isorhapontigenin/inflammation

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Isorhapontigenin, a bioavailable dietary polyphenol, suppresses airway epithelial cell inflammation through a corticosteroid-independent mechanism.

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Chronic obstructive pulmonary disease (COPD) is a corticosteroid-resistant airway inflammatory condition. Resveratrol exhibits anti-inflammatory activities in COPD but has weak potency and poor pharmacokinetics. This study aimed to evaluate the potential of isorhapontigenin, another dietary

Isorhapontigenin Suppresses Interleukin-1β-Induced Inflammation and Cartilage Matrix Damage in Rat Chondrocytes.

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Osteoarthritis (OA) is a common cause of joint pain and physical disability in the elderly. It is highly associated with local inflammatory reactions and cartilage degradation. Isorhapontigenin (ISO), a natural compound existing in various plants, has shown prominent anti-inflammatory and

Biomimetic synthesis of active isorhapontigenin dimers.

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Synthetic isorhapontigenin was treated with several kinds of inorganic reagents and peroxidase so as to prepare active stilbene dimers. Among them, silver acetate in methanol gave two new isorhapontigenin dimers 4 and 5, together with four known natural stilbene dimers 2, 3, 6, and 7. Their

[Transport mechanism of isorhapontigenin based on human intestinal Caco-2 cells].

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Isorhapontigenin (ISO) is suggested to have many different kinds of pharmacology activities, such as anti-inflammatory effect, anti-oxidation effect and anti-cancer effect. This paper mainly discussed the transport mechanism of ISO in Caco-2 cell models. The concentration of ISO was determined by

An isorhapontigenin tetramer and a novel stilbene dimer from Gnetum hainanense.

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The first isorhapontigenin tetramer, gnetuhainin R (1) and a novel dimeric stilbene, gnetuhainin S (2) were isolated from the lianas of Gnetum hainanense. Their structures were elucidated on the basis of spectroscopic and chemical evidence, especially 2D NMR analysis. The structure of 2 was further

A Stilbenoid Isorhapontigenin as a Potential Anti-Cancer Agent against Breast Cancer through Inhibiting Sphingosine Kinases/Tubulin Stabilization.

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Isorhapontigenin (ISO), a tetrahydroxylated stilbenoid, is an analog of resveratrol (Rsv). The various biological activities of Rsv and its derivatives have been previously reported in the context of both cancer and inflammation. However, the anti-cancer effect of ISO against breast cancer has not

Cardioprotective effect of resveratrol analogue isorhapontigenin versus omega-3 fatty acids in isoproterenol-induced myocardial infarction in rats.

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Myocardial infarction (MI) is a common cause of mortality worldwide. Isorhapontigenin is a derivative of stilbene with chemical structure similar to resveratrol. The omega-3 fatty acids (FA) have beneficial effects on neurodegenerative, inflammatory, and cardiovascular diseases. The aim of this

Isorhapontigenin, a resveratrol analogue selectively inhibits ADP-stimulated platelet activation.

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Isorhapontigenin is a polyphenolic compound found in Chinese herbs and grapes. It is a methoxylated analogue of a stilbenoid, resveratrol, which is well-known for its various beneficial effects including anti-platelet activity. Isorhapontigenin possesses greater oral bioavailability than resveratrol

Isorhapontigenin Improves Diabetes in Mice via Regulating the Activity and Stability of PPARγ in Adipocytes.

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Isorhapontigenin is a natural bioactive stilbene isolated from various plants and fruits. It has been reported to exhibit several physiological activities including anti-cancer and anti-inflammation in vitro and in experimental animal models. This study aimed to investigate whether isorhapontigenin

A new resveratrol trimer derivative from Gnetum brunonianum.

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A new resveratrol trimer derivative, named as gnetubrunol A (1), together with five known stilbene derivatives, shegansu B (2), resveratrol (3), isorhapontigenin (4), gnetifolin E (5), and isorhapontigenin-11-O-β-d-glucopyranoside (6) were isolated from the lianas of Gnetum brunonianum Griff. Their

Antioxidant Activity of Selected Stilbenoid Derivatives in a Cellular Model System.

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The stilbenoids, a group of naturally occurring phenolic compounds, are found in a variety of plants, including some berries that are used as food or for medicinal purposes. They are known to be beneficial for human health as anti-inflammatory, chemopreventive, and antioxidative agents. We have

Stilbenoids from the lianas of Gnetum pendulum.

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The first new isorhapontigenin dimer glucoside gnetupendin D (1) and a stilbene dimer coupled by a resveratrol and an oxyresveratrol with a cis-dihydrobenzofuran were obtained from the lianas of Gnetum pendulum C. Y. Cheng (Gnetaceae), along with nine known compounds. Their structures and

Optimization of Bioactive Polyphenols Extraction from Picea Mariana Bark.

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Reported for its antioxidant, anti-inflammatory and non-toxicity properties, the hot water extract of Picea mariana bark was demonstrated to contain highly valuable bioactive polyphenols. In order to improve the recovery of these molecules, an optimization of the extraction was performed using

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