karwinskia/asthenia

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Buckthorn neuropathy: effects of intraneural injection of Karwinskia humboldtiana toxins.

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Ingestion of the endocarp of the coyotillo fruit, Karwinskia humboldtiana, a shrub of the buckthorn family, causes "Buckthorn neuropathy" in man and animals. Two neurotoxic compounds T496 and T544 were isolated from the endocarp and each toxin was dissolved in sesame oil and injected into the

Experimental intoxication with fruit and purified toxins of buckthorn (Karwinskia humboldtiana).

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To determine the extent of extraneural lesions in buckthorn poisoning, 180 CD1 mice were administered either green or ripe fruit or toxins T-544 or T-514 obtained from the fruit of the plant and were observed over a period of three weeks. Marked weakness, hyporeflexia, hair bristling, ptosis, spinal

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