iris/tyrosine

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BRCA1-IRIS inactivation sensitizes ovarian tumors to cisplatin.

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Ovarian cancer is the first in mortalities among gynecologic cancers in the United States, often due to late diagnosis and/or acquired platinum-resistant recurrences. This study investigates whether BRCA1-IRIS is a novel treatment target for ovarian cancers and in platinum-resistant recurrences.

The effect of sympathectomy upon iris tyrosinase activity.

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It is generally accepted that interruption of the sympathetic pathway to the eye may result in iris hypochromia in human infants. Weanling Dutch belted rabbits were used as a model system to investigate whether the melanin synthesizing enzyme, tyrosinase, is regulated in the iris of the juvenile

Immunohistochemical demonstration of neurotensin and tyrosine hydroxylase in iris nerves of the rabbit eye.

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In previous studies we have provided evidence that intracameral administration of neurotensin (NT), an endogenous tridecapeptide, produces strong miosis in the rabbit. The presence of NT immunoreactivity was investigated in rabbit iris whole mounts by light microscopic immunohistochemistry, and its

Serotonin-accumulating cells in the iris-ciliary body and cornea of various species.

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Serotonin was biochemically shown to be present in the iris-ciliary body of the frog, pigeon, goldfish and guinea-pig eyes at a concentration of between 55 and 95 ng per g. The aqueous fluid, in contrast, had no measurable serotonin, though a small amount of dopamine was present.

Appearance of the noradrenergic markers tyrosine hydroxylase and neuropeptide Y in cholinergic nerves of the iris following sympathectomy.

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Selective autonomic denervations of the iris have been used to study the possible redistribution of adrenergic markers within adult nerve fiber systems and to reveal the cellular origin of a nonsympathetic fiber plexus induced to express such markers. The presence and distribution of fibers showing

Tyrosine kinase inhibitors suppress prostaglandin F2alpha-induced phosphoinositide hydrolysis, Ca2+ elevation and contraction in iris sphincter smooth muscle.

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We investigated the effects of the protein tyrosine kinase inhibitors, genistein, tyrphostin 47, and herbimycin on prostaglandin F2alpha- and carbachol-induced inositol-1,4,5-trisphosphate (IP3) production, [Ca2+]i mobilization and contraction in cat iris sphincter smooth muscle. Prostaglandin

Control of the neurotoxicity of 6-hydroxydopamine by intraneuronal noradrenaline in rat iris.

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In vitro studies with the neurotoxic compounds 6-hydroxydopamine (6-OH-DA) and 6-aminodopamine (6-A-DA) showed that noradrenaline (NA) markedly inhibited the autooxidation of 6-OH-DA, but not of 6-A-DA. In vivo studies of the adrenergic nerves in rat iris showed that the neurotoxic potency of

Ultrastructural analysis of tyrosine hydroxylase-, substance P-, and calcitonin gene-related peptide-immunoreactive nerve fibers in the rat iris.

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Different patterns of distribution of chemically different nerve fibers in the rat iris were studied by immunoelectron microscopy. The iris was immunostained either singly for tyrosine hydroxylase (TH), or doubly for substance P (SP) and calcitonin gene-related peptide (CGRP), or triply for TH, SP

Protein expression of KIT, BRAF, GNA11, GNAQ and RASSF1 in feline diffuse iris melanomas.

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Feline iris melanoma, the most common feline intraocular tumour, has a reported metastatic rate of 19-63%. However, there is a lack of knowledge about its molecular biology. Previous studies have reported that feline iris melanomas do not harbour mutations comparable to common mutations found in

Prejunctional alpha 2-adrenoceptors and adenylyl cyclase regulation in the rabbit iris-ciliary body.

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Agents that elevate intracellular cyclic AMP (cAMP) have been found to enhance the synaptic discharge of norepinephrine (NE) from sympathetic nerve terminals in the rabbit iris-ciliary body and other peripheral tissues. We explored the hypothesis that prejunctional alpha 2-adrenergic receptors that

[An immunoelectron microscopic study of distribution and density of nerve fibers innervating the rat iris].

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We studied the sympathetic, parasympathetic and sensory nerve fibers in the rat iris using electron microscopic immunohistochemical techniques. Antibodies raised against tyrosine hydroxylase (TH), substance P (SP), and calcitonin gene-related peptide (CGRP) were used alone or combined together to

Uptake and accumulation of 3H-noradrenaline in adrenergic nerves of rat iris. Effect of reserpine, monoamine oxidase and tyrosine hydroxylase inhibition.

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Parasympathetic, sympathetic, and sensory interactions in the iris: nerve growth factor regulates cholinergic ciliary ganglion innervation in vivo.

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Interactions between peptidergic sensory nerves, noradrenergic sympathetic nerves, and cholinergic parasympathetic fibers were examined in the rat iris. The putative peptide neurotransmitter, substance P (SP), was used as an index of the trigeminal sensory innervation, tyrosine hydroxylase (TH)

PTP1B inhibitors from the seeds of Iris sanguinea and their insulin mimetic activities via AMPK and ACC phosphorylation.

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To find PTP1B inhibitors from natural products, two new compounds (1 and 2), along with nine known compounds (3-11), were isolated from a methanol-soluble extract of Iris sanguinea seeds. The structures of compounds 1 and 2 were determined based on extensive spectroscopic data analysis including UV,

Establishment of effective methods for transducing genes into iris pigment epithelial cells by using adeno-associated virus type 2.

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OBJECTIVE To establish an efficient method of transferring the human brain-derived neurotrophic-factor (hBDNF) gene into human iris pigment epithelial (hIPE) cells by using recombinant adeno-associated virus type 2 (rAAV2). METHODS Cultured hIPE cells were treated with either hydroxyurea-sodium

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