basis of clinical, functional and metabolic data. There is a close relation between OHS and OSAHS. It is important to define this relation more precisely because

Comparing Fluticasone-salmeterol in Chronic Obstructive Pulmonary Disease (COPD) and Sleep

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RATIONALE: Chronic obstructive pulmonary disease (COPD) is a term that describes a disease state in which there is chronic irreversible airflow limitation. It has been well documented that patients with COPD have disturbed sleep. Certain published reports suggest that more than 50% of COPD patients

Pilot Study to Assess Safety and Feasibility of Resuscitation of Preterm Infants With Controlled Volume of Air/Oxygen

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Design Randomized controlled pilot study. Setting: The study will be conducted at the Mount Sinai Hospital (MSH), Toronto which is a tertiary care teaching hospital in the Greater Toronto Area. Approximately 50-75 neonates <28 weeks' completed gestation are delivered at MSH per year. The institute

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