hypoventilation/nausea

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Preoperative Oral Methadone for Patients Undergoing Cardiac Surgery: Reduction of Postoperative Pain

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Investigators propose a prospective, randomized, double-blind, placebo-controlled trial to investigate the effects of preoperative oral methadone on postoperative pain. The trial will be conducted in compliance with the protocol, Good Clinical Practice (GCP), and University of Saskatchewan Research

Assessment of Immediate Adverse Reactions From Dotarem in Children Under 2 Years of Age

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Our primary outcome is to assess the safety of Dotarem in these patients up to 24 hours after Dotarem injection. The patients will be monitored in the hospital for at least 2 hours following the completion of the MRI exam. Many of these patients will have received sedation for the MRI and would be

Comparison of Remifentanil as a Sole Agent or in Combination With Midazolam Versus Fentanyl/Midazolam During Sedation for Colonoscopy

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A Prospective Randomized Comparative Study to Evaluate the Use of Remifentanil as a Sole Agent or in Combination with Midazolam Versus Fentanyl/Midazolam during Sedation for Colonoscopy. Background: Audits of patient experiences and studies on quality improvement for colonoscopy have shown that

CO2 Monitoring Study

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1. Aim of study 1.1 Background Opioids are an effective instrument for patients with acute and chronic pain. Their route of administration ranges from transdermal to subcutaneous application through to Intravenous Patient-Controlled Analgesia (IV-PCA). The use of IV-PCA-pumps has considerable

Oral Oxycodone After Major Cardiac Surgery

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The Effect of Choice of Intraoperative Opioid on Postoperative Pain

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Patients will be randomized to receive either methadone or fentanyl on the basis of a computer generated random number table. Patients in each group will receive standard intraoperative doses of either methadone or fentanyl that will allow for early tracheal extubation (within 4-8 hours of the

Comparing the Outcome of Two Intraoperative Analgesia Techniques After Hepato-pancreato-biliary Surgery

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BACKGROUND Inadequate pain control after abdominal procedures might result in increased morbidity, length of stay, and delay in overall recovery. Epidural analgesia is currently an accepted technique in major abdominal surgery [1-4]. Postoperative coagulation disturbances related to liver surgery,

Pharmacokinetics of Low Dose Ketamine Infusion

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Background: There has been an increasing awareness of the need for adequate sedation and analgesia in critically ill pediatric patients. The choices of treatment for pain are numerous, but in the Pediatric ICU parenteral opioids are most commonly used. At equipotent doses, all mu agonist opioids

Impact of Low Dose Naloxone on Fentanyl Requirements in Pediatric ICU Patients

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Objective: To determine if Naloxone administration to pediatric ICU patients on Fentanyl infusions require less Fentanyl compared to control patients. Background: During recent years there has been an increased awareness of the need for adequate sedation and analgesia of critically ill pediatric

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